scholarly journals UJI EFEK TONIKUM EKSTRAK ETANOL DAUN SAMBILOTO (Andrographis paniculata, Nees.) TERHADAP MENCIT JANTAN (Mus musculus L.) GALUR SWISS

1970 ◽  
Vol 6 (02) ◽  
pp. 17-22 ◽  
Author(s):  
Susi Endrawati ◽  
Feni Indriyani
Keyword(s):  
Mus Musculus ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Probit Analysis ◽  
Control Group ◽  
Test Substance ◽  
Male Mice ◽  
Group I ◽  
Body Strength

The tonic is a substance that can improve our body strength. It can recover the staff our body shortly. It can also make our body stronger and can stimulates our appetite. Knowing the most effective tonic effect dose variation among ethanol extract of bitter leaf on male mice (Mus musculus L.) Swiss Strain. This study is an experimental research design with True experimental design approach Posttest Pretest with control group. The ethanol extract of bitter leaf is made with bitter leaf quote using ethanol 96% with maceration method. The provision of treatment in test animals distinguished on several variations of dosage. In preparation extracts there are 5 groups, namely: group I, II, III, IV, V treated positive control caffeine 13 mg / kg, cooking oil as a negative control, the ethanol extract at a dose of 50 mg / kg, 100 mg / kg, 200 mg / kg. Data obtained tonic effect of added time the mice's ability to defend itself when direnangkan. Data were analyzed by ANOVA using SPSS 18.0 for windows followed by a test post hoc test and ED50 probit analysis to determine the most effective dose as a tonic. Ethanol extract of bitter leaf at a dose of 50 mg / kg have a tonic effect of 9.2 minutes, a dose of 100 mg / kg have a tonic effect of 13.4 minutes, and a dose of 200 mg / kg have a tonic effect 23 minutes. Results yield of ethanol extract of bitter leaf maceration 7.8% b/b. The ethanol extract of bitter leaf tested in test animals male mice (Mus muculus L.) at all doses provide a tonic effect, and the effect will increase along with increasing doses of test substance preparation.

Efek Ekstrak Etanol Kulit Petai (Parkia speciosa Hassk) Terhadap Penurunan Kadar Glukosa Darah Mencit Jantan

2018 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Verawaty Verawaty ◽  
Dhea Claudia Novel
Keyword(s):  
Blood Glucose ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Male Mice ◽  
Glucose Levels ◽  
The Third ◽  
Blood Glucose Levels

<p>Penelitian ini bertujuan untuk melihat pengaruh pemberian ekstrak etanol kulit petai (Parkia speciosa Hassk) terhadap penurunan kadar glukosa darah mencit jantan yang diinduksi aloksan. Hewan percobaan dibagi atas 5 kelompok diantaranya kelompok kontrol negatif, kelompok kontrol positif,dosis I (280 mg/kgBB mencit), dosis II (560 mg/kg BB mencit), dosis III (840 mg/kg BB mencit). Penelitian dilakukan selama 21 hari. Persentase penurunan kadar glukosa darah mencit jantan setelah diberikan ekstrak etanol kulit petai pada hari ke-21 adalah dosis I (77,52 %) lebih besar dibandingkan dengan dosis II (69,5 %) dan dosis III (73,37 %). Data yang diperoleh dianalisis dengan uji Two Way Anova dengan program SPSS 17. Hasil penelitian ini menunjukkan bahwa pemberian ekstrak etanol kulit petai untuk tiga variasi dosis menyatakan perbedaan yang bermakna secara statistik terhadap penurunan kadar glukosa darah mencit jantan.</p><p><em>Petai (Parkia speciosa Hassk) has a compound β-sitosterol and stigmasterol that have efficacy to decreased blood glucose levels. This study aimed to determine the effect of ethanol extract of petai peel for decrease blood glucose levels of male mice induced by alloxan. Experimental animals were divided into 5 groups including negative control group, positive control group, the first dose (280 mg/kg in mice), the second dose (560 mg/kg in mice), the third dose (840 mg/kg in mice). The study was conducted for 21 days. After 21 days, the result found that the percentage of blood glucose levels after the male mice given the ethanol extract of petai peel was, the first dose (77.52%) biger than the second dose (69.5%) and the third dose (73.37%). The data obtained were analyzed by Two Way ANOVA using SPSS 17. The results showed that have signicantly difference between three dose variation of ethanol extract of petai peel in blood glucose levels.</em></p>

