scholarly journals Hubungan Dukungan Keluarga Dengan Tingkat Kecemasan Pada Pasien Gagal Ginjal Kronis Yang Menjalani Hemodialisis DI RSUD Dr. Soehadi Prijonegoro Sragen

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Ika Hayun Al Aziz ◽  
Sudiro Sudiro
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Family Support ◽  
Sampling Method ◽  
Cross Sectional ◽  
Support Level ◽  
Psychological Pressure ◽  
The Relationship

Abstract: Family Support, Level Of Anxiety, Chronic Renal Failure, And Hemodialysis. Chronic kidney disease is a threat for human because the prevalency increase every years. Patient of chronic kidney disease with teraphy hemodialysis can cause psychological pressure pasca hemodialysis. One example of psychological pressure is anxiety. For decrease anxiety of patient with terapy hemodialysis need family support. Objectives To identity the relationship among family support with level of anxiety chronic renal failure of patients with therapy hemodialisis in Dr.Soehadi Prijonegoro Hospital. Methods Design of the research used descriptive analytic with cross sectional approach. The sampling method is total sampling. Instrument that used for measure level anxiety and family support is a questionnaire. Analysis for data used Kendall Tau. Ressearch result The majority of family support level is good with amount 38 (70,4%). The majority of level anxiety is not anxiety with amount 38 (70,4%).The result of kendall tau is α : 0,000, τ : 0,865.Conclusion There is relationship between family support with level of anxiety chronic renal failure of patients with therapy hemodialysis.

THE RELATIONSHIP OF FAMILY SUPPORT WITH QUALITY OF LIFE AMONG PATIENTS WITH CHRONIC KIDNEY DISEASE IN RUNNING HEMODIALIZATION THERAPY AT PMI HOSPITAL BOGOR

2018 ◽  
Vol 10 (1) ◽  
pp. 15-19
Author(s):  
Fajar Adhie Sulistyo
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Family Support ◽  
Kidney Failure ◽  
Relationship Of ◽  
The Relationship

Background : Chronic kidney disease is a pathophysiological process with diverse etiology, resulting in a progressive decline in renal function, and the patients generally end up with kidney failure. Family support is a support given by families who have blood relations in favor of the health of patients with kidney failure. Quality of life is an individual perception of patients with kidney failure toward his position in life. The aim of this study was to determine the relationship of family support with the quality of life of patients with chronic renal failure undergoing hemodialysis therapy in PMI hospital Bogor. The method of this research uses uses descriptively analytic type with cross sectional approach. The sample of this researchconsists of 129 respondents. The sampling was taken by accidental sampling technique. The instrument in this study were questionnaires family support and quality of life. The data were analyzed by using univariate and bivariate (using the chi-square test with α = 0.05). Result : Based on the research results through 88 respondents that (68.2%) whose family support is good, then 86 respondents (93%) have a good quality of life, and 2 respondents (5%) have less quality of life. From 8 respondents (6.2%) whose family support is less, 1 respondent (2%) have a good quality of life, and 7 respondents (19%) have a less quality of life. Based on statistical test p = 0.000, it can be concluded that there is significant correlation between both variables. Clonclusion : It is concluded that there is a relationship between family support and the quality of life among patients with chronic renal failure undergoing hemodialysis therapy in PMI hospital Bogor. Through this research, it is expected to be used as a source reference of information for nurses in hemodialysis room.

scholarly journals Faktor yang berhubungan dengan tingkat depresi pada pasien gagal ginjal kronis yang menjalani tindakan hemodialisa

2020 ◽  
Vol 14 (1) ◽  
pp. 101-109
Author(s):  
Indra Maulana ◽  
Iwan Shalahuddin ◽  
Taty Hernawaty
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Psychosocial Factors ◽  
Health Workers ◽  
Depression Score ◽  
Cross Sectional ◽  
Depression Level ◽  
The Impact

