Seborrheic dermatitis prevalence in HIV patients

Objective. Highlighting seborrheic dermatitis prevalence in HIV patients and evaluating clinico-therapeutical correlations. Material and methods. Between 1.10.2011 – 31.12.2014 we performed a prospective study on a group of 121 HIV-positive patients hospitalized in the HIV Adults Department in the Infectious Diseases Hospital, Constanta, to determine the prevalence, clinical particularities and treatment response of seborrheic dermatitis in HIV + patients. Results. Seborrheic dermatitis has been reported in 33.05% of patients, predominantly male (M:F = 9:1), with peak incidence in the 20-30 age group. Lesions prevalence according to the site of seborrheic dermatitis was: face (15%), scalp (22.5%), face and scalp (45%), chest (12.5%). In terms of clinical severity, 27.5% patients had mild seborrheic dermatitis, while 62.5% had moderate seborrheic dermatitis, and 10% were diagnosed with the severe form. Therapeutic response was evaluated at day 7, 14 and after 8 weeks, assessing the decrease/disappearance of erythema and flaking, and pruritus improvement/remission. After 8 weeks of treatment, complete remission was reported in 70% patients. However, HIV+ patients with seborrheic dermatitis had between 2-5 episodes per year, relapses being reported at 4 to 12 weeks after discontinuation of treatment, mean 7 weeks. Conclusions. The present study indicates a moderate prevalence of seborrheic dermatitis in hospitalized HIV+ patients. Although clinical manifestations do not differ from those of seborrheic dermatitis in seronegative patients, the clinical course of disease reveals the extensive character of seborrheic dermatitis in HIV+ patients with more severe lesions, refractory to treatment, and frequent recurrences, even in patients receiving prolonged treatment.

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Inflammatory and Immune Biomarkers in Predicting the Severity in COVID-19

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2021/v33i1330950 ◽

2021 ◽

pp. 1-13

Author(s):

Shrishti Dhar Prasad ◽

Suprava Patel ◽

Ajoy Kumar Behera ◽

Dibakar Sahu ◽

Seema Shah ◽

...

Keyword(s):

Serum Ferritin ◽

Clinical Manifestations ◽

Clinical Score ◽

Severe Form ◽

Clinical Severity ◽

Close Monitoring ◽

Complement Factor ◽

Immune Biomarkers ◽

Mortality Outcome ◽

Complement Factor C3

Aims: An early diagnosis of severity can be confidently judged by monitoring the serum biomarkers in patients with COVID-19. The study was thus aimed to explore the relationship of the inflammatory and immune biomarkers in predicting the severity of the disease. Study design: It is a retrospective observational study. Methodology: The study included 79 confirmed cases of COVID-19 who had complete clinical record for the analytical variables. All cases were assigned a total clinical score as per their clinical manifestations, associated co-morbidities and mortality outcome. Laboratory inflammatory and immune biomarkers at the time of admission were noted. Results: The mean age of the study population was 55.38 (1.69) years. The percentage of admission for males (67.1%) was twice that of females (32.9%). Serum LDH (p=0.003) and ferritin (0.019) levels were remarkably raised in severe form. Total clinical score denoted a positive correlation with the inflammatory biomarkers (p<0.001). IgM exhibited a significant negative trend with increasing clinical score (p<0.001) and CRP levels (p=0.022) of the patients. The multivariate analysis reflected that the total clinical score was significantly influenced by initial SpO2 values (0.011), serum ferritin (0.027), IgM (0.001) and C3 levels (0.044) in the COVID-19 patients. Lower serum C3 values significantly influenced the hospitalization duration in moderate cases (p=0.034) and total clinical score in severe cases (p=0.01). Conclusion: The findings of the study signified that besides serum ferritin, a serial and close monitoring of serum IgM with complement factor C3 would aid in early prediction of clinical severity and thus guide physicians to start effective management strategy.

