Introducción. Situación mundial del Cáncer de Mama

Author(s):  
Alejandro Crismatt Zapata

<p>[Introduction. World situation of Breast Cancer]</p><p>Resumen<br />El cáncer de mama es el tumor de la mujer más diagnosticado en la gran mayoría de los países. Los factores no hereditarios son los principales impulsores de las diferencias internacionales e inter-étnicas observadas en la incidencia de este cáncer. Las tasas de incidencia del cáncer de mama han aumentado en la mayoría de los países en transición en las últimas décadas, en tanto que en la mayoría de los países más avanzados, las tasas de mortalidad por cáncer de mama han ido en descenso como resultado de la detección temprana de la enfermedad, los avances en el tratamiento y mayor accesibilidad a los servicios de salud. Los principales factores de riesgo para el cáncer de mama no son fácilmente modificables porque se derivan de exposiciones hormonales endógenas prolongadas. La prevención a través de la promoción de la lactancia materna, particularmente su mayor duración, pudiera ser beneficioso. La incidencia de cáncer de mama en Panamá se comporta de manera similar a los países con índice de desarrollo Humano en transición; ha ido en aumento en las últimas décadas como resultado del aumento en la prevalencia de los factores de riesgo conocidos y la mejoría en la recolección de datos.<br /><br />Abstract<br />Breast cancer is the most diagnosed woman's tumor in the vast majority of countries. The non-hereditary factors are the main drivers of the international and inter-ethnic differences observed in the incidence of this cancer. Breast cancer incidence rates have increased in most countries in transition in recent decades, while in most of the more advanced countries, breast cancer death rates have been declining as a result of breast cancer. early detection of the disease, advances in treatment and greater accessibility to health services. The main risk factors for breast cancer are not easily modifiable because they are derived from prolonged endogenous hormonal exposures. Prevention through the promotion of breastfeeding, particularly its longer duration, could be beneficial. The incidence of breast cancer in Panama behaves similarly to countries with a Human Development Index in transition; It has been increasing in recent decades as a result of the increase in the prevalence of known risk factors and the improvement in data collection.</p>

1998 ◽  
Vol 16 (9) ◽  
pp. 3105-3114 ◽  
Author(s):  
M Gail ◽  
B Rimer

PURPOSE To develop risk-based recommendations for mammographic screening for women in their 40s that take into account the woman's age, race, and specific risk factors. METHODS We assumed that regular mammographic screening is justified for a 50-year-old woman, even one with no risk factors, and that a younger woman with an expected 1-year breast cancer incidence rate as great or greater than that of a 50-year-old woman with no risk factors would benefit sufficiently to justify regular screening. Recommendations under this criterion were based on age- and race-specific breast cancer incidence rates from the National Cancer Institute's (NCI's) Surveillance, Epidemiology, and End Results (SEER) Program; assessments of risk factors from the Breast Cancer Detection and Demonstration Project (BCDDP); and reports in the literature. RESULTS Two methods, the exact-age procedure (EAP) and the grouped-age procedure (GAP), were developed. The less precise GAP only requires following a flow diagram. The proportion of white women recommended for screening by the EAP ranges from 10% for 40-year-old women to 95% for 49-year-old women, and the corresponding percentages for black women are 16% and 95%. The assumptions that underlie the guidelines are discussed critically. CONCLUSION For women or physicians who prefer an individualized approach in deciding whether to initiate regular mammographic screening in the age range of 40 to 49 years, the present report offers recommendations based on individualized risk-factor data and clearly stated assumptions that have an empiric basis. These recommendations can be used to facilitate the counseling process.


2020 ◽  
Vol 28 ◽  
pp. e49435
Author(s):  
Madja Rhuanna Soares Macêdo ◽  
Milka Leandro Saldanha Toscano ◽  
Walkiria Gomes da Nóbrega ◽  
Joyce Viana Barbosa ◽  
Flávia Barreto Tavares Chiavone ◽  
...  