UJI POTENSI EKSTRAK DAUN BENALU BATU (BEGONIA SP) TERHADAP KADAR GLUKOSA DALAM DARAH DAN GAMBARAN HISTOPATOLOGI PANKREAS TIKUS PUTIH JANTAN (RATTUS NORVEGICUS)

2020 ◽  
Vol 6 (2) ◽  
pp. 286
Author(s):  
Joni Tandi ◽  
Dela Erni Paerunan ◽  
Nurifa Nurifa ◽  
Yunlis Silintowe Kenta ◽  
Sri Mulyani
Keyword(s):  
Rattus Norvegicus ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Group Iii ◽  
Glucose Levels ◽  
White Rats ◽  
Group I ◽  
Ethanol Extracts

This study aims to determine the potential for glucose levels in the blood of ethanol extracts of the begonias (Begonia Sp.), the effect of the extract on the pancreatic histopathology of white rats (Rattus norvegicus) which was induced by streptozotocin, and the effective dose begonias’ extract leaves on the histopathological descriptions of pancreatic male white rats. This study was an experimental laboratory where the research group consisted of group I (the control group) as a normal control was given a standard feed, group II (negative control) was given a 0.5% Na CMC suspension, group III (positive control) was orally given glibenclamide and experimental groups IV, V, and VI (doses 50, 100, and 200 mg/kg BW). Were given ethanol extract of begonias leaves. The results showed that the ethanol extract of the begonias (Begonia Sp.) contained secondary metabolite compounds, namely flavonoids, alkaloids, saponins, polyphenols, and tannins. Ethanol extract of begonias leaves at adose of 50 mg/kg BW was an affective dose in reducing blood glucoselevels by an avarage of 101,8 mg/dL) and a dose of 50 mg/kg BW can affect the histopathological picture of the pancreas in STZ induuced rats with an average damage value of 2 from a maximum of 4.

scholarly journals PAPARAN EKSTRAK TERIPANG PASIR (Holothuria scabra) TERHADAP GAMBARAN HISTOPATOLOGI HATI MENCIT (Mus musculus)

2016 ◽  
Vol 2 (2) ◽  
pp. 160-169
Author(s):  
Yosep Matruty ◽  
Theopilus Watuguly
Keyword(s):  
Mus Musculus ◽  
Sea Cucumber ◽  
Normal Liver ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Holothuria Scabra ◽  
Liver Histopathology ◽  
Group I

Background: In Indonesia, traditionally sea cucumber (Holothuria scabra) is often used as a cure gout. The purpose of the research is to determine the effects of sea cucumber (Holothuria scabra) extracts against liver histopathology picture mice (Mus musculus). Method: Mice used were male mice as much as 15 tails and were divided into 5 groups. Each group consisted of three mice. Group I as a positive control given allopurino l0.1%. The second group was given distilled water as a negative control. Group III, IV and V as the treatment group was given sea cucumber extract with each concentration of 5%, a concentration of 10% and 15% concentration. Result: The results were analyzed quantitatively, showed that the administration of potassium bromate showed the presence of fatty and necrosis. But after being given a sea cucumber extract with a concentration of 10% and a concentration of 15% still showed the presence of inflammatory cells and remnants of fatty liver (same as the picture of liver histopathology in the positive control). At a concentration of 5% normal liver histopathology same as the picture of liver histopathology in the negative control. Conclution: Sea cucumbers with a concentration of 5% can be used as a gout medicine without any side effects for conditions onal liver function.

UJI AKTIVITAS ANALGETIK EKSTRAK ETANOL HERBA SEMBUKAN (Paederia foetida L.) PADA MENCIT PUTIH JANTAN (Mus musculus) YANG DIINDUKSI DENGAN ASAM ASETAT

2020 ◽  
Vol 5 (2) ◽  
pp. 358-363
Author(s):  
Triswanto Sentat ◽  
◽  
Fitri Handayani ◽  
Ellen Indraswari
Keyword(s):  
Body Weight ◽  
Analgesic Activity ◽  
Mus Musculus ◽  
Ethanol Extract ◽  
Optimal Dose ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Treatment Groups ◽  
Paederia Foetida

