scholarly journals Dynamics of background levels of serum cytokines in children with atopic dermatitis with concomitant pathology of oral mucosa in the course of optimized complex therapy

2020 ◽  
pp. 32-38
Author(s):  
Valentyna Slavinska
Keyword(s):  
Blood Pressure ◽  
Atopic Dermatitis ◽  
Oral Mucosa ◽  
Immunological Tolerance ◽  
Control Group ◽  
Healthy Donors ◽  
Independent Form ◽  
Complex Therapy ◽  
Dependent Form ◽  
And Control

The purpose of the study was to study the dynamics of changes in the background level of serum IL-2, IL-4, IL-5, IL-10, IL-13, IFN-g and TNF-a in patients with various forms of AD with concomitant pathology of oral mucosa to find the optimal ways of using complex therapy. Materials and methods. According to the design, 60 children (37 boys and 23 girls) with clinical manifestations of AD from 6 to 12 years of age participated in the study, who were on dispensary registration in the Department №6 of the Scientific and Diagnostic Center of Shevchenkivskyi district of Kyiv. No statistically significant differences were found between age groups. For the treatment of blood pressure, children with concomitant pathology of oral mucosa were prescribed the drug Montelukast. Children aged 6 to 12 years were advised to take a dose of 1 mg chewable tablet per night, in the evening. According to the study protocol Montelukast was taken 1 hour before or 2 hours after eating. In addition to Montelukast was proposed the use of Ketotifen. For children, Ketotifen was given at a dose of 1 mg 2 times daily, in the morning and in the evening, during meals for two weeks of systematic use. According to the study protocol for the treatment of blood pressure, children with concomitant  pathology of oral mucosa were prescribed Spiramycin. The drug was prescribed pe os, children from 6 years – 1.5-3 million IU per 10 kg/day for 2-3 times, the duration of therapy was 10 days. Serum cytokine levels (IL-2, IL-4, IL-5, IL-10, IL-13, IFN-g and TNF-a) were determined by enzyme-linked immunosorbent assay (ELISA). To determine the concentration of cytokines used commercial kits of test systems of «IMMUNOTECH» and «DIACLONE», France. Results. In patients with IgE-dependent AD after treatment there was a sharp increase in the concentration of IL-2 in the serum of peripheral blood 39.15 (30.5- 45.8)*, compared with the group of patients with IgE-independent AD 15.3 (10.6-29.9)* (p <0.001) and healthy donors 15.35 (10.1-14.3) (p<0.001). In patients with IgE-dependent AD, a marked decrease in the IFN-g concentration of 3.2 (2.6-3.9)* was observed in patients with children compared with that in the IgE-independent AD group of patients 0.6 (0.1-1.6)* (p<0.001) and healthy donors 0.6 (0-4.3) (p<0.001) and TNF-a concentration ratio of 1.15 (0.3-1.8)* in comparison with similar rates in the group of sick children with IgE-independent form of AD 0.9 (0.5-1.4)* (p<0.01) and healthy donors 2.05 (1.6-3.1) (p<0.001). And in patients with IgE-dependent AD with concomitant pathology of oral mucosa after treatment, there was a long-term increase in the concentration of IL-5 50.8 (45.7-65.7)* compared with the group of children with IgE-independent AD 22.25 (20.8-24.1)* (p<0.001) and control group 14.05 (11.5-16) (p<0.001). Serum IL-10 concentration levels were also significantly increased in patients with IgE-dependent AD 71.0 (61.7-89.5)* compared with those in children with IgE-independent AD 62.8 (59.6-67.1)* (p <0.011) and control group 45.25 (37.9-58,6) (p<0.001). The level of IL-4 was slightly increased in the group of patients with IgE-dependent AD 32.9 (29.2-36.6)* and in the group with IgE-independent AD 26.2 (22.2-28.9)* (p<0.001) and control group 17.05 (15.3-19.3) (p<0.001). The serum IL-13 concentration level was also slightly increased in patients with IgE-dependent AD 24.6 (21.5-26.3)* compared with IgE-independent AD patients 22.75 (20.5-23.9)* (p< 0.013) and control group 12.6 (11.4-16.7) (p<0.001). The study revealed sharp differences between serum IL-10 levels in patients with IgE-dependent and IgE-independent AD with concomitant pathology of oral mucosa after complex treatment. As it turned out, a sharp prolonged increase in IL-10 after treatment in serum was observed in all patients with IgE-dependent AD, in contrast to the level of this cytokine in groups of IgE-independent AD. This suggests that an imbalance in IL-10 level is not a leading pathogenetic factor in the development of an IgE-independent form of AD, unlike the IgE-dependent form, as previously reported. As you know, IL-10 is a known biological marker of immunological tolerance. However, serum IL-10 levels are also capable of inducing both immunosuppressive processes and immunodeficiency states. This suggests that an increase in IL-10 synthesis under the conditions of high IL-2 detected shifts cytokine synthesis in patients with IgE-dependent AD in the direction of cytokine production by regulatory lymphocytes. In support of this conclusion, in patients with children with IgE-dependent form of AD with concomitant pathology of oral mucosa in our study revealed a prolonged increase in serum concentration of IL-10 after combination therapy, which coincides with a significant improvement in clinical status. Conclusions High levels of IL-2 and IL-10 detected in children with IgE-dependent atopic dermatitis with concomitant pathology of oral mucosa in our study confirm the important relationship between cytokine concentration and the stage of skin disease. Continuous increase in the level of IL-10 subject to a decrease in the concentration of IL-4 in the blood of patients children on IgE-dependent form of BP with concomitant pathology of oral mucosa after the test combination therapy that coincides with the improvement of the clinical picture may serve as an important criterion for the formation of immunological tolerance.