Objetivo: identificar e mapear estratégias preconizadas para prevenção de linfedema em pacientes submetidas a esvaziamento axilar em tratamento do câncer de mama. Método: revisão de escopo realizada em agosto de 2019 considerando oito bases de dados e oito bases da literatura cinzenta. A amostra final foi composta por 13 artigos, selecionados de acordo com critérios de elegibilidade. Resultados: os estudos foram predominantemente randomizados, com nível de evidência 1a, e realizados na América do Norte. Medidas preventivas tradicionalmente utilizadas, como limitar exercícios com carga ou evitar punção venosa e aferição de pressão arterial, não se demonstraram efetivas em nenhum dos estudos encontrados. Foi evidenciado como medida preventiva o controle dos fatores de risco modificáveis associados ao linfedema: IMC elevado (> 25 kg/m2) e quimioterapia administrada no braço ipsilateral. Conclusões: não foram apresentadas evidências significativas para medidas cotidianamente preconizadas na prevenção do linfedema, e fatores de risco modificáveis se destacaram entre os riscos para seu desenvolvimento.ABSTRACTObjective: to identify and map strategies recommended for prevention of lymphedema in patients after axillary dissection during breast cancer treatment. Method: this scoping review was conducted in August 2019 across eight databases and eight gray literature data sources. The final sample comprised 13 journal articles that met eligibility criteria. Results: the studies, most of which were randomized, conducted in North America, and offered Level 1a evidence. None of the studies reviewed found traditionally employed preventive measures, such as limiting weight training or avoiding venipuncture and blood pressure measurements, to be effective. Evidence indicated that controlling modifiable lymphedema-related risk factors – namely high BMI (> 25 kg/m²) and chemotherapy administration in the ipsilateral arm – was a preventive measure. Conclusion: no significant evidence was reported for traditionally recommended preventive measures against lymphedema, and modifiable factors figured prominently among risk factors for lymphedema.RESUMENObjetivo: identificar y mapear las estrategias recomendadas para la prevención del linfedema en pacientes después de una disección axilar durante el tratamiento del cáncer de mama. Método: esta revisión de alcance se realizó en agosto de 2019 en ocho bases de datos y ocho fuentes de datos de literatura gris. La muestra final comprendió 13 artículos de revistas que cumplieron con los criterios de elegibilidad. Resultados: los estudios, la mayoría de los cuales fueron aleatorios, se realizaron en Norteamérica y ofrecieron evidencia de Nivel 1a. Ninguno de los estudios revisados encontró que las medidas preventivas empleadas tradicionalmente, como limitar el entrenamiento con pesas o evitar la punción venosa y las mediciones de la presión arterial, sean efectivas. La evidencia indicó que el control de los factores de riesgo relacionados con el linfedema modificables, a saber, un IMC alto (> 25 kg / m²) y la administración de quimioterapia en el brazo ipsilateral, era una medida preventiva. Conclusión: no se informó evidencia significativa de las medidas preventivas recomendadas tradicionalmente contra el linfedema, y los factores modificables figuraron de manera prominente entre los factores de riesgo para el linfedema.


Author(s):  
Alejandro Crismatt Zapata ◽  
Joel Moreno ◽  
Ruth M. Vergara ◽  
Héctor Tapia ◽  
Bleixen G. Admadé ◽  
...  

<p>Risk Assessment, Screening, Clinical - Pathological Diagnosis and Staging of Breast Cancer: 1st National Consensus of Breast Cancer of the Panamanian Society of Oncology (SPO)<br /><br /></p><p>Resumen<br />El cáncer de Mama es el tumor más frecuente de la mujer y su incidencia va en aumento. En la atención primaria del paciente, se debe establecer el riesgo de padecer cáncer de mama durante la vida, a través de una historia clínica orientada a los factores de riesgo familiares e individuales, de tal forma que podamos implementar las estrategias de tamizaje apropiadas. Las estrategias de tamizaje deben ser aplicadas de manera sistemáticas, y los resultados anormales referidos a un centro con experiencia en el diagnóstico. Los pacientes diagnosticados deben ser evaluador por un equipo multidisciplinario con experiencia en el manejo de la muestra, estadificación y tratamiento del cáncer de mama.<br /><br />Summary<br />Breast cancer is the most frequent tumor in women and its incidence is increasing. In the primary care of the patient, the risk of suffering from breast cancer should be established during life, through a clinical history focused on family and individual risk factors, in such a way that we can implement the appropriate screening strategies. Screening strategies should be applied systematically, and abnormal results referred to a center with experience in diagnosis. Patients diagnosed should be evaluated by a multidisciplinary team with experience in the management of the sample, staging and treatment of breast cancer.sk Assessment, Screening, Clinical - Pathological Diagnosis and Staging of Breast Cancer: 1st National Consensus of Breast Cancer of the Panamanian Society of Oncology (SPO)<br /><br /></p>