Sembukan plants (Paederia foetida L.) are wild vines that are usually used by people as potential medicinal plants for pain. The purpose of this study was to determine the ethanol extract of sembukan’s herbal analgesic activity in male white mice (Mus musculus) and determine the optimal dose of the ethanol extract from sembukan’s herbal (Paederia foetida L.) which has the potential as an analgesic. Sembukan’s herbal is extracted with 70% ethanol solvent and an analgesic activity test is divided into 5 treatment groups namely positive control group (potassium diclofenac), negative control, dose I (80 mg / kg body weight), dose II (160 mg / kg body weight) ) and dose III (320 mg / kg body weight) by oral administration. Thirty minutes after administration, the mice were given an indicator of pain, 0.5% acetic acid. Analgesic power is calculated by counting the amount of stretching of mice for 1 hour. From the results of the study, the ethanol extract of sembukan’s herbal has analgesic activity in male white mice with percent dose analgesic power 35.18%, dose II 53.58% and dose III 68.98%. The optimal dose that has potential as an analgesic in male white mice is dose III with 68.98% analgesic power.

scholarly journals Anti-inflammatory Activity of Ethanol Extract from Malacca Leaves (Phyllanthus emblica) in Carrageenan Induced Male Mice

2020 ◽  
Vol 151 ◽  
pp. 01066
Author(s):  
Nuzul Asmilia ◽  
Amalia Sutriana ◽  
Dwinna Aliza ◽  
Nurfadilla Sudril
Keyword(s):  
Ethanol Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Phyllanthus Emblica ◽  
Male Mice ◽  
Edema Volume ◽  
Volume Measurements ◽  
Group 2

The purpose of this study was to determine the effect of the ethanol extract of malacca leaves (Phyllanthus emblica) to reduce carrageenan-induced edema in mice. This study used 25 mice which were divided into 5 groups with 5 mice per group. All the mice were induced inflammation using carrageenan at a dose of 1%. Mice in group 1 were not given piroxicam and malacca leaves extract. Mice in group 2 were treated with 20 mg of piroxicam suspension. Mice in groups 3, 4, and 5 were given ethanol extract of malacca leaves with doses of 100 mg/kg bb, 200 mg/kg bb, and 300 mg/kg bb, respectively. Edema volume measurements were performed on 5th day by collecting exudates using a syringe. Data were analyzed using one-way analysis of variance and continued with the Duncan test. The result showed that the average of edema volume in the negative control group was 0.09 ± 0.02 mL, while in the positive control group was 0.05 ± 0.03 mL. The average edema volume in groups 3, 4, dan 5 were 0.07 ± 0.01 mL, 0.06 ± 0.02 mL dan 0.07 ± 0.01 mL, respectively. It is concluded that the ethanol extract of malacca leaves (Phyllanthus emblica) can reduce the carrageenan-induced edema in male mice.

scholarly journals Analgesic Activity of Ethanolic Extracts of Karika Leaves (Carica pubescens) In Vivo

2016 ◽  
Vol 1 (2) ◽  
pp. 83 ◽  
Author(s):  
Heru Sasongko ◽  
Sugiyarto Sugiyarto ◽  
Nur Rohman Efendi ◽  
Diah Pratiwi ◽  
Ahmad Dwi Setyawan ◽  
...  
Keyword(s):  
Analgesic Activity ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Chemically Induced

Karika (<em>Carica pubesce</em><em>ns</em>)is a typical plant of the Dieng plateau. Previous study showed that <em>Carica</em><em>pubescens</em>contains chemical compound such as flavonoid that play role in analgesic activity. This study was aimed to determine the analgesic activity of etanolic extracts of karika leaves) in vivo using writhing method. The study was conducted on 25 male mice strain Swiss-Webster (20-30 g, 2-3 months) that were randomly divided into 5 groups. Group I was given distilled water 1 mL (p.o) as negative control, group II was given tramadol 50 mg/kgBW (p.o) as positive control, and group III-V received an etanolic extracts of karika leaves in 3 doses, i.e. 20 mg/kgBW, 40 mg/kgBW, and 80 mg/kgBW (p.o), respectively. Acetic acid 0,5% (v/v) was used as pain inductor.  The writhe was observed within 1 hour. Data analysis was carried out by using one way ANOVA. The result showed that the ethanol extract of leaves Karika <em>(Carica </em><em>pubescens)</em> have activity as an analgesic at a dose of 20 mg / kg, 40 mg / kg and 80 mg / KgBW (p &lt;0.05), chemically induced, where a dose of 80 mg / KgBW (p.o) produce the most high analgesic activity.

scholarly journals Uji Efektifitas Ekstrak Kulit Petai (Parkia speciosa Hassk) Terhadap Mencit (Mus musculus) Sebagai Anti Inflamasi