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Clinical signs of tuberculosis relapses in HIV patients

Tuberculosis and lung diseases ◽

10.21292/2075-1230-2020-98-6-32-35 ◽

2020 ◽

Vol 98 (6) ◽

pp. 32-35

Author(s):

E. Yu. Zorkаltsevа ◽

Yu. O. Egorovа

Keyword(s):

Central Nervous System ◽

Hiv Infection ◽

Treatment Efficacy ◽

Medical Records ◽

Clinical Signs ◽

Clinical Manifestations ◽

Hiv Positive ◽

Hiv Patients ◽

The Central Nervous System ◽

Hiv Negative

The objective: to study clinical manifestations of tuberculosis relapses and their treatment outcomes in patients with HIV infection.Subjects and Methods. 132 medical records of patients with tuberculosis relapses were analyzed; 69 of them were HIV-positive and 63 were HIV-negative. All of them were admitted to Irkutsk Regional Clinical Tuberculosis Hospital from 2016 to 2019, and then continued treatment of tuberculosis on the out-patient basis. Treatment efficacy was assessed in February 2020.Results. More severe clinical forms of tuberculosis relapses were typical of HIV patients including generalized forms affecting the central nervous system. Therefore, among these patients, the mortality rate is significantly higher (24.6%) than in tuberculosis relapses with no concurrent HIV infection (6.3%), p ≤ 0.05.

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12 Novel Clonal Groups of Leptospira Infecting Humans in Multiple Contrasting Epidemiological Contexts in Sri Lanka

10.1101/2020.08.28.20177097 ◽

2020 ◽

Author(s):

Dinesha Jayasundara ◽

Indika Senavirathna ◽

Janith Warnasekara ◽

Chandika Gamage ◽

Sisira Siribaddana ◽

...

Keyword(s):

Sri Lanka ◽

Prospective Study ◽

Full Range ◽

Clinical Manifestations ◽

Kidney Injury ◽

Clinical Severity ◽

Isolation And Identification ◽

Dry Zone ◽

Culture Independent ◽

A Prospective Study

AbstractLeptospirosis is a ubiquitous disease and a major clinical challenge owing to the multitude of clinical presentations and manifestations that are possibly attributable to the diversity of Leptospira, the understanding of which is key to study the epidemiology of this emerging global disease threat. Sri Lanka is a hotspot for leptospirosis with high levels of endemic disease as well as annual epidemics. We carried out a prospective study of Leptospira diversity in Sri Lanka, covering the full range of climatic zones, geography, and clinical severity. Samples were collected for leptospiral culture from 1192 patients from 15 of 25 districts in Sri Lanka over two and half years period. Twenty five isolates belonging to four pathogenic Leptospira species were identified: L. interrogans, L. borgpetersenii, L. weilii, and L. kirschneri. At least six serogroups were identified among the isolates: Autumnalis (6), Pyrogenes (4), Icterohaemorrhagiae (2), Celledoni (1), Grippotyphosa (2) and Bataviae (1). Seven isolates did not agglutinate using available antisera panels, suggesting new serogroups. Isolates were sequenced by Illumina. These data add 25 new core genome sequence types and were clustered in 15 clonal groups, including 12 new clonal groups. L. borgpetersenii was found only in the dry zone and L. weilii only in the wet zone. Acute kidney injury and cardiovascular involvement were seen only with L. interrogans infections. Thrombocytopenia and liver impairment were seen in both L. interrogans and L. borgpetersenii infections. The inadequate sensitivity of culture isolation to identify infecting Leptospira species underscores the need for culture-independent typing methods for Leptospira.Author SummaryThere is a huge diversity in pathogenic Leptospira species worldwide, and our knowledge of the currently circulating species is deficient owing to limited isolation and identification of Leptospira species from endemic countries. This prospective study reveals the wide pathogen diversity that causes human leptospirosis in Sri Lanka, representing four species, more than six serogroups, and fifteen clonal groups. Further, the different geographic and climatic zone distributions and clinical manifestations observed underscores the need for prospective studies to expand the molecular epidemiological approaches to combat leptospirosis

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Cytopathology Lymphadenopathy Feature in HIV Positve Patient: Diagnosis Tools Comorbidities

Journal Of Medicine & Health ◽

10.28932/jmh.v1i3.517 ◽

2016 ◽

Vol 1 (3) ◽

Author(s):

Hasrayati Agustina ◽

Yenni Wisudarma ◽

Ris Kristiana ◽

Bethy S. Hernowo

Keyword(s):

