scholarly journals Requirement Prediction for Toluene Detox with Foods Intake Rich in CYP2E1 Enzyme and Glycine to Prevent Nerve and Kidney Damage at Shoe Home Industry Workers in Romokalisari Surabaya

2019 ◽  
Vol 7 (11) ◽  
pp. 1788-1793
Author(s):  
Abdul Rohim Tualeka ◽  
Pudji Rahmawati ◽  
Ahsan Ahsan ◽  
Yashwant Pathak ◽  
Syamsiar S. Russeng ◽  
...  
Keyword(s):  
Body Weight ◽  
Effective Dose ◽  
Descriptive Study ◽  
Threshold Limit Value ◽  
Working Time ◽  
Breathing Rate ◽  
Beef Liver ◽  
Toluene Concentration ◽  
Limit Value ◽  
The Subject

BACKGROUND: Toluene was an organic compound used in chemical and drug industries, the main source of toluene emissions from fires. To reduce and even eliminate toluene toxins in chemical component could be using detoxification by foods. AIM: This research aimed to calculate the intake of foods rich in CYP2E1 enzyme and glycine to improve toluene detoxification.METHODS: The type of research was a descriptive study. The subject of the study was 51 workers in Romokalisari Surabaya who had worked for more than or equal to 10 years. Variables were body weight, duration of working (years), working time per week (days), and working time per day (hours). The breathing rate, intake of non-carcinogen per respondent, can be calculated by variables before. Then, the effective dose of food rich in CYP2E1 enzyme and glycine will be obtained.RESULTS: Majority respondents had toluene concentrations below the threshold limit value (TLV). The highest effective dose of foods rich in CYP2E1 enzymes such as beef liver, beef brain, and salmon was 239.61 g, 745.45 g, and 203.3 g. Also, foods rich in glycines such as seaweed, tuna, and spinach were 432.98 mg, 934.41 mg, and 2070.71 mg. CONCLUSION: The level of adequacy of the CYP2E1 enzyme and glycine of each person was different and varied. The effective dose required by each respondent depending on weight, length of work, and concentration of benzene in the workplace. The greater the toluene concentration, the greater the needs for foods rich in CYP2E1 enzymes and glycine. Body weight can also be another factor in differences in individual intake. Weight, length of working, and toluene concentration can affect the intake of non-carcinogen in each which can affect the effective dose of foods.

scholarly journals Determination of Highest Dose of Ammonia without Effect at Work Environment through the Expression of Interleukin-2 Cell in Rattus Novergicus

2019 ◽  
Vol 7 (6) ◽  
pp. 897-902
Author(s):  
Abdul Rohim Tualeka ◽  
Dwi Ananto Wibrata ◽  
Ahsan Ahsan ◽  
Pudji Rahmawati ◽  
Syamsiar S Russeng ◽  
...  
Keyword(s):  
Body Weight ◽  
Statistical Tests ◽  
Interleukin 2 ◽  
Threshold Limit Value ◽  
Laboratory Research ◽  
Control Group ◽  
Control Group Design ◽  
Limit Value ◽  
Significant Difference

BACKGROUND: For determining the threshold limit value firstly determined the highest dose of ammonia without effect (NOAEL). However, research on the determination of NOAEL ammonia didn't conduct in Indonesia. AIM: The aim of this study to determine the value of the highest dose of ammonia without effect (No Observed Adverse Effect Level/NOAEL) through interleukin-2 (IL-2) expression on white mice. METHODS: This study used experimental laboratory research with post-test only control group design using white mice as experimental subjects. The treatment group divided into 6 groups (a group of controls and five groups with different ammonia exposure through inhalation). The trend curve of Remmele Scale Index (IRS) and histopathologic analysis could be used for determining NOAEL. RESULT: The location of the highest dose of ammonia without any effect (NOAEL) of white mice was in the second group, with 0.0103 mg/kg body weight dose. Analysis of statistical tests Kruskal Wallis stated there was no significant difference in interleukin-2 expression between the control with ammonia exposed group with a significance of p (0.747) > α (0.05). CONCLUSION: There is no difference between some interleukin-2 expression in the lymphocyte cell lung white mice group exposed to ammonia and control group. The highest dose of ammonia without any effect (NOAEL) on white mice was 0.0103 mg/kg body weight.

