scholarly journals Features of innate immunity in children with moderate course of acute urticaria

2018 ◽  
Vol 15 (3) ◽  
pp. 53-58
Author(s):  
S V Maltsev ◽  
L P Sizyakina ◽  
A A Lebedenko
Keyword(s):  
Innate Immunity ◽  
Activity Index ◽  
The Body ◽  
Immunological Methods ◽  
Total Serum ◽  
Parasitic Infections ◽  
Control Group ◽  
Healthy Children ◽  
Serum Ige ◽  
Acute Urticaria

Background. The prevalence of acute urticaria in children remains high. Urticaria is polietiologic disease, maintaining the homeostasis of the body is carried out by close cooperation of various parts of the immune system. The aim of this investigation was to study the features of innate immunity in children with moderate acute urticaria. Methods. To achieve this goal 71 children with moderate acute urticaria were examined. The control group included 30 healthy children of both sexes of the same age. Clinical methods of the study included disease history analysis, phisical examination of the child with determination of the degree of urticaria severity (calculation of the urticaria activity index within 7 days). Immunological methods included NK-lymphocytes, CD14+CD282+, CD14+CD284+, CD14+CD289+, serum IgE level, lactoferrin, IFN-y, IL-4, IL-6, test with NBT rate. Statistical calculations were performed in R Foundation for Statistical Computing. Results. Urticaria with undetermined causal factor happend more often, urticaria with allergic or pseudo-allergic genesis, as well as parasitic infections were established only in 17% of patients, family allergic history was found in a third of patients, in 41% of children acute urticaria proceeded with angioedema, in 9,3% of children urticaria acquired chronic course. Statistically significant increase of CD14+CD284+, decrease of CD14+CD289+, high concentrations of lactoferrin, decrease of natural killers, increase total serum IgE level in the half of the patients, low microbicidal activity with a decrease in adaptation reserves and reduced levels of IL-4, increased the content of IFN-y were found. Conclusion. The revealed changes indicate an imbalance in innate immunity, the launch of the cytokine cascade of inflammation, which is accompanied by further activation of the regulatory components of the inflammatory process in children suffering from acute urticaria.

scholarly journals Echocardiographic evaluation of ventricular septal defect haemodynamics

2007 ◽  
Vol 135 (9-10) ◽  
pp. 541-546
Author(s):  
Vesna Miranovic
Keyword(s):  
Ventricular Septal Defect ◽  
Pulmonary Artery ◽  
Body Surface ◽  
Septal Defect ◽  
Left Ventricular ◽  
The Body ◽  
Control Group ◽  
Healthy Children ◽  
And Control ◽  
The Relationship

Introduction Ventricular septal defect (VSD) is an opening in the interventricular septum. 30-50% of patients with congenital heart disease have VSD. Objective The aim of the study was to determine the dependence of the left ventricular diastolic dimension (LVD), left ventricular systolic dimension (LVS), shortening fraction (SF), left atrium (LA), pulmonary artery truncus (TPA) on the body surface and compare their values among experimental, control and a group of healthy children. Values of maximal systolic gradient pressure (Pvsd) of VSD were compared with children from one experimental and control group. Method Children were divided into three groups: experimental (32 children with VSD that were to go to surgery), control (20 children with VSD who did not require surgery) and 40 healthy children. Measurements of LVD, LVS, SF, LA, TPA were performed in accordance to recommendations of the American Echocardiographic Association. The value of Pvsd was calculated from the maximal flow velocity (V) in VSD using the following formula: Pvsd=4xV? (mm Hg). Results For children from the experimental group, the relationship between the body surface and the variability of the LVD was explained with 56.85%, LVS with 66.15%, SF with 4.9%, TPA with 58.92%. For children from the control group, the relationship between the body surface and the variability of LVD was explained with 88.8%, LVS with 72.5%, SF with 0.42%, PA with 58.92%. For healthy children, the relationship between the body surface and the variabilitiy of the LVD was explained with 88.8%, LVS with 88.78%, SF with 5.25% and PA with 84.75%. There was a significant statistical difference between average values of Pvsd in the experimental and control group (p<0.02). Conclusion The presence of the large VSD has an influence on the enlargement of LVD, LVS, SF, TPA. The enlargement of the size of the pulmonary artery depends on the presence of VSD and there is a direct variation in the magnitude of the shunt. There is a relationship and significant dependence of the LVS and LVD on the body surface. There is no statistically significant dependence between SF and body surface.

