Risk factors for recurrent wheezing in preterm infants who received prophylaxis with palivizumab

Objective: To determine the prevalence of recurrent wheezing (RW) in preterm infants who received prophylaxis against severe infection with respiratory syncytial virus (RSV) and to identify genetic susceptibility (atopy or asthma) and risk factors for RW. Methods: This was a cross-sectional study involving preterm infants who received prophylaxis with palivizumab at a referral center in Brazil during the first two years of age. A structured questionnaire was administered in a face-to-face interview with parents or legal guardians. Results: The study included 410 preterm infants (median age = 9 months [0-24 months]). In the sample as a whole, 111 children (27.1%; [95% CI, 22.9-31.5]) had RW. The univariate analysis between the groups with and without RW showed no differences regarding the following variables: sex, ethnicity, maternal level of education, gestational age, birth weight, breastfeeding, number of children in the household, day care center attendance, pets in the household, and smoking caregiver. The prevalence of RW was twice as high among children with bronchopulmonary dysplasia (adjusted OR = 2.08; 95% CI, 1.11-3.89; p = 0.022) and almost five times as high among those with a personal/family history of atopy (adjusted OR = 4.96; 95% CI, 2.62-9.39; p < 0.001) as among those without these conditions. Conclusions: Preterm infants who received prophylaxis with palivizumab but have a personal/family history of atopy or bronchopulmonary dysplasia are more likely to have RW than do those without these conditions.

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Respiratory morbidity of preterm infants of less than 33 weeks gestation without bronchopulmonary dysplasia: a 12-month follow-up of the CASTOR study cohort

Epidemiology and Infection ◽

10.1017/s0950268813001738 ◽

2013 ◽

Vol 142 (7) ◽

pp. 1362-1374 ◽

Cited By ~ 17

Author(s):

B. FAUROUX ◽

J.-B. GOUYON ◽

J.-C. ROZE ◽

C. GUILLERMET-FROMENTIN ◽

I. GLORIEUX ◽

...

Keyword(s):

Risk Factors ◽

Preterm Infants ◽

Bronchopulmonary Dysplasia ◽

Respiratory Morbidity ◽

Study Cohort ◽

Recurrent Wheezing ◽

Term Infants ◽

Independent Risk Factors ◽

Syncytial Virus

SUMMARYThe aim of this study was to describe the incidence and risk factors for respiratory morbidity during the 12-month period following the first respiratory syncytial virus (RSV) season in 242 preterm infants [<33 weeks gestational age (GA)] without bronchopulmonary dysplasia and 201 full-term infants (39–41 weeks GA) from the French CASTOR study cohort. Preterm infants had increased respiratory morbidity during the follow-up period compared to full-terms; they were more likely to have wheezing (21% vs. 11%, P = 0·007) and recurrent wheezing episodes (4% vs. 1%, P = 0·049). The 17 infants (14 preterms, three full-terms) who had been hospitalized for RSV-confirmed bronchiolitis during their first RSV season had significantly more wheezing episodes during the follow-up period than subjects who had not been hospitalized for RSV-confirmed bronchiolitis (odds ratio 4·72, 95% confidence interval 1·71–13·08, P = 0·003). Male gender, birth weight <3330 g and hospitalization for RSV bronchiolitis during the infant's first RSV season were independent risk factors for the development of wheezing episodes during the subsequent 12-month follow-up period.

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Risk Factors for Early Wheezing in Preterm Infants: A Retrospective Cohort Study

10.21203/rs.3.rs-42409/v1 ◽

2020 ◽

Author(s):

Xun Chen ◽

Minjing Yang ◽

Shengzhu Huang ◽

Xiaolian Qin ◽

Zhijian Pan ◽

...

Keyword(s):