Psychosocial factors: The depression level  in patients with chronic kidney disease maintained on dialysisBackground: Chronic renal failure undergoing hemodialysis therapy in the world is almost 1.5 million people, and in Indonesia there are approximately 0.2 people with chronic renal failure undergoing hemodialysis therapy. The impact of hemodialysis on the physical that will occur in patients become weak tired in living their daily lives, against the psychological impact that will occur on sleep problems, impurity and depression, the impact on social and economic conditions that will occur to patients on social relationships, and on the environment the client will also have an impact on the social environment in which he lives. Therefore hemodialysis therapy will have an impact on the quality of life of patients.Purpose: To determine Psychosocial factors: the depression level  in patients with chronic kidney disease maintained on dialysisMethod: A descriptive correlational study by a cross sectional design approach. The sample used was 40 respondents, data collection techniques using questionnaires and direct observation with results calculated based on the total answers to questions given by respondents with criteria: score <17 = no sign of depression, score 18-24 = mild depression, score 25-34 = moderate depression and a score of 35-51 = severe depression, while the bivariate test used chi-squareResults: There was a relationship among factors such as: age, educational, sex, duration of maintaine of hemodialysis therapy and sleep patterns with the depression level in patients with chronic kidney disease under maintained on dialysis at Garut dr. Slamet Hospital.Conclusion: Health workers (nurses) to provide motivational and therapeutic informing in implementing hemodialysis therapy so that patients are more excited and better understand the importance of hemodialysis and to reduce the level of depression.Keywords: Depression level; Patients; Chronic kidney disease; DialysisPendahuluan: Penyakit gagal ginjal kronik yang menjalani terapi hemodialisis di dunia hampir sekitar 1,5 juta orang, dan di indonesi hampitr sekitar 0,2 jiwa penderita gagal ginjal kronik yang menjalani terapi hemodialisis. Dampak hemodialisis terhadap fisik yang akan terjadi pada pasien menjadi lemah lelah dalam menjalani kehidupan sehari-hari, terhadap psikologis dampak yang akan terjadi pada masalah tidur, kecemasaan dan depresi, dampak terhadap sosial dan ekonomi yang akan terjadi pada pasien pada hubungan sosialnya, dan pada lingkungan klien juga akan berdampak pada sosial lingkungan dimana dia tinggal. Maka dari itu terapi hemodialisis akan berdampak pada kualitas hidup pasien.Tujuan: Mengetahui faktor-faktor yang berhubungan dengan tingkat depresi pada pasien gagal ginjal kronis yang menjalani tindakan HemodialisaMetode: Menggunakan rancangan deskriptif korelasional dengan pendekatan desain cross sectional dengan sampel sebanyak 40 responden, teknik pengambilan data menggunakan kuesioner dan observasi langsung dengan hasil dihitung berdasarkan  total jawaban dari pertanyaan yang diberikan responden dengan kriteri skor <  17 = tidak ada depresi,  skor 18-24 = depresi ringan,  skor 25-34= depresi sedang dan skor 35-51= depresi berat                        sedangkan uji bivariat menggunakan chi-square.Hasil: Menunjukan adanya hubungan antara faktor : usia, pendidikan, jenis kelamin, lamanya periode menjalani terapi hemodialisa dan pola tidur. Semua faktor tersebut sangat  berhubungan dengan tingkat depresi pada pasien gagal ginjal kronik yang menjalani tindakan hemodialisa di Ruang Hemodialisa RSUD dr. Slamet Garut.Simpulan: Petugas kesehatan (perawat) agar memberikan motivasi dan terapeutik informing dalam pelaksanaan terapi hemodialisa agar pasien lebih bersemangat dan lebih memahami pentingnya hemodialisa serta untuk mengurangi tingkat depresi.

scholarly journals THE INNTERRELATED FACTORS OF ANEMIA LEVEL ON CHRONIC KIDNEY DISEASE PATIENTS POST DIALYSIS IN DIALYSIS UNIT OF BETHESDA HOSPITAL YOGYAKARTA

2017 ◽  
Author(s):  
Vivi Retno Intening
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Logistic Regression ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Measurement Instrument ◽  
Nutrition Status ◽  
Cross Sectional ◽  
Dialysis Unit ◽  
Age Factor

