EPIDEMIOLOGICAL STUDY OF PERIORBITAL HYPERMELANOSIS

Background: Periorbital hypermelanosis also called dark circles form the major percentage of dermatology consultations. Importance of these disorders is growing as they cause easy visible cosmetic disfigurement and significant psychosocial consequences. Aims: To assess the patients of POH disorders for demographic, etiological and clinical profile. Methods: This prospective hospital-based clinical study, conducted in a tertiary medical center over a period of two years, involved 200 patients with POH disorders, assessed using detailed history taking and clinical examination for demographic, etiological and clinical data. Data is statistically described in frequencies (number of cases) and percentages(%) . Results: Majority of patients were in age group 18-40 years. Females dominated the study with a number of 169 (84.5%) , only 31 (15.5%) were males. Most of the patients belonged to Grade 2 (53%), grade 3 was seen in 27% patients followed by grade 1 (16.5% ) and grade 4 (3.5% ) POH. Family history was positive in 81.5% patients. POH was observed mostly in housewives 93 (46.5%) and patients with indoor occupation 69 (34.5%) and less commonly in patients with outdoor occupation 29 (14.5%). Almost all cases of POH gave history of exacerbation following sun exposure. Not a single patient showed hepatic, renal complaints, hypothyroidism or ecchymosis. Majority of patients (86.5%) had altered Sleeping habits. Alcohol and smoking did not have a significant co-relation with POH. It was found that only five percent females on oral contraceptives developed POH and there was no change in Pigmentation of POH in relation to menstrual cycle in any of the females. Limitations: The quantitative assessment of melanin by specialized instrument ( mexameter) could not be done because of lack of resources.

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Infective Endocarditis in a ?-thalassemia Major Child

Cardiovascular Journal ◽

10.3329/cardio.v7i2.22263 ◽

2015 ◽

Vol 7 (2) ◽

pp. 145-149

Author(s):

Sri Endah Rahayuningsih ◽

Rahmat Budi Kuswiyanto ◽

Herdiana Elizabeth Situmorang ◽

Evelyn Phangkawira

Keyword(s):

Infective Endocarditis ◽

Tricuspid Valve ◽

Heart Defects ◽

Good Condition ◽

Left Lung ◽

Thalassemia Major ◽

Sternal Border ◽

History Of ◽

Grade 3 ◽

Almost All

Almost all patients who develop infective endocarditis (IE) had history of congenital or acquired heart disease.We report a 9 years old boy who was diagnosed as ?-thalassemia major since age 1.5 years, admitted to hospital with chief complaint of difficulty of breathing for 1 week before admission, accompanied by fever. Holosystolic murmur of grade 3/6 was found in the lower left sternal border along with hepatosplenomegaly. Chest x-ray depicted right ventricle enlargement and opaque densities in the middle field of left lung. Blood culture showed growth of Staphylococcus aureus. Echocardiography detected thickening tricuspid valve with oscillating mass in the tricuspid valve, severe pulmonary hypertension, and minimal pericardial effusion. Diagnosis of IE was made. After clinical improvement he was discharged with good condition. The diagnosis of IE in children without heart defects is difficult to establish and right-sided IE is rare in children that a high suspicion index should be considered. DOI: http://dx.doi.org/10.3329/cardio.v7i2.22263 Cardiovasc. j. 2015; 7(2): 145-149

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Anesthetic and Surgical Difficulties of Substernal Goiters: A Series of 16 Cases

Advances in Thoracic Diseases ◽

10.15342/atd.v1ir.205 ◽

2019 ◽

Vol 1 (2) ◽

Author(s):

Akram Traibi ◽

Sarah Kettani ◽

Aziz Ouarssani ◽

Moulay Ahmed Hachimi

Keyword(s):