Risk Factors ◽

Family History ◽

Preterm Infants ◽

Gestational Age ◽

Premature Delivery ◽

Related Factors ◽

Recurrent Wheezing ◽

History Of ◽

Group A ◽

Group B

Abstract Background: The related factors that cause recurrent wheezing in children are complex, and premature delivery may be one of the reasons. Little is known about early wheezing in preterm infants. Methods: Data sourced from 1616 children born between 2007 and 2013 from 8 hospitals of Guangxi in China. All children were followed by telephone or questionnaire through the sixth year of life. Children were grouped by characters of age: Group A: gestational age (GA) ≤ 32 weeks, Group B: 32 weeks < GA < 37 weeks, Group C: 37 weeks ≤ GA < 42 weeks. Results: The incidence and the risk factors of early wheezing in preterm infants were analyzed. The incidence of early wheezing: Group A > Group B > Group C. In Group A, the proportion of small-for-gestational-age (SGA) infant was higher in early wheezing group than in normal group (P = 0.005). Male (95% CI: 1.611 to 4.601) and family history of allergy (95% CI: 1.222 to 3.411) were the risk factors for early wheezing in Group B. Conclusions: Newborns with younger GA had a higher risk of early wheezing. SGA was a possible factor influencing early wheezing in preterm infants with GA≤ 32 weeks. Male and family history of allergy were the risk factors for early wheezing in preterm infants with 32 weeks < GA < 37 weeks.

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Study on Associated Risk Factors of Hypertension at Sipaghat of Sindhupalchowk District, Nepal

Nepalese Journal of Statistics ◽

10.3126/njs.v1i0.18818 ◽

2017 ◽

Vol 1 ◽

pp. 73-82

Author(s):

Naresh Manandhar

Keyword(s):

Risk Factors ◽

Family History ◽

Alcohol Consumption ◽

Lifestyle Modification ◽

Percent Level ◽

Cross Sectional Study ◽

Cross Sectional ◽

History Of ◽

Family History Of Hypertension ◽

Associated Risk Factors

Background: Hypertension is a progressive cardiovascular syndrome arising from complex and interrelated etiologies. Males have slightly higher prevalence than female in most of countries of Southeast-Asian region.Objective: The objective of study is to find out prevalence and the risk factors of hypertension at Sipaghat, Sindhulchowk, Nepal.Materials and Methods: A cross-sectional study was conducted at Sipaghat of Sindhupalchowk district in May 2016 and 260 persons were selected randomly. Results: The prevalence of hypertension was higher in male (25.4%) than female (17.4%). Mean age of study population was 42.08 years with standard deviation, 15.95 years. Variables namely age group, smoking, alcohol consumption and family history of hypertension were found to be significant at 5 percent level of significance. Alcohol consumption and smokers have more than two times higher chance of getting hypertension compared to alcohol non-consumer and nonsmoker with 95% confidence intervals were 1.08-4.80 and 1.21-6.10, respectively. Persons with family history of hypertension have 3.8 times more chance of getting hypertension compared to no family history of hypertension with 1.89-7.61 of 95% confidence interval.Conclusion: Lifestyle modification reduces blood pressure which prevents or delays the incidence of hypertension. Hypertension can be controlled and prevented by modifying the lifestyle. People should be advised to avoid modifiable risk factors of hypertension like smoking, consumption of alcohol and physical inactivity through health education programs.Nepalese Journal of Statistics, 2017, Vol. 1, 73-82

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Prevalence of major cardiovascular disease risk factors among a group of sub-Saharan African young adults: a population-based cross-sectional study in Yaoundé, Cameroon

BMJ Open ◽

10.1136/bmjopen-2019-029858 ◽

2019 ◽

Vol 9 (10) ◽

pp. e029858 ◽

Cited By ~ 1

Author(s):

Jobert Richie Nansseu ◽

Bibiane Siaheu Kameni ◽

Felix Kembe Assah ◽

Jean Joel Bigna ◽

Saint-Just Petnga ◽

...

Keyword(s):

Risk Factors ◽

Family History ◽

Cross Sectional Study ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Cross Sectional ◽

