Concept for the Urban Production of Pharmaceuticals to Compensate for Local Shortages

2021 ◽  
pp. 46-59
Author(s):  
Joachim Berlak ◽  
Tobias Götz
Keyword(s):  
Paradigm Shift ◽  
Urban Areas ◽  
Local Population ◽  
Drug Shortages ◽  
Brownfield Sites ◽  
The World ◽  
Local Areas ◽  
General Production ◽  
Tablet Manufacturing ◽  
Pharmaceutical Production

Long and complex supply chains are one of the main reasons for drug shortages. The COVID-19 pandemic and abrupt global lockdown have highlighted how precarious the global pharmaceutical market is. This paper presents a concept for pharmaceutical production in greenfield, urban and local areas as a way to mitigate drug shortages around the world. This approach represents a paradigm shift because the production of medicine tablets still happens mostly at big brownfield sites. The concept is based on the VDI 5200 guidelines and procedures used for factory planning at general production plants. The derived methodology takes three phases into account and enables the integration of continuous tablet manufacturing into urban areas to supply the local population with medicine.

scholarly journals Socio-cultural and economic fundamentals of urban tourism

2021 ◽  
pp. 13-20
Author(s):  
L. Bozhko ◽  
M. Zaitseva
Keyword(s):  
Urban Areas ◽  
Local Community ◽  
Local Population ◽  
Economic Benefits ◽  
Cultural Development ◽  
Urban Tourism ◽  
Host Community ◽  
Practical Significance ◽  
Economic Aspects ◽  
The World

The relevance of the study. Today, tourism has become a strategic sector of the country’s development, which contributes to social and cultural development, spreads the welfare and level of the population and promotes the country on the world market, as well as increases its economic value. Urban tourism can play a vital role in rebuilding cities and promoting areas. This article discusses the importance of urban tourism, its impact on economic development and the country’s image, taking into account socio-cultural and economic aspects. The development of urban tourism will significantly contribute to the improvement of urban feeling, the correctness of the city’s image and new investments and employment opportunities. And most importantly, tourism depends on the great efforts of the local community and tourism investors, which are associated with the development of tourism infrastructure. The aim of the article is to study the socio-cultural and economic foundations of urban tourism. The methodology. The method of scientific modelling was used in the research process. The results. In modern society, urban tourism has become one of the fastest growing segments of travel around the world due to the growing interest in cultural resources and heritage, as well as urban renewal, image growth and attractiveness of territories and economic benefits for local communities. The trend of urban tourism, of course, will continue to grow. There is a sufficient level of interaction between visitors and residents, which has a positive perception of tourism and takes into account both economic and social and cultural aspects. Residents are an important part of the cultural phenomenon of urban life and a key part of the success of tourism. Exploring the relationship between tourism and urban areas, it is necessary to distinguish between primary, secondary and additional elements of tourist resources of the city, which are very important for the success of urban tourism and the attractiveness of visitors. The mass tourism sector extends to all boundaries of the infrastructure that support it. Thus, there is an intensive interaction between tourists and the host. This affects the perception of the community and residents about the socio-cultural and economic consequences. The local population plays a fundamental role, while being an integral part of tourist offers. The local community is a key element of tourism, without its support it is difficult for businesses to be sustainable. In addition, the host community influences the development process in the tourism direction. Thus, entrepreneurial success, although it depends on attractions and services, also depends on the residents. The scientific topicality. Consideration of the socio-cultural and economic aspects of tourism in close connection and benefits of tourism for urban communities and local people The practical significance. The materials of this article can be used to develop regional development programs or strategies for the development of cities and regions.