2020 ◽  
Vol 4 (1) ◽  
pp. 1-5
Author(s):  
Víctor Manuel Vargas-Hernández

In Mexico, breast cancer is the second most common site of cancer in women and in most developed and emerging countries. Incidence rates have increased in many countries, although in some, mortality has remained stable with a slight reduction. There are geographical differences with high rates of breast cancer in North America, Northern Europe and Oceania, and lower rates in Central and South America, South and East Europe; in addition to emerging countries in Africa and Asia. Genetic and hereditary factors constitute less than 5% of breast cancer cases and other risk factors for breast cancer are related to the reproductive life of the woman. This work was carried out in order to determine if the risk factors considered classic are really associated with breast cancer in our sample of Mexican women studied.


2018 ◽  
Vol 3 (3) ◽  
pp. 575
Author(s):  
Neila Sulung ◽  
Rizki Yananda ◽  
Adriani Adriani

<p>Cancer is one of the leading causes of death worldwide. In Indonesia every year 1: 3 women per 1000 population are affected by breast cancer. Breast cancer is a cancer that attacks most women. The incidence of breast cancer is currently estimated at 39 per 100,000 population in 2008. The purpose of this study was to determine the factors associated with the risk of female breast cancer in surgical outpatient poly patients at Dr. Achmad Mochtar, Bukittinggi City. This study uses descriptive analytic method with a case control approach. The sampling technique in this study was accidental sampling. The sample in this study were all women diagnosed with breast cancer, amounting to 50 cases and 50 controls with data processing through computerization. The instrument used in this study is a questionnaire. Data analysis was performed using Chi-Square test (α = 0.05). The results showed that the factors associated with the incidence of breast cancer were genetic (p = 0.009), menarche (p = 0.014), menopause (p = 0.016), hormonal contraception (p = 0,045), obesity (p = 0,043), and high food fat (p = 0.028).  Conclusions of the study are factors related to the risk of breast cancer incidence are genetic, menarche, menopause, hormonal contraception, obesity and high-fat foods.<br /> </p><p>Penyakit kanker merupakan salah satu penyebab kematian utama di seluruh dunia. Di Indonesia setiap tahun 1:3 wanita per 1000 penduduk terserang kanker payudara. Kanker payudara merupakan kanker yang paling banyak menyerang perempuan. Angka kejadian kanker payudara saat ini diperkirakan 39 per 100.000 penduduk pada tahun 2008. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang berhubungan dengan risiko kanker payudara wanita pada pasien poli rawat jalan bedah di RSUD Dr. Achmad Mochtar Kota Bukittinggi. Penelitian ini menggunakan metode <em>deskriptif analitik</em> dengan pendekatan <em>case control</em>. Teknik pengambilan sampel dalam penelitian ini adalah <em>accidental sampling.</em> Sampel dalam penelitian ini adalah semua wanita yang terdiagnosis kanker payudara, berjumlah 50 kasus dan 50 kontrol dengan pengolahan data melalui komputerisasi. Instrument yang digunakan dalam penelitian ini adalah lembar kuisioner. Analisis data dilakukan menggunakan uji <em>Chi-Square </em>(α=0,05). Hasil penelitian menunjukkan faktor yang berhubungan dengan kejadian kanker payudara adalah genetik (p=0,009), <em>menarche</em> (p=0,014;), <em>menopause</em> (p=0,016), kontrasepsi hormonal (p=0,045), <em>obesitas </em>(p=0,043), dan makanan tinggi lemak (p=0,028). Simpulan penelitian adalah faktor yang berhubungan dengan risiko kejadian kanker payudara adalah genetik, <em>menarche, menopause,</em> kontrasepsi hormonal, <em>obesitas</em> dan makanan tinggi lemak.</p>


2021 ◽  
Author(s):  
Yizhen Li ◽  
Jinxin Zheng ◽  
Yujiao Deng ◽  
Xinyue Deng ◽  
Weiyang Lou ◽  
...  