Prevalence Estimates ◽

Hazardous Alcohol ◽

History Of ◽

Hazardous Alcohol Consumption

ObjectiveTo determine the prevalence estimates of some major risk factors for cardiovascular disease (CVD) in a young adult-aged population living in Yaoundé, Cameroon.DesignA cross-sectional study held from May to July 2017.SettingParticipantsStudents aged 18–35 years, with no known history of CVD, found at the campus during recruitment and who voluntarily agreed to be included in the study.Primary and secondary outcome measuresData were collected on personal and family history as well as lifestyle and nutritional habits; anthropometric parameters and blood pressure were also measured. Prevalence rates were calculated with their respective 95% CI.ResultsOverall, 931 participants (53.8% males) were included, with a median age of 23 years (IQR 21–25). The prevalence estimates for some major CVD risk factors were: 3.1% (95% CI 2.0 to 4.2) for family history of heart attack, 6.3% (95% CI 4.7 to 7.9) for family history of stroke, 26.7% (95% CI 23.9 to 29.5) for hazardous alcohol consumption, 0.9% (95% 0.3 to 1.5) for current tobacco smoking, 27.6% (95% CI 24.7 to 30.5) for secondhand smoking, 88.9% (95% CI 86.9 to 90.9) for physical inactivity, 99.0% (95% CI 98.4 to 99.6) for inadequate fruits and/or vegetables consumption, 39.8% (95% CI 36.7 to 42.9) for self-reported anxiety, 49.2% (95% CI 46.0 to 52.4) for self-reported depression, 22.1% (95% CI 19.4 to 24.8) for overweight, 3.9% (95% CI 2.7 to 5.1) for obesity, 14.4% (95% CI 12.1 to 16.7) for abdominal obesity, 14.5% (95% CI 12.2 to 16.8) for excess body fat mass, 30.0% (95% CI 27.1 to 32.9) for suspected prehypertension and 2.8% (95% CI 1.7 to 3.9) for suspected hypertension.ConclusionThe prevalence of some major CVD risk factors is high among young adults living in Yaoundé, Cameroon. Therefore, specific actions should be undertaken in this population to mitigate the upcoming burden of CVD. Accordingly, younger-aged adult populations should be encouraged and accompanied to practice physical activity, eat healthily, and stop or avoid smoking and/or hazardous alcohol consumption.

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Cardiovascular Risk Factors in Patients with Acute MI in a Secondary Hospital in Bangladesh

Cardiovascular Journal ◽

10.3329/cardio.v12i2.47985 ◽

2020 ◽

Vol 12 (2) ◽

pp. 96-101

Author(s):

Mohammad Ullah ◽

Suman Kumar Saha ◽

Md Toufiqur Rahman ◽

Md Abdul Karim ◽

Rashid Ahmed

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Family History ◽

Cardiovascular Diseases ◽

General Population ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

History Of ◽

Secondary Hospital

Background: Incidence of noncommunicable disease, specially cardiovascular diseases, is increasing in Bangladesh. Prevalence of risk factors in ischaemic heart disease (IHD) has been studied in different tertiary hospitals and institutes. This study was done in a secondary hospital with a patient population mainly of low socioeconomic condition and was compared with other patient groups of the country and Indian subcontinent. Methods: this cross sectional study was conducted in Manikganj Sadar Hospital from July 2019 to December 2019. All the patients admitted with the diagnosis of myocardial infarction (MI) were included. Cardiovascular risk factors, like smoking, diabetes mellitus (DM), hypertension (HTN), family history of premature cardiovascular diseases, dyslipidaemia and obesity, were evaluated among the patients. Results: This cross-sectional study showed most of the patients were in the age group of 50-59 years. 66% of the male patients and 2% of the female patients were smoker. 66% of the patients were hypertensive, 44% patients were diabetic, 28.5% patients were overweight, 60.4% patients had total cholesterol > 200mg/dl, 73.6% patients had LDL>130 mg/dl, 110 76.3% patients had HDL < 40 mg/ dl, 72.2% had triglyceride >150 mg/dl and 39% patients had family history of premature cardiovascular disease. Ninety (62.5%) patients had anterior MI, 50 (34.7%) patients had inferior MI and 4 (2.7%) patients had NSTEMI. 65 patients had no major risk factor and 57 % had three or more risk factors. Conclusion: The study population was more aged in comparison to other studies conducted in different parts of Bangladesh. Prevalence of smoking habit was lower but the prevalence of HTN, DM and dyslipidaemia were higher than the general population and other cohorts of MI patients. The prevalence of major risk factors was much higher than the general population of Bangladesh. Cardiovasc. j. 2020; 12(2): 96-101

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Risk Factors for Early Recurrence of Gallstones in Patients Undergoing Laparoscopy Combined With Choledochoscopic Lithotomy: A Single-Center Prospective Study

Frontiers in Surgery ◽

10.3389/fsurg.2021.759390 ◽

2021 ◽

Vol 8 ◽

Author(s):

Bo Wang ◽

Anhua Huang ◽

Min Jiang ◽

Haidong Li ◽

Wenqing Bao ◽

...

