scholarly journals UJI AKTIVITAS ANTIULCER AIR ALKALI TERIONISASI PADA MENCIT PUTIH JANTAN (MUS MUSCULUS)

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Adriyan Suhada ◽  
Bq. Fitria Maharani ◽  
Ni Komang Wijiani Yanti ◽  
Nur'aini Nur'aini
Keyword(s):  
Mus Musculus ◽  
Mucosal Damage ◽  
Positive Control ◽  
Negative Control ◽  
Gastric Mucosal Damage ◽  
Group Vi ◽  
Alkaline Water ◽  
Water Group ◽  
Group I ◽  
Water Ph

Alkaline water is water that has antioxidant content and has a structure that is rich in active hydrogen that can cure stomach ulcers. The purpose of this study was to determine the effectiveness of ionized alkaline water as an antiulcers in male white mice (mus musculus). Method of induction of gastric ulcer using aspirin, used as many as 24 male mice (mus musculus) aged 2-3 months used as mice test animals divided into 6 groups each group consisting of 3 animals all groups were given ulcer treatment for 7 days, then group I (negative control) were given aquadest group II (positive control) were given sucralfate, group III were given ph 8 alkaline water group IV was given ph 9.0 alkaline water, group V was given ph 9.5 alkaline water, and group VI was given alkaline water pH 11.5 treatment of each group for the next 7 days on the 14th day the mice were dissected and the gastric mucosa structure was observed and the mucosal damage value was determined. The results showed that alkaline water 9.5 and 11.5 had lower mucosal damage values than negative controls. It can be concluded that the alkaline water ph 9.5 and 11.5 are said to be effective in reducing gastric mucosal damage compared to the negative group given aquadest.

scholarly journals Comparative Evaluation of Apical Sealing Ability of Different Obturation Techniques by Confocal Microscopy: An In Vitro Study

2020 ◽  
Vol 8 (02) ◽  
pp. 55-59
Author(s):  
Reetu Arora ◽  
Yogesh Kumar ◽  
Neetu Jindal ◽  
Renu Aggarwal ◽  
Kavneet Takhar
Keyword(s):  
Root Canal ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Group Iv ◽  
Control Group ◽  
Group Vi ◽  
Group V ◽  
Group Iii ◽  
Group I

Abstract Introduction The aim of obturation in the root canal is to completely seal the canal space to eliminate all the portals of entry and exit between root canal and periodontal space. Various techniques have been developed to achieve a hermetic seal. Materials and Methods As many as 150 extracted human maxillary central incisors were taken for the study. Biomechanical preparation was done up to F5 protaper file. According to different obturation techniques, samples were divided into six groups, keeping 30 samples in experimental and 15 samples in control groups. Group I–Lateral Condensation, Group II–Thermafil, Group III–Beefill, Group IV–GuttaFlow, Group V–Positive Control group, Group VI–Negative Control group. After obturation, the samples were immersed in 2% Rhodamine-B dye for 24 hours. Each sample was longitudinally sectioned to examine under confocal laser scanning microscope. Statistical Analysis The results were evaluated with ANOVA and posthoc Tukey honest significant difference (HSD) comparison test. Results The mean values of dye penetration of different groups were Group I (Lateral Condensation) 1.51 ± 0.451, Group II (Thermafil) 0.918 ± 0.399, Group III (Beefill) 1.30 ± 0.559. Group IV (GuttaFlow) 0.655 ± 0.396, Group V (Positive Control group) 1.96 ±0.046, Group VI (Negative Control group) 0 ± 0. The lowest mean value of apical microleakage was found in GuttaFlow amongst all experimental groups. Conclusion It can be concluded that the GuttaFlow obturating material exhibited better apical sealing ability with canal walls.

scholarly journals PAPARAN EKSTRAK TERIPANG PASIR (Holothuria scabra) TERHADAP GAMBARAN HISTOPATOLOGI HATI MENCIT (Mus musculus)

2016 ◽  
Vol 2 (2) ◽  
pp. 160-169
Author(s):  
Yosep Matruty ◽  
Theopilus Watuguly
Keyword(s):  
Mus Musculus ◽  
Sea Cucumber ◽  
Normal Liver ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Holothuria Scabra ◽  
Liver Histopathology ◽  
Group I

