scholarly journals Podávanie vitamínu C zlepšuje reológiu plnej krvi u zdravých ľudí / Vitamin C supplementation promotes whole blood rheology in healthy humans

2020 ◽  
Vol 29 (04) ◽  
pp. 348-255
Author(s):  
J. Radošinská ◽  
T. Jasenovec ◽  
A. Púzserová ◽  
J. Krajčír ◽  
J. Laceková ◽  
...  
Keyword(s):  
Vitamin C ◽  
Whole Blood ◽  
Blood Rheology ◽  
Healthy Humans ◽  
Vitamin C Supplementation

Promotion of whole blood rheology after vitamin C supplementation: focus on red blood cells

2019 ◽  
Vol 97 (9) ◽  
pp. 837-843 ◽  
Author(s):  
Jana Radosinska ◽  
Tomas Jasenovec ◽  
Angelika Puzserova ◽  
Juraj Krajcir ◽  
Jana Lacekova ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cardiovascular Diseases ◽  
Vitamin C ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Sodium Pump ◽  
Blood Rheology ◽  
Nitric Oxide Production ◽  
Pump Activity ◽  
Vitamin C Supplementation

Hemorheological properties represent significant contributors in the pathogenesis of cardiovascular diseases. As plasma vitamin C is inversely associated with blood viscosity in humans, we aimed to characterize the effect of vitamin C supplementation on hemorheology with an emphasis on erythrocyte functions. Twenty young healthy volunteers were asked to take vitamin C (1000 mg per day) for 3 weeks. We observed beneficial effect of intervention on multiple hemorheological parameters: whole blood viscosity in the range of medium to high shear rates, Casson yield stress, complex viscosity, and storage and loss moduli. As erythrocyte properties play a significant role in hemorheology, we characterized their deformability, nitric oxide production, and sodium pump activity in erythrocyte membranes. We can conclude that observed promotion in whole blood rheology may be consequence of improved erythrocyte functionality as concerns their ability to pass through narrow capillaries of the microcirculation, nitric oxide production, and sodium pump activity. Parameters reflecting oxidative stress and antioxidant status in plasma were not affected by our intervention. As improvement in hemorheology may play an important role in cardioprotection, it would be challenging to investigate the vitamin C supplementation to patients suffering from microcirculatory disturbances and worsened organ perfusion in the case of cardiovascular diseases.

Any Role of High-Dose Vitamin C for Septic Shock in 2021?

2021 ◽  
Vol 42 (05) ◽  
pp. 672-682
Author(s):  
Ankita Agarwal ◽  
David N. Hager ◽  
Jonathan E. Sevransky
Keyword(s):  
Septic Shock ◽  
Vitamin C ◽  
Outcome Measures ◽  
Randomized Clinical Trials ◽  
Secondary Outcome ◽  
High Dose ◽  
Healthy Humans ◽  
Vitamin C Supplementation ◽  
High Dose Vitamin

AbstractWhile the use of vitamin C as a therapeutic agent has been investigated since the 1950s, there has been substantial recent interest in the role of vitamin C supplementation in critical illness and particularly, sepsis and septic shock. Humans cannot synthesize vitamin C and rely on exogenous intake to maintain a plasma concentration of approximately 70 to 80 μmol/L. Vitamin C, in healthy humans, is involved with antioxidant function, wound healing, endothelial function, and catecholamine synthesis. Its function in the human body informs the theoretical basis for why vitamin C supplementation may be beneficial in sepsis/septic shock.Critically ill patients can be vitamin C deficient due to low dietary intake, increased metabolic demands, inefficient recycling of vitamin C metabolites, and loss due to renal replacement therapy. Intravenous supplementation is required to achieve supraphysiologic serum levels of vitamin C. While some clinical studies of intravenous vitamin C supplementation in sepsis have shown improvements in secondary outcome measures, none of the randomized clinical trials have shown differences between vitamin C supplementation and standard of care and/or placebo in the primary outcome measures of the trials. There are some ongoing studies of high-dose vitamin C administration in patients with sepsis and coronavirus disease 2019; the majority of evidence so far does not support the routine supplementation of vitamin C in patients with sepsis or septic shock.