Background of the Research: A Chronic Kidney Disease (CKD) is a kind of disease (or a renal failure) which shows significant number of rising evidence in recent years. A patient of chronic renal failure needs a renal succession therapy such as dialysis in order to make a longer life. When the disease is getting worst, the patient is generally suffering anemia as the effect of the renal damaged. The interrelated factors of the anemia level are: age, sex, the period of dialysis therapy, nutrition status, illness-stadium, and the enclose disease.Significance of the Research: This research is conducted in order to know the interrelated factors of anemia level in chronic renal failure patients post dialysis.Research Methods: This is a non-experiment correlation research with a cross sectional approximation. The research is conducted in the Dialysis Unit of Bethesda HospitalYogyakarta, from February to March 2009. The researcher uses purposive sampling with 30 respondents. The measurement instrument is observation sheets and hemoglobin tests. The data analysis is done through distribution frequency; Kolmogorov-Smirnov test for the bivariate analyses and Logistic Regression for the multivariate analyses.Research findings: The research which was conducted on 30 respondents showed result of 93, 3% easy-anemia patients’ sufferings. The age factor, sex, dialysis period, nutrition status, illness-stadium, and the enclose disease were statistically unrelated to the level of anemia, with p&gt;0, 05. The statistic accounting of logistic regression showed that the illness-stadium was the most probable factor related to the level of anemia, with p=0, 09 ;CI=0, 734 – 73, 248; Exp (B) 7, 333.Conclusion: The age factor, sex, dialysis period, nutrition status, illness-stadium, and the enclose disease were statistically unrelated to the level of anemia, but the most probable factor related to the level of anemia was the illness-stadium.Keywords: Chronic Kidney Disease, Anemia Level, Dialysis

scholarly journals A clinical study of cutaneous and mucosal manifestations in patients with chronic renal failure on hemodialysis

2017 ◽  
Vol 3 (1) ◽  
pp. 120
Author(s):  
Mohamed Rafeek M. ◽  
Kaliaperumal Karthikeyan
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Chronic Kidney Failure ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Major Health Problem ◽  
Cutaneous Manifestations ◽  
Medical College

<p class="abstract"><strong>Background:</strong> Chronic kidney disease is defined as presence of kidney damage, manifested by abnormal albumin excretion or decreased kidney function, quantified by measured or estimated glomerular filtration rate (GFR) that persists for more than 3 months.<span>Chronic kidney disease is major health problem. Chronic kidney failure presents with an array of cutaneous manifestations. </span>The objective of the present study was to determine the pattern of muco-cutaneous manifestations of chronic renal failure on hemodialysis<span lang="EN-IN">.</span></p><p class="abstract"><strong>Methods:</strong> A cross sectional study done in the Dermatology &amp; Nephrology OPD of Sri Manakula Vinayagar Medical College and Hospital from October 2014 to May 2016. About 38 consenting patients who fulfilled the inclusion criteria were chosen for the study. The demographic characteristics were included in the study and the clinical profile of the patient such as hematological investigation and renal function tests were assessed. KOH mount, skin biopsy, Woods lamp, Grams stain and culture &amp; sensitivity were done if needed after getting informed consent from the patients.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">The most common cutaneous manifestations in haemodialysis patients were xerosis and uraemic pruritus. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Cutaneous manifestations like uraemic pruritus, Xerosis, Kyrle’s disease, infections, icthyosis &amp; other lesions were seen with Xerosis beimg the most common feature. At least one cutaneous manifestation is found in all CRF patients.</span></p>

scholarly journals To Study the Association of Parathyroid Hormone with Severe Anaemia in Chronic Renal Failure Patients

2021 ◽  
Vol 10 (10) ◽  
pp. 724-728
Author(s):  
Madhavi Sarkari ◽  
Mahim Mittal ◽  
Ashutosh Kumar Rai
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Parathyroid Hormone ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Secondary Hyperparathyroidism ◽  
Clinical History ◽  
Intact Parathyroid Hormone ◽  
Mineral And Bone Disorder ◽  
Cross Sectional