Background: In Indonesia, traditionally sea cucumber (Holothuria scabra) is often used as a cure gout. The purpose of the research is to determine the effects of sea cucumber (Holothuria scabra) extracts against liver histopathology picture mice (Mus musculus). Method: Mice used were male mice as much as 15 tails and were divided into 5 groups. Each group consisted of three mice. Group I as a positive control given allopurino l0.1%. The second group was given distilled water as a negative control. Group III, IV and V as the treatment group was given sea cucumber extract with each concentration of 5%, a concentration of 10% and 15% concentration. Result: The results were analyzed quantitatively, showed that the administration of potassium bromate showed the presence of fatty and necrosis. But after being given a sea cucumber extract with a concentration of 10% and a concentration of 15% still showed the presence of inflammatory cells and remnants of fatty liver (same as the picture of liver histopathology in the positive control). At a concentration of 5% normal liver histopathology same as the picture of liver histopathology in the negative control. Conclution: Sea cucumbers with a concentration of 5% can be used as a gout medicine without any side effects for conditions onal liver function.

scholarly journals HEPATOPROTECTIVE ACTIVITY COMBINATION OF CURANGA FEL-TERRAE LOUR LEAVES AND CURCUMA HEYNEANA VALETON AND ZIJP RHIZOME IN RAT INDUCED BY COMBINATION OF RIFAMPIN AND ISONIAZID

2017 ◽  
Vol 9 (5) ◽  
pp. 23
Author(s):  
Marianne . ◽  
Jessy Chrestella ◽  
Maria Andriani Ginting ◽  
Aminah Dalimunthe ◽  
Rosnani Nasution
Keyword(s):  
Normal Control ◽  
Hepatoprotective Activity ◽  
Positive Control ◽  
Negative Control ◽  
The Body ◽  
Group Vi ◽  
Group V ◽  
Treatment Groups ◽  
Group I ◽  
Male Wistar Rats

Objective: The liver is a vital organ in the body, it is often exposured to the xenobiotics that can cause injury. Pugun tano (Curanga fel-terrae) and temu giring (Curcuma heyneana) are plants that have been claimed to cure many ailments including protecting the liver. But the hepatoprotective properties of the combination of these plants has not been well studied. In this regard, the current study was undertaken to evaluate the activity combination of those plants.Methods: The male Wistar rats were divided into 6 groups, group I was a negative control (CMC-Na); group II-IV were the treatment groups and were given combination extracts at the doses of 50 mg/kg, 75 mg/kg and 100 mg/kg respectively; group V was positive control (catechin) and group VI was normal control. All of groups except group VI were given combination rifampin 100 mg/kg and isoniazid 50 mg/kg for 15 d along with administration of extracts. At the day 16, rats were sacrificed. Histopathology of the liver and biochemical assay of blood was done at the end of the administration.Results: The administration of the combination of C. fel-terrae and C. heyneana at the doses of 75 and 100 mg/kg significantly inhibited the elevation of aspartate aminotransferase (AST) and alanine transaminase (ALT) compared to negative control (p<0.05). Histopathological assessment of the liver was comparable to the normal control (p>0.05).Conclusion: The combination of C. fel-terrae and C. heyneana at the dose of 75 and 100 mg/kg is able to protect the liver from damage induced by rifampin and isoniazid.

scholarly journals UJI EFEK ANALGESIK EKSTRAK ETANOL KELOPAK BUNGA MATAHARI (Helianthus annuus Linn.) PADA MENCIT SWISS (Mus musculus)

2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Citra R. Irianty ◽  
Jimmy Posangi ◽  
P. M. Wowor
Keyword(s):  
Helianthus Annuus ◽  
Mus Musculus ◽  
Analgesic Effect ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Group Iii ◽  
Helianthus Annuus L ◽  
Swiss Mice ◽  
Group I

