Polysaccharides from Ganoderma lucidum Supplementation Prevents Exhaustive Exercise-Induced Apoptosis in Mice Liver
The main purpose of this study was to examine the effects of polysaccharides from Ganoderma lucidum (GLP) supplementation on exhaustive exercise-induced apoptosis in mice liver. The mice were randomly divided into four groups of ten per group. One of the groups was the control group, the others were GLP treated groups (25, 50 and 100 mg/kg body weight). Exhaustive swimming exercise of mice were carried out after 28 days of GLP administration, and the expression of Bcl-2 and Bax proteins in the liver tissues were determined. The data showed that GLP supplementation was able to up-regulate the expression of Bcl-2 proteins and Bcl-2/Bax ratio, down-regulate the expression of Bax proteins. The results suggest that GLP supplementation prevents exhaustive exercise-induced apoptosis.