scholarly journals ANALYSIS OF THE EFFECTIVENESS OF IMMUNOTHERAPY USING AN AUTOLOGOUS COMPLEX OF IMMUNOPEPTIDES IN THE SURGICAL TREATMENT OF PERIODONTITIS

2020 ◽  
Vol 17 (35) ◽  
pp. 381-390
Author(s):  
Andrei SEVBITOV ◽  
Alla DAVIDYANTS ◽  
Roman BALYKIN ◽  
Anton TIMOSHIN ◽  
Mariya KUZNETSOVA
Keyword(s):  
Innate Immunity ◽  
Surgical Treatment ◽  
Bone Tissue ◽  
Pathogenic Bacteria ◽  
Alveolar Bone ◽  
The State ◽  
The Body ◽  
Immunological Methods ◽  
Periodontal Tissues ◽  
Antimicrobial Protection

Periodontal disease in the adult population is one of the most pressing problems of dentistry around the world. Thanks to the introduction of modern technologies in practice, it was possible to identify the main mechanisms of the development of this disease at the molecular and genetic level. The interaction of periodontal pathogens with immune factors of antimicrobial protection of the body is the basis of periodontal tissue inflammation and further leads to the destruction of the alveolar bone. Epithelial cells of the gum mucosa play a crucial role against periodontal pathogenic bacteria. Factors of innate immunity play a role not only in antimicrobial protection, but they also support the conditions necessary for the healing and regeneration of periodontal tissues. Therefore, various therapeutic approaches that affect the factors of innate immunity are considered as effective and promising. Clinical examination and determination of factors of innate immunity were performed in 115 patients. Healthy individuals made up a group of 30 people. Patients with chronic generalized periodontitis with varying degrees of severity were 85 people. Each patient underwent orthopantomography on the orthopantomograph Orthophosis XG DS/Ceph (SIRONA Dental System GmbH, Germany) in order to assess the state of the bone tissue of the jaws (the degree of destruction of the cortical layer, the degree of resorption of the interalveolar partitions). Targeted intraoral radiographs were used to assess the state of bone tissue and the quality of surgical treatment. Immunological methods of research were carried out in several stages. The findings of this article make the claim that the use of autologous complex immunopeptides in the surgical treatment of periodontitis reduces the time of achieving a therapeutic effect 2 times, resulting in the rapid relief of the symptoms of inflammation and acceleration of reparative processes.

scholarly journals THE STATE OF HYGIENE AND LOCAL IMMUNITY OF THE ORAL CAVITY IN PATIENTS WITH ANOREXIA NERVOSA

2019 ◽  
pp. 10-13
Author(s):  
M. Yu. Antonenko ◽  
L. L. Reshetnyk ◽  
E. V. Moskalenko ◽  
N. A. Zelinska ◽  
O. A. Znachkova
Keyword(s):  
Oral Hygiene ◽  
Oral Fluid ◽  
Mirror Image ◽  
The State ◽  
The Body ◽  
Immunological Methods ◽  
Control Group ◽  
Poor Oral Hygiene ◽  
Local Immunity ◽  
Group I