Urban Transport

2018 ◽  
Author(s):  
José van
Keyword(s):  
Urban Areas ◽  
Urban Transport ◽  
Transport Sector ◽  
Public And Private ◽  
Transport Services ◽  
Ride Sharing ◽  
The World ◽  
Private And Public ◽  
Selection Mechanisms

Platformization affects the entire urban transport sector, effectively blurring the division between private and public transport modalities; existing public–private arrangements have started to shift as a result. This chapter analyzes and discusses the emergence of a platform ecology for urban transport, focusing on two central public values: the quality of urban transport and the organization of labor and workers’ rights. Using the prism of platform mechanisms, it analyzes how the sector of urban transport is changing societal organization in various urban areas across the world. Datafication has allowed numerous new actors to offer their bike-, car-, or ride-sharing services online; selection mechanisms help match old and new complementors with passengers. Similarly, new connective platforms are emerging, most prominently transport network companies such as Uber and Lyft that offer public and private transport options, as well as new platforms offering integrated transport services, often referred to as “mobility as a service.”

scholarly journals Current Understanding of Novel Coronavirus: Molecular Pathogenesis, Diagnosis, and Treatment Approaches

Immuno ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 30-66
Author(s):  
Niraj Kumar Jha ◽  
Madhan Jeyaraman ◽  
Mahesh Rachamalla ◽  
Shreesh Ojha ◽  
Kamal Dua ◽  
...  
Keyword(s):  
Paradigm Shift ◽  
Functional Outcomes ◽  
Cellular Therapy ◽  
Treatment Modalities ◽  
Unknown Etiology ◽  
Huge Number ◽  
The World ◽  
To Come ◽  
Novel Coronavirus ◽  
Nano Medicine

An outbreak of “Pneumonia of Unknown Etiology” occurred in Wuhan, China, in late December 2019. Later, the agent factor was identified and coined as SARS-CoV-2, and the disease was named coronavirus disease 2019 (COVID-19). In a shorter period, this newly emergent infection brought the world to a standstill. On 11 March 2020, the WHO declared COVID-19 as a pandemic. Researchers across the globe have joined their hands to investigate SARS-CoV-2 in terms of pathogenicity, transmissibility, and deduce therapeutics to subjugate this infection. The researchers and scholars practicing different arts of medicine are on an extensive quest to come up with safer ways to curb the pathological implications of this viral infection. A huge number of clinical trials are underway from the branch of allopathy and naturopathy. Besides, a paradigm shift on cellular therapy and nano-medicine protocols has to be optimized for better clinical and functional outcomes of COVID-19-affected individuals. This article unveils a comprehensive review of the pathogenesis mode of spread, and various treatment modalities to combat COVID-19 disease.

scholarly journals Mapping 20 Years of Urban Expansion in 45 Urban Areas of Sub-Saharan Africa

2021 ◽  
Vol 13 (3) ◽  
pp. 525
Author(s):  
Yann Forget ◽  
Michal Shimoni ◽  
Marius Gilbert ◽  
Catherine Linard
Keyword(s):  
Case Studies ◽  
Urban Areas ◽  
Urban Expansion ◽  
Local Population ◽  
Sub Saharan Africa ◽  
Annual Growth Rate ◽  
Urban Dynamics ◽  
Mapping Approach ◽  
Sub Saharan ◽  
The Impact

By 2050, half of the net increase in the world’s population is expected to reside in sub-Saharan Africa (SSA), driving high urbanization rates and drastic land cover changes. However, the data-scarce environment of SSA limits our understanding of the urban dynamics in the region. In this context, Earth Observation (EO) is an opportunity to gather accurate and up-to-date spatial information on urban extents. During the last decade, the adoption of open-access policies by major EO programs (CBERS, Landsat, Sentinel) has allowed the production of several global high resolution (10–30 m) maps of human settlements. However, mapping accuracies in SSA are usually lower, limited by the lack of reference datasets to support the training and the validation of the classification models. Here we propose a mapping approach based on multi-sensor satellite imagery (Landsat, Sentinel-1, Envisat, ERS) and volunteered geographic information (OpenStreetMap) to solve the challenges of urban remote sensing in SSA. The proposed mapping approach is assessed in 17 case studies for an average F1-score of 0.93, and applied in 45 urban areas of SSA to produce a dataset of urban expansion from 1995 to 2015. Across the case studies, built-up areas averaged a compound annual growth rate of 5.5% between 1995 and 2015. The comparison with local population dynamics reveals the heterogeneity of urban dynamics in SSA. Overall, population densities in built-up areas are decreasing. However, the impact of population growth on urban expansion differs depending on the size of the urban area and its income class.

