Poor nutrition and alcohol consumption are related to high serum homocysteine level at post-stroke

Hyperhomocysteinemia is a risk factor of coronary artery disease associated to arterial thrombosis. We report a case in which coronary angiography showed full of thrombus causing total obstruction of the left anterior descending artery. Patient was managed successfully with intravenous thrombolysis. Biochemical analysis revealed a high serum homocysteine level. DOI: http://dx.doi.org/10.3126/njh.v11i1.10982 Nepalese Heart Journal 2014;11(1): 49-52

Download Full-text

Serum homocysteine level in children with Juvenile Idiopathic Arthritis

Bangladesh Medical Research Council Bulletin ◽

10.3329/bmrcb.v46i1.47463 ◽

2020 ◽

Vol 46 (1) ◽

pp. 12-16

Author(s):

Md Fakhrul Alam ◽

Mohammed Mahbubul Islam ◽

Mujammel Haque ◽

Shahana A Rahman

Keyword(s):

Juvenile Idiopathic Arthritis ◽

Homocysteine Level ◽

High Serum ◽

Control Group ◽

Cross Sectional ◽

Serum Homocysteine ◽

Duration Of Illness ◽

Short And Long Term ◽

Medical University

Background: Juvenile Idiopathic Arthritis (JIA) is the most common chronic rheumatic disease of childhood and a leading cause of short and long-term disability. Abnormal level of serum homocysteine (Hcy) may be found in Juvenile idiopathic arthritis (JIA) patients. Some studies were done on serum homocyestine levels in children with JIA which showed conflicting results. So far, no study regarding the Hcy level in JIA patients was done in Bangladesh. Objectives: The study was aimed to assess the homocysteine level in children with different subtypes of JIA. Methods: It was a cross sectional and case control study. Fifty newly diagnosed cases of JIA attending the Pediatric Rheumatology clinic of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from January 2016 to March 2017 were included. Fifty age and sex matched controls were selected. Serum homocysteine levels were measured in both cases and controls. Results: Among JIA patients, 36% had high serum homocysteine (Hcy) level whereas 100% of controls had normal level. Mean hcy level was significantly (p<0.05) higher among cases than controls. Significantly higher number and level of hyperhomocystaeinemia was found among JIA patients having duration of illness more than 1 year than duration less than 1 year. Mean homocysteine level of polyarticular RF positive cases was found as 14.38±3.79 µmol/L and that of SJIA was found as 13.0±4.66 µmol/L. When compared with homocysteine levels of control group these two groups had significantly higher homocysteine level. Conclusion: More than one third of JIA patients had hyperhomocysteinaemia. Mean hcy level of JIA cases was significantly higher than that of controls. Significant association of hyperhomocysteinaemia was present with duration of illness and certain types of JIA. Bangladesh Med Res Counc Bull 2020; 46(1): 12-16

Download Full-text

Serum Homocysteine Level in Parkinson’s Disease and Its Association with Duration, Cardinal Manifestation, and Severity of Disease

Parkinson s Disease ◽

10.1155/2018/5813084 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Payam Saadat ◽

Alijan Ahmadi Ahangar ◽

Seyed Ehsan Samaei ◽

Alireza Firozjaie ◽

Fatemeh Abbaspour ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Homocysteine Level ◽

Financial Burden ◽

Multivariate Logistic Regression Analysis ◽

High Serum ◽

Control Group ◽

Healthy Individuals ◽

Mobility Impairment ◽

Serum Homocysteine

Background and Purpose. Due to the high prevalence of Parkinson’s disease (PD) in the elderly, a large financial burden is imposed on the families and health systems of countries in addition to the problems related to the mobility impairment caused by the disease for the patients. Studies on controversial issues in this disease are taken into consideration, and one of these cases is the role of serum homocysteine level in Parkinson’s patients. In this study, the serum level of homocysteine and its association with various variables in relation to this disease was compared with healthy individuals. Materials and Methods. In this study, 100 patients with PD and 100 healthy individuals as control group were investigated. Serum homocysteine level and demographic and clinical data were included in the checklist. Data were analyzed by SPSS version 23. In all tests, the significance level was below 0.05. Results. The mean level of serum homocysteine in case and control groups was 14.93 ± 8.30 and 11.52 ± 2.86 µmol/L, respectively (95% CI: 1.68; 5.14, P<0.001). In total patients, 85 had normal serum homocysteine level, while 15 had high serum homocysteine level. In controls, the homocysteine level was 98 and 2, respectively (P=0.002). In multivariate logistic regression analysis, serum homocysteine level higher than 20 µmol/L was accompanied by 8.64-fold in Parkinson’s disease involvement (95% CI: 1.92; 38.90, P=0.005). Conclusion. Increasing serum homocysteine level elevates the rate to having PD. Serum homocysteine levels did not have any relationship with the duration of the disease, type of cardinal manifestation, and the severity of Parkinson’s disease.

