scholarly journals The Use of Bioacoustic Stimulation of the Respiratory System in Complex Medical Rehabilitation at a Health Resort Facility for Patients who have had COVID-associated Pneumonia

2021 ◽  
Vol 9 (B) ◽  
pp. 1607-1614
Author(s):  
Mikhail Bragin ◽  
Evgeny Goloborodko ◽  
Gennady Erofeev ◽  
Sergey Razinkin ◽  
Alexey Vladimirovich Sukhinin ◽  
...  
Keyword(s):  
Respiratory System ◽  
High Intensity ◽  
Low Frequency ◽  
Stress Disorders ◽  
Medical Rehabilitation ◽  
Psychological Status ◽  
Health Resort ◽  
Before And After ◽  
Rehabilitation Measures ◽  
Stimulation Of

BACKGROUND: In the context of the COVID-19 pandemic, the relevance of rehabilitation measures for patients with COVID-associated pneumonia has increased. AIM: The study aimed to review the effect of bioacoustic stimulation of the respiratory system (BSRS) with high-intensity low-frequency sounds on the dynamics of functional indicators of the respiratory system and the cardiovascular system, as well as indicators of psychoemotional and somatic states, the severity of post-traumatic stress disorders (PTSD) and cognitive capabilities in patients who have had COVID-associated pneumonia in the process of their medical rehabilitation at a health resort immediately after treatment of the disease in a hospital. MATERIALS AND METHODS: The randomized controlled open parallel prospective clinical study involved 28 patients undergoing medical rehabilitation after suffering moderate to severe COVID-19 complicated by community-acquired bilateral polysegmental pneumonia (COVID-associated pneumonia) of moderate to severe severity. Spirometry, pulse oximetry, compression oscillometry, bioelectrography, Mississippi Scale (civil version), and cognitive speed test were used to assess the functional parameters of the respiratory and cardiovascular systems, as well as indicators of psychoemotional and somatic states, the intensity of PTSD and cognitive abilities of patients before and after the course of rehabilitation measures. RESULTS: According to significant differences in changes in the indexes of external respiration, cardiac activity, psychological status, and the intensity of PTSD in patients of the main and control groups before and after a course of rehabilitation measures, it has been reliably established that the use of BSRS as a part of a complex of rehabilitation measures significantly increases the effectiveness of medical rehabilitation at a health resort for patients after COVID-associated pneumonia. CONCLUSION: The possibility and feasibility of using medical technology of BSRS with high-intensity low-frequency sound in complex medical rehabilitation of patients after COVID-associated pneumonia at the health resort stage have been scientifically substantiated.

Electrical Stimulation of the Guinea Pig Cochlea

1987 ◽  
Vol 96 (4) ◽  
pp. 349-361 ◽  
Author(s):  
Mark J. Maslan ◽  
Josef M. Miller
Keyword(s):  
Electrical Stimulation ◽  
Low Frequency ◽  
Damage Threshold ◽  
Auditory Brainstem ◽  
Cochlear Prosthesis ◽  
Before And After ◽  
Auditory Brainstem Evoked Responses ◽  
Straight Lines ◽  
Histopathologic Findings ◽  
Stimulation Of

As a result of practical considerations, histopathologic findings of the temporal bone in humans with cochlear prosthesis implants have been limited. This project attempts to better define safe parameters of electrical stimulation of the inner ear and compare the safe limits of intracochlear vs. extracochlear stimulation sites. Guinea pigs were implanted with single electrodes either on the promontory or in the scala tympani and were stimulated relative to a remote indifferent for 12 hours distributed over a 4-week period. Electrical auditory brainstem evoked responses (EABRs) were tested before and after each of four 3-hour stimulation sessions. Six weeks after implantation, the animals were killed, and their cochleas were examined under the scanning electron microscope. Intracochlear electrodes exhibited thresholds for damage well below one half of that found for most extracochlear stimulation sites. The function-relating damage threshold (in amperes) to frequency of intracochlear stimulation is represented by two straight lines, with an intercept of 1 kHz. The low-frequency limb exhibited a slope of 3 to 4 dB/octave, whereas the high-frequency limb exhibited a slope of 9 to 10 dB/octave. Extracochlear results were too variable to permit speculation. Changes in EABRs were only variably related to histopathologic findings.

Repetitive stimulation induced potentiation of excitatory transmission in the rat dorsal horn: an in vitro study

1994 ◽  
Vol 71 (1) ◽  
pp. 216-228 ◽  
Author(s):  
S. Jeftinija ◽  
L. Urban
Keyword(s):  
Peripheral Nerve ◽  
Dorsal Horn ◽  
High Intensity ◽  
Action Potentials ◽  
Dorsal Root ◽  
Low Frequency ◽  
Nerve Trunk ◽  
Primary Afferents ◽  
Repetitive Stimulation ◽  
Stimulation Of