2020 ◽  
Vol 1 (2) ◽  
pp. 80
Author(s):  
Ilham Maulana ◽  
Ajeng Kurniati Roddu ◽  
Suriani Suriani
Keyword(s):  
Diclofenac Sodium ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Group V ◽  
Group I ◽  
Anti Inflammatory ◽  
Group 5

ABSTRAKTelah dilakukan penelitian uji efektifitas ekstrak etanol kulit petai dengan tujuan untuk mengetahui efek anti inflamasi dari ekstrak etanol kulit petai (Parkia speciosa Hassk).Pengujian dilakukan terhadap hewan uji mencit dengan melihat volume udem telapak kaki dari mencit, yang sebelumnya di induksi oleh putih telur 1%. Perhitungan hasil pengujian menggunakan uji analisis varians dan uji newman - keuls. Pengujian dilakukan dengan membagi 5 kelompok penguian, kelompok I dengan pemberian Na.CMC 1 % sebagai kelompok kontrol negatif   kelompok II dengan pemberian suspensi ekstrak etanol kulit petai dengan konsentrasi 1 %, kelompok III dengan konsentrasi 3%, kelompok IV dengan konsentrasi 5% dan kelompok V dengan pemberian suspensi natrium diklofenak 0,195%b/v sebagai kelompok kontrol positif. Hasil penelitian menunjukkan bahwa ekstrak etanol kulit petai dengan konsentrasi 1%, 3%, dan 5% memiliki efek sebagai anti inflamsi.Kata Kunci: Ekstrak Etanol; Kulit Petai; Anti Inflamasi; Mencit.ABSTRACTHas conducted research Study On Effectiveness of Petai (Parkia speciosa Hassk) Extract, with the aim to determine the anti -inflammatory effect of the ethanol petai extract (Parkia speciosa Hassk). Testing forum mice to test animals by looking at the volume of foot edema of mice , which previously induced by egg white 1 %. Calculations results of testing using analysis of variance test and test newman – keuls. Testing is done by dividing the testing group 5, group I with giving Na. CMC 1% as a negative control, group II and group administration of ethanol extract of petai suspension with a concentration of 1%, group III with a concentration 3%, group IV with a concentration 5% and the group V with the provison of 0,195% diclofenac sodium suspension as the positive control group. The result showed that the ethanol extract of petai with concentration of 1%, 3%, and 5% have anti – Inflamamatory effect.Keywords: Extract Ethanol; Petai; Anti Inflammatory; Mice.

scholarly journals UJI EFEK ANALGESIK EKSTRAK ETANOL KELOPAK BUNGA MATAHARI (Helianthus annuus Linn.) PADA MENCIT SWISS (Mus musculus)

2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Citra R. Irianty ◽  
Jimmy Posangi ◽  
P. M. Wowor
Keyword(s):  
Helianthus Annuus ◽  
Mus Musculus ◽  
Analgesic Effect ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Group Iii ◽  
Helianthus Annuus L ◽  
Swiss Mice ◽  
Group I

Abstrak: Penggunaan tanaman obat semakin berkembang luas di masyarakat, salah satunya yaitu bunga matahari (Helianthus annuus L.). Tumbuhan ini dipercaya memiliki berbagai khasiat, diantaranya sebagai analgesik. Penelitian ini bertujuan untuk mengetahui efek analgesik dari ekstrak etanol kelopak bunga matahari (Helianthus annuus L.) pada mencit Swiss (Mus musculus). Penelitian ini merupakan penelitian eksperimental dengan menggunakan metode rangsangan panas berupa suhu 55°C. Pada penelitian ini digunakan hewan uji berupa mencit jantan yang dibagi dalam 3 kelompok masing-masing terdiri dari 3 ekor. Kelompok I kontrol negatif diberi Aquades 0,3 ml, kelompok II kontrol positif diberi Tramadol 0,18 mg/20grBB mencit dan kelompok III perlakuan diberi ekstrak etanol kelopak bunga matahari 0,3 ml untuk tiap mencit. Penelitian dilakukan selama 1 menit dengan menilai respon mencit berupa meloncat dan atau menjilat kakinya sebagai reaksi untuk mengurangi nyeri. Dari hasil percobaaan dengan pemberian rangsang panas berupa suhu 55°C menunjukkan bahwa respon mencit yang diberikan 0,3 ml ekstrak etanol kelopak bunga matahari, mulai menurun di menit ke-30 dan mencapai maksimal pada menit ke-90. Dari hasil penelitian ini didapatkan bahwa ekstrak etanol kelopak bunga matahari (Helianthus annuus L.) memiliki efek analgesik terhadap mencit Swiss.     Abstract: Sunflower (Helianthus annuus L.) is one of medical herbs where the use of medical plants is getting growth on social community. Those plants believed has many efficacious, one of them was as  analgesic. The aim of this research is to know the analgesic effect of ethanol extract of sunflowers petals (Helianthus annuus L.) in Swiss mice (Mus musculus). This study is an experimental study using heat stimuli of 55°C. This study used male mice which were divided into 3 groups each consisting of three mice. Group I was given distilled water and act as negative control which were given 0,3 ml, group II as positive control were given  0,18 mg/20grBB mice of Tramadol and the group III were given sunflower petals ethanol extract of 0,3 ml. An observation was carried out for 1 minute with expexted response being jumping and licking as a reaction to reduce pain. Results obtained by appling heat stimuli in the temperature of 55°C showed that sunflower petals ethanol extract in the dosase of 0,3 ml of ethanol extract sunflowers petals, start to decline in the 30th minute and reached a maximum in the 90th minute. From the result of this study found that ethanol extract of sunflower petals (Helianthus annuus L.) has an analgesic effect on Swiss mice.