BACKGROUND Chronic kidney disease is defined as abnormalities of kidney structure or function, present for > 3 months, with implications for health. In India, the prevalence of chronic kidney disease (CKD), ranges from 0.79 % to 1.4 %. Secondary hyperparathyroidism (SHPT) is one of the less recognized reasons of anaemia in chronic kidney disease (CKD). In this study, we evaluated the role of SHPT as a cause of anaemia, and correlation of intact parathyroid hormone (iPTH) and haemoglobin (Hb) levels in chronic renal failure (CRF) patients on haemodialysis and also in CRF patients who are not on haemodialysis. METHODS This is an observational cross-sectional study done in the department of medicine in BRD Medical College, Gorakhpur, Uttar Pradesh, India, over a period of one year among a total of 101 patients. All patients underwent detailed clinical history, clinical examination & relevant biochemical investigations. RESULTS Parathyroid hormone level was found elevated in 82.2 % CRF patients in our study; out of these 76.2 % patients were severely anaemic. CONCLUSIONS Anaemia mainly normocytic & normochromic is a common complication of chronic kidney disease. Hormonal failure in CRF patients is very commonly reflected as anaemia & mineral and bone disorder (CKD-MBD). Parathyroid hormone was found elevated in most (82.2 %) of the CRF patients with anaemia. KEY WORDS Chronic Renal Failure (CRF), Intact Parathyroid Hormone (iPTH), Secondary Hyperparathyroidism (SHPT), Chronic Kidney Disease (CKD)

scholarly journals The Relationship between Regiousity and Family Support with Meaningfulness of Life of Chronic Kidney Failure’s Clients in Curup Hospital

2018 ◽  
Vol 25 (2) ◽  
pp. 31-38
Author(s):  
Mulyadi Mulyadi ◽  
Almaini Almaini
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Family Support ◽  
Age Group ◽  
Cross Sectional ◽  
Analytical Research ◽  
The Relationship ◽  
The Rose ◽  
Descriptive Method ◽  
Basic Medical

Basic medical research 2013 pointed to an increasing prevalence GGK by province in Indonesia in 2013, interviews doctor's diagnosis increases with age, the rose sharply in the age group 35-44 years (0.3%), was followed the age of 45-54 years (0.4%) and aged 55-74 years (0.5%) is the highest in the age group 75 years (0.6%). The study aims to know the relationship religiousity and family support to the meaningfulness life of patients with chronic renal failure undergoing hemodialysis. Design Analytical research using descriptive method with cross sectional approach. Samples are renal failure patients undergoing hemodialysis in hospitals Curup is counted many as 56 people. The results showed there significant relationship between religiutitas and family support to the meaningfulness life of patients. By increasing religiutitas family support will increase the motivation of patients in hemodialysis therapy. Keywords : CRF, haemodialysis, meaningfulness life, religiousity

Avaliação da Resiliência em Pacientes com Insuficiência Renal Crônica Submetidos à Hemodiálise / Assessment of Resilience in Patients With Chronic Kidney Disease Undergoing Hemodialysis

1970 ◽  
Vol 6 (1) ◽  
pp. 5-13
Author(s):  
Renata Izabel dos Santos ◽  
Otávia Regina Souza Costa
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Health Status ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Renal Insufficiency ◽  
Social Economic ◽  
Descriptive Study ◽  
Psychological Resilience ◽  
Resilience Scale

RESUMOObjetivo: Avaliar o nível de resiliência dos portadores de insuficiência renal crônica em tratamento de hemodiálise. Materiais e Métodos: Estudo prospectivo, quantitativo e de abordagem descritiva. A amostra foi constituída por 61 pacientes em tratamento dialítico. Para obtenção dos resultados, foi utilizada a escala de resiliência, desenvolvida por Wagnild e Young (1993) e adaptada por Pesce et al., (2005). Foi aplicado, também, um questionário para caracterização pessoal, familiar, social, econômica e de saúde do grupo. Resultados: Foi constatado que 61% dos pacientes apresentaram tendência à resiliência. O gênero masculino obteve maior pontuação, sugerindo maior tendência à resiliência, bem como os pacientes que são praticantes de uma religião.  Conclusão: Os resultados assinalam que os pacientes em tratamento dialítico no hospital apresentam capacidade à resiliência, o que sugere melhor adaptação ao tratamento.Palavras-chave: Avaliação, Resiliência psicológica, Insuficiência renal crônica.ABSTRACTObjective: To evaluate de the level of resilience in patients with chronic renal failure undergoing dialysis. Materials and Methods: Prospective, quantitative and descriptive study. The sample consisted of 61 patients on dialysis. To obtain the results we used Resilience Scale developed by Wagnild and Young (1993) and adapted by Pesce et al., (2005). A questionnaire to characterize personal, familiar, social, economic and health status was applied. Results: It was found that 61% of patients showed trend to resilience. Males had higher scores, suggesting more likelihood to resilience, as well as patients who were practitioners of a religion. Conclusion: The results indicate that the majority of patients on dialysis have capability of resilience, which suggests better adaptation to treatment.Keywords: Evaluation, Psychological resilience, Chronic renal insufficiency.

