scholarly journals Effect of Adjuvant Vitamin C on Brain-Derived Neurotrophic Factor Levels and Improvement of Negative Symptoms in Schizophrenic Patients

2021 ◽  
Vol 9 (T3) ◽  
pp. 353-357
Author(s):  
Andi Jayalangkara Tanra ◽  
Herwina Sabaruddin ◽  
Kristian Liaury ◽  
Andi Alfian Zainuddin
Keyword(s):  
Vitamin C ◽  
Negative Symptoms ◽  
Serum Vitamin ◽  
University Hospital ◽  
Blood Levels ◽  
Control Groups ◽  
Treatment Groups ◽  
Average Value ◽  
Before And After ◽  
Schizophrenic Patients

AIM: This study aims to determine the effect of adjuvant Vitamin C on brain-derived neurotropic factors (BDNF) levels and improvement of negative symptoms in schizophrenic patients. METHODS: This study was conducted at Hasanuddin University Hospital and its affiliate with 60 schizophrenic patients (30 controls, 27 treatments, and three dropout patients). The ELISA sample examination method was used to examine blood levels of BDNF, and Vitamin C levels before and after administration of Vitamin C. In addition, the negative symptoms were measured using the PANSS score. RESULTS: There was a significant increase in BDNF levels in treatments group compared the control at 4th–8th weeks with p = 0.005 (4th week) and ≤0.0001 (<0.05) (8th week). The improvement in PANSS scores for negative symptoms in the treatment groups compared to the controls at the 2nd, 4th, and 8th weeks resulted in p = 0.042 (2nd week) and <0.0001 (4th–8th weeks). Furthermore, there was an increase in serum Vitamin C levels in the treatment groups with an initial average value = 4.762 and after 8 weeks = 148.155. Strong correlation between increased BDNF levels and improvement in negative symptoms on the PANSS score was found with p = 0.001 (4th week) and ≤0.0001 (8th week). CONCLUSION: The administration of Vitamin C significantly increases BDNF levels and improves the PANSS score for negative symptoms in the treatments compared to the control groups.

scholarly journals PENGARUH SENAM OTAK TERHADAP PENINGKATAN MOTORIK KASAR PADA ANAK USIA 4-6 TAHUN

2018 ◽  
Vol 8 (2) ◽  
pp. 8-13
Author(s):  
Lina Madyastuti R ◽  
Retno Twistiandayani ◽  
Arifatul Widya Rahayu
Keyword(s):  
Sampling Method ◽  
Control Groups ◽  
Gross Motor ◽  
Brain Gym ◽  
Treatment Groups ◽  
Before And After ◽  
Independent Variable ◽  
Motor Improvement ◽  
Brain And Spinal Cord ◽  
The Brain

Children aged 4-6 years the most prominent development is motor, motor is closely related to physical activity. Gross motor is the development of motion control through the coordinated between the nerves, brain and spinal cord. One way to optimize the use of all the dimensions of the brain is brain gymnastics. Doing brain gym is one type of nonfarmacologis therapy that serves to improve the gross motor. The purpose of this study was to the effect of brain gym on gross motor improvement in children aged 4-6 years. This research method  used Quasy experimentalwith two control groups and treatment groups. Sample was selected using the Purposive Sampling method. Samples obtained as many 30 children. Independent variable in this study ware brain gym, while the dependent variable in this study was the change rough motor of children aged 4-6 years. Data collected before and after the intervention. Analysis used of the data used stastical test of  Wilcoxon Signed Ranks Test with the  value <0.05. The results of research showed value significant (2-tailed) = 0.001 meaning there was influence of brain gym to the increase of gross motor in children aged 4-6 years. By giving the brain gym will provide stimulation of the brain so as to improve the coordination of the eyes and hands that can improve the development of gross motor in children.

scholarly journals Vibrator-Assisted Start–Stop Exercises Improve Premature Ejaculation Symptoms: A Randomized Controlled Trial