Feedback based on health advice via tracing bracelet and smartphone in the management of Blood Pressure among hypertensive patients: A Community-based RCT Trial in Chongqing, China (Preprint)

2020 ◽  
Author(s):  
Yong Zhang ◽  
Yang Tao ◽  
Yun Zhong ◽  
Jacqueline Thompson ◽  
Jamal Rahmani ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Control Group ◽  
Community Settings ◽  
Post Intervention ◽  
Attrition Rates ◽  
Hypertensive Patients ◽  
Professional Health ◽  
Group A ◽  
And Control ◽  
Study Intervention

UNSTRUCTURED Lifestyle interventions have been recognised as a line treatment of non-communicable diseases. The aimed of this study was to evaluate a bespoke mHealth approach to delivers personalised feedback to improve blood pressure and weight for hypertensive patients in community settings. A total of 307 participants, 50 from each community, were expected to be in the intervention or control group. A professional health facilitator was assigned for each of the 6 communities. The primary outcomes of the study are the reduction in blood pressure and weight at baseline and post-intervention. Of 307 recruited,192 (62.5%) participants completed the study (intervention: 104 and control: 88). There was no difference in attrition rates between the two groups (33.5%vs41.9%, p=0.291). After 6-months of intensive feedback intervention through mHealth approach, patients had better blood pressure, weight, and BMI compared with control. People who were adherent to the intervention demonstrated a clinical benefit with regards to weight and blood pressure.

scholarly journals PERBEDAAN PENURUNAN TEKANAN DARAH PRA LANSIA PRE HIPERTENSI YANG DIBERI JUS TOMAT (Lycopersicum grandifilum)

2018 ◽  
Vol 10 (2) ◽  
pp. 152-158
Author(s):  
Hari Yani Fadillah
Keyword(s):  
Blood Pressure ◽  
Treatment Group ◽  
Block Design ◽  
Pressure Control ◽  
Tomato Juice ◽  
Control Group ◽  
Randomized Block Design ◽  
Before And After ◽  
Blood Pressure Treatment ◽  
And Control

