scholarly journals Left Hemiparesis in Acute Myeloblastic Leukemia with High Mortality

2020 ◽  
Vol 8 (C) ◽  
pp. 113-116
Author(s):  
Edward Kurnia Setiawan Limijadi ◽  
Noegroho Harbani ◽  
Nani Widorini ◽  
Imam Budiwijono
Keyword(s):  
Clinical Manifestations ◽  
Peripheral Blood Smear ◽  
Malignant Cell ◽  
The Body ◽  
Acute Myeloblastic Leukemia ◽  
Normocytic Anemia ◽  
Left Hemiparesis ◽  
Fluid Analysis ◽  
The Central Nervous System ◽  
Immature Cells

BACKGROUND: Leukemia is a blood malignancy that has a variety of types with a variety of clinical manifestations in the body organs in each patient. Acute myeloblastic leukemia (AML) occurs more frequently in adults with clinical manifestations in the central nervous system, especially on the M4 and M5 subtypes. CASE REPORT: A 42-year-old woman came with a complaint of sudden left hemiparesis. The laboratory results obtained leukocytosis, normochromic normocytic anemia, and thrombocytopenia. Peripheral blood smear found immature cells of the myeloblasts and monoblasts series and monocytosis. CONCLUSION: The conclusion of the clinical diagnosis and laboratory of the patient is left hemiparesis caused by AML with the suspect of subtype M4 or M5. Patients died within a few hours later, so bone marrow puncture and brain fluid retrieval for malignant cell analysis could not be performed. Brain fluid analysis is important to be performed to enforce the diagnosis of cerebral leukemia.

scholarly journals Modern aspects of neuropathogenesis and neurological manifestations of COVID-19

2021 ◽  
Vol 17 (2) ◽  
pp. 6-15
Author(s):  
L.A. Dziak ◽  
O.S. Tsurkalenko ◽  
K.V. Chekha ◽  
V.M. Suk
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Psychiatric Symptoms ◽  
Clinical Manifestations ◽  
The Body ◽  
Altered Level ◽  
Wide Range ◽  
The Central Nervous System ◽  
The Brain

Coronavirus infection is a systemic pathology resulting in impairment of the nervous system. The involvement of the central nervous system in COVID-19 is diverse by clinical manifestations and main mechanisms. The mechanisms of interrelations between SARS-CoV-2 and the nervous system include a direct virus-induced lesion of the central nervous system, inflammatory-mediated impairment, thrombus burden, and impairment caused by hypoxia and homeostasis. Due to the multi-factor mechanisms (viral, immune, hypoxic, hypercoagulation), the SARS-CoV-2 infection can cause a wide range of neurological disorders involving both the central and peripheral nervous system and end organs. Dizziness, headache, altered level of consciousness, acute cerebrovascular diseases, hypogeusia, hyposmia, peripheral neuropathies, sleep disorders, delirium, neuralgia, myalgia are the most common signs. The structural and functional changes in various organs and systems and many neurological symptoms are determined to persist after COVID-19. Regardless of the numerous clinical reports about the neurological and psychiatric symptoms of COVID-19 as before it is difficult to determine if they are associated with the direct or indirect impact of viral infection or they are secondary to hypoxia, sepsis, cytokine reaction, and multiple organ failure. Penetrated the brain, COVID-19 can impact the other organs and systems and the body in general. Given the mechanisms of impairment, the survivors after COVID-19 with the infection penetrated the brain are more susceptible to more serious diseases such as Parkinson’s disease, cognitive decline, multiple sclerosis, and other autoimmune diseases. Given the multi-factor pathogenesis of COVID-19 resulting in long-term persistence of the clinical symptoms due to impaired neuroplasticity and neurogenesis followed by cholinergic deficiency, the usage of Neuroxon® 1000 mg a day with twice-day dosing for 30 days. Also, a long-term follow-up and control over the COVID-19 patients are recommended for the prophylaxis, timely determination, and correction of long-term complications.

scholarly journals Lecture on neurology for intern doctors «Ataxia: etiology, pathogenesis, clinical features»

2018 ◽  
pp. 30-36
Author(s):  
N. Khanenko ◽  
R. Sulik ◽  
N. Svyrydova ◽  
E. Trufanov ◽  
G. Chuprina ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Clinical Features ◽  
Clinical Manifestations ◽  
Supportive Therapy ◽  
The Body ◽  
Vertical Position ◽  
Dynamic Coordination ◽  
Medicinal Treatment ◽  
The Central Nervous System