2019 ◽  
Vol 49 (5) ◽  
pp. 1559-1573 ◽  
Author(s):  
Daniel Ventus ◽  
Annika Gunst ◽  
Stefan Arver ◽  
Cecilia Dhejne ◽  
Katarina G. Öberg ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
Premature Ejaculation ◽  
Mindfulness Meditation ◽  
Controlled Trial ◽  
Waiting List ◽  
Control Group ◽  
Adequate Treatment ◽  
Treatment Groups ◽  
Sexual Distress ◽  
Before And After

AbstractPremature ejaculation (PE) is associated with decreased quality of life, lower confidence and self-esteem, and higher levels of depression, anxiety, and interpersonal difficulties. Here we investigated the effectiveness of vibrator-assisted start–stop exercises for treatment of PE, and whether the treatment effect could be enhanced by an additional psychobehavioral intervention. Fifty participants with a mean age of 41.7 years were included and randomized into two treatment groups and a waiting list control group. Participants were instructed to perform start–stop exercises while stimulating the penis with a purpose-made vibrator, 3 times a week for 6 weeks. Additionally, participants in one of the treatment groups received additional psychoeducation and performed mindfulness meditation-based body scan exercises three times a week. Data were gathered through online questionnaires before and after treatment, as well as 3 and 6 months after treatment. The interventions reduced PE symptoms with large effect sizes (partial η2 = .20 across the three groups, d [95% CI] = 1.05 [.27, 1.82] and 1.07 [.32, 1.82] for treatment groups compared to waiting list control group). The additional psychobehavioral intervention did not further reduce PE symptoms, but did decrease PE-associated negative symptoms such as levels of sexual distress, anxiety, and depression. No side effects were reported. Vibrator-assisted start–stop exercises can be offered as an adequate treatment option for PE.

Acute Changes in Vitamin B6, Status in Endurance Athletes before and after a Marathon

1994 ◽  
Vol 4 (2) ◽  
pp. 154-165 ◽  
Author(s):  
Lothar Rokitzki ◽  
Andree N. Sagredos ◽  
Friedrich Reuß ◽  
Michael Büchner ◽  
Josef Keul
Keyword(s):  
Reference Values ◽  
Whole Blood ◽  
Serum Vitamin ◽  
Endurance Athletes ◽  
Blood Levels ◽  
Serum Samples ◽  
Marathon Race ◽  
Balanced Diet ◽  
Before And After ◽  
Acute Changes

The vitamin status of 13 endurance athletes was determined by whole blood (microbiological) and urine 4-pyridoxic acid (4-PA) (HPLC), serum vitamin (pyridoxal, pyridoxol, pyridoxamin) (HPLC), and erythrocyte α- EGOT measurements with the aid of 7-day records. In addition, blood and serum samples and urine were collected before (Time A), directly after (Time B), and 2 hr after a marathon race (Time C). The total energy intake was 12,303 ± 3,464 Wday (34% fat, 48% carbohydrates, 14% protein). The vitamin intake, serum concentrations, α-EGOT value, and 4-PA excretion were higher than the reference values at Time A. Only the vitamin whole blood levels were below the normal level at Time A. The vitamin B, status of the athletes corresponded essentially to reference values obtained for untrained individuals. There was a mean loss of about 1 mg vitamin as a result of the marathon race. Vitamin supplementation does not appear necessary if a balanced diet is consumed.

scholarly journals Study of Kidney Repair Mechanism of Cassava Leaf Extract on Gentamicin induced Nephrotoxicity

2017 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Rena Normasari ◽  
Rosita Dewi ◽  
Sheilla Rachmania
Keyword(s):  
Statistical Analysis ◽  
Vitamin C ◽  
Leaf Extract ◽  
Renal Damage ◽  
Serum Levels ◽  
Repair Mechanism ◽  
Control Groups ◽  
Treatment Groups ◽  
Cassava Leaves