Abstrak: Penggunaan tanaman obat semakin berkembang luas di masyarakat, salah satunya yaitu bunga matahari (Helianthus annuus L.). Tumbuhan ini dipercaya memiliki berbagai khasiat, diantaranya sebagai analgesik. Penelitian ini bertujuan untuk mengetahui efek analgesik dari ekstrak etanol kelopak bunga matahari (Helianthus annuus L.) pada mencit Swiss (Mus musculus). Penelitian ini merupakan penelitian eksperimental dengan menggunakan metode rangsangan panas berupa suhu 55°C. Pada penelitian ini digunakan hewan uji berupa mencit jantan yang dibagi dalam 3 kelompok masing-masing terdiri dari 3 ekor. Kelompok I kontrol negatif diberi Aquades 0,3 ml, kelompok II kontrol positif diberi Tramadol 0,18 mg/20grBB mencit dan kelompok III perlakuan diberi ekstrak etanol kelopak bunga matahari 0,3 ml untuk tiap mencit. Penelitian dilakukan selama 1 menit dengan menilai respon mencit berupa meloncat dan atau menjilat kakinya sebagai reaksi untuk mengurangi nyeri. Dari hasil percobaaan dengan pemberian rangsang panas berupa suhu 55°C menunjukkan bahwa respon mencit yang diberikan 0,3 ml ekstrak etanol kelopak bunga matahari, mulai menurun di menit ke-30 dan mencapai maksimal pada menit ke-90. Dari hasil penelitian ini didapatkan bahwa ekstrak etanol kelopak bunga matahari (Helianthus annuus L.) memiliki efek analgesik terhadap mencit Swiss.     Abstract: Sunflower (Helianthus annuus L.) is one of medical herbs where the use of medical plants is getting growth on social community. Those plants believed has many efficacious, one of them was as  analgesic. The aim of this research is to know the analgesic effect of ethanol extract of sunflowers petals (Helianthus annuus L.) in Swiss mice (Mus musculus). This study is an experimental study using heat stimuli of 55°C. This study used male mice which were divided into 3 groups each consisting of three mice. Group I was given distilled water and act as negative control which were given 0,3 ml, group II as positive control were given  0,18 mg/20grBB mice of Tramadol and the group III were given sunflower petals ethanol extract of 0,3 ml. An observation was carried out for 1 minute with expexted response being jumping and licking as a reaction to reduce pain. Results obtained by appling heat stimuli in the temperature of 55°C showed that sunflower petals ethanol extract in the dosase of 0,3 ml of ethanol extract sunflowers petals, start to decline in the 30th minute and reached a maximum in the 90th minute. From the result of this study found that ethanol extract of sunflower petals (Helianthus annuus L.) has an analgesic effect on Swiss mice.

scholarly journals UJI EFEK ANALGESIK EKSTRAK ETANOL BUAH MENGKUDU (Morinda citrifolia L.) PADA MENCIT (Mus musculus)

2013 ◽  
Vol 1 (2) ◽  
Author(s):  
Randy Nicholas Lesiasel
Keyword(s):  
Treatment Group ◽  
Medicinal Plants ◽  
Mus Musculus ◽  
Analgesic Effect ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Morinda Citrifolia ◽  
Laboratory Animals ◽  
Group I

Abstract: Population Indonesia has long been known and used medicinal plants in effort to cope with health problems. Noni plant (Morinda citrifolia L.) is included in the medicinal plants that have been used for traditional medicine in Indonesia, one of them as analgesic. According Younos et al. (1990), noni extract has analgesic effect. Xeronine compound of the noni fruit is suspected to have an analgesic effect. The purpose of this study whether there analgesic effect of ethanol extract of noni fruit (Morinda citrifolia L.) in mice (Mus musculus). This study is an experimental study using heat stimuli such as temperature of 55˚C. This study used laboratory animals such as female mice which were divided into five groups, each consisting of three mices. Group I as negative control was given 0.4 ml of distilled water, group II as positive control was given paracetamol 1000mg/50kgBB, group III as treatment group was given ethanol extract of noni fruit 200mg/kgBB, group IV as treatment group was given ethanol extract of noni fruit 400mg/kgBB and group V as treatment group was given ethanol extract of noni fruit 800mg/kgBB. An observation was carried out for one minute with the expected response being jumping and licking its feet as a reaction to reduce the pain. From the experimental results by providing heat stimuli such as temperature of 55˚C showed that the response of mice decreased in all thre treatment groups compared with the positive control which was given paracetamol.The ethanol extract of noni fruit(Morinda citrifolia L.) has an analgesic effect on mice (Mus musculus). Keywords: Analgesic, Noni fruit (Morinda citrifolia L.), Paracetamol.     Abstrak: Penduduk Indonesia telah lama mengenal dan menggunakan tanaman berkhasiat obat sebagai salah satu upaya dalam menanggulangi masalah kesehatan. Tanaman mengkudu (Morinda citrifolia L.) termasuk dalam tumbuhan obat yang sudah dimanfaatkan untuk pengobatan tradisional di Indonesia salah satunya sebagai analgesik. Menurut Younos et al. (1990), ekstrak mengkudu mempunyai efek analgesik. Senyawa xeronine yang terdapat pada buah mengkudu diduga mempunyai efek analgesik. Tujuan penelitian ini ialah mengetahui ada tidaknya efek analgesik dari ekstrak etanol buah mengkudu (Morinda citrifolia L.) pada mencit (Mus musculus).Penelitian ini ialah penelitian eksperimental dengan menggunakan metode rangsang panas berupa suhu 55˚C. Pada penelitian ini digunakan hewan uji berupa mencit betina yang dibagi dalam lima kelompok masing-masing terdiri dari tiga ekor. Kelompok I kelompok negatif diberi aquades 0,4 ml, kelompok II kelompok positif diberi parasetamol 1000mg/50kgBB, kelompok III kelompok perlakuan diberi ekstrak etanol buah mengkudu 200mg/kgBB, kelompok IV kelompok perlakuan diberi ekstrak etanol buah mengkudu 400mg/kgBB dan kelompok V kelompok perlakuan diberi ekstrak etanol buah mengkudu 800mg/kgBB. Penilaian dilakukan selama satu menit dengan menilai respon mencit berupa melompat dan atau menjilat kakinya sebagai reaksi untuk mengurangi nyeri.Dari hasil percobaan dengan pemberian rangsang panas berupa suhu 55˚C menunjukkan bahwa respon mencit pada ketiga kelompok perlakuan menurun dibandingkan dengan kontrol positif yang diberi parasetamol.Ekstrak etanol buah mengkudu  (Morinda citrifolia L.) memiliki efek analgesik terhadap mencit (Mus musculus). Kata kunci: Analgesik, Buah mengkudu (Morinda citrifolia L.), Parasetamol.