Medical Records ◽

Demographic Characteristics ◽

Age Group ◽

Single Patient ◽

Average Hospital Stay ◽

Average Hospital ◽

Substernal Goiter ◽

Surgical History ◽

Almost All ◽

Preoperative Examination

Introduction: Haller first described substernal goiter in 1749. Authors report different definitions, but the most commonly used defines substernal goiter as a goiter that does not sit in the neck in the operating position and has a lower extensionto more than two fingers breadth under the manubrium.The aim of our work is to highlight the peri operative anesthetic and surgical difficulties within substernal goiters' care.Materials and methods: This is a retrospective study conducted in both anesthesiology and thoracic surgery departments in Moulay Ismail hospital in Meknes over a period of three years from January 2013 to December 2015. This study has been based on the medical records of all patients operated for substernal goiter. The data investigated were: demographic characteristics, medical and surgical history, Mallampati and intubation difficulties, surgical approach and finally the intraoperative and post operative complications.Results: The average age of our patients was 61.5 years with extremes ranging from 34 to 83 years old. The most affected age group was between 50 and 70 years old, 9 out of 56 cases. The sex ratio was 1.5, 10 women and 6 men. The approach was anterior cervicotomy, with total thyroidectomy, in almost all patients. A thoracotomy decided from the outset for a single patient with goiter missed in endothoracic after thyroid surgery. The evolution was favorable in 16 patients of our series. Redon drains were removed 48 to 72 hours after surgery and the average hospital stay was five days.Conclusion: The substernal goiter care is easier if a full preoperative examination is made, allowing the anticipation of eventual anesthetic and surgical difficulties.

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Clinical and etiopathological aspects of muscle and joint sports injuries

ARS Medica Tomitana ◽

10.2478/v10307-012-0033-7 ◽

2012 ◽

Vol 18 (4) ◽

pp. 179-183

Author(s):

I. Moldovan ◽

S. Mureşan ◽

S. T. Pop ◽

C. Trimbitas ◽

D.M. Iliescu ◽

...

Keyword(s):

Sports Injuries ◽

Medical Center ◽

Knee Injuries ◽

Body Part ◽

Body Parts ◽

Age Group ◽

Muscle Injuries ◽

Ligament Injuries ◽

Almost All ◽

Different Levels

Abstract This descriptive study was conducted on a group of 92 patients during January 2012 - December 2012, treated at the Sports Rehabilitation Department of NOVA VITA Medical Center, Tîrgu Mures. We investigated the incidence of muscle and joint injuries by age group, gender, region of the injured muscle and joint, type of sport. Football is the main sport practiced at a professional level, thus the leg is the most exposed body part to diseases at different levels and degrees, especially the ankle, knee and thigh with muscle damage and ligament injuries. Playing tennis at an amateur level can harm body parts like the shoulder and the elbow and can cause tendon and muscle injuries. The most affected region is the knee. Knee injuries are present in almost all sports. Nearly 40% of the injuries are ligament injuries.

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A clinico-epidemiological study of melasma

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20184457 ◽

2018 ◽

Vol 4 (4) ◽

pp. 539

Author(s):

Akshy Kumar ◽

Mukul Sharma

Keyword(s):

Positive Family History ◽

Sun Exposure ◽

Cross Sectional Study ◽

Age Group ◽

Cross Sectional ◽

Oral Contraceptive Pills ◽

Medical College ◽

Contraceptive Pills ◽

History Of ◽

One Year

Background: Melasma is an acquired increased pigmentation of the skin, characterized by gray-brown symmetrical patches, mostly in the sun-exposed areas of the skin.Methods: The proposed study is an epidemiological cross sectional study which was carried out in the department of dermatology in a teaching institute from October 2007 to September 2008 at Pramukh Swami Medical College, Karamsad, Gujarat. A total of 60 patients were enrolled for the study over a period of one year.Results: The main age group affected was 30-39 years i.e. 48.33% patients. 50 patients were females.18 patients had a positive family history of melasma. 12 patients had a positive history of using OC Pills. Malar region was the commonest affected area found in 52 patients followed by Centro-facial in 31 and least involvement was seen in forehead region in 24 patients. 20 patients reported association of occurrence of the lesions with pregnancy, 09 patients reported sunlight to be the offending agent.Conclusions: Females were affected more commonly during their late third decade of life. Although we did not find the exact cause of melasma, we noticed that sun-exposure, pregnancy, and taking of oral contraceptive pills could precipitate or exacerbate the melasma.

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Epidemiological study and cervical cancer screening by pap smear in Delhi

Journal of Preventive Medicine and Holistic Health ◽

10.18231/j.jpmhh.2021.017 ◽

2021 ◽

Vol 7 (2) ◽

pp. 84-88

Author(s):

Paras Wani ◽

Urmila Bhardwaj ◽

Ayesha Raza

Keyword(s):

Cervical Cancer ◽

Demographic Characteristic ◽

Pap Smear ◽

Educational Status ◽

Sexually Active ◽

Age Group ◽

Normal Cervix ◽

History Of ◽

Almost All ◽

Epidemiological Characteristics

To study the epidemiological characteristics of cervical cancer in Delhi. With this background we intended to find out the epidemiological characteristics associated with cervical cancer and screening of participants by pap smear. Pap smear were conducted and detail socio demographic records were obtained and details of demographic characteristic and other risk factors were noted. A total of 98 participants were evaluated of which 76.5% of women were in the age group of 30-40 years, By educational status about 46.94% were illiterate. Forty seven percent of the study subjects had a history of abortion. More than half of the study subjects (60.5%) had history of induced abortion in non-licensed clinics (70%). More than half of the study subjects (62%) were sexually active before 15 years of age and almost all the study subjects were sexually active by 18 years of age. Almost one third of the subjects did not Two third of the subjects (72%) among those using contraceptives used IUD and Tubal ligation use any contraceptive method. Thirty eight percent of the study subjects had normal cervix on per speculum examination and 40 % had cervical erosion.8.2% participants tested positive to pap smear.