Lymph Nodes ◽

Medical Records ◽

Fine Needle Aspiration Biopsy ◽

Clinical Manifestations ◽

Needle Aspiration ◽

Hiv Positive ◽

Tuberculous Lymphadenitis ◽

Patient Diagnosis ◽

Granulomatous Lymphadenitis ◽

Anatomical Pathology

Lymphadenopathy is enlarged lymph nodes caused by infection, inflammation or malignancy. On HIV positive patients, lymphadenopathy is one of the most common clinical manifestations and it is usually persistent. Fine-needle aspiration biopsy (FNAB) is an effective cytology technique in determining the diagnosis of lymphadenopathy. This study aimed to describe the cytopathology of lymphadenopathy in HIV positive patients. This is a descriptive study of 21 cases of lymphadenopathy in patients with HIV positive who underwent FNAB examination in Anatomical Pathology Department of Dr.Hasan Sadikin Hospital between 2013-2014. Medical data was taken from the patient medical records including age, sex, location, size and cytopathological diagnosis. Cytopathology overview of FNAB specimens were reassessed by 2 pathologists. In this study, lymphadenopathy in HIV positive patients were mainly found in men (n = 15.71%) with an average age between 20-30 years. The most frequent location was the neck (n = 20.95.2%). The lymph nodes size were found between 0.5-3 cm. Most diagnosis was tuberculous lymphadenitis (n = 15.71%) with the most common cytology feature was granulomatous lymphadenitis (n = 5.33.3%) and suppurative lymphadenitis (n = 5.33.3%). FNAB examination in lymphadenopathy is very helpful to identify the cause of infection in HIV positive patients. Keywords: FNAB, HIV, lymphadenopathy, cytopathology

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Generalized mycobacteriosis with secondary lesions of the spine in HIV positive patients

MedAlliance ◽

10.36422/23076348-2020-8-1-54-60 ◽

2020 ◽

Vol 8 (1) ◽

pp. 54-60

Keyword(s):

Antibiotic Therapy ◽

Granulomatous Inflammation ◽

Hiv Positive ◽

Hiv Patients ◽

Histological Picture ◽

Clinical Observations ◽

Spinal Lesion ◽

Secondary Lesion

2 clinical observations of generalized forms of mycobacteriosis in HIV (+) patients complicated by secondary spinal lesion are described. Anamnestic data on the presence of mycobacteriosis of the lungs allowed to suspect a secondary lesion of the spine. Verification of the diagnosis is possible only with bacteriological confirmation, since the histological picture is nonspecific and resembles tuberculous granulomatous inflammation. Treatment of spondylitis caused by non-tuberculous mycobacteria is complex and includes both surgical rehabilitation of the focus and long-term (at least 1 year) antibiotic therapy.

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Clinical outcomes of syphilis in HIV-negative and HIV-positive MSM: occurrence of repeat syphilis episodes and non-treponemal serology responses

Sexually Transmitted Infections ◽

10.1136/sextrans-2020-054887 ◽

2021 ◽

pp. sextrans-2020-054887

Author(s):

Silvia Achia Nieuwenburg ◽

Ricardo Jamie Sprenger ◽

Maarten Franciscus Schim van der Loeff ◽

Henry John Christiaan de Vries

Keyword(s):

Hiv Infection ◽

Controlled Trial ◽

Clinical Manifestations ◽

Response To Treatment ◽

Disease Stage ◽

Hiv Positive ◽

Sexual Risk Behaviour ◽

Serological Response ◽

History Of ◽

Hiv Negative

ObjectivesHIV-positive men who have sex with men (MSM) may be at a higher risk of repeat syphilis, have different clinical manifestations and have a different serological response to treatment compared with HIV-negative MSM. The objective of this study was to assess whether HIV-negative and HIV-positive MSM with infectious syphilis (primary, secondary or early latent) differed in history of previous syphilis episodes, disease stage and non-treponemal titre of initial and repeat episodes, and the titre response 6 and 12 months after treatment. Furthermore, determinants associated with an inadequate titre response after treatment were explored.MethodsThis retrospective analysis used data of five longitudinal studies (four cohorts; one randomised controlled trial) conducted at the STI clinic in Amsterdam, the Netherlands. Participants were tested for syphilis and completed questionnaires on sexual risk behaviour every 3–6 months. We included data of participants with ≥1 syphilis diagnosis in 2014–2019. Pearson’s χ² test was used to compare HIV-negative and HIV-positive MSM in occurrence of previous syphilis episodes, disease stage of initial and repeat syphilis episode and non-treponemal titre treatment responses.ResultsWe included 355 participants with total 459 syphilis episodes. HIV-positive MSM were more likely to have a history of previous syphilis episodes compared with HIV-negative MSM (68/90 (75.6%) vs 96/265 (36.2%); p<0.001). Moreover, HIV-positive MSM with repeat syphilis were less often diagnosed with primary syphilis (7/73 (9.6%) vs 36/126 (28.6%)) and more often diagnosed with secondary syphilis (16/73 (21.9%) vs 17/126 (13.5%)) and early latent syphilis (50/73 (68.5%) vs 73/126 (57.9%)) (p=0.005). While not significantly different at 12 months, HIV-negative MSM were more likely to have an adequate titre response after 6 months compared with HIV-positive MSM (138/143 (96.5%) vs 66/74 (89.2%); p=0.032).ConclusionsIn repeat syphilis, HIV infection is associated with advanced syphilis stages and with higher non-treponemal titres. HIV infection affects the serological outcome after treatment, as an adequate titre response was observed earlier in HIV-negative MSM.