The research aims to know the effect of tomato juice on blood pressure in pre-elderly pre hypertension at Posbindu Puskesmas Nusa Indah Bengkulu City.The design of research was a quasi experiment include pre test post test. This population was all patients posbindu aged 45-59 years. Sampling of this research randomized block design of one factorial were 6 samples divided into treatment and control group. The data which have been analyzed using univariate and bivariate. From this research were obtained the results such as the mean of sistole blood pressure before and after intervention in treatment group p = 0,273 and diastole p = 0,27. Mean systole blood pressure control group p = 0.060 and diastole p = 2.14. Distribution of tomato juice (Lycopersicum grandifilum) did not given affect the decrease in blood pressure of systole diastole before and after intervention in pre-elderly pre hypertension. Whereas the difference in mean systole of blood pressure treatment and control group p = 0.935 and diastolic of blood pressure p = 0.678. There ware not difference in mean of blood pressure in the tomato juice treatment group and control of Vitamin C. The result concluded there were not effect of tomato juice (Lycopersicum grandifilum) on systolic of blood pressure in pre-elderly pre hypertension at Posbindu Puskesmas Nusa Indah Bengkulu City.

scholarly journals NOSOGENIC DEPRESSION IN PATIENTS WITH PATHOLOGY OF THE MUCOUS ORAL CAVITY

2020 ◽  
Vol 15 (4) ◽  
pp. 50-54 ◽  
Author(s):  
Karen Karakov ◽  
Tatyana Vlasova ◽  
Artur Oganyan ◽  
Araksia Khachaturyan ◽  
Svetlana Karakova ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Oral Cavity ◽  
Treatment Regimen ◽  
Oral Mucosa ◽  
New Technologies ◽  
Well Being ◽  
Diagnostic Methods ◽  
Control Group ◽  
Traditional Treatment ◽  
And Control

Importance. Despite the improvement of diagnostic methods and the introduction of new technologies in the treatment of pathology of the oral mucosa, it is difficult to achieve stable remission, since 70 % of cases are based on somatic and bodily suffering factors. The article presents data from a comparative analysis of the use of the traditional treatment regimen for patients with pathology of the oral cavity and the inclusion of the latest generation of antipsychotics in the treatment regimen. It was established that, when applied, a tendency towards normalization of psychological and autonomic status was observed. The inclusion of anxiolytics and antioxidants in the complex of general therapy for patients with pathology of the oral mucosa contributed to a more pronounced positive dynamics of achieving and prolonging the phase of remission. Objectives — to evaluate the effectiveness of introducing drugs of the latest generation of antipsychotics into the traditional treatment regimen for patients with pathology of the oral cavity. Methodology. Under our supervision, there were 30 patients aged 40 to 60 years with a diagnosis of pathology of the oral mucosa and pathology of the periodontium. All examined were divided into 2 groups: the main (15 people) and control (15 people). Results. Clinical well-being, manifested in a subjective decrease in pain in the tongue, feelings of rawness, tingling, numbness, awkwardness, in the tongue, was noted already at the 5th visit in 67 % of patients of the main group, while in the control group in 17 % of patients. Conclusions. The inclusion of anxiolytics and antioxidants in the complex of general therapy for patients with pathology of the oral mucosa contributed to a more pronounced positive dynamics of achieving and prolonging the phase of remission. Our data allow us to implement this treatment regimen in practical healthcare.

scholarly journals EFFECTIVENESS OF LAVENDER AROMATHERAPY AND CLASSICAL MUSIC THERAPY IN LOWERING BLOOD PRESSURE IN PREGNANT WOMEN WITH HYPERTENSION

2017 ◽  
Vol 3 (6) ◽  
pp. 750-756
Author(s):  
Sri Maisi ◽  
Suryono Suryono ◽  
Melyana Nurul Widyawati ◽  
Ari Suwondo ◽  
Suryati Kusworowulan
Keyword(s):  
Blood Pressure ◽  
Music Therapy ◽  
Systolic Blood Pressure ◽  
Pregnant Women ◽  
Classical Music ◽  
Combination Group ◽  
Control Group ◽  
P Value ◽  
The Mean ◽  
And Control