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Pseudotumor cerebri secondary to secondary hypoparathyroidism and association to Fahr´s yndrome: a case report

Headache Medicine ◽

10.48208/headachemed.2020.19 ◽

2020 ◽

pp. 68-71

Author(s):

Patrick Giordanni Gomes Sampaio ◽

Hiago Diniz Maracajá ◽

Francielle Lopes de Araújo Batista ◽

Virgínia Gabriela Nóbrega Figueiredo ◽

Nátalia Meg Adijuto de Melo

Keyword(s):

Case Report ◽

Clinical Presentation ◽

Nodular Goiter ◽

Signs And Symptoms ◽

Pseudotumor Cerebri ◽

Horizontal Position ◽

History Of ◽

Grade 3 ◽

Orthostatic Position ◽

Almost All

Introduction Headaches are extremely common complications in emergency departments, accounting for up to 16% of visits, according to some studies and are observed in almost all patients with Idiopathic Intracranial Hypertension (IIH), which is characterized by signs and symptoms that include, in addition to headache, nausea, vomiting, diplopia, decreased visual acuity, pulsatile tinnitus, back and neck pain, among other possible manifestations. However, the clinical presentation is highly variable, which can delay diagnosis. Case report A.T.F, female, 33 years old, BMI 40.17 kg / m², with grade 3 obesity, caucasian, single, with Down Syndrome. Presents a history of post-surgical hypothyroidism, whose thyroidectomy was performed 10 years ago, due to nodular goiter. This patient presented subacute nausea, visual turbidity, diarrhea and pulsatile holocranial headache, which worsened in the horizontal position and presented slight relief in the orthostatic position. Conclusion The conduct of Fahrs Syndrome, in this case, was focused on the treatment of hypoparathyroidism and which consists of correcting metabolism disorders of phosphorus and calcium, which naturally resulted in clinical and radiological improvement, however, without definitive resolution of the condition.

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Study of profile of polymorphous light eruption at a tertiary referral center

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20175702 ◽

2018 ◽

Vol 4 (1) ◽

pp. 75

Author(s):

Amruta A. Kulkarni ◽

Yoganand J. Phulari

Keyword(s):

Family History ◽

Sun Exposure ◽

Working Environment ◽

Common Symptom ◽

Age Group ◽

Tertiary Referral ◽

Tertiary Referral Center ◽

Polymorphous Light Eruption ◽

Number Of Patients ◽

History Of

Background: Polymorphous light eruption (PMLE) is the most common endogenous photodermatosis.But only few studies are available from India regarding this photodermatosis. It is common in women, often worse in spring. The lesions are usually monomorphous in an individual patient but polymorphic in different patients.Methods: The study was conducted between October 2010 and March 2012. 78 patients with clinical diagnosis of PMLE, who attended Dermatology OPD at Dr. D. Y. Patil Hospital and Research Institute, Kolhapur were included in present study. Detailed history, clinical examination and relevant investigations were done. The collected data were tabulated and analyzed.Results: The age group of the patients ranged from 3 years to 58 years. Maximum number of patients were seen in the age group of 21-30 years. The female to male ratio was found to be 1.78:1.Onset of PMLE lesions was maximum in the month of March. Majority of patients were housewives. Itching was the most common symptom. In 32.05% of patients, lesions developed within 30 minutes of sun exposure. Family history of PMLE was present in 6 (7.69%) cases. Conclusions: PMLE was found most commonly in second and third decades of life since people in this age group are more exposed to sun, more in women probably because of hormonal differences.The maximum number of cases was noted in the month of March when the sun exposure is high. The maximum cases in housewives, as they have short intermittent sun exposure and absence of hardening phenomenon. Higher incidence was noted with cotton clothing as it has lower UV protection. Most of the patients developed lesions within 30 minutes of sun exposure. History of recurrence of PMLE was noted in 30 patients. Only 6 patients gave family history of PMLE because of milder nature of the disease along with difference in clothing and working environment.