Vitamin E and Vitamin C Supplementation in Patients with Chronic Obstructive Pulmonary Disease

2007 ◽  
Vol 77 (4) ◽  
pp. 272-279 ◽  
Author(s):  
Wu ◽  
Huang ◽  
Hsu ◽  
Wang ◽  
Yeh
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin E ◽  
Vitamin C ◽  
Pulmonary Disease ◽  
Whole Blood ◽  
Controlled Study ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Vitamin C Supplementation ◽  
Oxidative Challenge

The purpose of this study was to determine whether vitamin E or vitamin C supplementation alters the DNA damage of whole blood white blood cells (WBC) in patients with chronic obstructive pulmonary disease (COPD). Thirty-five patients with stable COPD were recruited in this randomized and placebo-controlled study. Patients were randomly assigned to placebo (n = 8), 400 mg/day vitamin E (E400, n = 9), 200 mg/day vitamin E (E200, n = 9), or 250 mg/day vitamin C (C250, n = 9) for 12 weeks. The results showed that vitamin E or C supplementation did not significantly change the mean level of endogenous DNA breakages. Whereas, after 12 weeks of vitamin supplementation, the H2O2-induced DNA breakages were significantly suppressed by 45%, 59%, and 52%, respectively, in E400, E250 and C250 groups (p < 0.05). In addition, neither the level of thiobarbituric acid-reactive substances (TBARS) nor spirometric parameters were significantly changed after 12 weeks of supplementation. In conclusion, vitamin E or C supplementation for 12 weeks may improve the resistance of DNA in whole blood WBC against oxidative challenge, although more research is needed to demonstrate the beneficial effect on slowing the decline of lung function in patients with COPD.

Effects of acute methionine loading and vitamin Con endogenous fibrinolysis, endothelium-dependent vasomotion and platelet aggregation

2000 ◽  
Vol 100 (2) ◽  
pp. 127-135 ◽  
Author(s):  
Catherine LABINJOH ◽  
David E. NEWBY ◽  
Ian B. WILKINSON ◽  
Ian L. MEGSON ◽  
Helen MACCALLUM ◽  
...  
Keyword(s):  
Blood Flow ◽  
Platelet Aggregation ◽  
Substance P ◽  
Vitamin C ◽  
Double Blind ◽  
Healthy Humans ◽  
Aggregation Substance ◽  
Vitamin C Supplementation ◽  
Dose Dependent ◽  
Fibrinolytic Capacity

We assessed forearm blood flow and plasma fibrinolytic factors in eight healthy males who received unilateral brachial artery infusions of the endothelium-dependent vasodilator, substance P, and the endothelium-independent vasodilator, sodium nitroprusside. These measurements, together with platelet aggregation studies, were performed on four occasions after double-blind randomized ingestion of placebo, methionine (0.1 mg/kg), vitamin C (2 g) and methionine plus vitamin C. Blood flow and platelet aggregation responses were unaffected by methionine loading. Substance P caused dose-dependent increases in plasma tissue plasminogen activator (t-PA) antigen (from 3.0±0.1 to 4.7±0.4 ng/ml; P < 0.001) and activity (from 1.2±0.2 to 4.2±0.4 i.u./ml; P < 0.001), which were augmented during acute methionine loading (4.7±0.4 to 5.6±0.5 ng/ml and 4.2±0.4 to 5.5±0.9 i.u./ml respectively; P⩽0.05). Moreover, the estimated net release of t-PA was enhanced during methionine loading (two-way ANOVA; P = 0.02), but this was unaffected by vitamin C supplementation. We conclude that, in the absence of alterations in endothelium-dependent vasomotion or platelet aggregation, substance P-induced t-PA release is enhanced following methionine loading. This suggests that the acute endogenous fibrinolytic capacity is augmented during acute hyperhomocysteinaemia in healthy humans via an oxidation-independent mechanism.

The Effect of Vitamin C Supplementation on Cardiac Enzymes After Coronary Artery Bypass Graft: A Double-blind Randomized Control Trial

2020 ◽  
Vol 16 (5) ◽  
pp. 833-838
Author(s):  
Jalal Moludi ◽  
Mohammad Alizadeh ◽  
Godarz Chehri ◽  
Hamed Jafari-Vayghyan ◽  
Elaheh Foroumandi ◽  
...  
Keyword(s):  
Vitamin C ◽  
Randomized Control Trial ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Group Comparison ◽  
Artery Bypass Graft ◽  
Cardiac Enzymes ◽  
Vitamin C Supplementation ◽  
Antioxidant Agent ◽  
Randomized Control