Drugs consumption like gentamicin caused damage and decreased of kidney function. Cassava leaf contain lots of micronutrients, such as vitamin C, vitamin A and carotenoids, which also as an antioxidant. The results of the study conducted by Almashuri proved that cassava leaf have high levels of carotenoid compounds. The purpose of this study was to determine the effect of cassava leaf extract on the repairment of renal damage in mice in vivo. This research is true experimental using mice (mus musculus) and were grouped into 5 groups. Two control groups (positive and negative) and 3 treatment groups (cassava leaves 150, 300, and 450 mg / day). Gentamicin is given every day for 14 days and then observed on serum levels of creatinine along with histopathological scores of kidneys’ damage. Statistical analysis showed a significant reduction in serum levels of creatinine (P <0.05) and a significant decrease in renal histopathologic score. This study suggests that cassava leaf extract can repair kidney damage as a result gentamicin-induced nephrotoxicity in mice.Keywords: cassava leaf extract, creatinin, kidney histopathology

The Effect of Humor Intervention Program on Positive and Negative Symptoms among Schizophrenic Patients

2021 ◽  
Vol 15 (7) ◽  
pp. 2022-2028
Author(s):  
Eman Asran Mohamed ◽  
Enayat Abd El Wahab Khalil ◽  
Zeinab Abd El Halim Osman ◽  
Mona Rakhawy ◽  
Naglaa Mostafa G
Keyword(s):  
Intervention Program ◽  
Negative Symptoms ◽  
Demographic Data ◽  
Intervention Group ◽  
University Hospital ◽  
Control Group ◽  
Significant Difference ◽  
Schizophrenic Patients ◽  
And Control ◽  
Positive And Negative Symptoms

Background: Schizophrenia is a chronic disease characterized by distortions in thinking, perception, emotions, language, sense of self and behavior. Humor could be used as an alternative to conventional treatment with the goal of helping patients with schizophrenia cope with symptoms, enhance recovery through its emotional, cognitive, social and physiological effects. The aim of the study was to evaluate the effect of humor intervention program on positive and negative symptoms among schizophrenic patients. Design: Randomized control trial (RCT) design was used. Sample: Purposive sample consisted of 40) schizophrenic patients, the study group (n= 20) and control group (n= 20). The patients were selected and allocated randomly into two groups, intervention group (received the humor interventions program) and control group (received traditional care). The study conducted in the Psychiatry and Addiction Prevention "El Kasr AlAini University Hospital and al Rakhawy Hospital for Mental Health. Tools: three tools were used for data collection were; the Socio Demographic Data Sheet, Positive and Negative Syndrome Scale (PANSS) and Multidimensional Sense of Humor Scale (MSHS). Results: revealed that, there was a statistical significant difference between total score of PANSS between study and control groups post intervention. Conclusion: The present study emphasizes the importance of humor intervention program in reducing severity of symptoms of patients with schizophrenia. Key words: schizophrenia, humor intervention, positive symptoms, negative symptoms

A cryoprotectant supplemented with pentoxifylline can improve the effect of freezing on the motility of human testicular sperm

Zygote ◽  
2021 ◽  
pp. 1-6
Author(s):  
Yang Xian ◽  
Min Jiang ◽  
Bo Liu ◽  
Wenrui Zhao ◽  
Bin Zhou ◽  
...  
Keyword(s):  
Sperm Motility ◽  
University Hospital ◽  
Control Group ◽  
Testicular Sperm ◽  
Freezing And Thawing ◽  
Control Groups ◽  
West China ◽  
Before And After ◽  
And Control ◽  
Experimental Group

Summary This study examined the effect of a cryoprotectant with and without pentoxifylline supplementation on the motility and viability of human testicular sperm, both before and after freezing. Testicular samples were obtained from 68 patients with azoospermia who came to the Andrology Service of West China Second University Hospital, Sichuan University, for testicular biopsies from December 2019 to April 2020. All patients were assigned randomly to two groups: experimental, whose testicular sperm were added to the cryoprotectant with pentoxifylline, and the control, whose testicular sperm were added to the cryoprotectant without pentoxifylline. Both groups used the same freezing and thawing methods. Testicular sperm motility in the experimental group was significantly higher than that of the control group, both before and after cryopreservation. The recovery rate of sperm motility in the experimental group was significantly higher than that of the control group. The percentage of samples with motile testicular sperm in the experimental group was significantly higher than that of the control group after thawing. Sperm viability was unchanged between the experimental and control groups, both before and after freezing. Overall, a pentoxifylline-supplemented cryoprotectant can significantly improve the motility of testicular sperm before and after cryopreservation.

