Teaching New Dogs Old Tricks

2019 ◽  
pp. 479-496
Author(s):  
Neal Duckworth ◽  
Eugenie de Silva
Keyword(s):  
Risk Assessment ◽  
Early Stage ◽  
Digital Age ◽  
Mitigation Measures ◽  
Past Century ◽  
Public And Private ◽  
Physical Protection ◽  
The Past

This chapter discusses how the basics of espionage have remained the same, even in the digital age. The pendulum of espionage--and protection from it--has swung wide over the past century. Different public and private sectors have renewed focus on not only cyber protections, but on increased physical protection of critical assets and ensuring trusted personnel in the workforce. Within this chapter, the authors review the basics of protecting critical assets to ensure that changes in espionage can be mitigated at an early stage. While the techniques of espionage have many variables, especially in a digital age, the authors have established that the use of a risk assessment that focuses on identifying the threats, the specific variables or methods of espionage, and developing and implementing mitigation measures is of the utmost importance.

Teaching New Dogs Old Tricks

2016 ◽  
pp. 78-95 ◽  
Author(s):  
Neal Duckworth ◽  
Eugenie de Silva
Keyword(s):  
Risk Assessment ◽  
Early Stage ◽  
Digital Age ◽  
Mitigation Measures ◽  
Past Century ◽  
Public And Private ◽  
Physical Protection ◽  
The Past

This chapter discusses how the basics of espionage have remained the same, even in the digital age. The pendulum of espionage--and protection from it--has swung wide over the past century. Different public and private sectors have renewed focus on not only cyber protections, but on increased physical protection of critical assets and ensuring trusted personnel in the workforce. Within this chapter, the authors review the basics of protecting critical assets to ensure that changes in espionage can be mitigated at an early stage. While the techniques of espionage have many variables, especially in a digital age, the authors have established that the use of a risk assessment that focuses on identifying the threats, the specific variables or methods of espionage, and developing and implementing mitigation measures is of the utmost importance.

Advances on NDT Methods and Technologies for Early Stage Diagnosis of Materials

2011 ◽  
Vol 681 ◽  
pp. 461-467 ◽  
Author(s):  
Giovanni Berti ◽  
Francesco De Marco ◽  
S. Aldrighetti
Keyword(s):  
Structural Integrity ◽  
New Technologies ◽  
Early Stage ◽  
Past Century ◽  
X Ray Diffraction ◽  
The Past ◽  
Atomic Flux ◽  
Investigation Methods ◽  
Significant Step

The early stage diagnoses of material lattices is becoming a crucial requirement where investigation methods and technologies are faced with both aging of components and materials. The mixing effects of wear, fatigue, temperature variation and environment conditions translate into variations of the atomic flux rate and internal rearrangement of grain size and boundaries of lattices. The related lattice measurements (e.g. the d-.spacing is one important among others) become the only one usable for early stage diagnoses of the lattice structural integrity. When such a diagnoses are the base to identify the qualification of material for the use or the re-qualification for the maintenance in the use, new technologies are required, with methods and appropriate concepts shall be used. The authors bid here to describe shortly the historical evolution of methods and techniques since the 70’s, along with the basic tests performed during the early 90’s of the past century. The technological follow up from those tests is reported along with some results which indicate the significant step up of the most recent technology toward the early stage diagnosis of material via on site x-ray diffraction. Further foreseeable development and advances are also mentioned.

scholarly journals Exploring of Classification Methods for Early Detection of Alzheimer’s Disease

2019 ◽  
Vol 8 (6) ◽  
pp. 5206-5211
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Learning Strategies ◽  
Early Stage ◽  
Research Work ◽  
Past Century ◽  
Classification Methods ◽  
The Past ◽  
Significant Research ◽  
Work Done

Alzheimer's disease (AD) is a degenerative brain disease, a common health problem in elderly pesople which causes decline in memory and affected on nerve cells. AD has different stages like mild congestive impairment (MIC) (early stage), moderate (middle stage), severe (late stage) it is essential to detect AD early in MIC, so that pre-emptive measures can be taken. Significant research was carried out over the past century to diagnose and detect this disease early. The objective of the article is provide a review evaluation and critical analysis of the recent research work done to early diagnosis of AD using Machine Learning Strategies.

scholarly journals A Novel Method to Identify Pneumonia through Analyzing Chest Radiographs Employing a Multichannel Convolutional Neural Network

Sensors ◽  
2020 ◽  
Vol 20 (12) ◽  
pp. 3482
Author(s):  
Abdullah-Al Nahid ◽  
Niloy Sikder ◽  
Anupam Kumar Bairagi ◽  
Md. Abdur Razzaque ◽  
Mehedi Masud ◽  
...  
Keyword(s):  
Deep Learning ◽  
Early Stage ◽  
Machine Learning Techniques ◽  
Past Century ◽  
Radiographic Images ◽  
X Ray ◽  
The Past ◽  
Learning Techniques ◽  
Chest X Ray ◽  
Pneumonia Diagnosis