Aim: to study the state of local immunity and oral hygiene in patients with GP suffering from AN.Materials and methods: 35 patients with AN were examined at the age of 19-35 years. In the study we used immunological methods, an index assessment of the state of oral hygiene (PMA, API, GI).Results and discussion: in patients of I group poor oral hygiene was established. The amount of lysozyme in the oral fluid in I group was 0.014 ± 0.07 g/l. A decrease SIgA (11SIgA) was established in patients of I group: I, II and control (135.31 ± 23.17, 130.26 ± 24.21 and 300.34 ± 27.38 mg/l, respectively). A tendency to an increase in the level of IgG in the oral fluid in patients of group II compared with I and the control group (5.35 ± 0.36, vs. 4.57 ± 0.04 and 4.98 ± 0.23 g/l, respectively) was established.Conclusions: poor oral hygiene is an objective indicator which reflects low motivation to maintain oral health. The observed immunodeficiency (11SIgA) in patients with GP is a mirror image of changes occurring in the body of patients with AN.

scholarly journals Application of biomechanical research methods in evaluating results of surgical treatment of children with Legg – Calve – Perthes disease

2020 ◽  
Vol 37 (2) ◽  
pp. 54-64
Author(s):  
A. G. Baindurashvili ◽  
E. A. Kostomarova ◽  
I. E. Nikityuk ◽  
E. L. Kononova ◽  
D. B. Barsukov ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Center Of Pressure ◽  
Pelvic Osteotomy ◽  
Functional Results ◽  
The Body ◽  
Perthes Disease ◽  
Control Group ◽  
Healthy Children ◽  
Varus Osteotomy ◽  
Walking Biomechanics

Objective. To study the functional state of the musculoskeletal system in patients with Legg Calve Perthes disease after surgical treatment. Material and methods. The study of 31 patients at the age of 8 to 13 years with unilateral Legg Calve Perthes disease (LCPD) was performed in the period from 2 to 5 years after surgical treatment. In the control group (15 children), correcting (varus) osteotomy (VO) was fulfilled, in the main group (16 children) triple pelvic osteotomy (TPO), and the group of healthy children (18 persons) was examined as well. Walking biomechanics was studied using of the STEDIS complex (Neurosoft LLC, Ivanovo, Russia). The vertical balance of the body was evaluated on a stabilometric platform MBN "Biomechanics" (LLC NMF MBN, Moscow). Results. After surgical treatment, the indicators of vertical balance and biometry of the step phases in both groups of children with LCPD did not reach the same level as in healthy individuals at the indicated follow-up dates. The least significant indicators of step phase asymmetry were found in patients after TPO compared with patients after VO. In patients after VO, the destabilization of the center of pressure significantly exceeded that in patients after TPO. Conclusions. Biomechanical studies allow us to compare the functional results of various techniques of surgical treatment of children with unilateral LCPD. After TPO operation, patients have a more complete restoration of the supportability of the affected lower limb compared to VO operation.

scholarly journals A Study to Evaluate Use of Platelet Indices in Hyperdestructive Thrombocytopenia: A Two-year Experience from Tertiary Care Rural Hospital

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Roniya Francis ◽  
Shruthi N Shetageri ◽  
Roopa A N ◽  
S R Raja Parthiban
Keyword(s):  
Tertiary Care ◽  
Study Groups ◽  
The Body ◽  
Parasitic Infections ◽  
Control Group ◽  
Platelet Destruction ◽  
Distribution Width ◽  
Platelet Indices ◽  
Group I ◽  
Group Ii

Background: Thrombocytopenia is one of the most common causes of abnormal bleeding and is defined as platelet counts < 1.5 lakhs/cumm. Three processes can cause thrombocytopenia, namely: Deficient platelet production, accelerated platelet destruction, and abnormal pooling of the platelets within the body. Of these, accelerated platelet destruction is the most common cause for thrombocytopenia and has variety of etiologies. The usefulness of bone marrow analysis in assessing accelerated platelet destruction is still debated. Therefore, a new simple and non-invasive diagnostic approach for thrombocytopenia is needed. Aims and Objectives: The present study was done with an aim to evaluate the use of platelet indices, namely, mean platelet volume (MPV), Platelet Distribution Width (PDW), and Platelet Large Cell Ratio (P-LCR) in differentiating the various causes of hyperdestructive thrombocytopenia. Materials and Methods: This was a prospective study conducted over a period of 2 years and consisted of 206 cases of hyperdestructive thrombocytopenia. After recording relevant clinical details, platelet count along with platelet indices – MPV, PDW, and P-LCR was recorded. Based on the etiopathology identified, cases were categorized into three groups: Group I: Immunologic – cases of Immune thrombocytopenic purpura (ITP), Group II: Non-immune: Cases of sepsis and other non-immune causes of platelet destruction, and Group III: Viral and parasitic infections. Platelet indices were compared between the study groups and the control group which included 100 healthy individuals. Comparison was done among the three study groups as well. Results & Conclusions: Dengue accounted for the highest number of 131 (89.72%) cases in the study. MPV, PDW, and P-LCR were significantly higher (P < 0.0001) when compared to the healthy controls except P-LCR in Group II. A statistically significant increase in MPV was noted among ITP cases when compared to other causes of thrombocytopenia. There wa

