scholarly journals A Pilot Study of the Evaluation of Using Antibiotics in Sepsis Patients in Palu, Indonesia

2020 ◽  
Vol 8 (B) ◽  
pp. 1036-1040
Author(s):  
Alwiyah Mukaddas ◽  
Tatat Rahmita Utami ◽  
Amelia Rumi

BACKGROUND: Treatment therapy with antibiotics is one of the factors supporting success in the treatment of sepsis. AIM: This study aims to evaluate the use of antibiotics in patients with sepsis using parameters of the day of decline in body temperature, heart rate, respiration rate, changes in consciousness status, and comorbid factors. MATERIALS AND METHODS: The design of this study is pilot study with a retrospective approach on sample of 14 sepsis patients who met the inclusion criteria. Descriptive analysis using the univariate method for see changes in levels of body temperature, length of stay, respiration rate, heart rate, comorbid factors, and changes in the consciousness status. RESULTS: The results showed an average value for decline of body temperature after using antibiotics with a baseline of 38.47°C–37.87°C, heart rate shows the average value from baseline heart rate after using antibiotics from baseline of 110.8 bpm to 88.4 bpm, the respiration rate shows the average value for the respiration rate after using antibiotics from baseline of 30.8 x/min to 22.1 x/min, Glasgow Coma Scale (GCS) score showed an average value after using antibiotics from baseline 9 to 7, on comorbid factors showing six patients with one comorbid and eight patients with more than 1 comorbid factor. CONCLUSION: The study concluded that body temperature is still in the category of fever, heart rate, and respiration rate which are the normal category, patient consciousness is still at the level of somnolence even though patient’s GCS score has decreased, and patients with one factor of comorbidities are faster in death because they have a fatal type of comorbid such as acute of hepatitis, coma hepaticum, and acute kidney injury.

2017 ◽  
Vol 22 (2) ◽  
pp. 127-132
Author(s):  
Agik Suprayogi ◽  
◽  
Ganjar Alaydrussani ◽  
Asep Yayan Ruhyana ◽  
◽  
...  

2008 ◽  
Vol 12 (2) ◽  
pp. 115-120
Author(s):  
Tori Rihiantoro ◽  
Elly Nurachmah ◽  
Rr. Tutik Sri Hariyati

AbstrakPenelitian ini bertujuan mengetahui pengaruh terapi musik terhadap status hemodinamika pasien koma. Penelitian ini menggunakan desain kuasi eksperimen one group pre-post dan dengan teknik consecutive sampling didapatkan sampel 21 pasien di ruang ICU sebuah RS di Lampung. Analisis deskriptif menggambarkan bahwa sesudah terapi musik terjadi penurunan rerata MAP (6,80 mmHg), penurunan rerata frekuensi jantung (6,76 kali/menit), dan penurunan rerata frekuensi pernapasan (4,08 kali/menit). Hasil analisis bivariat dengan tes T dependen menyimpulkan bahwa terdapat pengaruh yang bermakna terapi musik terhadap MAP (p value = 0,031), frekuensi jantung (p value = 0,015) dan frekuensi napas (p value = 0,000). Penurunan indikator status hemodinamika pada pasien koma dengan cidera kepala dan stroke akan membantu stabilisasi hemodinamika pasien sekaligus membantu proses pemulihan pasien. AbstractThis research attempted to identify the effect of music therapy on hemodynamic status of coma patients. The design used was a quasi experimental one group pre-post test design with a consecutive sampling method. Twenty one samples in the ICU of a hospital in Lampung were participated in the study. The descriptive analysis showed decreasing mean of MAP (6,80 mmHg), heart rate (6,76 bpm), and respiration rate (4,08 bpm) after music therapy. The bivariate analysis using the dependent t test showed a significant relationship of music therapy to MAP (p value = 0,031), heart rate (p value = 0,015) and respiration rate (p value = 0,000). Decreasing the hemodynamic indicators to coma patients with stroke and severe head injury could help to stabilize their hemodynamic balance and to promote faster recovery.