scholarly journals High Diversity in Urban Areas: How Comprehensive Sampling Reveals High Ant Species Richness within One of the Most Urbanized Regions of the World

Diversity ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 358
Author(s):  
François Brassard ◽  
Chi-Man Leong ◽  
Hoi-Hou Chan ◽  
Benoit Guénard
Keyword(s):  
Exotic Species ◽  
Urban Areas ◽  
Urban Landscapes ◽  
Dual Roles ◽  
Ant Communities ◽  
Continuous Increase ◽  
Tropical Regions ◽  
The World ◽  
Ant Diversity ◽  
The Vertical Distribution

The continuous increase in urbanization has been perceived as a major threat for biodiversity, particularly within tropical regions. Urban areas, however, may still provide opportunities for conservation. In this study focused on Macao (China), one of the most densely populated regions on Earth, we used a comprehensive approach, targeting all the vertical strata inhabited by ants, to document the diversity of both native and exotic species, and to produce an updated checklist. We then compared these results with 112 studies on urban ants to illustrate the dual roles of cities in sustaining ant diversity and supporting the spread of exotic species. Our study provides the first assessment on the vertical distribution of urban ant communities, allowing the detection of 55 new records in Macao, for a total of 155 ant species (11.5% being exotic); one of the highest species counts reported for a city globally. Overall, our results contrast with the dominant paradigm that urban landscapes have limited conservation value but supports the hypothesis that cities act as gateways for exotic species. Ultimately, we argue for a more comprehensive understanding of ants within cities around the world to understand native and exotic patterns of diversity.

scholarly journals Patterns of variation in the rDNA cistron within and among world populations of a mosquito, Aedes albopictus (Skuse).

Genetics ◽  
1989 ◽  
Vol 121 (3) ◽  
pp. 539-550
Author(s):  
W C Black ◽  
D K McLain ◽  
K S Rai
Keyword(s):  
Aedes Albopictus ◽  
Local Population ◽  
Population Level ◽  
Restriction Map ◽  
Repeat Region ◽  
Molecular Drive ◽  
Nontranscribed Spacer ◽  
Coding Regions ◽  
The World ◽  
Ribosomal Cistron

Abstract A restriction map was constructed of the ribosomal cistron in a mosquito, Aedes albopictus (Skuse). The 18s, 28s and nontranscribed spacer (NTS) regions were subcloned and used to probe for intraspecific variation. Seventeen populations were examined throughout the world range of the species. No variation was detected in the coding regions but extensive and continuous variation existed in the NTS. The NTS consisted of two nonhomologous regions. The first region contained multiple 190-bp AluI repeats nested within larger XhoI repeats of various sizes. There was a large number of length variants in the AluI repeat region of the NTS. No repeats were found in the second region and it gave rise to relatively fewer variants. An analysis of NTS diversity in individual mosquitoes indicated that most of the diversity arose at the population level. Discriminant analysis was performed on spacer types in individual mosquitoes and demonstrated that individuals within a population carried a unique set of spacers. In contrast with studies of the NTS in Drosophila populations, there seems to be little conservation of spacers in a population. The importance of molecular drive relative to drift and selection in the generation of local population differentiation is discussed.

Beyond studentification in United States College Towns: Neighborhood change in the knowledge nodes, 1980–2010

2017 ◽  
Vol 49 (6) ◽  
pp. 1341-1360 ◽  
Author(s):  
Nathan S Foote
Keyword(s):  
United States ◽  
Middle Class ◽  
Knowledge Economy ◽  
Urban Areas ◽  
Global Economy ◽  
Neighborhood Change ◽  
Global Knowledge ◽  
College Towns ◽  
The World ◽  
Social Geographies