Keyword(s):

Risk Factors ◽

Family History ◽

Prospective Study ◽

Cox Regression ◽

Univariate Analysis ◽

Gallbladder Wall ◽

Postoperative Recurrence ◽

Factors Associated ◽

History Of

Objective: For patients with gallstones, laparoscopy combined with choledochoscopic lithotomy is a therapeutic surgical option for preservation rather than the removal of the gallbladder. However, postoperative recurrence of gallstones is a key concern for both patients and surgeons. This prospective study was performed to investigate the risk factors for early postoperative recurrence of gallstones.Methods: The clinical data of 466 patients were collected. Each patient was followed up for up to 2 years. The first follow-up visit occurred 4 months after the operation, and a follow-up visit was carried out every 6 months thereafter. The main goal of each visit was to confirm the presence or absence of gallbladder stones. The factors associated with gallstone recurrence were analyzed by univariate analysis and Cox regression.Results: In total, 466 eligible patients were included in the study, and 438 patients (180 men and 258 women) completed the 2-year postoperative follow-up. The follow-up rate was 94.0%. Recurrence of gallstones was detected in 5.71% (25/438) of the patients. Univariate analysis revealed five risk factors for the recurrence of gallstones. Multivariate Cox regression analysis showed that multiple gallstones, a gallbladder wall thickness of ≥4 mm, and a family history of gallbladder stones were the three predictive factors for postoperative recurrence of gallstones (P < 0.05).Conclusion: The overall 2-year recurrence rate of gallstones after the operation was 5.71%. Multiple gallstones, a gallbladder wall thickness of ≥4 mm, and a family history of gallstones were the three risk factors associated with early postoperative recurrence of gallstones.

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Manifestations and Risk Factors in Children Hospitalized with Respiratory Syncytial Virus Infection

Archives of Pediatric Infectious Diseases ◽

10.5812/pedinfect.108723 ◽

2020 ◽

Vol In Press (In Press) ◽

Author(s):

Karolina Kuczborska ◽

Agnieszka Rustecka ◽

Agata Wawrzyniak ◽

Agata Będzichowska ◽

Bolesław Kalicki

Keyword(s):

Risk Factors ◽

Respiratory Syncytial Virus ◽

Respiratory Failure ◽

Family History ◽

Inflammatory Markers ◽

Laboratory Test Results ◽

Rsv Infection ◽

History Of ◽

Syncytial Virus ◽

Common Manifestation

Background: Acute lower respiratory infection (ALRI) is one of the main causes of morbidity and mortality in children under five years of age, and the respiratory syncytial virus (RSV) remains its leading etiological factor. Although RSV infections occur in all age groups, the most severe course is observed among children. The clinical manifestations include both mild upper respiratory infections and severe infections of the lower tract, such as bronchiolitis and pneumonia that can lead to hospitalization and severe complications, including respiratory failure. Objectives: The study aimed to evaluate the manifestations of RSV infection in hospitalized children younger than 18 months of age and predictors of disease severity, as well as their comparison with the same age group hospitalized due to ALRI of different etiology. Methods: A retrospective analysis was performed on medical records of 448 children hospitalized due to ALRI. The analysis was performed on the total study group and subgroups of children with positive and negative results of the nasal swab for RSV detection. In each group, clinical data, laboratory test results, and imaging results were analyzed. Results: The most common manifestation was pneumonia (n = 82; 63.08%). Otitis media was observed mainly in children under six months of age with lowered inflammatory markers (P < 0.05), conjunctivitis in those with a positive family history of allergies (P < 0.05), and pneumonia in children under six months of age, with lower blood oxygen saturation and inflammatory markers, features of acidosis, and fever-free course (P < 0.05). Respiratory failure affected 13 children (10%). However, no predictors of this complication were noted. Conclusions: As pneumonia was the most common manifestation in children with both RSV-positive and RSV-negative ALRI, it seems advisable to perform the imaging of the lungs on admission and carefully monitor the child’s condition during hospitalization. In both groups, special attention should be paid to the youngest children with low inflammatory markers on hospital admission, increased clinical symptoms, and family history of allergies. Nevertheless, widely known risk factors of RSV infection itself do not reflect the risk of developing pneumonia or respiratory failure in its course.

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Cardiovascular Disease and Its Risk Factors Among Employees of Sindh Government; A Cross Sectional Survey from Karachi, Pakistan

The International Journal of Frontier Sciences ◽

10.37978/tijfs.v3i2.52 ◽

2019 ◽

Vol 3 (2) ◽

pp. 84-90

Author(s):