scholarly journals Relationship of Nutritional Substance toward HB Content of Chronic Kidney Failure Patients which Running Hemodialysis

2019 ◽  
Vol 9 (1) ◽  
pp. 1145-1450
Keyword(s):  
Renal Failure ◽  
Folic Acid ◽  
Chronic Renal Failure ◽  
Vitamin C ◽  
Chronic Kidney Failure ◽  
Cross Sectional Study ◽  
Research Subjects ◽  
Chi Square ◽  
Cross Sectional ◽  
The Relationship

Chronic Renal Failure (CRF) is a disease caused due to kidney damage or deterioration glomerulus filtrate rate (GFR/GFR/Glomerular Filtration Rate) <60 ml/min /1.73 m2 for ≥ 3 months. One of the complications that often appears in CRF is anemia or decrease of hemoglobin level in the blood that is related to the relationship intake of nutrients (protein, vitamin C, folic acid and iron). The purpose of this study was to determine the relationship Intake of nutrients (protein, vitamin C, folic acid and iron) on Hb levels of chronic renal failure patients undergoing hemodialysis in RSI Siti Khadijah Palembang. This type of research is an observational analytic with a cross-sectional study design. Population in this study were all outpatients with chronic renal failure undergoing hemodialysis in RSI Siti Khadijah Palembang with total research subjects were 50 subjects, taken using purposive sampling and analyzed using chi-square test. The result showed that there are 52% of patients with chronic renal failure are male more than female. The aged 50-64 years old is 44% and 30-49 years old are 32%. The percentage of outpatients who had an adequate intake of protein, vitamin C, folic acid and iron were 28%, 10%, 0%, and 18% respectively, meanwhile, most of the patients had low hemoglobin levels which were 94%. There was not a significant association between intake of nutrients (protein, vitamin C, folic acid and iron) on Hb levels of chronic renal failure patients undergoing hemodialysis in RSI Siti Khadijah Palembang. Based on these results, should be noted again nutrient intake (protein, vitamin C, folic acid and iron) outpatient before and after undergoing hemodialysis to support the optimal outcome of hemodialysis therapy.

scholarly journals CONDITION AFTER HEMOLYTIC-UREMIC SYNDROME IN A CHILD WITH 3RD STAGE CHRONIC KIDNEY DISEASE (case report)

2017 ◽  
Vol 4 (3) ◽  
pp. 136-138
Author(s):  
M.O. Gonchar ◽  
T.B. Ishenko ◽  
N.V. Orlova ◽  
G.R. Muratov ◽  
T.F. Kolibaeva ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Case Report ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Hemolytic Uremic Syndrome ◽  
Clinical Case ◽  
Disease Case ◽  
Uremic Syndrome ◽  
The Given