scholarly journals UJI EFEK ANALGESIK EKSTRAK ETANOL BUAH MENGKUDU (Morinda citrifolia L.) PADA MENCIT (Mus musculus)

2013 ◽  
Vol 1 (2) ◽  
Author(s):  
Randy Nicholas Lesiasel
Keyword(s):  
Treatment Group ◽  
Medicinal Plants ◽  
Mus Musculus ◽  
Analgesic Effect ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Morinda Citrifolia ◽  
Laboratory Animals ◽  
Group I

Abstract: Population Indonesia has long been known and used medicinal plants in effort to cope with health problems. Noni plant (Morinda citrifolia L.) is included in the medicinal plants that have been used for traditional medicine in Indonesia, one of them as analgesic. According Younos et al. (1990), noni extract has analgesic effect. Xeronine compound of the noni fruit is suspected to have an analgesic effect. The purpose of this study whether there analgesic effect of ethanol extract of noni fruit (Morinda citrifolia L.) in mice (Mus musculus). This study is an experimental study using heat stimuli such as temperature of 55˚C. This study used laboratory animals such as female mice which were divided into five groups, each consisting of three mices. Group I as negative control was given 0.4 ml of distilled water, group II as positive control was given paracetamol 1000mg/50kgBB, group III as treatment group was given ethanol extract of noni fruit 200mg/kgBB, group IV as treatment group was given ethanol extract of noni fruit 400mg/kgBB and group V as treatment group was given ethanol extract of noni fruit 800mg/kgBB. An observation was carried out for one minute with the expected response being jumping and licking its feet as a reaction to reduce the pain. From the experimental results by providing heat stimuli such as temperature of 55˚C showed that the response of mice decreased in all thre treatment groups compared with the positive control which was given paracetamol.The ethanol extract of noni fruit(Morinda citrifolia L.) has an analgesic effect on mice (Mus musculus). Keywords: Analgesic, Noni fruit (Morinda citrifolia L.), Paracetamol.     Abstrak: Penduduk Indonesia telah lama mengenal dan menggunakan tanaman berkhasiat obat sebagai salah satu upaya dalam menanggulangi masalah kesehatan. Tanaman mengkudu (Morinda citrifolia L.) termasuk dalam tumbuhan obat yang sudah dimanfaatkan untuk pengobatan tradisional di Indonesia salah satunya sebagai analgesik. Menurut Younos et al. (1990), ekstrak mengkudu mempunyai efek analgesik. Senyawa xeronine yang terdapat pada buah mengkudu diduga mempunyai efek analgesik. Tujuan penelitian ini ialah mengetahui ada tidaknya efek analgesik dari ekstrak etanol buah mengkudu (Morinda citrifolia L.) pada mencit (Mus musculus).Penelitian ini ialah penelitian eksperimental dengan menggunakan metode rangsang panas berupa suhu 55˚C. Pada penelitian ini digunakan hewan uji berupa mencit betina yang dibagi dalam lima kelompok masing-masing terdiri dari tiga ekor. Kelompok I kelompok negatif diberi aquades 0,4 ml, kelompok II kelompok positif diberi parasetamol 1000mg/50kgBB, kelompok III kelompok perlakuan diberi ekstrak etanol buah mengkudu 200mg/kgBB, kelompok IV kelompok perlakuan diberi ekstrak etanol buah mengkudu 400mg/kgBB dan kelompok V kelompok perlakuan diberi ekstrak etanol buah mengkudu 800mg/kgBB. Penilaian dilakukan selama satu menit dengan menilai respon mencit berupa melompat dan atau menjilat kakinya sebagai reaksi untuk mengurangi nyeri.Dari hasil percobaan dengan pemberian rangsang panas berupa suhu 55˚C menunjukkan bahwa respon mencit pada ketiga kelompok perlakuan menurun dibandingkan dengan kontrol positif yang diberi parasetamol.Ekstrak etanol buah mengkudu  (Morinda citrifolia L.) memiliki efek analgesik terhadap mencit (Mus musculus). Kata kunci: Analgesik, Buah mengkudu (Morinda citrifolia L.), Parasetamol.