Background: Hypertension during pregnancy remains high in Indonesia. It is a major cause of maternal death. Aromatherapy lavender and classical music therapy are considered effective in lowering blood pressure in hypertension.Objective: To examine the effect of lavender aromatherapy and classical music therapy in lowering blood pressure in pregnant women with hypertension.Methods: A quasy experimental study with pretest-posttest control group design. There were 52 pregnant women with the inclusion criteria selected as samples using simple random sampling, divided into lavender aromatherapy group, classical music group, combination of aromatherapy and music group, and control group. Sphygmomanometer was used to measure blood pressure. Mann Whitney and Post Hoc test were used for data analysis.Results: Results showed that four groups have a significant decrease in systolic blood pressure after given intervention with p-value <0.05. The mean decrease of systolic blood pressure among four groups was: lavender group (5.77 mmHg), music group (7.23 mmHg), combination group (9.54 mmHg), and control group (3.67 mmHg); and the mean decrease of diastolic blood pressure was: the lavender group (2.77 mmHg), music group (0.61 mmHg), combination group (8.23 mmHg), and control group (3.42 mmHg).Conclusion: there was a significant effect of lavender aromatherapy and classical music therapy in lowering blood pressure in pregnant women with hypertension. However, the combination of both interventions was more effective than lavender aromatherapy or music therapy alone.

scholarly journals Increased Efficiency of Leukocyte Collection by the Addition of Hydroxyethyl Starch to the Continuous Flow Centrifuge

Blood ◽  
1974 ◽  
Vol 44 (4) ◽  
pp. 571-581 ◽  
Author(s):  
John Milton Mishler ◽  
Daniel C. Hadlock ◽  
Ignacio E. Fortuny ◽  
Robert W. Nicora ◽  
Jeffrey J. McCullough
Keyword(s):  
Hydroxyethyl Starch ◽  
Continuous Flow ◽  
Malignant Disease ◽  
Supportive Therapy ◽  
Control Group ◽  
Input Line ◽  
Healthy Donors ◽  
And Control ◽  
Continuous Flow Centrifuge ◽  
Differential Counts

Abstract A total of 67 leukaphereses were performed with the continuous-flow centrifuge (CFC) on 27 healthy donors for the purpose of obtaining increased yields of granulocytes for infusion into septic patients with acute leukemia accompanied by severe granulocytopenia. The addition of hydroxyethyl starch (HES) to the input line of the CFC significantly (p < 0.005) increased the total number of leukocytes and/or granulocytes collected per donation. A mean yield of 9.72 x 109 and 4.65 x 109 total granulocytes were collected by the HES-treated and control-group donors, respectively. The efficiency of cell collection as evidenced by the total number of leukocytes and/or granulocytes harvested per liter of processed blood was also significantly (p < 0.005) improved by the addition of HES to the continuous-flow centrifuge. Significant alterations in hematologic parameters were not experienced by HES-treated donors undergoing initial and multiple procedures. Pre- and postdonation leukocyte and platelet counts, hemoglobin, prothrombin time, partial thromboplastin time, and leukocyte differential counts were no different whether or not HES was employed for granulocyte collection. The results of the present study demonstrate that increased yields of granulocytes can be harvested by the addition of HES to the continuous-flow centrifuge and made available for supportive therapy to patients experiencing granulocytopenia induced by malignant disease or its treatment.

scholarly journals EFFECT OF PHYSICAL EXERCISE AND YOGA ON BLOOD PRESSURE AMONG SCHOOL CHILDREN

2018 ◽  
Vol 11 (4) ◽  
pp. 399 ◽  
Author(s):  
Premalatha P ◽  
Kanniammal C ◽  
Valli G ◽  
Jaydeep Mahendra
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Physical Exercise ◽  
Cost Effective ◽  
World Health ◽  
Control Group ◽  
Blood Institute ◽  
Health Organization ◽  
Childhood Hypertension ◽  
And Control