1. The effects of repetitive stimulation of primary afferents in lumbar dorsal roots on synaptic transmission in the dorsal horn (DH) were studied in a rat spinal cord slice-dorsal root ganglion (DRG)-peripheral nerve trunk preparation by the use of intracellular recording from neurons (n = 115) of the spinal dorsal horn (depth 147 +/- 139, mean +/- SD). All DH neurons were excited synaptically by electrical stimulation of the dorsal root or the peripheral nerve trunk. The electrical shocks were calibrated to produce activation either of large fibers (10–20 V, 0.02 ms) or the whole fiber population including unmyelinated afferents (supramaximal stimulus: > 35 V, 0.5 ms). Postsynaptic potentials induced by low intensity repetitive stimulation of primary afferents at frequencies below 5 Hz failed to produce a prolonged change in the resting membrane potential. In 97/115 DH neurons, slow excitatory postsynaptic potentials (EPSP)--evoked by high intensity low-frequency repetitive stimulation (0.1–2 Hz) of primary afferents--summated, producing a prolonged cumulative depolarization. In the remaining 18/115 DH neurons, high intensity low-frequency stimulation produced a cumulative hyperpolarizing response. 2. In 22 of 97 neurons that responded to high intensity repetitive stimulation with a cumulative depolarization, wind-up in the firing of action potentials was recorded. In all but two experiments, neurons that responded with wind-up to stimulation of one root responded with wind-up to stimulation of the adjacent dorsal root. In 14/22 wind-up neurons, the synaptic response to high intensity stimulation of primary afferents was composed of a short latency EPSP, followed by an inhibitory postsynaptic potential (IPSP), followed by a slow EPSP. The decrease of the amplitude and duration of the IPSP obtained during train stimulation did not seem to contribute to facilitation of transmission induced by repetitive stimulation. 3. The wind-up in firing of action potentials was followed by a prolonged potentiation of synaptic transmission in tetanized synapses. A test of other, adjacent primary afferents revealed that these synapses in the neurons in the superficial laminae had not undergone potentiation. This “synaptic specificity” of post-wind-up potentiation suggested that the mechanism for the induction of stimulation-dependent changes in the excitability of the DH neuron is presynaptic to the recorded-from neuron. 4. In a concentration of 0.5 microM and higher, tetrodotoxin (TTX) applied to sensory neurons selectively blocked action potentials in large myelinated primary afferents.(ABSTRACT TRUNCATED AT 400 WORDS)

scholarly journals An innovative technology of an athlete’s organism functional reserves increase based on bioacoustical stimulation of the respiratory system

2020 ◽  
Vol 26 ◽  
pp. 00037
Author(s):  
Sergey Dragan ◽  
Alexey Bogomolov ◽  
Sergei Razinkin ◽  
Igor Berzin ◽  
Gennady Erofeev
Keyword(s):  
Cross Section ◽  
Respiratory System ◽  
Sound Wave ◽  
Sound Pressure ◽  
Low Frequency ◽  
Innovative Technology ◽  
Tonal Signal ◽  
Functional Reserves ◽  
Level Of Sound Pressure ◽  
Stimulation Of

In order to increase an athlete’s organism functional reserves we created the innovative technology based on low-frequency vibrations influence on respiratory system. First we measured acoustic impedance of an athlete’s organism for three phases of respiration at polyharmonic acoustic signal within the range of frequency from 3 Hz to 51 Hz. After that during 2 weeks we organized six sessions of bioacoustical stimulation among the group of 20 athletes, divided into subgroups with an effective (130 dB) and placebo (60 dB) effect. It was stated that six-fold effect of a scanning tonal signal with the level of sound pressure 130 dB within the range 22-36 Hz led to resonance frequency of respiratory system increase, respiratory system sound vibrations imbibitio coefficient decrease and its resistance to sound wave increase because of reserve alveoli opening and the increase of area of cross section of alveolar ways and respiratory bronchial tubes.

Evaluation of the effectiveness of low-frequency magnetotherapy in the rehabilitation of patients with pneumonia caused by the SARS-CoV-2 virus (the causative agent of COVID-19)

2021 ◽  
Vol 15 (6) ◽  
pp. 1706-1708
Author(s):  
Nikolay Larinskiy ◽  
Irina Larinskaya ◽  
Yuriy Byalovskiy ◽  
Sergey Glotov ◽  
Anton Shakhanov
Keyword(s):  
Magnetic Field ◽  
Low Frequency ◽  
Medical Rehabilitation ◽  
Pulsed Magnetic Field ◽  
Control Group ◽  
External Respiration ◽  
Standard Drug ◽  
Functional Capabilities ◽  
Rehabilitation Measures ◽  
Magnetic Therapy

The study aimed to evaluate the effectiveness of the low-frequency magnetic therapy with a "running" magnetic field in medical rehabilitation after COVID-19 pneumonia. Materials and research methods: The study included 42 patients (24 men and 18 women) aged 40 to 65 years, who had pneumonia (J16.8) caused by the new coronavirus SARS-CoV-2. The first group included 22 patients who received standard drug therapy and starting from the 20th day after discharge from the hospital, this group of patients received low-frequency magnetotherapy with a “running” pulsed magnetic field of the ALMAG-02 apparatus. The second group included 20 patients who received the same treatment, except for magnetotherapy. Results: The course of rehabilitation measures carried out led to an increase in the functional capabilities of the cardio-respiratory system in patients of both groups, an increase in chest excursions, an increase in the vital capacity of the lungs, the normalization of the act of breathing and ventilation of the lungs, and an improvement in the psychosomatic status of patients. In the main group, these changes are more pronounced than in the control group, which is associated with the inclusion in the complex treatment of low-frequency magnetotherapy with a “running” pulsed magnetic field. Conclusion: The use of low-frequency magnetic therapy with a "running" pulsed magnetic field in the complex of rehabilitation measures for patients who have suffered from COVID-19 pneumonia significantly improves the somatic status of patients, increases exercise tolerance, and optimizes the function of external respiration. Keywords: magnetotherapy, COVID-19, pneumonia