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Hereditary Heparin Cofactor II Deficiency and the Risk of Development of Thrombosis

Thrombosis and Haemostasis ◽

10.1055/s-0038-1651093 ◽

1987 ◽

Vol 57 (02) ◽

pp. 196-200 ◽

Cited By ~ 74

Author(s):

R M Bertina ◽

I K van der Linden ◽

L Engesser ◽

H P Muller ◽

E J P Brommer

Keyword(s):

Liver Disease ◽

Venous Thrombosis ◽

Healthy Volunteers ◽

Mean Value ◽

Age Group ◽

Normal Range ◽

Heparin Cofactor Ii ◽

History Of ◽

Group 2 ◽

Hereditary Nature

SummaryHeparin cofactor II (HC II) levels were measured by electroimmunoassay in healthy volunteers, and patients with liver disease, DIC, proteinuria or a history of venous thrombosis. Analysis of the data in 107 healthy volunteers revealed that plasma HC II increases with age (at least between 20 and 50 years). HC II was found to be decreased in most patients with liver disease (mean value: 43%) and only in some patients with DIC. Elevated levels were found in patients with proteinuria (mean value 145%). In 277 patients with a history of unexplained venous thrombosis three patients were identified with a HC II below the lower limit of the normal range (60%). Family studies demonstrated hereditary HC II deficiency in two cases. Among the 9 heterozygotes for HC II deficiency only one patient had a well documented history of unexplained thrombosis. Therefore the question was raised whether heterozygotes for HC II deficiency can also be found among healthy volunteers. When defining a group of individuals suspected of HC II deficiency as those who have a 90% probability that their plasma HC II is below the 95% tolerance limits of the normal distribution in the relevant age group, 2 suspected HC II deficiencies were identified among the healthy volunteers. In one case the hereditary nature of the defect could be established.It is concluded that hereditary HC II deficiency is as prevalent among healthy volunteers as in patients with thrombotic disease. Further it is unlikely that heterozygosity for HC II deficiency in itself is a risk factor for the development of venous thrombosis.

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From the Tower of London to the Thomas More Society of Buenos Aires: “Give me thy grace, good Lord, to set the world at nought”

Moreana ◽

10.3366/more.2005.42.4.13 ◽

2005 ◽

Vol 42 (Number 164) (4) ◽

pp. 187-206

Author(s):

Clare M. Murphy

Keyword(s):

Buenos Aires ◽

Short History ◽

Thomas More ◽

Tower Of London ◽

Hebrew Poetry ◽

Prayer Book ◽

The World ◽

History Of ◽

Book Of Hours ◽

Almost All

The Thomas More Society of Buenos Aires begins or ends almost all its events by reciting in both English and Spanish a prayer written by More in the margins of his Book of Hours probably while he was a prisoner in the Tower of London. After a short history of what is called Thomas More’s Prayer Book, the author studies the prayer as a poem written in the form of a psalm according to the structure of Hebrew poetry, and looks at the poem’s content as a psalm of lament.

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Breast carcinoma in young females below the age of 35 years - histopathological and prognostic significance

Journal of Pathology of Nepal ◽

10.3126/jpn.v2i3.6021 ◽

1970 ◽

Vol 2 (3) ◽

pp. 198-202

Author(s):

D Ghartimagar ◽

A Ghosh ◽

OP Talwar ◽

R Narasimhan

Keyword(s):

Breast Carcinoma ◽

Young Women ◽

Early Stage ◽

Prognostic Significance ◽

Age Group ◽

Breast Cancers ◽

Young Females ◽

Younger Age ◽

Grade 3 ◽

Group Grade

Background: Breast cancers rarely occur in young women but are known to have more aggressive behaviors and poorer outcome. We here compare the significance of breast carcinoma in female below the age of 35 to the age over 35 whose specimens were submitted to Manipal teaching hospital, Pokhara. Materials and Methods: All cases of mastectomy with carcinoma from January 2000 to September 2011 were included in the study. Clinical and histopathological datas of all cases were reviewed and collated. Results: A total of 148 mastectomy specimens were received, among which, 23 cases (16%) were below 35 years; whereas 125 cases (84%) were above 35 years of age. In both groups, Stage II was the commonest stage but stage III was much more common in older group (33% versus 9%) and stage I was more common in younger age group (39% versus 27%). Bloom Richardson grading showed that in the older age group, grade 1 is the commonest grade (50%) while in the younger group; grade 3 is the commonest (39%). Patients were followed for a varying period of 6 months to 5 years. Two cases (2% of followed up cases) in older group and 3 cases (15% of followed up cases) in the younger group showed recurrence. Conclusion: Breast carcinoma in the patients younger than 35 years though presented at an early stage has higher grade tumor and poorer outcome. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6021 JPN 2012; 2(3): 198-202

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