With the rise of the cognitive-cultural (or knowledge) economy, urban areas around the world have experienced significant changes in their social geographies. Studentification is one such change that has occurred in cities hosting major universities around the world. This study extends the analysis of social change to vital knowledge nodes in the networked global economy: United States college towns. K-means cluster analysis is used to identify neighborhood types in ten cities with major research universities across four Census years: 1980, 1990, 2000, and 2010. Temporal and spatial analyses are then conducted to determine how these knowledge nodes have changed with the decline of the industrial economy and the rise of the knowledge economy. The analysis indicates the presence of six neighborhood types in these college towns: Middle Class, Minority-Concentrated, Stability, Elite, Mix/Renter, and Student. Over the course of the study period, the number of Elite neighborhoods increased considerably, while the number of Middle Class neighborhoods plummeted. The number of Mix/Renter neighborhoods also increased. Spatially, Student and Minority-Concentrated neighborhoods generally remained fairly clustered in the same areas across the study period. Elite neighborhoods spread across wider geographical areas over the course of the study period. These results are compared to previous studies on neighborhood change. The comparisons reveal that the knowledge nodes show some similar patterns to studentifying cities and to rapidly growing nodes in areas with ties to the global knowledge economy.

Integrated community-based sexual health services for young people in urban areas: are we meeting the needs of the local community?

2008 ◽  
Vol 19 (10) ◽  
pp. 713-714 ◽  
Author(s):  
K M Forbes ◽  
N Rahman ◽  
S Mccrae ◽  
I Reeves
Keyword(s):  
Health Services ◽  
Sexual Health ◽  
Urban Areas ◽  
Local Community ◽  
Local Population ◽  
Nucleic Acid Amplification ◽  
Community Based ◽  
Transmitted Infection ◽  
Sti Testing ◽  
Hiv Test

Community-based sexual health services (SHS) are intended to improve access for people who may have difficulty attending traditional genitourinary medicine clinics. The objective of this study was to review uptake of sexually transmitted infection (STI) testing in an outreach clinic for those under 25 in an area where Black and minority ethnic groups comprise the majority of the local population. A retrospective case-notes review was undertaken of those attending. Standards were that Fraser guidelines should be completed in all under 16-year-old and all clients should be offered STI testing, HIV testing and contraception (if applicable) in accordance with local standards. One hundred and seventeen clients attended. Ten percent self-reported ethnicity was Asian. Thirty-six (31%) clients tested for chlamydia. Thirty (26%) had an HIV test. Five (14% of those tested) had a positive nucleic acid amplification test for chlamydia. Five (13%) of those requesting long term contraception had STI testing. This service has successfully improved access to STI screening. However, there may have been missed opportunities to offer tests in those requesting contraception. Under-representation of those of non-white ethnicity suggests access to SHS may be a particular problem and further work is required to improve the sexual health of the local community.

Reconceptualizing the Public Spaces of New Urban Areas in Hanoi: The End or the New of Public-Making?

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Minh-Tung Tran ◽  
◽  
Tien-Hau Phan ◽  
Ngoc-Huyen Chu ◽  
◽  
...  
Keyword(s):  
Public Space ◽  
Urban Areas ◽  
Public Spaces ◽  
The Public ◽  
Doi Moi ◽  
The World ◽  
Relationship Of ◽  
The Relationship ◽  
The City ◽  
Neighborhood Level

Public spaces are designed and managed in many different ways. In Hanoi, after the Doi moi policy in 1986, the transfer of the public spaces creation at the neighborhood-level to the private sector has prospered na-ture of public and added a large amount of public space for the city, directly impacting on citizen's daily life, creating a new trend, new concept of public spaces. This article looks forward to understanding the public spaces-making and operating in KDTMs (Khu Do Thi Moi - new urban areas) in Hanoi to answer the question of whether ‘socialization’/privatization of these public spaces will put an end to the urban public or the new means of public-making trend. Based on the comparison and literature review of studies in the world on public spaces privatization with domestic studies to see the differences in the Vietnamese context leading to differences in definitions and roles and the concept of public spaces in KDTMs of Hanoi. Through adducing and analyzing practical cases, the article also mentions the trends, the issues, the ways and the technologies of public-making and public-spaces-making in KDTMs of Hanoi. Win/loss and the relationship of the three most important influential actors in this process (municipality, KDTM owners, inhabitants/citizens) is also considered to reconceptualize the public spaces of KDTMs in Hanoi.

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