Download Full-text

Association of Maternal Hyperhomocysteinemia with Preeclampsia: A Hospital Based Case-Control Study

Proceedings of Shaikh Zayed Medical Complex Lahore - October to December ◽

10.47489/p000s351z7831-6mc ◽

2021 ◽

Vol 35 (1) ◽

pp. 45-50

Author(s):

Zoofishan Qureshi

Keyword(s):

Homocysteine Level ◽

Tertiary Care ◽

Case Control ◽

High Serum ◽

P Value ◽

Serum Homocysteine ◽

Maternal Morbidity And Mortality ◽

Matched Case ◽

Immuno Assay ◽

Tertiary Care Hospitals

Introduction: Preeclampsia is among the leading causes of feto-maternal morbidity and mortality throughout the world, especially in developing countries like Pakistan. The exact pathophysiology of preeclampsia is still unclear but recent research on homocysteine shows its important role. Aims & Objectives: The aim of this study was to determine association of high serum homocysteine level with preeclampsia among antenatal women. Place and duration of study: Tertiary Care Hospitals of Lahore (Services, Lahore General Hospital and Sir Ganga Ram Hospitals) from 1st January 2019 to 30th June 2019. Material & Methods: A matched case-control design was employed. Sixty-six diagnosed pre-eclamptic antenatal women were selected as cases and they were age and gestational weeks matched with sixty-six normotensive antenatal women as control, with a case to control ratio of 1:1. Serum homocysteine level in fasting sample was estimated by Enzyme linked immuno assay. Data was entered and analyzed through SPSS version 20. Results: The mean plasma homocysteine was significantly higher in cases (16.05 ± 2.25) as compared to controls (9.44±2.83) with a p value <0.001. Highly Significant statistical association was found between Hyperhomocysteinemia and Preeclampsia (p-value < 0.001 with adjusted Odds Ratio of 4.72). Conclusion: Homocysteine levels a high in preeclamptic women as compared to normotensives showing that hyperhomocysteinemia is significantly associated with preeclampsia in antenatal women.

Download Full-text

Comparison of Different Risk Factors and Coronary Angiographic Profile in Younger and Older Patients with Ischeamic Heart Disease

Cardiovascular Journal ◽

10.3329/cardio.v8i1.24764 ◽

2015 ◽

Vol 8 (1) ◽

pp. 23-29 ◽

Cited By ~ 1

Author(s):

Kazi Nazrul Islam ◽

Abdul Wadud Chowdhury ◽

Azizul Hasan Khandaker ◽

Khandker Md Nurus Sabah ◽

Md Gaffar Amin ◽

...

Keyword(s):

Risk Factors ◽

Heart Disease ◽

Older Patients ◽

Homocysteine Level ◽

Young Patients ◽

High Serum ◽

Younger Patients ◽

Vessel Disease ◽

Serum Homocysteine ◽

Group I

Background: Due to socio-economic improvement and changes in the life style, ischeamic heart disease is becoming a major burden to our health care system. In recent years, the incidence is increasing among younger age groups as well.Methods: A total of 120 patients with ischeamic heart disease admitted for coronary angiogram were included in the study and were divided into two groups. Among them, 60 younger patients were in Group-I (d 40 years of age); 60 older patients in Group-II (>40 years of age). We compared demographic profiles, different risk factors and angiographic profiles between two age groups.Results: Among the common risk factors, smoking (63.3% vs 40%, p=0.011) & family history of ischeamic heart disease (21.7% vs 8.3%, p=0.040) were more common in younger group. Whereas, hypertension (41.7% vs 65.0%, p=0.010) and DM (18.3% vs 36.7%, p=0.024) were more common in older patients. Serum Homocysteine level was found significantly higher in younger patients (30.0% vs 13.3%, p=0.026). In group-I. coronary angiography revealed normal coronaries in 15 patients (25%), single vessel disease in 29 (48.3%) and multi-vessel disease in 16 patients (26.6%). Whereas, 40(66.6%) patients in group-II were found to have multi-vessel disease and 2 of them had significant left main coronary disease. However, young patients who had high serum homocysteine level showed more angiographic severity than older patients.Conclusion: There are significant differences in the clinical, biochemical and angiographic profile of young patients with ischeamic heart disease as compared to older patients. Young patients with ischeamic heart disease has got less angiographic severity, except in those with high serum homocysteine level.Cardiovasc. j. 2015; 8(1): 23-29