scholarly journals Uji Efek Stimulansia Ekstrak Etil Asetat Kulit Kayu Akway (Drymis piperita) Asal Papua Pada Tikus (Ratus norvegicus) Jantan

2020 ◽  
Vol 12 (1) ◽  
pp. 37-42
Author(s):  
Rani D. Pratiwi ◽  
Eva S. Simaremare
Keyword(s):  
Body Weight ◽  
Treatment Group ◽  
Research Result ◽  
Stem Bark ◽  
Positive Control ◽  
Negative Control ◽  
The Body ◽  
Group Vi ◽  
Group I ◽  
Significant Difference

Drymis sp. stem bark from Papua widely utilized by local people especially in Sougb Tribe from Sururey Distric Pegunungan Arfak West Papua, one of them is used to increase the stamina of the body. The aim of this study was to investigate the tonic effect of Drymis sp. stem bark of Ratus norvegicus. Ratatory exhaustion method was used to the tonic effect. Selected rats (30) were divided into 6 groups, each consisting of 5 rats. Tested extract was administrated oraly one dose to the rats. Group I, II and III was given the ethil acetat fraction of Drymis sp. stem bark 10mg/kg body weight, 30mg/kg body weight and 50mg/kg body weight consecutively. Group IV was given CMC-Na 0,5% (as negative control). Goup V was given caffein 15 mg/kg body weight (as positive control) and Group VI as a control. The total swimming period until exhaustion was measured and use as index of swimming capacity. Research result show that the highest dose 50 mg/body weight of the tested fraction the longer swimming time and with better stamina. The result of One Way ANOVA test showed that there was a significant difference between treatment group, followed by tukey test, tukey result obtained the ethil acetat fraction and negative control (CMC Na) showed that there was significant difference, and there is no real difference between between treatment group and positive control.   Key words: Drymis sp, Papua, tonic effect, rats.   

scholarly journals Pengaruh Ekstrak Tanaman Putri Malu (Mimosa pudica Linn) Terhadap Penurunan Kadar Glukosa Darah Pada Mencit (Mus musculus)

2017 ◽  
Vol 6 (1) ◽  
pp. 7
Author(s):  
Kasmudin Mustapa ◽  
Amalia Rizky ◽  
Minarni Rama Jura
Keyword(s):  
Blood Sugar ◽  
Plant Extract ◽  
Positive Control ◽  
Negative Control ◽  
Effective Concentration ◽  
Mimosa Pudica ◽  
Group Vi ◽  
Test Analysis ◽  
Group I ◽  
Sugar Levels