scholarly journals UJI EFEK ANALGESIK EKSTRAK KULIT BATANG POHON MATOA (Pometia pinnata) PADA MENCIT (Mus musculus)

2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Rafly F. Lumintang ◽  
Jane Wuisan ◽  
Pemsy M. Wowor
Keyword(s):  
Mus Musculus ◽  
Analgesic Effect ◽  
Negative Control Group ◽  
Treated Group ◽  
Positive Control ◽  
Negative Control ◽  
Bark Extract ◽  
Control Group ◽  
Group Iii ◽  
Group I

Abstract: Pain is an unpleasant sensation that derives from the complex neurochemical processes in the central and peripheral nervous systems. Side effects of drugs inter alia opioids and NSAIDs can cause serious disorders, therefore, it is necessary to find and develop other effective analgesic drugs with low toxicity. In Indonesia, matoa (Pometia pinnata) is known as a typical plant in Papua especially in West Papua. In some countries, parts of matoa plants are used as traditional medicine. This study aimed to determine the analgesic effect of matoa bark extract (Pometia pinnata) on mice Mus musculus. This was an experimental study. Nine male mice weighed 30 g were divided into 3 groups, each consisted of 3 mice. Group I, the negative control group, was given aquadest; group II, the positive control group, was given aspirin solution; and group III, the treated group, was given matoa bark extract. Analgesic effect was determined by counting the mice movements (licking their back legs or jumping) during 1 minute in a beaker with a temperature of 550C. The results showed that after 30 minutes the average number of movements of the treated group decreased from 22 times to 19.3 times, and continued to decrease until 1 movement after 120 minutes. Conclusion: Matoa bark extract showed analgesic effect on mice Mus musculus.Keywords: analgesic effect, matoa bark, miceAbstrak: Nyeri adalah sensasi yang tidak menyenangkan yang berasal dari proses neurokimia kompleks di sistem saraf pusat dan perifer. Opioid dan golongan AINS dapat menimbulkan efek samping yang cukup berat; oleh karena itu, diperlukan obat analgesik yang efektif dengan toksisitas rendah. Di Indonesia, matoa (Pometia pinnata) dikenal sebagai tanaman khas Papua terutama Papua Barat. Di beberapa negara, bagian-bagian dari tanaman matoa telah digunakan sebagai obat tradisional. Penelitian ini bertujuan untuk mengetahui efek analgesik ekstrak kulit batang pohon matoa (Pometia pinnata) pada mencit Mus musculus. Penelitian ini menggunakan metode eksperimental. Sembilan ekor mencit jantan dengan berat rata-rata 30 g dibagi atas 3 kelompok hewan uji yang masing-masing terdiri dari 3 ekor mencit. Kelompok I yaitu kelompok kontrol negatif diberikan akuades; kelompok II yaitu kelompok kontrol positif diberikan larutan aspirin; dan kelompok III yaitu kelompok perlakuan diberikan ekstrak kulit batang matoa. Efek analgesik berupa jumlah gerakan mencit selama 1 menit saat diletakan di dalam beker dengan suhu tetap 550C. Gerakan yang dihitung berupa gerakan menjilat kaki belakang atau meloncat. Hasil penelitian menunjukkan bahwa pada menit ke-30 terjadi penurunan rerata jumlah respon gerakan mencit dari 22 kali menjadi 19,3 kali yang terus berkurang hingga menit ke-120 dimana hanya terdapat 1 gerakan. Simpulan: Ekstrak kulit batang pohon matoa memiliki efek analgesik pada mencit Mus musculus.Kata kunci: efek analgesik, kulit batang matoa, mencit

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