Background: Coronary artery bypass graft (CABG) is associated with oxidative stress and tissue damage. Vitamin C, as an antioxidant agent, has an important role in attenuating the oxidative stress damage and might have cardio-protective effects after CABG. We aimed to evaluate the probable roles of vitamin C supplementation in cardiac biomarkers after CABG. Methods:: In this randomized control trial, 122 patients undergoing CABG were randomly assigned to the intervention (n=54) and control group (n=68) and received vitamin C (2 g intravenously) or placebo, respectively. The surgical methods of the patients in the two groups were identical. The primary efficacy endpoint of this trial is the difference in the levels of CK-MB, Troponin and Total Antioxidant Capacity (TAC) were measured at study entry and 24 hrs after surgery between the two groups. Results:: The two groups were not significantly different in terms of basic variables. Within-group comparison showed significant rises in the level of troponin (P < 0.001) and CK-MB (P < 0.001) over time. However, between-group comparison showed no significant difference between the two groups in terms of CK-MB (P=0.826) and troponin (P=0.821). As a whole, the correlation between cardiac enzymes and surgical characteristic was not seen. Conclusion:: The results showed that pretreatment with vitamin C could not reduce cardiac marker following CABG. After the intervention, TAC did not differ between and within the intervention and the control groups. Pretreatment with vitamin C as an antioxidant agent could not reduce ischemicreperfusion resulting in CABG.

scholarly journals Effect of six weeks 1000 mg/day vitamin C supplementation and healthy training in elderly women on genes expression associated with the immune response - a randomized controlled trial

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Małgorzata Żychowska ◽  
Agata Grzybkowska ◽  
Mariusz Zasada ◽  
Anna Piotrowska ◽  
Danuta Dworakowska ◽  
...  
Keyword(s):  
Immune Response ◽  
Vitamin C ◽  
Body Mass ◽  
Elderly Women ◽  
Controlled Trial ◽  
Expression Of Genes ◽  
Genes Expression ◽  
Vitamin C Supplementation ◽  
Group A ◽  
Adaptation To Training

Abstract Background In this study, we investigated the effects of supplementation and exercise on the expression of genes associated with inflammation like CCL2, CRP, IL1, IL6, IL10 mRNA in elderly women. Methods Twenty four participants divided randomly into two groups were subjected to 6 weeks of the same health training program (three times per week). SUP group (supplemented, n = 12, mean age 72.8 ± 5.26 years and mean body mass 68.1 ± 8.3 kg) received 1000 mg of Vitamin C/day during the training period, while CON group (control, n = 12, mean age 72.4 ± 5.5 years and body mass 67.7 ± 7.5 kg) received placebo. Results No significant changes in IL-1, IL-6, IL-10 and CRP mRNA were observed within and between groups. However, there was a clear tendency of a decrease in IL-6 (two-way ANOVA, significant between investigated time points) and an increase in IL-10 mRNA noted in the supplemented group. A significant decrease in CCL2 mRNA was observed only in the CON group (from 2^0.2 to 2^0.1, p = 0.01). Conclusions It can be concluded, that 6 weeks of supplementation and exercise was too short to obtain significant changes in gene expression in leukocytes, but supplementation of 1000 mg vitamin C positively affected IL-6 and IL-10 expression – which are key changes in the adaptation to training. However, changes in body mass, IL1 and CCL2 were positive in CON group. It is possible that Vitamin C during 6 weeks of supplementation could have different effects on the expression of individual genes involved in the immune response. Trial registration Retrospectively registered. 

scholarly journals Effect of Dietary or Supplemental Vitamin C Intake on Vitamin C Levels in Patients with and without Cardiovascular Disease: A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2330
Author(s):  
Bianca J. Collins ◽  
Mitali S. Mukherjee ◽  
Michelle D. Miller ◽  
Christopher L. Delaney
Keyword(s):  
Systematic Review ◽  
Cardiovascular Disease ◽  
Vitamin C ◽  
Antioxidant Properties ◽  
Plasma Vitamin ◽  
Healthy Population ◽  
Post Intervention ◽  
Supplemental Vitamin ◽  
Vitamin C Supplementation ◽  
Elderly Cohort

Atherosclerosis is a pro-oxidative and pro-inflammatory disease state, which is the underlying cause of most cardiovascular events, estimated to affect 5.2% of the Australian population. Diet, and specifically vitamin C, through its antioxidant properties can play a role in impeding the development and progression of atherosclerosis. This systematic review conducted comprehensive searches in Medline, Emcare, Scopus, PubMed, and Cochrane using key search terms for vitamin C, plasma vitamin C, supplementation, and cardiovascular disease (CVD). The results demonstrated that vitamin C supplementation resulted in a significant increase in vitamin C levels in populations with or without CVD, except for one study on the CVD population. It was also seen that the healthy population baseline and post-intervention vitamin C levels were high compared to the CVD population. However, further research is indicated for CVD population groups with varying baseline vitamin C levels, such as low baseline vitamin C, within a more representative elderly cohort in order to formulate and update vitamin C repletion guidelines.

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