The research aim is to determine the effect of mimosa plant (mimosa pudica Linn) to reduce blood sugar levels in mice and determining the effective concentration of mimosa plant extracts as an alternative to decrease blood sugar levels. The extract is produced by the infusion method. The animal test used is male mice with amount 18 mice that induced by EDTA (ethylene diamine tetraacetic acid). Mice are divided into 6 groups randomly with different treatment. The group I, II, III and IV were given the mimosa plant extract with a concentration of 10, 20, 30, and 40% (w/v) respectively while group V is given glibenclamide suspension as positive control (+) and group VI is given Na-CMC 1% as negative control (-). Data were analyzed using the statistical test analysis of variance (ANOVA) and then followed by Duncan test. The results showed that the mimosa plant extract contains flavonoids, alkaloids, and tannins. In preclinical testing of mimosa plant extract proven to reduce blood sugar levels in mice and the most effective concentration is a concentration of 20% (w/v) with significantly α = 0.05.

scholarly journals The Number of Macrophages and Heterophils on Chick Embryo Chorioallantoic Membrane After Gynura procumbens (Lour) Merr Extract Treatment and bFgF Induction

2012 ◽  
Vol 3 (2) ◽  
pp. 398
Author(s):  
Iwan Sahrial Hamid ◽  
Yuseni Kusuma P. ◽  
Retno Bijanti ◽  
Bimo Aksono
Keyword(s):  
Chick Embryo ◽  
Chorioallantoic Membrane ◽  
Ethanolic Extract ◽  
Positive Control ◽  
Negative Control ◽  
Group Vi ◽  
Antiangiogenic Effect ◽  
Treatment Groups ◽  
Group I ◽  
Chick Embryo Chorioallantoic Membrane

Antiangiogenesis (inhibition of new blood vessels formation) has become a strategy to inhibit cancer development. The aim of this experiment was to investigate antiangiogenic effect of Gynura procumbens (Lour) Merr focusing on the decreasing of the number of macrophages and heterophils on chick embryo chorioallantoic membrane. Nine-days-aged-eggs were divided into six groups (eight eggs each group). Group I (positive control) eggs were induced with bFGF+Tris HCl. Group II (negative control) eggs were treated with DMSO+Tris HCl. Group III (treatment I) eggs were induced with 60 ng bFGF and treated with ethanolic extract of G. procumbens leaves with the dose of 60 µg. The following treatment groups, i.e. group IV (treatment II), group V (treatment III), and group VI (treatment IV) were treated with increasing dose of extract, starting from 75 µg, 90 µg, and the last was 110 µg. Eggs were incubated until they reach the age of twelve days to observe macrophages, while to observe heterophils, eggs were incubated until the age of seventeen days. Based on haematoxylin-eosin staining, macrophages in the treatment groups were less than the control positive group (bFGF+Tris HCl), but based on giemsa staining, the effect of Gynura procumbens in decreasing the number of heterophils could not be observed because some blood smears. These analysis suggest that the ethanolic extract of Gynura procumbens leaves can perform as antiangiogenic agent decreasing the number of macrophages.Keywords: antiangiogenic, macrophages, heterophils, Gynura procumbens

scholarly journals UJI EFEK ANALGESIK EKSTRAK KULIT BATANG POHON MATOA (Pometia pinnata) PADA MENCIT (Mus musculus)

2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Rafly F. Lumintang ◽  
Jane Wuisan ◽  
Pemsy M. Wowor
Keyword(s):  
Mus Musculus ◽  
Analgesic Effect ◽  
Negative Control Group ◽  
Treated Group ◽  
Positive Control ◽  
Negative Control ◽  
Bark Extract ◽  
Control Group ◽  
Group Iii ◽  
Group I