Abstract Background This study aimed to describe the latest epidemiology of female breast cancer globally, analyze the change pattern of the incidence rates and the disease’s association with age, period, and birth cohort, and subsequently present a forecast of breast cancer incidence.Methods Data for analysis were obtained from Global Burden of Disease (GBD) Study 2019 and World Population Prospects 2019 revision by the United Nations (UN). We described the age-standardized incidence rates (ASIRs) from 1990 to 2019 and then calculated the relative risks of period and cohort using an age-period-cohort model, and predicted the trends of ASIRs to 2035.Results In 2019, the global incidence of breast cancer in women increased to 1,977,212 (95% uncertainty interval = 1 807 615 to 2 145 215), with an ASIR of 45.86 (41.91 to 49.76) per 100 000 persons. Among the six selected countries facing burdensome ASIRs, only the USA showed a downward trend from 1990 to 2019, whereas the others showed an increasing or stable trend. The overall net drift was similar in Japan (1.78%), India (1.66%), and Russia (1.27%), reflecting increasing morbidity from 1990 to 2019. The increase in morbidity was particularly striking in China (2.60%) and not significant in Germany (0.42%). The ASIRs were predicted to continue to increase globally, from 45.26 in 2010 to 47.36 in 2035. In most countries and regions, the age specific incidence rate is the highest in those aged over 70 years and will increase in all age groups until 2035. In high-income regions, the age specific incidence rates are expected to decline in women aged over 50 years. Conclusions The global burden of female breast cancer is becoming more serious, especially in developing countries. Raising awareness of the risk factors and prevention strategies for female breast cancer is necessary to reduce future burden.


2021 ◽  
Vol 66 ◽  
Author(s):  
Hang-Hang Luan ◽  
Li-Sha Luo ◽  
Zhi-Yan Lu

Objectives: This study aimed to estimate the long-term trends of breast cancer incidence in Shanghai, Hong Kong, and Los Angeles (LA).Methods: Data were obtained from Cancer Incidence in Five Continents (CI5plus) database. The average annual percent change (AAPC) was conducted by joinpoint regression analysis, and the age, period and cohort effects were estimated by age-period-cohort (APC) analysis.Results: The age-standardized incidence rates (ASIRs) in LA were higher than Shanghai and Hong Kong. During 1988–2012, the ASIRs significantly decreased in white women in LA (AAPC = −0.6%, 95% CI: −0.9% to −0.4%) while increased in Shanghai (2.5%: 2.1%–2.9%) and Hong Kong (2.2%: 2.0%–2.5%). The APC analysis revealed significantly increased effects of age and period, and decreased effect of birth cohort.Conclusion: Although age and cohort effects were relatively strong, the period effect may be the key factor affecting trends of incidence, which may be caused by increasing exposures to carcinogens and risk factors. Therefore, more effective measures should be carried out promptly to protect high-risk populations such as elder women, to avoid exposures to risk factors of breast cancer.


2020 ◽  
Vol 66 (1) ◽  
Author(s):  
Monique Binotto ◽  
Gilberto Schwartsmann

Introdução: O câncer de mama pode alterar a qualidade de vida relacionada à saúde das pacientes. Objetivo: Compreender o impacto da quimioterapia para câncer de mama na qualidade de vida relacionada à saúde de pacientes. Método: Trata-se de uma revisão integrativa da literatura, compreendendo artigos publicados entre 2007 e 2019, disponíveis nas bases de dados PubMed, LILACS e SciELO. Analisaram-se 25 artigos na íntegra. Resultados: Os questionários mais frequentemente utilizados nos estudos foram o European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) e o módulo complementar European Organization for Research and Treatment of Cancer Breast Cancer-specific Quality of Life Questionnaire (EORTC QLQ-BR23). Em relação às alterações da qualidade de vida, a saúde global diminui durante a quimioterapia, mas pode melhorar após o término do tratamento. O aumento dos sintomas é relatado em diversos estudos e prejudicou a qualidade de vida relacionada à saúde das pacientes. Entretanto, os sintomas diminuem após o término da quimioterapia, exceto para algumas escalas. As escalas de imagem corporal, função sexual e funcionamento físico pioram ao longo do tratamento. A qualidade de vida mental/psicológica tem oscilações durante o tratamento, assim como a escala sobre as relações sociais. Conclusão: A qualidade de vida relacionada à saúde de mulheres com câncer de mama é afetada negativamente pelo tratamento quimioterápico, expressando maior impacto nas escalas de sintomas.


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