Pneumonia is a virulent disease that causes the death of millions of people around the world. Every year it kills more children than malaria, AIDS, and measles combined and it accounts for approximately one in five child-deaths worldwide. The invention of antibiotics and vaccines in the past century has notably increased the survival rate of Pneumonia patients. Currently, the primary challenge is to detect the disease at an early stage and determine its type to initiate the appropriate treatment. Usually, a trained physician or a radiologist undertakes the task of diagnosing Pneumonia by examining the patient’s chest X-ray. However, the number of such trained individuals is nominal when compared to the 450 million people who get affected by Pneumonia every year. Fortunately, this challenge can be met by introducing modern computers and improved Machine Learning techniques in Pneumonia diagnosis. Researchers have been trying to develop a method to automatically detect Pneumonia using machines by analyzing and the symptoms of the disease and chest radiographic images of the patients for the past two decades. However, with the development of cogent Deep Learning algorithms, the formation of such an automatic system is very much within the realms of possibility. In this paper, a novel diagnostic method has been proposed while using Image Processing and Deep Learning techniques that are based on chest X-ray images to detect Pneumonia. The method has been tested on a widely used chest radiography dataset, and the obtained results indicate that the model is very much potent to be employed in an automatic Pneumonia diagnosis scheme.

scholarly journals Knut Hamsun at the movies in transnational contexts

Nordlit ◽  
2009 ◽  
Vol 13 (2) ◽  
pp. 41
Author(s):  
Arne Lunde
Keyword(s):  
United States ◽  
The Netherlands ◽  
Digital Age ◽  
Third Reich ◽  
The United States ◽  
Past Century ◽  
Historical Overview ◽  
Silent Cinema ◽  
The Past ◽  
Knut Hamsun

 This historical overview examines how the literary works of Knut Hamsun have been adapted into films over the past century, from early silent cinema to the digital age. It traces how different national and transnational cinemas have appropriated the author's texts at different historical moments. Nazi propaganda minister Joseph Goebbels, for example, took a keen interest in two Third Reich adaptations of Hamsun novels (Victoria and Pan) in the 1930s. Pan remains the Hamsun novel most frequently adapted, while Henning Carlsen's 1966 pan-Scandinavian version of Hunger is arguably the artistic highpoint to date. Nations producing or co-producing Hamsun films include Norway, Sweden, Denmark, Germany, France, the Netherlands, Russia, the United States, and Canada (Guy Maddin's 1997 Twilight of the Ice Nymphs). Hamsun at the movies has shown remarkable elasticity, crossing multiple borders, and being appropriated by disparate national cinemas for surprisingly diverse ends.

The zoonotic potential of bat-borne coronaviruses

2020 ◽  
Vol 4 (4) ◽  
pp. 365-381
Author(s):  
Ny Anjara Fifi Ravelomanantsoa ◽  
Sarah Guth ◽  
Angelo Andrianiaina ◽  
Santino Andry ◽  
Anecia Gentles ◽  
...  
Keyword(s):  
Genetic Material ◽  
Field Research ◽  
Sympatric Species ◽  
Animal Origin ◽  
Mammalian Host ◽  
Past Century ◽  
The Past ◽  
Novel Host ◽  
Horseshoe Bat ◽  
Human Infections

Seven zoonoses — human infections of animal origin — have emerged from the Coronaviridae family in the past century, including three viruses responsible for significant human mortality (SARS-CoV, MERS-CoV, and SARS-CoV-2) in the past twenty years alone. These three viruses, in addition to two older CoV zoonoses (HCoV-229E and HCoV-NL63) are believed to be originally derived from wild bat reservoir species. We review the molecular biology of the bat-derived Alpha- and Betacoronavirus genera, highlighting features that contribute to their potential for cross-species emergence, including the use of well-conserved mammalian host cell machinery for cell entry and a unique capacity for adaptation to novel host environments after host switching. The adaptive capacity of coronaviruses largely results from their large genomes, which reduce the risk of deleterious mutational errors and facilitate range-expanding recombination events by offering heightened redundancy in essential genetic material. Large CoV genomes are made possible by the unique proofreading capacity encoded for their RNA-dependent polymerase. We find that bat-borne SARS-related coronaviruses in the subgenus Sarbecovirus, the source clade for SARS-CoV and SARS-CoV-2, present a particularly poignant pandemic threat, due to the extraordinary viral genetic diversity represented among several sympatric species of their horseshoe bat hosts. To date, Sarbecovirus surveillance has been almost entirely restricted to China. More vigorous field research efforts tracking the circulation of Sarbecoviruses specifically and Betacoronaviruses more generally is needed across a broader global range if we are to avoid future repeats of the COVID-19 pandemic.