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AB1045 CLINICAL, ANALYTICAL AND RADIOLOGICAL CHARACTERISTICS OF A COHORT OF PATIENTS WITH SARCOIDOSIS.

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.6414 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1814.2-1814

Author(s):

I. Madroñal García ◽

C. Aguilera Cros ◽

L. Mendez Diaz

Keyword(s):

Systemic Disease ◽

Immunosuppressive Treatment ◽

Clinical Manifestations ◽

Corticosteroid Treatment ◽

Pulmonary Involvement ◽

List Type ◽

Chi Square ◽

Course Of Disease ◽

Chronic Course ◽

Radiological Stage

Background:Sarcoidosis is a systemic disease whose etiology is unknown. It is characterized by the formation of granulomas in any tissue of the organism. Ganglionic, pulmonary and cutaneus involvement is the most prevalent.Objectives:Describe clinical characteristics of a cohort of patients with sarcoidosis diagnosed.Define the association between the ACE’s number at diagnosis, radiological lung stage, treatment and course of disease.Evaluate if the extrapulmonary involvement is related to the course of the disease.Methods:Descriptive retrospective study of patients with S diagnosis treated in our Hospital in 2019. Data were obtained by reviewing medical records. Chi-square tests and parametric tests have been used to establish the differences described in the objectives.Results:102 patients diagnosed with sarcoidosis have been included, (51% females) with an average age of 56±11 years. Suspected diagnosis at the onset of disease was S in 70.6% of patients, followed by suspected lymphoma (20.6%). The average time for the definitive diagnosis of S was 9.5 months. 70.6% of the patients had elevated ACE titles at the beginning. Regarding the clinical manifestations, 18.6% of the patients presented fever at the beginning and 66.7% extrathoracic clinical manifestations. 72.5% have lymph node adenopathies, and in 91% there is thoracic involvement (the most frequent pulmonary stage is stage II). A biopsy was performed in 84.3% of the patients, the lung biopsy being the most performed (52.3%). 88.2% of patients received corticosteroid treatment at the onset of the disease (currently under treatment with corticosteroids 37.3%). 50% of patients are treated with immunosuppressants, Methotrexate was the most used. 5 patients are treated with biological therapy (AntiTNF).Regarding the course of the disease, 51% of the patients have a chronic course, 45.1% are in remission and 3.9% have suffered a relapse of the disease. In this study, no significant relationship was found between the ACE values at the onset of the disease, the pulmonary stage and the course of the disease.According to our data, patients presenting with extrathoracic clinical manifestations need more frequently corticosteroid treatment (p = 0.017) and immunosuppressive treatment (p = 0.001) with respect to patients who do not have an extrathoracic clinic. In addition, patients with an extrathoracic clinic present more frequently a chronic course of the disease than those who do not (p = 0.019).Conclusion:The results described in this study are similar to those found in the literature. The differences found can be explained because patients presenting with extrathoracic clinical manifestations have a more complicated management and need more treatment than those with only pulmonary involvement, even patients with radiological stage I do not usually need treatment, only surveillance.Disclosure of Interests:None declared

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Lack of Medical Support in HIV Infection and Unstable Mood States

Psychological Reports ◽

10.2466/pr0.1997.81.2.635 ◽

1997 ◽

Vol 81 (2) ◽

pp. 635-639

Author(s):

Motoko Hayashi ◽

Isao Fukunishi

Keyword(s):