scholarly journals The Cost Prediction for Chromium Detox Using Foods Intake Containing Glutathione at the Leather Tanning Industry in Magetan, Indonesia

2019 ◽  
Vol 7 (21) ◽  
pp. 3698-3703
Author(s):  
Abdul Rohim Tualeka ◽  
Pudji Rahmawati ◽  
Ahsan Ahsan ◽  
Syamsiar S. Russeng ◽  
Sukarmin Sukarmin ◽  
...  
Keyword(s):  
Effective Dose ◽  
Descriptive Study ◽  
Chromium Concentration ◽  
Metal Alloys ◽  
Breathing Rate ◽  
Inclusion Criteria ◽  
Leather Tanning ◽  
The Cost ◽  
Detoxification Process ◽  
Chromium Detoxification

BACKGROUND: Chromium was an organic compound which was used in metal alloys such as stainless steel, chrome plating, metal ceramics, leather tanning, etc. To reduce and eliminate toxin of chromium from the human body could be using detoxification process, one of them was using foods. AIM: The aim was to calculate the foods intake contain glutathione to improve chromium detoxification and calculate the cost of foods intake. METHOD: The type of research was a descriptive study. The subjects were 10 workers. Inclusion criteria of subjects were workers who had worked for more than or equal to 10 years. Variables were body weight, duration of work, and chromium concentration. After getting all variables above, breathing rate and intake non-carcinogen per respondent can be calculated. Then, the effective dose of foods rich in glutathione and costs of foods will be obtained. RESULTS: The results of this research indicated that the highest cost of foods intake containing glutathione was 5948 idr of broccoli per week and the lowest cost of foods intake was 535 idr of avocado per week. CONCLUSION: Intake of foods containing glutathione (avocado, broccoli, carrot, tomato, and grape) was expected to increase detoxification of chromium. Each individual had a different amount of cost. This depends on the effective dose, chromium concentration, weight, and duration of work per respondent.

scholarly journals Determination of Carcinogenic Toluena Detox Mass In Printing Industrial Workers In Surabaya

2020 ◽  
Author(s):  
Rista Novianti ◽  
abdul rohim tualeka ◽  
Ng Yee Guan
Keyword(s):  
Body Weight ◽  
Threshold Value ◽  
Printing Industry ◽  
Industrial Workers ◽  
Cross Sectional ◽  
Beef Liver ◽  
Toluene Concentration ◽  
Work Duration ◽  
Benzene Concentration

Abstract Background This study aims to calculate the intake of foods rich in CYP2E1 enzymes and glutathione to increase toluene detoxification. Methods The research design used was a cross sectional method. The research location is printing industry in Surabaya, East Java. The number of respondents was 30 workers of the printing industry. The calculated variables included body weight, work duration (years), work frequency per week (days), average workday (hours) of the respondent and benzene concentration. After all variables were obtained, respiration rate and carcinogenic detox benzene food intake per respondent were determined. Results All respondents who were at work showed benzene concentrations below the threshold value (TLV). Foods containing CYP2E1 enzyme included beef liver, salmon and fish oil while food with glutathione included grapes, avocados and asparagus. Conclusion Adequacy levels of CYP2E1 enzymes and glutathione are different and varied. The effective dose required by each respondent depends on body weight, length of work, and toluene concentration at work. In sum, the greater the toluene concentration, the greater the dietary needs which are rich in enzymes and CYP2E1 glutathione. Each respondent can choose benzene detox food depending on their needs and appetite.

scholarly journals Analysis of dynamic of tropospheric ozone and nitrogen dioxide in the highest region of the Quito city

2020 ◽  
Vol 169 ◽  
pp. 01017 ◽  
Author(s):  
Cristian Salazar ◽  
Freddy Mullo
Keyword(s):  
Nitrogen Dioxide ◽  
Regression Models ◽  
Descriptive Study ◽  
Threshold Limit Value ◽  
Central Tendency ◽  
Moderate Correlation ◽  
Linear Regression Models ◽  
Limit Value ◽  
The City ◽  
Multiple Linear Regression Models

A descriptive study of behavior of daily concentrations of ozone (O3) and nitrogen dioxide (NO2) in the period from January 2017 to December 2019 was conducted with the purpose to describe air pollution in the south of the city of Quito. The data collected was processed using the Excel and SPSS v25. The statistical analysis included central tendency values, percentages of violation of the threshold limit value (TLV), maximum values and 25th, 75th and 95th percentiles. The correlation between pollutants was evaluated using the Spearman’s Rho coefficient. Multiple linear regression models were made for each pollutant and meteorological variables (wind speed and mean ambient temperature). Inverse moderate correlation was found between the contaminants analyzed. The daily and monthly concentrations of O3 and NO2 were lower than the TLV, therefore, the air quality in the period studied with respect to the analyzed pollutants is satisfactory.