scholarly journals Determination of multiple vitamins in 178 patients undergoing chemotherapy for lung cancer

2021 ◽  
Author(s):  
lanqing liang ◽  
wei yu ◽  
boning cai ◽  
qianqian wang ◽  
xiang huang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Vitamin A ◽  
Vitamin C ◽  
Serum Vitamin ◽  
Disease Status ◽  
Vitamin B2 ◽  
Serum Concentrations ◽  
Pathological Type ◽  
Before And After

IntroductionThe aim of the study was to investigate the changes in serum concentrations of nine vitamins in patients undergoing chemotherapy for lung cancer and explore their clinical values and influencing factors.Material and methodsPatients receiving chemotherapy for lung cancer in our centre from February 2018 to May 2020 were enrolled in this study. Serum concentrations of the nine vitamins including vitamins A, D, E, B9, B12, B1, C, B2, and B6 were measured in all subjects, and the changes in the concentrations of these vitamins were compared before and after 2 cycles of chemotherapy. In addition, the potential correlations of serum vitamin levels with age, gender, pathological type, and disease status were analysed.ResultsIn the 178 patients with lung cancer, there were different degrees of vitamin A, vitamin D, vitamin C, and in particular, vitamin B2 deficiencies. Before chemotherapy, the concentrations of vitamin A and vitamin C were significantly different between males and females and among patients in different clinical stages (both p < 0.05), the concentrations of vitamin C and vitamin B2 significantly differed among different pathological types of lung cancer (p < 0.05), and vitamin D level was significantly related to the disease status (p < 0.05). In addition, the proportion of vitamin B2 deficiency differed significantly among different pathological types (p < 0.05). There were significant differences in the concentrations of vitamins D, C, and B2 before and after chemotherapy (all p < 0.05). There was a correlation between the change of serum vitamin B1 concentration before and after chemotherapy and the change of body mass index (p < 0.05).ConclusionsDuring chemotherapy, lung cancer patients are more likely to develop vitamins A, D, C, and B2 deficiencies. Different vitamin deficiencies are related to gender, clinical stage, pathological type, and disease status. Vitamin determination and reasonable supplementation of nutrients in patients undergoing chemotherapy for lung cancer can help improve the nutritional status and increase chemotherapy tolerance.

scholarly journals Effects of graded levels of vitamin C supplemented feed of layers on serum concentrations of vitamin A and vitamin C

2015 ◽  
Vol 1 (2) ◽  
pp. 158-162
Author(s):  
ME Sanda ◽  
A Suleiman
Keyword(s):  
Vitamin A ◽  
Vitamin C ◽  
Serum Concentration ◽  
Serum Vitamin ◽  
Experimental Period ◽  
Serum Concentrations ◽  
Treatment Groups ◽  
Vitamin C Supplementation ◽  
All Treatment

The study was conducted to determine the effects of layers? diets containing 0, 100, 150 and 200 mg/kg vitamin C on vitamin A and C concentrations in serum of layers. A total of 80 Isa brown layers (28 weeks of age) were used in this study. There were a control and three treatment groups each containing 20 hens. The experimental period lasted 8 weeks. Serum vitamin A and vitamin C concentrations were determined twice at 32 and 36 weeks of age. Serum vitamin A and serum vitamin C concentrations increased as vitamin C supplementation increased in the diet. During the study, serum concentration of vitamin C was increased significantly (P<0.05) by the addition of 150 and 250 mg/kg vitamin C and serum concentration of vitamin A was increased significantly (P<0.01) in all treatment groups in increasing order as vitamin C supplementation increases in the diet. It has been concluded that vitamin C protected vitamin A against oxidation and increased serum vitamin A levels in parallel with increased serum vitamin C.Asian J. Med. Biol. Res. June 2015, 1(2): 158-162

scholarly journals Effect of vitamin C supplementation on serum Cotinine, MDA and vitamin C levels in smokeless Tobacco chewers