Download Full-text

Gender and Regional Differences in the Life Expectancy in Russia

Voprosy statistiki ◽

10.34023/2313-6383-2020-27-1-106-120 ◽

2020 ◽

Vol 27 (1) ◽

pp. 106-120 ◽

Cited By ~ 1

Author(s):

L. A. Rodionova ◽

E. D. Kopnova

Keyword(s):

Drinking Water ◽

Alcohol Consumption ◽

Life Expectancy ◽

Gender Gap ◽

Poor Quality ◽

Living Conditions ◽

Regional Differentiation ◽

Russian Regions ◽

Poor Nutrition

The relevance of the chosen topic is closely related to the development of a system for monitoring the implementation of the May Presidential Decree (2018) to increase life expectancy and improve the quality of life of the population. It has been stated that despite the positive dynamics of life expectancy over the past decade, Russia still has a huge regional differentiation (16,6 years for women, 18,2 years for men in 2016) and an average gender gap - 10,6 years. The choice of factors affecting the gender gap in life expectancy in Russian regions is supported by a conclusion most common in foreign studies that climatic conditions, living conditions, the quality of food and drinking water, alcohol consumption are essential components of public health and life expectancy.The article provides an overview of studies on assessment factors of life expectancy, presents the authors’ approach to identifying gender gaps in life expectancy, living conditions, and lifestyle affecting the indicator of life expectancy. The paper presents the results of a comparative analysis of gender gap in life expectancy in Russia and foreign countries. The paper studies the correlation between living conditions and lifestyle, and life expectancy.Classiﬁcation of the regions by the life expectancy at birth for men and women is an important component of this study. The authors used Rosstat data for 2016 and the k-means method to select three clusters of Russian regions taking into account gender, living conditions and lifestyle. The paper identiﬁes similar health problems of the regions that are associated with alcohol consumption, poor nutrition and poor quality of drinking water, poor housing and living conditions. The lowest life expectancy rates for men and women are recorded in regions of the 1st cluster (Jewish Autonomous Region, Republic of Tuva, Chukotka Autonomous Area). High mortality rates are a result of external causes. There is a poor quality of drinking water and poor nutrition, excessive alcohol consumption, and inadequate housing conditions.Based on the obtained results were determined possible reserves for reducing the gender and regional differentiation of life expectancy.

Download Full-text

Association of Serum Homocysteine Level and Interstitial Lung Disease in Systemic Sclerosis: A Case-control Study

Current Rheumatology Reviews ◽

10.2174/1573397114666180628162907 ◽

2018 ◽

Vol 15 (1) ◽

pp. 74-78

Author(s):

Mohammadali Nazarinia ◽

Asghar Zare ◽

Mohammad javad Fallahi ◽

Mesbah Shams

Keyword(s):

Systemic Sclerosis ◽

Healthy Subjects ◽

Case Control Study ◽

Homocysteine Level ◽

Case Control ◽

Control Group ◽

Lung Involvement ◽

Serum Homocysteine ◽

The Mean ◽

Control Study

Background:Systemic sclerosis is a disorder of connective tissue with unknown cause, affecting the skin and internal organs, characterized by fibrotic changes.Objective:To determine the correlation between serum homocysteine level and interstitial lung involvement in systemic sclerosis. </P><P> Materials and Methods: In this case – control study, 59 patients who fulfilled the ACR/EULAR classification criteria for systemic sclerosis and were referred to Hafez Hospital of Shiraz, Iran, were included as the case group. Fifty nine healthy subjects were involved as the control group. Patients were divided into two groups based on interstitial lung involvement and two subtypes, diffuse and limited type. Serum homocysteine, vitamin B12, and folate levels compared between the controls, and cases groups.Results:Of 59 case and control group, 53 (%89.8) were female and the mean age did not differ in both groups (P=0.929). Thirty five (%59.3) patients had interstitial lung involvement and 38(%64.4) had diffuse cutaneous systemic sclerosis. The mean serum homocysteine level was 13.9±6.3 µmol/L in the case and 13.7±9.2 µmol/L in the control group (P=0.86). The mean serum homocysteine level did not differ between the patients with and without interstitial lung involvement (P=0.52). The patients with lung involvement was older than those without lung involvement (P=0.004). Lung disease was more common in diffuse type (P=0.014).Conclusion:In our study, serum homocysteine level did not differ between the patients and healthy subjects. Also, there was no correlation between serum homocysteine level and lung involvement, but lung involvement was more common in older patients and also diffuse subtype.

Download Full-text