Determination of Carcinogenic Toluena Detox Mass In Printing Industrial Workers In Surabaya
Abstract Background This study aims to calculate the intake of foods rich in CYP2E1 enzymes and glutathione to increase toluene detoxification. Methods The research design used was a cross sectional method. The research location is printing industry in Surabaya, East Java. The number of respondents was 30 workers of the printing industry. The calculated variables included body weight, work duration (years), work frequency per week (days), average workday (hours) of the respondent and benzene concentration. After all variables were obtained, respiration rate and carcinogenic detox benzene food intake per respondent were determined. Results All respondents who were at work showed benzene concentrations below the threshold value (TLV). Foods containing CYP2E1 enzyme included beef liver, salmon and fish oil while food with glutathione included grapes, avocados and asparagus. Conclusion Adequacy levels of CYP2E1 enzymes and glutathione are different and varied. The effective dose required by each respondent depends on body weight, length of work, and toluene concentration at work. In sum, the greater the toluene concentration, the greater the dietary needs which are rich in enzymes and CYP2E1 glutathione. Each respondent can choose benzene detox food depending on their needs and appetite.