2019 ◽  
Vol 10 (2) ◽  
pp. 803-811
Author(s):  
Jaywant Thorat ◽  
Anand Joshi ◽  
Ajit Sontakke ◽  
Kanchan Wingkar
Keyword(s):  
Vitamin C ◽  
Smokeless Tobacco ◽  
Daily Intake ◽  
Serum Vitamin ◽  
Tobacco Consumption ◽  
Serum Cotinine ◽  
Before And After ◽  
Vitamin C Supplementation ◽  
Healthy Participants ◽  
Tobacco Chewing

Smokeless tobacco is a commonly used drug in the world. Tobacco use in any form is a rising crisis for the population in developing countries. Tobacco contributes significantly to oxidative stress induced morbidity and mortality. The study was aimed to evaluate the effect of vitamin C supplementation on serum cotinine, malondialdehyde (MDA) and serum vitamin C level in smokeless tobacco (ST) chewers. In addition, the study was aimed to evaluate the effect of duration of tobacco chewing on above-said parameters. A total number of 338 healthy participants of aged between 31 to 60 years were classified into two groups comprising of tobacco chewers and tobacco non-chewers. Tobacco chewers group further divided into three subgroups with respect to tobacco chewing duration. Participants were asked to take 1000 mg of vitamin C daily for 45 days. Serum cotinine, MDA and serum vitamin C were measured in all the participants before and after supplementation of vitamin C. Serum cotinine (p<0.001) and MDA (p<0.001) were significantly increased whereas serum vitamin C level (p<0.001) was significantly decreased in smokeless tobacco chewers as than to controls. However, serum cotinine (p<0.001) and MDA (p<0.001) were significantly decreased whereas vitamin C (p<0.001) level was significantly increased in both the groups after supplementation of vitamin C as compared to before. It was observed that the changes become more prominent with increased smokeless tobacco consumption duration. Daily intake of vitamin C may be beneficial to restore the oxidant-antioxidant balance in tobacco chewers.

scholarly journals EFFECTIVENESS OF SHOOTING BASKETBALL MODEL BASED OF DRILL AT FACULTY OF SPORT SCIENCE OF STATE UNIVERSITY OF MEDAN

2018 ◽  
Vol 4 (1) ◽  
pp. 74-82
Author(s):  
Ibrahim Ibrahim ◽  
Moch. Asmawi ◽  
Iman Sulaiman
Keyword(s):  
Data Analysis ◽  
Learning Model ◽  
State University ◽  
Control Groups ◽  
Significance Level ◽  
Treatment Groups ◽  
Average Value ◽  
Count Ratio ◽  
Model Based ◽  
Basketball Shooting

The purpose of this research is to get an overview of the implementation of basketball-based shooting learning on the students, to produce basketball shooting learning model, and to develop conceptual model and procedural model of shooting set shoot learning, jump shoot and basketball shoot layup and also to know effectiveness of efficient model. This research and development use Research & Development (R & D) development method from Borg and Gall. Group trials were conducted on second semester students who took basic basketball courses consisting of 4 classes totaling 120 people, 60 treatment groups and 60 as control groups with eight (8) meetings. The effectiveness test of the learning model uses shooting skill set shoot skill instruments, jump shoot and basketball shoot layup using portofolio (process assessment). Analysis of research data using t test with a significance level of 0.05. Data analysis for shoot shooting set obtained an average value of pretest 50.43 and posttest 75.57 t-count ratio and t-table -188.500 <1.67065, while the jump shoot obtained the average value of pretest 57.55 and posttest 82 , 85 t-count comparisons and t-tables -89,235 <1,67065 and for shoot layups, the average pretest score is 48,02 and posttest 73,17 t-count ratio and t-table -167,667 <1,67065, significance (2-tailed) 0.000 with a significance level of 0.05 then of the three H0 rejected. Based on the data analysis, it can be said that the set shoot, jump shoot and drill layup-based learning models for students are developed, effective and can improve the results of basketball shooting learning.   Keywords: Effectiveness, Shooting Basketball Model, Based of Drill

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