Social Support ◽

Depressive Symptoms ◽

Major Depression ◽

Hiv Infection ◽

Mood Disorders ◽

Early Stage ◽

Mood States ◽

Hiv Positive ◽

Medical Support ◽

Hiv Patients

This study examined what kinds of social support are related to mood states in a sample of 50 HIV-positive patients without AIDS (46 men and 4 women; M age 36.5 yr., SD = 9.8). In the early stage of HIV infection, HIV patients without AIDS may be prone to depressive symptoms although none of these HIV-positive patients' symptoms fulfilled the DSM-III-R Mood Disorders including Major Depression. The depressive symptoms were not significantly related to lack of ordinary social support such as friends and family but were significantly associated with dissatisfaction with HIV/AIDS-related medical support

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Evaluation of microalbumin, cystatin c, creatinine and uric acid levels in HIV patients in Nnamdi Azikiwe University Teaching Hospital, Nnewi

The Journal of Community Health Management ◽

10.18231/j.jchm.2021.030 ◽

2021 ◽

Vol 8 (3) ◽

pp. 132-142

Author(s):

Ezeugwunne Ifeoma Priscilla ◽

Amaifeobu Clement ◽

Meludu Samuel Chukwuemeka ◽

Analike Rosemary Adamma ◽

Nnamdi Johnjude Chinonso ◽

...

Keyword(s):

Uric Acid ◽

Cystatin C ◽

Teaching Hospital ◽

University Teaching ◽

Hiv Positive ◽

Hiv Patients ◽

Voluntary Counseling And Testing ◽

Group B ◽

And Control ◽

Hiv Negative

This study evaluated the microalbumin, cystatin C, creatinine and uric acid levels in HIV patients in Nnamdi Azikiwe University Teaching Hospital, Nnewi (NAUTH). A total of one hundred (100) male and female HIV positive and control participants who were aged between 18 and 60 years attending the voluntary counseling and testing unit (VCT) and antiretroviral therapy unit (ART) of NAUTH were randomly recruited for the study and grouped thus: Group A (HIV positive symptomatic participants on long term ART (HPSPLTART) (n= 25); Group B (HIV positive symptomatic participants on short term ART (HPSPSTART) (n= 25); Group C: Asymptomatic HIV positive participants NOT on ART (AHPPNART) (n=25) and Group D: control (n=25).6mls of blood sample and 10mls of freshly voided urine samples were collected from each of the participants for the evaluation of biochemical parameters using standard laboratory methods. Results showed significantly higher BMI and SBP in HPSPSTART than in control (p=0.04; 0.02). SBP was significantly higher in HPSPLTART than in AHPPNART and Control (p=0.00). DBP was significantly higher in HPSPLTART than in HPSPSTART and control respectively (p=0.00). There were significantly higher plasma creatinine and Cys-C levels in both male HIV positives and male HIV positive participants on ART than in both females respectively (p0.00; 0.02). Also, BMI, creatinine, uric acid and Cystatin C levels were significantly higher in male HIV negative participants than in female HIV negative participants (p=0.00; 0.04; 0.02; 0.01). This study has revealed greater risk for renal disease among the HIV participants studied.

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The rarity of gonococcal arthritis in association with HIV infection

The Journal of Infection in Developing Countries ◽

10.3855/jidc.4450 ◽

2014 ◽

Vol 8 (09) ◽

pp. 1222-1227 ◽

Cited By ~ 2

Author(s):

Rasha Maharaj ◽

Girish M Mody

Keyword(s):

Neisseria Gonorrhoeae ◽

Hiv Infection ◽

Skin Rash ◽

Throat Swab ◽

Hiv Positive ◽

Hiv Patients ◽

Acute Arthritis ◽

Gonococcal Urethritis ◽

The Right

Gonococcal urethritis is common with HIV, but gonococcal arthritis is rare. We report two HIV-positive patients with gonococcal arthritis and review previously published reports. A 27-year-old HIV-positive female presented with a pustular skin rash and acute oligoarthritis. Neisseria gonorrhoeae was cultured from the right elbow aspirate. The second patient, a 24-year-old HIV-positive female on zidovudine for one month, presented at 28 weeks gestation with acute oligoarthritis and peroneal tenosynovitis. Neisseria gonorrhoeae was cultured from the throat swab. Both patients responded to ceftriaxone. Gonococcal arthritis must be considered in HIV patients with acute arthritis.

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