Lecture on neurology for internists "Ataxia: etiology, pathogenesis, clinical features" reveals the most important clinical manifestations of various forms of ataxia with a disorder of the function of balance and coordination of movements. Most doctors, due to the dominance of ideas about the association of dizziness and imbalance of the body with the pathology of the vestibular apparatus, often do not take into account the essential role of various diseases of the central nervous system and the appearance of these symptoms, therefore the disorder of this pathology in the lecture course for interns specialty "nerve diseases" is relevant. Given the classification, distinguish static ataxia - disturbances in the normal vertical position, dynamic - coordination disorders in motion. In clinical practice, there are several types of ataxia: sensitized, cerebellar, vestibular and cortical. The neurological examination has two main objectives: to detect disturbances of the cerebellum and other parts of the central nervous system. Correctly collected history can already at this stage to form an idea of ​​the disease with a clear assessment of the course and language. The instrumental methods of examination allow to detect or rule out disturbances in other parts of the nervous system. Medicinal treatment of ataxia is symptomatic. Positive effect is provided by supportive therapy: physiotherapeutic methods, massage, acupuncture, classes with speech therapist.

scholarly journals A typical case of syphilitic spinal cord injury

2020 ◽  
Vol VI (3) ◽  
pp. 132-140
Author(s):  
A. Yanishevsky
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Clinical Manifestations ◽  
Typical Case ◽  
The Body ◽  
Single Infection ◽  
Anatomical Changes ◽  
Cord Injury ◽  
The Central Nervous System ◽  
Single Organ

There is not a single poison, not a single infection that would produce such a variety of changes in the body as syphilis. Not a single organ is guaranteed against this terrible scourge of modern humanity. More syphilis does not spare the central nervous system, which, thanks to the modern conditions of life, is a locus mi-noris resistentiae. Damaging this organ, it produces an extremely variegated picture of both pathological and anatomical changes and clinical manifestations and course, depending on the diversity of the nature of the process, very different localization, speed or slowness of development.

SPECIAL REVIEWS

PEDIATRICS ◽  
1950 ◽  
Vol 6 (3) ◽  
pp. 488-499
Author(s):  
HAROLD K. FABER
Keyword(s):  
Alimentary Tract ◽  
Clinical Manifestations ◽  
Nerve Fibers ◽  
The Body ◽  
Focus Of Infection ◽  
The Central Nervous System ◽  
Upper Respiratory ◽  
Usual Site ◽  
Primary Focus ◽  
Established Infection

Application of experimental results to human problems in poliomyelitis is valid and helpful, especially when the modes of inoculation infection are similar. The disease is spread largely by contact, probably much more often from pharyngeal than from fecal sources. The concept that infection is introduced into and spreads by way of nerve fibers, with multiplication in the nerve cells, appears to explain adequately the various phenomena of the disease, without resort to hypothetic extraneural infection. The usual site of entry is the upper respiratory and alimentary tract, notably the pharynx, rather than the intestine. The usual primary site of infection is probably the peripheral ganglia supplying the upper respiratory and alimentary tracts and the usual primary focus of infection in the central nervous system is probably the lower brainstem, to which many of the earliest and most characteristic clinical manifestations can be traced, particularly to the reticular formation. This nonparalytic form of bulbar poliomyelitis is to be distinguished from the paralytic form. The so-called constitutional symptoms of poliomyelitis are as readily referable to neural infection as to extraneural and presumably are due to the former. In diphasic ("dromedary") cases, the onset of the first phase is essentially of a neurologic, not of a nonspecific or "systemic" character. The diphasic case is regarded as a simple example of remission and relapse. Contributory factors are of two kinds: (1) those that serve to introduce virus into the body; (2) those that increase the severity of already established infection. Avoidance or minimization of these factors is of preventive value.