Gonchar M.O., Ishchenko T.B., Orlova N.V., Muratov G., Kolibaeva T., Khmara N., Podvalnaya N.Currently, hemolytic-uremic syndrome is one of the frequent causes of acute kidney failure in children, so the timeliness of diagnosis and treatment determines the outcome of the disease. In the given clinical case, a set of certain factors that lead to an unfavorable outcome of the disease and the progression of chronic renal failure are presented. Clinical case of a 14-year-old child K., who was admitted to the nephrology department of the Regional Children's Clinical Hospital with the diagnosis: 3rd stage CKD, subcompensated stage of chronic renal failure and condition after hemolytic-uremic syndrome.KeyWords: hemolytic-uremic syndrome in children, chronic kidney disease. СТАН ПЫСЛЯ ПЕРЕНЕСЕНОГО ГЕМОЛІТИКО-УРЕМІЧНОГО СИНДРОМУ У ДИТИНИ З III СТАДІЄЮ ХРОНІЧНОГО ЗАХВОРЮВАННЯ НИРОК (КЛІНІЧНЕ СПОСТЕРЕЖЕННЯ)Гончарь М.О., Іщенко Т.Б., Орлова Н.В., Муратов Г.Р., Колібаєва Т.Ф., Хмара Н.В., Підвальна Н.А. В даний час гемолітико-уремічний синдром є однією з найчастіших причин гострої ниркової недостатності у дітей, тому своєчасність постановки діагнозу і лікування визначає результат захворювання. На наведеному клінічному випадку, представлено сукупність певних факторів, які привели до несприятливого результату захворювання і прогресування хронічної ниркової недостатності. Клінічний випадок дитини К. 14 років, який знаходився в нефрологічному відділенні Обласної дитячої клінічної лікарні з діагноз: ХХН III ст. Хронічна ниркова недостатність субкомпенсированная стадія. Стан після перенесеного гемолітико-уремічного синдрому.Ключові слова: гемолітико-уремічний синдром, діти, клінічний випадок, хронічне захворювання нирок. СОСТОЯНИЕ ПОСЛЕ ПЕРЕНЕСЕННОГО ГЕМОЛИТИКО-УРЕМИЧЕСКОГО СИНДРОМА У РЕБЕНКА С III СТАДИЕЙ ХРОНИЧЕСКОГО ЗАБОЛЕВАНИЯ ПОЧЕК (КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕ)Гончарь М.А., Ищенко Т.Б., Орлова Н.В., Муратов Г.Р., Колибаева Т.Ф., Хмара Н.В., Подвальная Н.А. В настоящее время гемолитико-уремический синдром является одной из частых причин острой почечной недостаточности у детей, поэтому своевременность постановки диагноза и лечения определяет исход заболевания. На приведенном клиническом случае, представлено совокупность определенных факторов, которые привели к неблагоприятному исходу заболевания и прогрессированию хронической почечной недостаточности. Клинический случай ребенка К. 14 лет, который находился в нефрологическом отделении Областной детской клинической больнице с диагноз: ХБП III ст. Хроническая почечная недостаточность субкомпенсированная стадия. Состояние после перенесенного гемолитико-уремического синдрома.Ключевые слова: гемолитико-уремический синдром, дети, клинический случай, хроническое заболевание почек.

Abstract P116: Chronic Kidney Disease And Cardiac Arrhythmias: A Systematic Review and Meta-analysis

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Esther D Kim ◽  
Ning Ding ◽  
Junichi Ishigami ◽  
Xuejuan Ning ◽  
Yijing Feng ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Systematic Review ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Prospective Studies ◽  
Cardiac Arrhythmias ◽  
Meta Analysis ◽  
Case Control ◽  
Cross Sectional ◽  
The Relationship

Background: Chronic kidney disease (CKD) strongly predicts sudden cardiac death and may elevate the risk of certain cardiac arrhythmias like atrial fibrillation; however, the relationships between CKD and various types of arrhythmia are not well-characterized. Methods: We performed a systematic review and meta-analysis by searching Embase and PubMed for prospective, cross-sectional, and case-control studies examining the associations of two key CKD measures, estimated glomerular filtration rate (eGFR) and albuminuria, with arrhythmias in adults that were published until July 2018. We performed qualitative assessment of studies using the Newcastle Ottawa Quality Assessment Scale. We pooled the results using random-effects models. Results: Among 16,245 articles, we identified 34 prospective (n=24,213,233), 21 cross-sectional (n=253,328), and 4 case-control (n=1,694) studies that included diverse study populations from 19 countries and were mostly high quality. Most prospective studies examined the relationship between eGFR and atrial fibrillation (AF), and demonstrated that lower eGFR was associated with a higher risk of AF (pooled hazard ratio [HR] 1.72 [95% CI: 1.30, 2.27] comparing reduced vs. referent eGFR groups)[ Figure ]. A few studies examined albuminuria and demonstrated its associations with AF (pooled HR 2.16 [95% CI: 1.74, 2.67] comparing high vs. low albuminuria). Results were similar for cross-sectional studies. Four prospective studies reported a higher incidence of ventricular tachycardia resulting in ICD shock according to reduced eGFR (pooled HR 2.32 [95% CI: 1.74, 3.09] comparing reduced vs. referent eGFR groups). Limited number of studies examined other types of arrhythmia. Conclusion: We identified robust data on the relationship between CKD (eGFR and albuminuria) and AF. Reduced eGFR was associated with life-threatening ventricular arrhythmias. Our review highlights the need of future studies for non-AF arrhythmias, especially in the context of albuminuria.

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