Objective: The principal aim of the study is to identify the effect of physical exercise and yoga on blood pressure (BP) among children, a common cardiovascular risk factor among children in recent years. Methods: A true experimental design was adopted to find the effect of physical exercise and yoga on selected children with increased BP and weight. The weight was inferred based on the World Health Organization (WHO) chart on body mass index for age. BP and height were measured and interpreted using the WHO height percentile chart for boys/girls and BP references of National Heart, Lung, and Blood Institute, to identify hypertensive children. Hypertensive children were given physical exercise and yoga, 5 days a week, for 6 months and control group led a normal lives. Results: In the pretest, 100% of the study and control group were prehypertensive. After 3 months of physical exercise and yoga, 21% of study group became normotensive which was significant at p=0.000 and it increased to 93% after 6 months with the significance of p=0.000. The weight and systolic BP (SBP) had a significant positive correlation. The age (p=0.001), number of family members, type of family (p=0.01), mother’s occupation, family history of obesity, and chronic illness among fathers (p=0.05) had a significant association with SBP of the children. Conclusion: The study concluded that physical exercise and yoga reduced childhood hypertension as well as is a cost effective and easily practicable intervention for children to minimize cardiovascular risk during their adulthood.

scholarly journals Investigation of the effect of the virtual reality application on experimental pain severity in healthy

2019 ◽  
Vol 65 (3) ◽  
pp. 446-451
Author(s):  
Dilek Karaman ◽  
Funda Erol ◽  
Dilek Yılmaz ◽  
Yurdanur Dikmen
Keyword(s):  
Blood Pressure ◽  
Virtual Reality ◽  
Control Group ◽  
Control Groups ◽  
Adult Type ◽  
Significant Difference ◽  
The Mean ◽  
And Control ◽  
Experimental Group ◽  
Virtual Reality Application

SUMMARY OBJECTIVE: This study aimed to investigate the effect of virtual reality application on experimental ischemic pain created with a blood pressure instrument in healthy volunteers. METHODS: The research sample consisted of 172 volunteer adult students who conformed to the inclusion criteria. These individuals were assigned into an experimental (n=86) and a control group (n=86) by a simple randomization method. All individuals in the experimental and control groups wereexperimentally subjected to pain for two minutes by applying 260 mmHg of pressure 3-4 cm above the antecubital region of the left arm with an aneroid adult-type blood pressure instrument. During the procedure, the volunteers in the experimental group watched virtual reality images, while those in the control group received no intervention. Immediately after the procedure, the pain levels of the individuals in both groups were assessed with a Visual Analog Scale (VAS). RESULTS: We found that the mean pain score of the individuals in the experimental group was 2.62±1.82, and that of individuals in the control group was 5.75±1.65. Results of the statistical analysis showed a statistically significant difference between the mean pain scores of the individuals in the experimental and control groups (p<0.001). CONCLUSION: This study found that the use of virtual reality was effective in reducing the level of pain in healthy individuals. This method used a smartphone with widespread availability and ease of transportation, which can be used by health professionals as a non-pharmacological method in the management of pain.

scholarly journals Hypothalamus-Related Resting Brain Network Underlying Short-Term Acupuncture Treatment in Primary Hypertension

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Hongyan Chen ◽  
Jianping Dai ◽  
Xiaozhe Zhang ◽  
Kai Wang ◽  
Shuhua Huang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular System ◽  
Acupuncture Treatment ◽  
Bodily Pain ◽  
Brain Network ◽  
Control Group ◽  
Control Groups ◽  
Short Term ◽  
Sf 36 ◽  
And Control