Madiha Shafi ◽

Humaira Mehmood ◽

Saeed Afsar ◽

Zoaib Raza Bokhari ◽

Saleem Abbasi

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Family History ◽

Life Style ◽

Positive Family History ◽

Cross Sectional ◽

Obesity And Diabetes ◽

History Of ◽

Sedentary Life ◽

Sedentary Life Style

Abstract: Introduction: Globally it is documented that CVD has multi-factorial aetiology and many factors like increased BMI, hypertension (HTN), stress and diabetes determine the risk of CVD. The prevalence of risk factors for cardio vascular disease (CVD) is on increase in the developing nations of the world. Objectives: The purpose of the study was to find out the prevalence of cardiovascular disease and its risk factors among employees of Sindh Government in Karachi, Pakistan.Method: It was hospital based cross sectional study. A total of 150 subjects (govt employees of Sindh Government) were interviewed by using consecutive sampling technique. Data on serum cholesterol, BMI, blood pressure, history of hypertension, diabetes and cardiovascular diseases was collected, in addition to demographic data. Results: Out of 150 subjects interviewed, 20.6% reported to have CVD. The most prevalent risk factor was hypertension, found in 58% respondents. Other risk factors were diabetes (45%), sedentary life style (50%), obesity (28%), dyslipidaemia (30%), smoking (20%), positive family history (26%). In 6% of subjects, three major risk factors were present. The risk factors, strongly associated with CVD in our study were diabetes (p<0.01), hypertension (p<0.001) and family history of CVD (p<0.02). There is strong association of increasing age on risk of developing CVD (p< 0.001). Conclusion: The results show that there is high frequency of CVD risk factors in employees of health department in Karachi. The high prevalence of risk factors, especially hypertension, sedentary life style, obesity and diabetes should be of great concern.

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An epidemiological study on prevalence of hypertension and its risk factors among school boys of Burdwan municipal area

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20174831 ◽

2017 ◽

Vol 4 (11) ◽

pp. 4213

Author(s):

Kaushik Nag ◽

Manas Patra ◽

Avijit Paul ◽

Indranil Saha ◽

Krishnadas Bhattacharyya ◽

...

Keyword(s):

Risk Factors ◽

Family History ◽

Random Sampling ◽

Statistical Tests ◽

Categorical Variables ◽

Childhood And Adolescence ◽

Adolescent Boys ◽

Cross Sectional ◽

Chewing Tobacco ◽

History Of

Background: High blood pressure in childhood and adolescence is an important part of the natural history of hypertension. The objective of the study was to determine the prevalence and risk factors of hypertension among the adolescent boys of class nine (IX) to twelve (XII).Methods: A school based cross sectional study was undertaken among 894 adolescent boys aged 13 to 18 years from May 2013 to October 2014 of Burdwan municipal area. Schools were selected by Simple random sampling and systematic random sampling was used to include sample students from each school. Statistical tests like chi-square test were applied for categorical variables and p<0.05 taken as statistical significance.Results: The prevalence of hypertension was found to be 5.7%. The study revealed highest prevalence of hypertension in the age group of 13-14 and 17-18 years (6.5%), Muslim religion (17%), General caste (8.4%), and upper socio-economic status (9.3%) among which religion and caste showed significant association with hypertension (P<0.05). Students taking non-vegeterian items ≥5 days a week, chewing tobacco users, obese and having family history were more hypertensive which was statistically significant (p<0.05).Conclusions: The association of hypertension with food habit, tobacco chewing, obesity & family history of hypertension was found to be statistically significant.

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We are Family

Californian Journal of Health Promotion ◽

10.32398/cjhp.v8i1.2034 ◽

2010 ◽

Vol 8 (1) ◽

pp. 88-97 ◽

Cited By ~ 4

Author(s):

Alexander Omolafe ◽

Michele Mouttapa ◽

Shari McMahan ◽

Sora Park Tanjasiri

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Type 2 Diabetes ◽

Family History ◽

African Americans ◽

Positive Family History ◽

Self Report ◽

Cross Sectional ◽

History Of

This cross-sectional study sought to describe an association between family history of type-2 diabetes and the awareness of risk factors, perceived threat and physical activity levels in African Americans. With a prevalence of 11.8%, African Americans remain disproportionately affected by the epidemic of diabetes. A risk factor that cannot be modified, but is important and closely linked with diabetes expression, family history, can be a considerable tool in promoting behavior change and reducing the risk of developing the condition in African Americans. A self-report questionnaire was administered to 133 church going African Americans, with 55 of them with a positive family history of type-2 diabetes (41.4%) and 78 (58.6%) without. None of the participants had been previously been diagnosed with type-2 diabetes. The results from the study indicated that African Americans with positive family history had a greater knowledge of risk factors, were more likely to indicate that their concern about the disease influences their eating habits and physical activity, and engaged in significantly more physical activity than those with no family history.

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