Overtraining of aerobic physical exercise reduce rats (Rattus norvegicus) memory

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Ni Made Ridla Parwata
Keyword(s):  
Body Weight ◽  
Physical Exercise ◽  
Rattus Norvegicus ◽  
Research Method ◽  
Male Rat ◽  
Control Group ◽  
Adult Male Rat ◽  
The Subject ◽  
Heavy Training

Overtraining syndrome is a decrease in physical capacity, emotions and immunity due to training that is too often without adequate periods of rest. Overtraining is often experienced by athletes who daily undergo heavy training with short break periods. This research aims to look at the effect of overtraining aerobic physical exercise on memory in mice. The research method was experimental in vivo with the subject of adult male rat (Rattus Norvegicus) Winstar strain aged 8-10 weeks, body weight 200-250 gr. Divided into three groups, namely the control group, aerobic group and overtraining group. The results of memory tests with water E Maze showed an increase in the duration of travel time and the number of animal errors made by the overtraining group (p = 0.003). This study concludes that overtraining aerobic physical exercise can reduce memory in rat hippocampus.

EXPERIMENTAL SUBSTANTIATION OF THE MAXIMUM ALLOWABLE CONCENTRATION OF DIOCTYL TEREPHTHALATE IN THE AIR OF THE WORKING AREA

2020 ◽  
pp. 34-38
Author(s):  
A. S. Radilov ◽  
S. A. Solntseva ◽  
I. E. Shkaeva ◽  
S. A. Dulov ◽  
E. V. Vivulanets ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Functional State ◽  
Hematological Parameters ◽  
Inhalation Exposure ◽  
Threshold Limit Value ◽  
Maximum Allowable Concentration ◽  
Limit Value ◽  
Threshold Limit ◽  
The Central Nervous System

Toxicity and hazard assessment of dioctyl terephthalate (DOTP) was performed in acute, subacute, and chronic experiments, and its principal toxicometry parameters were determined.It was found that on single exposure DOTP exhibits low toxicity and hazard. No resorptive and irritant effects on skin and mucous membrane of eyes were detected in animal experiments. The single inhalation exposure threshold limit value was set at 300 mg/m3, based on the results of monitoring of the functional state of the central nervous system and myocardium and hematological parameters.Thirty-day subacute experiments (oral administration, inhalation exposure, and skin applications) revealed no accumulation of the compound.Four-month chronic exposure to DOTP aerosols (concentration 96,8 mg/m3) caused disorder of the functional state of the central nervous system and myocardium, changes in the hematological and biochemical parameters, gas and acid-base status of the blood, and morphological changes in the lungs and heart. Embryotoxic, genotoxic and gonadotoxic effects were not detected.The chronic inhalation exposure threshold limit value for DOTP (Limch) was set at 18,6 mg/m3, and the concentration of 3,4 mg/m3 was found to be ineffective.The maximum allowable concentration of DOTP in the air of the working area was set at 3,0 mg/m3, hazard class 3.

Habilidades do Enfermeiro no Diagnóstico e Cuidado ao Portador de Depressão / Nursing Skills in Diagnosis and Care For Patients With Depression

1970 ◽  
Vol 5 (4) ◽  
pp. 13-19
Author(s):  
Cristiane Rosa Guedes ◽  
Bianca Del Ducca Alvarenga ◽  
Isabella Rotella ◽  
Débora Vitória Alexandrina Lisboa Vilella
Keyword(s):  
Data Collection ◽  
Family Involvement ◽  
Nursing Care ◽  
Direct Contact ◽  
Descriptive Study ◽  
Structured Interview ◽  
Qualitative Approach ◽  
Patient Relationship ◽  
The Subject ◽  
The City