scholarly journals Indicators of vegetative homeostasis in children with mitral valve prolapse before and after treatment

2019 ◽  
Vol 23 (2) ◽  
pp. 234-237
Author(s):  
A. V. Kuleshov ◽  
Y. A. Medrazhevska
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Mitral Valve ◽  
Mitral Valve Prolapse ◽  
Medical Literature ◽  
The Body ◽  
Control Group ◽  
Healthy Children ◽  
Before And After

For children with mitral valve prolapse (MVP) characterized by disorders of vegetative homeostasis, especially pronounced effect on the body sympathetic link of the autonomic nervous system. In the medical literature, the question of correction of vegetative tone in children with primary MVP is now open. The purpose of the study was to study the parameters of vegetative homeostasis in children with mitral valve prolapse before and after treatment. 66 children with primary and primary MVP stage I and II at the age of 13–17 years were examined. The control group consisted of 23 practically healthy children. The evaluation of vegetative homeostasis was performed using a clinorostatic test and cardiointervalography, followed by an analysis of the parameters and parameters of the heart rate variability spectral analysis. To restore vegetative homeostasis to patients with PMC, an existing treatment regimen with our correction was prescribed. Namely, we added therapies levocarnitine and magnesium. According to the data obtained from the CP, we found that treatment led to the normalization of vegetative maintenance of the organism, mainly in the form of a decrease in the hypersympathicotonic tonic type after treatment, along with the baseline (p<0.05). Consequently, the proposed treatment scheme with the use of levocarnitine and magnesium, positively affects the autonomic system in children with primary MVP, reducing its dysfunction.

scholarly journals Psyсhologiсal defense mechanisms of children with cerebral palsy in the context of mothers attitude to a child’s disease

2017 ◽  
Vol 5 (3) ◽  
pp. 58-65
Author(s):  
Galina V. Pyatakova ◽  
Irina I. Mamajchuk ◽  
Valery V. Umnov
Keyword(s):  
Cerebral Palsy ◽  
Defense Mechanisms ◽  
Defense Mechanism ◽  
Parental Behavior ◽  
The Body ◽  
Control Group ◽  
Healthy Children ◽  
Psychological Defense ◽  
Prolonged Immobilization ◽  
High Level

Introduction. Cerebral palsy (CP) has a significant prevalence in industrialized countries and is characterized by a high level of disability. Children and adolescents with CP face challenging situations. Physical defects repeatedly manifest in the daily life of a child in the form of other extraordinary events such as hospitalization, surgery, prolonged immobilization, and separation from family. Such events can be accompanied by feelings of fear, anxiety, helplessness, and pronounced symptoms of maladjustment. Under these conditions, certain biological and social compensatory manifestations help to identify such complicated conditions and restore the normal functioning of the body. Compensatory manifestations are a type of compensatory defense mechanisms. The major role in establishing a system of protection is played by the relationship between a child and his or her parents. Defense mechanisms can be formed during the process of assimilation of protective parental behavior, or because of the inappropriate attitude of mothers to the child’s illness. The purpose of the research was to study the defense mechanisms in children with CP in the context of mothers’ relationship to her child’s illness. Materials and methods. The research involved 120 people. The experimental group included 30 children with CP aged 5 to 11 years and their mothers. The control group consisted of relatively healthy children (30) and their mothers. The following was used to achieve the goal: the elements of clinical and biographical method, projective technique, the technique of diagnostics of attitude to the child’s illness. Results and discussion. The repertoire of psychological defense mechanisms in children with CP is limited in comparison with those in healthy children. Children with CP are dominated by the defense mechanism of “denial” that can play a negative role in the process of adaptation of these children in a situation involving complex treatments. The mothers of children with CP share an emotionally intense relationship with their child’s disease. Excessively disturbing attitudes of the mother to the disease of her child can contribute to the formation of negative psychological defense mechanisms of negation type in the child, which reduces the child’s psychological compensatory capacity and capability of adaptation in conditions of complex treatment.