Postoperative cognitive dysfunction: progress mechanisms and clinical characteristics

2019 ◽  
Vol 2 (19) ◽  
pp. 29-33
Author(s):  
K. B. Manysheva ◽  
M. A. Akhmedov ◽  
A. A. Rakhmanova ◽  
S. M. Khutalieva
Keyword(s):  
Cognitive Dysfunction ◽  
Clinical Characteristics ◽  
Cognitive Deficit ◽  
Neuropsychological Testing ◽  
Postoperative Cognitive Dysfunction ◽  
Clinical Manifestations ◽  
Postoperative Recovery ◽  
Neuropsychological Rehabilitation ◽  
Brain Barrier Permeability ◽  
The Central Nervous System

The article is devoted to the study of postoperative cognitive dysfunction — a syndrome that is often found in the postoperative period and does not depend on the volume of surgeon. Based on the analysis of the results of modern studies, the authors cite the most likely etiological causes of the syndrome, grouped according to different categories of risk factors. The pathogenetic algorithm for cognitive dysfunction includes the appearance of systemic inflammation, improving blood-brain barrier permeability with the endothelial dysfunction, the migration of inflammatory agents into the central nervous system, and the formation of oxidative stress. The clinical manifestations of cognitive deficit in the outcome of surgeon performed under general anesthesia, the authors illustrate with their own observations of patients with a neurosurgical profile with spinal pathology operated on with the use of propofol anesthesia, comparing the results of neuropsychological testing with an assessment of the level of anxiety. In conclusion, the authors outline a strategy for the prevention of postoperative cognitive dysfunction and recommend conducting neuropsychological rehabilitation as an important component of postoperative recovery for all patients with a diagnosed cognitive deficit that occurred after surgery.

Clinical, morphological and biochemical signs of polymycotoxicosis in highly productive cows

2020 ◽  
pp. 14-17
Author(s):  
Irina A. Shkuratova ◽  
◽  
Lyudmila I. Drozdova ◽  
Aleksander I. Belousov ◽  
Keyword(s):  
Metabolic Disorders ◽  
Hepatorenal Syndrome ◽  
Morphological Changes ◽  
Clinical Manifestations ◽  
The Body ◽  
Feed Mixture ◽  
Milk Productivity ◽  
Structural Disorders ◽  
Increased Sensitivity ◽  
Penicillium Spp

Mycotoxicological monitoring of forages shows that the problem of mycotoxicosis has been relevant for several decades. Minimal doses of mycotoxins in feed lead to a decrease in milk productivity, increased sensitivity to infectious and non-infectious diseases. When several mycotoxins enter the body simultaneously, a synergistic effect develops, causing a significant increase in toxicity. Feed contaminated with several types of fungi and their toxins is dangerous for dairy cattle. It was found that the feed mixture contained the types of associations of Aspergillus spp. fungi + Fusarium; Aspergillus spp. + Penicillium spp. + Mucor spp; Fusarium + Penicillium; Mucor spp. + Fusarium + Ustilaginales. Pathogenetic features of metabolic and morphological changes in highly productive cows with polymycotoxicosis were studied. Feeding food contaminated with various metabolites of mold fungi leads to the development of signs of chronic toxemia in animals. Clinical manifestations are the development of diarrhea and dehydration, with a decrease in milk productivity. Metabolic disorders feature the development of an inflammatory process, metabolic acidosis, hyperfermentonemia, with an increase in the amount of creatinine and urea in the blood serum. Metabolic signs indicate the development of hepatorenal syndrome due to structural disorders of the liver and kidneys. Histological signs of polymicotoxicosis are intracapillary and hemorrhagic glomerulonephritis, hepatocyte micronecrosis, and proliferation of connective tissue stroma cells, which leads to the development of atrophic cirrhosis in the interstitial and circular phases.

HISTOLOGICAL CHANGES IN THE INTESTINES OF POULTRY DURING FODDER INTOXICATION

2020 ◽  
Author(s):  
E.P. Dolgov ◽  
◽  
A.A. Abramov ◽  
E.V. Kuzminova ◽  
E.V. Rogaleva ◽  
...  
Keyword(s):  
Body Weight ◽  
Histological Examination ◽  
Aflatoxin B1 ◽  
Structural Changes ◽  
Clinical Manifestations ◽  
Feed Additives ◽  
The Body ◽  
Histological Changes ◽  
Beet Pulp

The article presents the data on the study of the influence of mycotoxins combination (T-2 toxin at the concentration of 0.095 mg/kg and aflatoxin B1 in the concentration of 0.019 mg/kg) on the body of quails and the results of pharmacocorrection of toxicosis with a complex consisting of beet pulp and lecithin. Structural changes in the intestines of quais at fodder mycotoxicosis are described. The use of antitoxic feed additives in poultry led to a weakening of the action of xenobiotics, which was confirmed by an increase in the safety of poultry and increase in body weight of quails, a decrease in the clinical manifestations of intoxication, as well as in positive changes in the structure of the intestine of the poultry during histological examination.