Abstract: Pain is an unpleasant sensation that derives from the complex neurochemical processes in the central and peripheral nervous systems. Side effects of drugs inter alia opioids and NSAIDs can cause serious disorders, therefore, it is necessary to find and develop other effective analgesic drugs with low toxicity. In Indonesia, matoa (Pometia pinnata) is known as a typical plant in Papua especially in West Papua. In some countries, parts of matoa plants are used as traditional medicine. This study aimed to determine the analgesic effect of matoa bark extract (Pometia pinnata) on mice Mus musculus. This was an experimental study. Nine male mice weighed 30 g were divided into 3 groups, each consisted of 3 mice. Group I, the negative control group, was given aquadest; group II, the positive control group, was given aspirin solution; and group III, the treated group, was given matoa bark extract. Analgesic effect was determined by counting the mice movements (licking their back legs or jumping) during 1 minute in a beaker with a temperature of 550C. The results showed that after 30 minutes the average number of movements of the treated group decreased from 22 times to 19.3 times, and continued to decrease until 1 movement after 120 minutes. Conclusion: Matoa bark extract showed analgesic effect on mice Mus musculus.Keywords: analgesic effect, matoa bark, miceAbstrak: Nyeri adalah sensasi yang tidak menyenangkan yang berasal dari proses neurokimia kompleks di sistem saraf pusat dan perifer. Opioid dan golongan AINS dapat menimbulkan efek samping yang cukup berat; oleh karena itu, diperlukan obat analgesik yang efektif dengan toksisitas rendah. Di Indonesia, matoa (Pometia pinnata) dikenal sebagai tanaman khas Papua terutama Papua Barat. Di beberapa negara, bagian-bagian dari tanaman matoa telah digunakan sebagai obat tradisional. Penelitian ini bertujuan untuk mengetahui efek analgesik ekstrak kulit batang pohon matoa (Pometia pinnata) pada mencit Mus musculus. Penelitian ini menggunakan metode eksperimental. Sembilan ekor mencit jantan dengan berat rata-rata 30 g dibagi atas 3 kelompok hewan uji yang masing-masing terdiri dari 3 ekor mencit. Kelompok I yaitu kelompok kontrol negatif diberikan akuades; kelompok II yaitu kelompok kontrol positif diberikan larutan aspirin; dan kelompok III yaitu kelompok perlakuan diberikan ekstrak kulit batang matoa. Efek analgesik berupa jumlah gerakan mencit selama 1 menit saat diletakan di dalam beker dengan suhu tetap 550C. Gerakan yang dihitung berupa gerakan menjilat kaki belakang atau meloncat. Hasil penelitian menunjukkan bahwa pada menit ke-30 terjadi penurunan rerata jumlah respon gerakan mencit dari 22 kali menjadi 19,3 kali yang terus berkurang hingga menit ke-120 dimana hanya terdapat 1 gerakan. Simpulan: Ekstrak kulit batang pohon matoa memiliki efek analgesik pada mencit Mus musculus.Kata kunci: efek analgesik, kulit batang matoa, mencit

scholarly journals UJI EFEK ANALGETIKA EKSTRAK BUAH KAKTUS (Opuntia elatior Mill.) PADA MENCIT (Mus musculus) YANG DIINDUKSI ASAM ASETAT

2015 ◽  
Vol 1 (1) ◽  
pp. 16-21
Author(s):  
Gissa Amellia ◽  
Ihwan Ihwan ◽  
Akhmad Khumaidi
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Effective Dose ◽  
Mus Musculus ◽  
Positive Control ◽  
Negative Control ◽  
Group Iv ◽  
Group V ◽  
Group Iii ◽  
Group I

Pain is a mechanism of body defense. One way to allay or decreasing the pain is using medicines that have analgetic effect. The aim of this study is determine the analgetic effect of cactus fruits (Opuntia elatior Mill.) extract and the most effective dose to giving analgetic effect. This study used writhing method by the injection acetic acid 1% as induced. Group I as a negative control used natrium carboxy methylcellulose 1%, group II as a positive control used aspirin suspension which dosage was 1,3 mg/20g BB, group III as a extract of cactus fruits give to dose 50 mg/kg BB, group IV dose 100 mg/kg BB, and group V dose 150 mg/kg BB. The result shows that cactus fruits extract to giving analgetic effect judging from the reduction strength writhing reflex to protection percentage at dose 50 mg/kg BB (11,26%), 100 mg/kg BB (42,10%), 150 mg/kg BB(60,14%) and the positif control (75,34%), at the positif control shows that higher protection percentage. Effectiveness percentage analgetic extract of cactus fruits at dose of 50 mg/kg BB (14,4%), 100 mg/kg BB (55,36%), 150 mg/kg BB (79,95%) and positif control (100%). The data which is got from the calculation later is analyzed by Kruskal Wallis. The result showed that at dose of 150 mg/kg BB is p: 0,016 (p<0,05) when compared with the positive control. So that is different significantly between dose 150 mg/kg BB and the positive control. The extract showed a optimal analgetic effect characterized by a significant reduction in the number of writhes or abdominal stretches in mice with dose 150 mg/kg BB body weight used when compared to the cactus fruits extract dose 50 and 100 mg/kg BB

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