scholarly journals Neuromotor Development of Children Aged 6 and 7 Years Born before the 30th Week Gestation

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Joanna Majewska ◽  
Katarzyna Zajkiewicz ◽  
Kamila Wacław-Abdul ◽  
Joanna Baran ◽  
Daniel Szymczyk
Keyword(s):  
Muscle Tone ◽  
Hand Function ◽  
Full Term ◽  
The Body ◽  
Control Group ◽  
Study Group ◽  
Healthy Children ◽  
Neuromotor Function ◽  
Premature Children

Introduction. The aim of this study was to evaluate and compare the level of neuromotor function and somatic development in 6- and 7-year-old children born before the 30th week gestation with that in full-term children at the same age, as well as the correlation between prematurity and motor development. Material and Methods. The study group consisted of prematurely born 40 children. Their mean gestational age at birth was 27.8±1.6 weeks (range 24–30 weeks). The control group consisted of 40 healthy children born with normal birth weight (>2500 g). The neuromotor function was assessed using Touwen neurological examination criteria. During the examination, the attention was focused on the hand preference, laterality, synkinesis, and asymmetry. In addition, children’s weight, height, and BMI index were measured. Results. Premature children showed much worse results than full-term ones in hand function (p<0,001). They obtained the best results in paper tearing while crossing the body midline turned out to be the most difficult. Considering the quality of walking, the biggest difficulty for the premature children was to walk backwards along the straight line while during normal walking they showed the best results. The results for the muscle tone subcategory in the study group were also significantly worse than those in control group (p<0,001), as well as the total outcome for the movement coordination and diadochokinesis subcategories (p<0,001). Conclusion. The nondisabled, prematurely born children have significantly lower average outcomes regarding hand function, quality of walking, muscle tone, coordination, and diadochokinesis at age of six to seven, compared to the full-term peers.

scholarly journals A study of voice quality in obese Egyptian children

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Asmaa Abdel Hamid ◽  
Hend Soliman ◽  
Rasha Abdelhalim
Keyword(s):  
Voice Quality ◽  
Cross Sectional Study ◽  
The Body ◽  
Voice Disorder ◽  
Control Group ◽  
Healthy Children ◽  
Cross Sectional ◽  
Egyptian Children ◽  
Significant Difference ◽  
The Impact

Abstract Background Obesity is considered a health problem that affects many systems of the body among which the respiration and voice. The objective of the study was to analyze the impact of obesity in children on quality of their voice. Thirty obese children were included in this cross-sectional study and compared to 30 age- and sex-matched healthy children as a control group. Voice of cases and controls were assessed subjectively by auditory perceptual assessment and objectively by studying acoustic parameters using Computerized Speech Lab. Flexible laryngoscopy was done for cases with dysphonia. Results Dysphonia perceived in 60% of cases, voice analysis revealed increased jitter and noise to harmonic ratio with significant difference than controls. Conclusion The voice of children with morbid obesity reveals significant modifications pertaining to vocal characteristics in comparison to non-obese persons, so voice hygiene and voice therapy could be added to their therapy program as prophylactic or therapeutic management of voice disorder.

Sign in / Sign up

Export Citation Format

Share Document