Sensors ◽  
2020 ◽  
Vol 20 (8) ◽  
pp. 2171 ◽  
Author(s):  
Toshiaki Negishi ◽  
Shigeto Abe ◽  
Takemi Matsui ◽  
He Liu ◽  
Masaki Kurosawa ◽  
...  

Background: In the last two decades, infrared thermography (IRT) has been applied in quarantine stations for the screening of patients with suspected infectious disease. However, the fever-based screening procedure employing IRT suffers from low sensitivity, because monitoring body temperature alone is insufficient for detecting infected patients. To overcome the drawbacks of fever-based screening, this study aims to develop and evaluate a multiple vital sign (i.e., body temperature, heart rate and respiration rate) measurement system using RGB-thermal image sensors. Methods: The RGB camera measures blood volume pulse (BVP) through variations in the light absorption from human facial areas. IRT is used to estimate the respiration rate by measuring the change in temperature near the nostrils or mouth accompanying respiration. To enable a stable and reliable system, the following image and signal processing methods were proposed and implemented: (1) an RGB-thermal image fusion approach to achieve highly reliable facial region-of-interest tracking, (2) a heart rate estimation method including a tapered window for reducing noise caused by the face tracker, reconstruction of a BVP signal with three RGB channels to optimize a linear function, thereby improving the signal-to-noise ratio and multiple signal classification (MUSIC) algorithm for estimating the pseudo-spectrum from limited time-domain BVP signals within 15 s and (3) a respiration rate estimation method implementing nasal or oral breathing signal selection based on signal quality index for stable measurement and MUSIC algorithm for rapid measurement. We tested the system on 22 healthy subjects and 28 patients with seasonal influenza, using the support vector machine (SVM) classification method. Results: The body temperature, heart rate and respiration rate measured in a non-contact manner were highly similarity to those measured via contact-type reference devices (i.e., thermometer, ECG and respiration belt), with Pearson correlation coefficients of 0.71, 0.87 and 0.87, respectively. Moreover, the optimized SVM model with three vital signs yielded sensitivity and specificity values of 85.7% and 90.1%, respectively. Conclusion: For contactless vital sign measurement, the system achieved a performance similar to that of the reference devices. The multiple vital sign-based screening achieved higher sensitivity than fever-based screening. Thus, this system represents a promising alternative for further quarantine procedures to prevent the spread of infectious diseases.


2021 ◽  
pp. 1357633X2110118
Author(s):  
Nobuyuki Kagiyama ◽  
Makoto Hiki ◽  
Yuya Matsue ◽  
Tomotaka Dohi ◽  
Wataru Matsuzawa ◽  
...  

Introduction In the ongoing COVID-19 pandemic, the development of a system that would prevent the infection of healthcare providers is in urgent demand. We sought to investigate the feasibility and validity of a telemedicine-based system in which healthcare providers remotely check the vital signs measured by patients with COVID-19. Methods Patients hospitalized with confirmed or suspected COVID-19 measured and uploaded their vital signs to secure cloud storage. Additionally, the respiratory rates were monitored using a mat-type sensor placed under the bed. We assessed the time until the values became available on the Cloud and the agreements between the patient-measured vital signs and simultaneous healthcare provider measurements. Results Between 26 May–23 September 2020, 3835 vital signs were measured and uploaded to the cloud storage by the patients ( n=16, median 72 years old, 31% women). All patients successfully learned how to use these devices with a 10-minute lecture. The median time until the measurements were available on the cloud system was only 0.35 min, and 95.2% of the vital signs were available within 5 min of the measurement. The agreement between the patients’ and healthcare providers’ measurements was excellent for all parameters. Interclass coefficient correlations were as follows: systolic (0.92, p<0.001), diastolic blood pressure (0.86, p<0.001), heart rate (0.89, p<0.001), peripheral oxygen saturation (0.92, p<0.001), body temperature (0.83, p<0.001), and respiratory rates (0.90, p<0.001). Conclusions Telemedicine-based self-assessment of vital signs in patients with COVID-19 was feasible and reliable. The system will be a useful alternative to traditional vital sign measurements by healthcare providers during the COVID-19 pandemic.


SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A130-A130
Author(s):  
Ya-Chuan Huang ◽  
Hsin-Chien Lee ◽  
Chien-Ming Yang

Abstract Introduction Stress reactivity and autonomic nervous system (ANS) dysregulation have been suggested to be the pathophysiology of insomnia. Based on the finding PSG-measured short sleep duration was associated with higher morbidity of metabolic and cardiovascular disease. Vgontzas and Fernandez-Mandoza (2013) proposed that objective sleep duration is a biomarker for insomnia phenotypes. The phenotype with short objective sleep duration is associated with increased stress-related physiological hyperarousal. The present study aims to test this hypothesis by comparing the stress-induced cardiovascular reactivity between insomnia patients with short and long objective sleep durations. Methods 27 insomnia patients (age mean 34.48 ±12.87, Male: Female= 6:21) without comorbidity of psychiatric, medical or sleep disorders participated in this study. They went through one night of 8-hour PSG recording and were divided into two groups by their total sleep time with a cutoff of 6 hours. Nine participants were in short sleep duration group and 18 in longer sleep duration group. Psychophysiological reactivity profile, as recorded with EKG, skin conductance (SC), body temperature (BT), blood volume pulse (BVP), respiration rate (RR), was measured under three conditions: baseline resting state, arithmetic word problems solving, and recovery resting state. Results Both groups showed similar stress physiological response with increased heart rate (HR) and SC, nearly equivalent BT and BVP, and decreased RR when solving arithmetic problems, and opposite reaction during recovery resting state. Mann-Whitney U test comparing the changes from baseline resting state on all the psychophysiological measures between two phenotypes of insomnia showed no significant differences: stress-induced heart-rate (U=106, p=.119.) recovery heart-rate (U=44, p=.095), stress-induced skin conductance (U=104.5, p=.132),recovery skin conductance (U=51.5, p=.198), stress-induced body temperature (U=79, p=.897),recovery body temperature (U=60.5, p=.418), stress-induced blood volume pulse amplitude (U=77, p=1.0), and recovery blood volume pulse amplitude (U=69, p=.735), stress-induced respiration rate (U=76, p =.696), and recovery respiration rate (U=85, p=.658). Conclusion Our results indicate that the insomnia phenotypes with short and long objective sleep duration are not different in their stress-induced physiological responses. Future studies are needed to confirm these results and to explore other mechanisms for the increased metabolic and cardiovascular disease risk in insomnia patients with short objective sleep duration. Support (if any):


2010 ◽  
Vol 298 (1) ◽  
pp. R130-R140 ◽  
Author(s):  
Joseph L. Hunt ◽  
Dmitry V. Zaretsky ◽  
Sumit Sarkar ◽  
Joseph A. DiMicco

Previous studies suggest that sympathetic responses evoked from the preoptic area in anesthetized rats require activation of neurons in the dorsomedial hypothalamus. Disinhibition of neurons in the dorsomedial hypothalamus in conscious rats produces physiological and behavioral changes resembling those evoked by microinjection of muscimol, a GABAA receptor agonist and neuronal inhibitor, into the medial preoptic area. We tested the hypothesis that all of these effects evoked from the medial preoptic area are mediated through neurons in the dorsomedial hypothalamus by assessing the effect of bilateral microinjection of muscimol into the DMH on these changes. After injection of vehicle into the dorsomedial hypothalamus, injection of muscimol into the medial preoptic area elicited marked increases in heart rate, arterial pressure, body temperature, plasma ACTH, and locomotor activity and also increased c-Fos expression in the hypothalamic paraventricular nucleus, a region known to control the release of ACTH from the adenohypophysis. Prior bilateral microinjection of muscimol into the dorsomedial hypothalamus produced a modest depression of baseline heart rate and body temperature but completely abolished all changes evoked from the medial preoptic area. Microinjection of muscimol just anterior to the dorsomedial hypothalamus had no effect on autonomic and neuroendocrine changes evoked from the medial preoptic area. Thus, activity of neurons in the dorsomedial hypothalamus mediates a diverse array of physiological and behavioral responses elicited from the medial preoptic area, suggesting that the latter region represents an important source of inhibitory tone to key neurons in the dorsomedial hypothalamus.