PCSK9 inhibition for LDL lowering and beyond – implications for patients with peripheral artery disease

VASA ◽  
2018 ◽  
Vol 47 (3) ◽  
pp. 165-176 ◽  
Author(s):  
Katrin Gebauer ◽  
Holger Reinecke
Keyword(s):  
Cardiovascular Risk ◽  
Risk Reduction ◽  
Ldl Receptor ◽  
Density Lipoprotein ◽  
Past Century ◽  
Pcsk9 Inhibitors ◽  
Cardiovascular Risk Reduction ◽  
Simultaneous Application ◽  
The Past ◽  
Pcsk9 Inhibition

Abstract. Low-density lipoprotein cholesterol (LDL-C) has been proven to be a causal factor of atherosclerosis and, along with other triggers like inflammation, the most frequent reason for peripheral arterial disease. Moreover, a linear correlation between LDL-C concentration and cardiovascular outcome in high-risk patients could be established during the past century. After the development of statins, numerous randomized trials have shown the superiority for LDL-C reduction and hence the decrease in cardiovascular outcomes including mortality. Over the past decades it became evident that more intense LDL-C lowering, by either the use of highly potent statin supplements or by additional cholesterol absorption inhibitor application, accounted for an even more profound cardiovascular risk reduction. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a serin protease with effect on the LDL receptor cycle leading to its degradation and therefore preventing continuing LDL-C clearance from the blood, is the target of a newly developed monoclonal antibody facilitating astounding LDL-C reduction far below to what has been set as target level by recent ESC/EAS guidelines in management of dyslipidaemias. Large randomized outcome trials including subjects with PAD so far have been able to prove significant and even more intense cardiovascular risk reduction via further LDL-C debasement on top of high-intensity statin medication. Another approach for LDL-C reduction is a silencing interfering RNA muting the translation of PCSK9 intracellularly. Moreover, PCSK9 concentrations are elevated in cells involved in plaque composition, so the potency of intracellular PCSK9 inhibition and therefore prevention or reversal of plaques may provide this mechanism of action on PCSK9 with additional beneficial effects on cells involved in plaque formation. Thus, simultaneous application of statins and PCSK9 inhibitors promise to reduce cardiovascular event burden by both LDL-C reduction and pleiotropic effects of both agents.

Archaeology in the Past Century

1901 ◽  
Vol 51 (1309supp) ◽  
pp. 20976-20977
Author(s):  
W. M. Flinders Petrje
Keyword(s):  
Past Century ◽  
The Past

Catholicism and Cosmopolitanism: the Confluence of Three Catholic Scholars and the Cosmopolitan Democrats on State Sovereignty and the Future of Global Governance

2016 ◽  
Vol 3 (2) ◽  
pp. 37-51
Author(s):  
Matthew Bagot
Keyword(s):  
Global Governance ◽  
State Sovereignty ◽  
Current Debate ◽  
Past Century ◽  
Jacques Maritain ◽  
The Past ◽  
Technological Advances ◽  
The Future ◽  
Cosmopolitan Democracy ◽  
Catholic Tradition

One of the central questions in international relations today is how we should conceive of state sovereignty. The notion of sovereignty—’supreme authority within a territory’, as Daniel Philpott defines it—emerged after the Treaty of Westphalia in 1648 as a result of which the late medieval crisis of pluralism was settled. But recent changes in the international order, such as technological advances that have spurred globalization and the emerging norm of the Responsibility to Protect, have cast the notion of sovereignty into an unclear light. The purpose of this paper is to contribute to the current debate regarding sovereignty by exploring two schools of thought on the matter: first, three Catholic scholars from the past century—Luigi Sturzo, Jacques Maritain, and John Courtney Murray, S.J.—taken as representative of Catholic tradition; second, a number of contemporary political theorists of cosmopolitan democracy. The paper argues that there is a confluence between the Catholic thinkers and the cosmopolitan democrats regarding their understanding of state sovereignty and that, taken together, the two schools have much to contribute not only to our current understanding of sovereignty, but also to the future of global governance.

Aftershocks

2017 ◽  
Author(s):  
Seva Gunitsky
Keyword(s):  
Twentieth Century ◽  
Regime Change ◽  
International System ◽  
Political Legitimacy ◽  
Great Powers ◽  
Past Century ◽  
The Past ◽  
Sudden Rise ◽  
The World ◽  
National Borders

Over the past century, democracy spread around the world in turbulent bursts of change, sweeping across national borders in dramatic cascades of revolution and reform. This book offers a new global-oriented explanation for this wavelike spread and retreat—not only of democracy but also of its twentieth-century rivals, fascism, and communism. The book argues that waves of regime change are driven by the aftermath of cataclysmic disruptions to the international system. These hegemonic shocks, marked by the sudden rise and fall of great powers, have been essential and often-neglected drivers of domestic transformations. Though rare and fleeting, they not only repeatedly alter the global hierarchy of powerful states but also create unique and powerful opportunities for sweeping national reforms—by triggering military impositions, swiftly changing the incentives of domestic actors, or transforming the basis of political legitimacy itself. As a result, the evolution of modern regimes cannot be fully understood without examining the consequences of clashes between great powers, which repeatedly—and often unsuccessfully—sought to cajole, inspire, and intimidate other states into joining their camps.

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