RESUMOObjetivo: Identificar o significado para o enfermeiro em prestar cuidados para pacientes com Depressão.  Materiais e métodos: Estudo exploratório e descritivo com abordagem qualitativa, a amostra foi de 12 enfermeiras, o cenário de estudo foram Unidades Básicas de Saúde e Estratégias de Saúde da Família, urbanas da cidade de Itajubá-MG. A coleta de dados foi por meio do roteiro de entrevista semiestruturada composta por questionário contendo uma pergunta inerente ao assunto. Resultados: Encontramos oito categorias como estigma da depressão, suicídio, dificuldade em lidar, tempo escasso, envolvimento familiar, aceitação da doença, acolhimento e dar medicamento, de acordo com os discursos dos sujeitos coletados na entrevista. Conclusão: Os enfermeiros não estão em contato direto com portadores de depressão no seu trabalho, não entendem que é sua tarefa identificar e encaminha-los para tratamento especializado. Sugerimos que outros estudos sejam desenvolvidos sobre essa temática.Palavras-chave: Depressão. Relação Enfermeiro-Paciente. Assistência de Enfermagem. ABSTRACTObjective: To identify the meaning for nurses when providing care for patients with depression. Materials and Methods: exploratory and descriptive study with qualitative approach, the sample consisted of 12 nurses, the study scenario was the urban Unidades Básicas de Saúde e Estrategia de Saúde da Família, in the city of Itajubá. Data collection was done through semi-structured interview guides consisting of a questionnaire containing a question related to the subject. Results and Discussion: we found eight categories as stigma of depression, suicide, coping difficulties, scarce time, family involvement, acceptance of the disease, host and give medicine, according to the speeches of the subjects collected in the interview. Conclusion: nurses are not in direct contact with individuals with depression in their work, do not understand that it is their job to identify and refer them to specialized treatment. We suggest that other studies be developed on this theme.Keywords: Depression, Nurse-patient Relationship, Nursing care.

RIGOR MORTIS: PHYSIOLOGY

2021 ◽  
Vol 6 ◽  
Author(s):  
Heron Teixeira
Keyword(s):  
Body Weight ◽  
Causes Of Death ◽  
Natural Course ◽  
Important Task ◽  
Time Of Death ◽  
Post Mortem ◽  
Rigor Mortis ◽  
Intrinsic Factors ◽  
The Subject ◽  
Extrinsic And Intrinsic Factors

Introduction: Estimating the time of death is an important task in day-to-day forensic work and many factors for its designation are understood, one of which is rigor mortis. They can be altered by extrinsic and intrinsic factors, such as temperature location, humidity, heat, age, sex, length and body weight, and can be used as a parameter for approximate identification of the time of death. Objective: To carry out a brief review on the topic in order to promote a better understanding of the subject addressed and fully understand its physiology. Materials and Methods: Pubmed, Scielo and Medline databases were searched without date restrictions for articles published in English and Portuguese using the descriptors rigor mortis, autolysis and changes after death. Results: The theme presents consolidated researches regarding its natural course, being an important tool to estimate the time of death along other signs that appear after death, as well as to estimate some causes of death. Conclusion: Understanding the development of rigor mortis, helps to identify and distinguish processes that may have led to death and the post-mortem time.

Analisis Kemampuan Literasi Matematika Siswa SMA Ditinjau dari Gender

2020 ◽  
Vol 8 (4) ◽  
pp. 336-347
Author(s):  
Mida Nurani ◽  
Mayya Shofa Mahfud ◽  
Riska Lail Agustin ◽  
Hendrata Vive Kananda
Keyword(s):  
High School Students ◽  
Descriptive Study ◽  
Study Data ◽  
Female Students ◽  
Literacy Skills ◽  
Male Students ◽  
School Students ◽  
Qualitative Descriptive ◽  
The Subject ◽  
Better Than

The purpose of this research is to analyze the mathematics literacy skills of high school students in terms of gender, especially in the material linear program. This research is a qualitative descriptive study. Data Collection was carried out on the eleventh-grade students of SMA Negeri 1 Meraksa Aji. The subject was 31 students which consisted of 14 females and 17 males. The data was collected using tests and interviews and analyze use method triangulation. The results showed that female students' literacy skills were better than male students. Female students find the indicators of interpreting mathematics to solve problems, formulate problems systematically and use concepts, facts, procedures, and reasoning in mathematics. Meanwhile, male students have only fulfilled the indicators of interpreting mathematics to solve problems.

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