Antiparasitic Treatment of Patients with P. falciparum Malaria Reduces the Ability of Patient Serum to Induce Tissue Factor by Decreasing NF-κB Activation

1995 ◽  
Vol 73 (01) ◽  
pp. 039-048 ◽  
Author(s):  
A Bierhaus ◽  
Ch J Hemmer ◽  
N Mackman ◽  
R Kutob ◽  
R Ziegler ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Falciparum Malaria ◽  
De Novo ◽  
Neutralizing Antibody ◽  
Mobility Shift ◽  
Before And After ◽  
Tf Gene ◽  
Electrophoretic Mobility Shift Assays ◽  
Antiparasitic Treatment ◽  
Stimulation Of

SummarySerum from patients with P. falciparum malaria at day 1 (pretherapy) induces tissue factor (TF) in cultured endothelial cells. TF induction depends on de novo transcription as shown in Nuclear Run On assays. Electrophoretic mobility shift assays demonstrated binding of AP-1 and NF- κB/Rel proteins to their recognition sites in the TF promotor. After therapy (day 28), stimulation of TF antigen by patient serum is reduced by 70%. When serum obtained before and after therapy was compared, a decrease of NF-κB activation was evident. Activation of NF-κB-like proteins was in part dependent on TNFα in patient serum, since a TNFα neutralizing antibody reduced induction of TF transcription and translation and induction of NF-κB-like proteins. Induction of TF activity was suppressed by pDTC, an inhibitor of NF-κB activation. When different promotor constructs of the TF gene were tested, induction was dependent upon the presence of the intact NF-κB-like binding site in the TF promotor. A mutant with deleted NF-κB, but intact AP-1 sites was not inducible. Mutation of the AP-1 sites did not prevent induction, but reduced inducibility by pretherapy serum. Therefore, NF-κB/Rel proteins are responsible for induction of TF transcription by pretherapy serum, but AP-1 is needed for highest inducibility. The effect of antiparasitic therapy on the induction of TF by serum from patients with complicated P. falciparum malaria is dependent on a therapy-mediated loss of activation of NF-κB-like proteins in post-treatment patient serum.

On the issue of criteria for recognition of occupational disease as an insured event in health care workers

2020 ◽  
pp. 618-619
Author(s):  
L. V. Dovgusha ◽  
N. N. Petruhin
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Occupational Disease ◽  
Occupational Diseases ◽  
Medical Rehabilitation ◽  
Care Workers ◽  
Rehabilitation Measures ◽  
Professional Capacity ◽  
Insured Event

The publication deals with cases of occupational diseases in medical workers, in which the degree of loss of professional capacity is not determined, but patients need medical rehabilitation measures.

scholarly journals Deep Brain Stimulation of the Posterior Insula in Chronic Pain: A Theoretical Framework

2021 ◽  
Vol 11 (5) ◽  
pp. 639
Author(s):  
David Bergeron ◽  
Sami Obaid ◽  
Marie-Pierre Fournier-Gosselin ◽  
Alain Bouthillier ◽  
Dang Khoa Nguyen
Keyword(s):  
Chronic Pain ◽  
Electrical Stimulation ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
High Frequency ◽  
Brain Lesion ◽  
Low Frequency ◽  
Posterior Insula ◽  
Deep Brain ◽  
Stimulation Of

Introduction: To date, clinical trials of deep brain stimulation (DBS) for refractory chronic pain have yielded unsatisfying results. Recent evidence suggests that the posterior insula may represent a promising DBS target for this indication. Methods: We present a narrative review highlighting the theoretical basis of posterior insula DBS in patients with chronic pain. Results: Neuroanatomical studies identified the posterior insula as an important cortical relay center for pain and interoception. Intracranial neuronal recordings showed that the earliest response to painful laser stimulation occurs in the posterior insula. The posterior insula is one of the only regions in the brain whose low-frequency electrical stimulation can elicit painful sensations. Most chronic pain syndromes, such as fibromyalgia, had abnormal functional connectivity of the posterior insula on functional imaging. Finally, preliminary results indicated that high-frequency electrical stimulation of the posterior insula can acutely increase pain thresholds. Conclusion: In light of the converging evidence from neuroanatomical, brain lesion, neuroimaging, and intracranial recording and stimulation as well as non-invasive stimulation studies, it appears that the insula is a critical hub for central integration and processing of painful stimuli, whose high-frequency electrical stimulation has the potential to relieve patients from the sensory and affective burden of chronic pain.

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