2020 ◽  
Vol 98 (Supplement_2) ◽  
pp. 83-83
Author(s):  
Gabrielle Abbott ◽  
Kathi Jogan ◽  
Erin L Oberhaus ◽  
Jason Apple ◽  
Charles Rosenkrans

Abstract Equine therapy is used to assist people suffering from various physical and mental disabilities. Equine-assisted activities and therapies (EAAT) include therapeutic riding and hippotherapy. Our objective was to determine the effects of EAAT on horse heart rate, respiration rate, temperature, and serum cortisol. Horses (n = 7) were assigned to activity type (groundwork or riding) in a Latin square design in which all horses performed both activities twice. Heart rate, respiration rate, rectal temperature, and serum cortisol concentrations were determined at 15 minutes before, and 15, 45, and 75 minutes after activity was initiated. Pearson correlations revealed that cortisol was not correlated (r &lt; 0.12; P &gt; 0.22) with heart rate, respiration rate, or rectal temperature. Heart rate was correlated (P &lt; 0.05) with respiration rate (r = 0.77) and body temperature (r = 0.2); and body temperature was correlated with respiration rate (r = 0.21; P &lt; 0.05). Analysis of variance was performed with horse within date as the experimental unit, main effects of activity type, horse, date, experimental time, and interactions. Serum concentrations of cortisol (varied from 2.8 to 89.7 ng/mL) and body temperature (37.4 ± 0.06) were affected (P &lt; 0.01) by an interaction between experimental time and horse. Heart rate (61 ± 2.1) and respiration rate (30 ± 1.4) were affected (P &lt; 0.01) by interactions between experimental time and horse; and experimental time and activity type. Our results demonstrate that equine athletes serving in EAAT programs have altered physiological responses depending on the horse, type of activity, and length of time performing the task. Based on our results, cortisol concentrations are not the best indicator of a horse’s response to EAAT work, and we recommend that trainers monitor horses’ heart and respiration rates as an indicator of horse well-being while working with patients.


1981 ◽  
Vol 59 (9) ◽  
pp. 985-993 ◽  
Author(s):  
A. D. Graham ◽  
R. J. Christopherson

The heat production (HP), heart rate (HR), respiration rate, rumen motility, and body temperature responses to 2.5-h adrenaline (A) and noradrenaline (NA) intrajugular infusions at 0.00, 0.15, 0.30, 0.60, and 0.90 μg∙kg−1∙min−1 were studied in 10 shorn wethers which had been chronically (3–8 weeks) exposed to warm (19–24 °C) or moderately cold (8–13 °C) temperatures. Heat production, as estimated from respired gas analysis, increased 40–45% with all doses of A and the effect was potentiated by chronic cold exposure. Only the higher dose rates of NA induced an increase in HP. The maximum HP increase due to NA was 30% and the effect was not influenced by chronic cold exposure. Thermoneutral HP was greater by 16–19% in cold-acclimated as compared with warm-acclimated sheep. Corresponding to the HP effects of A and NA, all doses of A and the highest dose of NA resulted in slight increases in rectal temperature. Respiration rate increased with increased dose rate of NA but only the highest dose of A resulted in an increase in respiration rate. HR, rectal temperature, and respiration rate responses to A and NA were not influenced by cold acclimation.


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