Characteristics of the dynamics of the central nervous system and att ention function in workers of shoe production

2020 ◽  
pp. 64-68
Author(s):  
F. L. Azizova ◽  
U. A. Boltaboev
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Women Workers ◽  
Functional State ◽  
The Body ◽  
Conflict Of Interests ◽  
Professional Groups ◽  
Universal Device ◽  
The Central Nervous System ◽  
Working Day

The features of production factors established at the main workplaces of shoe production are considered. The materials on the results of the study of the functional state of the central nervous system of women workers of shoe production in the dynamics of the working day are presented. The level of functional state of the central nervous system was determined by the speed of visual and auditory-motor reactions, installed using the universal device chronoreflexometer. It was revealed that in the body of workers of shoe production there is an early development of inhibitory processes in the central nervous system, which is expressed in an increase in the number of errors when performing tasks on proofreading tables. It was found that the most pronounced shift s in auditory-motor responses were observed in professional groups, where higher levels of noise were registered in the workplace. The correlation analysis showed a close direct relationship between the growth of mistakes made in the market and the decrease in production. An increase in the time spent on the task indicates the occurrence and growth of production fatigue.Funding. The study had no funding.Conflict of interests. The authors declare no conflict of interests.

Assessment of the Biochemical Status of Workers Manufacturing Ethylbenzene and Styrene

2020 ◽  
pp. 40-43
Author(s):  
RR Galimova ◽  
ET Valeeva ◽  
GV Timasheva ◽  
AB Bakirov
Keyword(s):  
Catalase Activity ◽  
Free Radical Oxidation ◽  
The Body ◽  
Atherogenic Index ◽  
Radical Oxidation ◽  
Professional Groups ◽  
Biochemical Status ◽  
The Central Nervous System ◽  
Hepatic Protein Synthesis ◽  
Increased Activity

Introduction: Production of ethylbenzene and styrene (EBS) is one of the most important stages in organic synthesis. The products have general toxic, hepatotoxic, irritating and narcotic effects on the human body. Severe exposures to EВS can induce pronounced disorders of the central nervous system such as styrene sickness and encephalopathy and of peripheral blood such as leukopenia and lymphocytosis. Materials and methods: We studied homeostasis indices in 376 workers of the main professional groups engaged in the production of EBS including equipment operators, repairmen, and instrumentation and automation fitters. Results: We established an increase in lipid peroxidation by the level of malondialdehyde amid an increase in catalase activity and a decrease in blood retinol and α-tocopherol levels. We also noted an increased activity of indicator enzymes including ALT, AST, GGT, and alkaline phosphatase. Significant changes in lipid metabolism in the form of cholesterolemia, triglyceridemia, a higher atherogenic index, and lower cholesterol of non-atherogenic blood serum lipids demonstrating atherogenic changes in the body were revealed. Conclusions: The earliest prenosological disorders in the body of the examined workers included an impaired hepatic protein synthesis, the development of cytolysis processes and a change in the integrity and functional activity of the liver cell in individuals, an imbalance in the oxidant-antioxidant system, one of the reasons of which was the adverse occupational exposure to hazardous chemicals. An increase in catalase activity is a protective compensatory reaction during the activation of free radical oxidation processes.

Neural Stem Cells to Glial Cells an Important Factor for Brain Injury

2020 ◽  
Author(s):  
Prithiv K R Kumar
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Neural Stem Cells ◽  
Glial Cells ◽  
Brain Injuries ◽  
The Body ◽  
The Central Nervous System ◽  
Near Future

Stem cells have the capacity to differentiate into any type of cell or organ. Stems cell originate from any part of the body, including the brain. Brain cells or rather neural stem cells have the capacitive advantage of differentiating into the central nervous system leading to the formation of neurons and glial cells. Neural stem cells should have a source by editing DNA, or by mixings chemical enzymes of iPSCs. By this method, a limitless number of neuron stem cells can be obtained. Increase in supply of NSCs help in repairing glial cells which in-turn heal the central nervous system. Generally, brain injuries cause motor and sensory deficits leading to stroke. With all trials from novel therapeutic methods to enhanced rehabilitation time, the economy and quality of life is suppressed. Only PSCs have proven effective for grafting cells into NSCs. Neurons derived from stem cells is the only challenge that limits in-vitro usage in the near future.

Sign in / Sign up

Export Citation Format

Share Document