The present study attempted to explore modulated hypothalamus-seeded resting brain network underlying the cardiovascular system in primary hypertensive patients after short-term acupuncture treatment. Thirty right-handed patients (14 male) were divided randomly into acupuncture and control groups. The acupuncture group received a continuous five-day acupuncture treatment and undertook three resting-state fMRI scans and 24-hour ambulatory blood pressure monitoring (ABPM) as well as SF-36 questionnaires before, after, and one month after acupuncture treatment. The control group undertook fMRI scans and 24-hour ABPM. For verum acupuncture, average blood pressure (BP) and heart rate (HR) decreased after treatment but showed no statistical differences. There were no significant differences in BP and HR between the acupuncture and control groups. Notably, SF-36 indicated that bodily pain (P= 0.005) decreased and vitality (P= 0.036) increased after acupuncture compared to the baseline. The hypothalamus-related brain network showed increased functional connectivity with the medulla, brainstem, cerebellum, limbic system, thalamus, and frontal lobes. In conclusion, short-term acupuncture did not decrease BP significantly but appeared to improve body pain and vitality. Acupuncture may regulate the cardiovascular system through a complicated brain network from the cortical level, the hypothalamus, and the brainstem.

scholarly journals Effectiveness of Beetroot (Beta Vulgaris L) Extracts On Blood Pressure Level Among Postpartum Mothers With Hypertension

2020 ◽  
Vol 9 (2) ◽  
pp. 678-685
Author(s):  
Merisa Restiani Arma ◽  
Ta'adi Ta'adi ◽  
Sri Sumarni
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Level ◽  
Total Sample ◽  
Medical Problem ◽  
Nitrate Content ◽  
Control Group ◽  
Lower Blood Pressure ◽  
Lower Blood ◽  
Postpartum Mothers ◽  
And Control

Hypertension is the most medical problem encountered in pregnancy to postpartum period and remains one of the most causes of maternal death. High nitrate content of beetroot as well as potassium and flavonoids of celery may lower blood pressure. This study investigate the effectiveness of beetroot extracts on reducing blood pressure postpartum mothers with hypertension. The study was a Quasy-experimental control group pre-posttest design. A total sample of 30 postpartum mothers with hypertention was enrolled in the study and randomly assigned in 2 groups. The consumption of beetroot extract decreased systolic BP 27,40 and diastolic 13,47. Meanwhile in CG, BP was reduced by 8,40 for systolic and 10,53 for diastolic. There was a difference in mean decrease systolic BP between the intervention and control group (p<0.05), there was no differences in mean diastolic BP (p>0.05). Beetroot extract effective reducing blood pressure postpartum mother with hypertension without worrying about side effects.

scholarly journals Is bone health of young atopic dermatitis patients a significant healthcare problem?

2021 ◽  
Author(s):  
Sooyoung Kim ◽  
Jimi Choi ◽  
Moon Kyun Cho ◽  
Nam Hoon Kim ◽  
Sin Gon Kim ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Lumbar Spine ◽  
Bone Health ◽  
Smoking Status ◽  
Control Group ◽  
Z Score ◽  
Mineral Density ◽  
Control Groups ◽  
Femur Neck ◽  
And Control

Abstract Background Atopic dermatitis (AD) incidence has increased over the past decades, especially among young adults. However, their bone health has not been clearly elucidated with discordant results. Objective We aimed to investigate the bone mineral density (BMD) measured by double energy X-ray absorptiometry and Z-score at the lumbar spine, femur neck, and total femur to evaluate the risk of osteoporosis in men aged <50 years and premenopausal women with AD.Methods The Korea National Health and Nutrition Examination Survey 2007-2009 data were used in this case-control cohort study. We included young AD patients (aged 19≤ and <50 years) diagnosed by a doctor and compared these patients with 1:5 propensity score weighting controls by age, sex, body mass index (BMI), vitamin D level, and alcohol/smoking status. Results We analyzed 311 (weighted n=817,014) AD patients and 1,555 (weighted n=4,155,855) controls. BMD at the lumbar spine was significantly lower in the male AD group than in the male control group (mean ± SE, 0.989 ± 0.002 vs. 0.954 ± 0.016, P = 0.03) while BMDs at the femur neck and total femur were comparable. For women, BMDs at the three sites were not significantly different between the AD and control groups. Low bone mass (defined by a Z-score of ≤2.0) was not significantly different between the AD and control groups in both sexes. Conclusions Bone health, especially BMD and Z-score, in young AD patients were comparable with those without AD. AD was not a risk factor for low BMD.

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