scholarly journals AN AYURVEDIC APPROACH TOWARDS POSTMENOPAUSAL OSTEOPOROSIS - A REVIEW

2021 ◽  
Vol 09 (1) ◽  
pp. 183-189
Keyword(s):  
Bone Cells ◽  
Modern Science ◽  
Signs And Symptoms ◽  
Bone Fragility ◽  
The Body ◽  
Related Disorder ◽  
Holistic Management ◽  
Structural Framework ◽  
Structural Deterioration ◽  
Increased Risk

India is the second largest country in the world regarding population. As the life expectancy has increased, the population of postmenopausal women is also increased. Hence the problems associated with increasing age are increased. The studies of last two decades suggest that women in menopausal age report more phys-iological and psychological problems. Osteoporosis is one among them. Osteoporosis or porous bone is a worldwide problem, characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility and an increased risk of fractures. In modern science treatment available for menopausal symptoms is mainly symptomatic and has some adverse effects too. In Ayurveda we cannot find the name of this disease, but signs and symptoms of Asthi- Kshaya are found quite similar to osteoporosis. The func-tion of dhatu is dharaṇa (To maintain the structure) of the body. Among all dhatus, asthidhatu is responsi-ble for maintenance of structural framework of the body. It shapes the body and protects the vital organs. Acharya Charaka in Sutra Sthan has explained the concept of osteoporosis. Aggravation of Vata is a main cause of Asthi- Kshaya and so it is mentioned as a Vata related disorder in Samhitas. Principle of treatment mentioned in Charak Samhita is as, “Samanagunabhyaso Hi Dhatunaam Vruddhi Karanam”. According to it, things, which contain similar properties to a particular Dhatu of body, can be helpful to increase that one Dhatu. So Vatashamak medicines, diet, exercise having similar properties to Asthi Dhatu, Panchakarma, Rasayana can be very effective to promote bone cells in body. This study is an attempt to understand Ni-dana panchaka of this disease, and its holistic management in context of Ayurveda. Keywords: Menopause, Rajonivrutti, Osteoporosis, Asthikshaya

scholarly journals AMA FROM AYURVEDIC AND MODERN PERSPECTIVE

2021 ◽  
Vol 9 (12) ◽  
pp. 3055-3062
Author(s):  
Archana Arun Kulkarni ◽  
Rashmi Arvindkumar Dohare
Keyword(s):  
Modern Science ◽  
Signs And Symptoms ◽  
The Body ◽  
Human Beings ◽  
Disease Entity ◽  
Objective Parameter ◽  
All Diseases ◽  
Modern Perspective

Agni is one of most powerful transformative principles of Ayurveda. Deranged Agni leads to the formation of Ama. Ama is responsible for causing most of the diseases in human beings. The disease produced, clinically mani- fests itself in form of various signs and symptoms. These signs and symptoms are the principal tools for a physi- cian to diagnose the disease and treat it promptly. On the basis of these symptoms, all diseases can be classified in Samavastha and Niramavastha. If an objective Parameter that could measure the severity of Ama is searched, it will prove to be an advantage for the physician, who could then catch the cause (Ama) and save patients from this harmful disease entity. A definite line of treatment of Ama can be planned after considering the symptoms and severity of the condition. Keeping this approach, the review is carried out to understand Ama from Ayurvedic and Modern perspectives. After reviewing it can be concluded that Ama has no direct correlation in modern science but can best be equated to 'toxins'. They may be endotoxins like enzymes, hormones, catalysts, etc. when these are unable to function properly or entirely, different metabolites are formed which are not acquired by the body. On further process these go on accumulating in different systems, affecting the normal mechanism of that respective system or exotoxins produced by some bacteria or micro-organism when they enter into the body. Keyword: Agni, Ama, Toxin

scholarly journals Characterization and Childhood Tumor Risk Assessment of Genetic and Epigenetic Syndromes Associated With Lateralized Overgrowth

2020 ◽  
Vol 8 ◽  
Author(s):  
Jessica R. Griff ◽  
Kelly A. Duffy ◽  
Jennifer M. Kalish
Keyword(s):  
Tumor Development ◽  
Current Data ◽  
The Body ◽  
Proteus Syndrome ◽  
Related Disorder ◽  
Screening Guidelines ◽  
Tumor Risk ◽  
Increased Risk ◽  
Segmental Overgrowth ◽  
Cell Growth And Proliferation

Lateralized overgrowth (LO), or segmental overgrowth, is defined as an increase in growth of tissue (bone, muscle, connective tissue, vasculature, etc.) in any region of the body. Some overgrowth syndromes, characterized by both generalized and lateralized overgrowth, have been associated with an increased risk of tumor development. This may be due to the underlying genetic and epigenetic defects that lead to disrupted cell growth and proliferation pathways resulting in the overgrowth and tumor phenotypes. This chapter focuses on the four most common syndromes characterized by LO: Beckwith-Wiedemann spectrum (BWSp), PIK3CA-related overgrowth spectrum (PROS), Proteus syndrome (PS), and PTEN hamartoma tumor syndrome (PHTS). These syndromes demonstrate variable risks for tumor development in patients affected by LO, and we provide a comprehensive literature review of all common tumors reported in patients diagnosed with an LO-related disorder. This review summarizes the current data on tumor risk among these disorders and their associated tumor screening guidelines. Furthermore, this chapter highlights the importance of an accurate diagnosis when a patient presents with LO as similar phenotypes are associated with different tumor risks, thereby altering preventative screening protocols.

scholarly journals Obesity, insulin resistance and comorbidities ? Mechanisms of association

2014 ◽  
Vol 58 (6) ◽  
pp. 600-609 ◽  
Author(s):  
Ana Valeria B. Castro ◽  
Cathryn M. Kolka ◽  
Stella P. Kim ◽  
Richard N. Bergman
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Molecular Mechanisms ◽  
Metabolic Diseases ◽  
Polycystic Ovary ◽  
Bone Fragility ◽  
The Body ◽  
Ectopic Fat ◽  
Increased Risk ◽  
Fat Liver

Overall excess of fat, usually defined by the body mass index, is associated with metabolic (e.g. glucose intolerance, type 2 diabetes mellitus (T2DM), dyslipidemia) and non-metabolic disorders (e.g. neoplasias, polycystic ovary syndrome, non-alcoholic fat liver disease, glomerulopathy, bone fragility etc.). However, more than its total amount, the distribution of adipose tissue throughout the body is a better predictor of the risk to the development of those disorders. Fat accumulation in the abdominal area and in non-adipose tissue (ectopic fat), for example, is associated with increased risk to develop metabolic and non-metabolic derangements. On the other hand, observations suggest that individuals who present peripheral adiposity, characterized by large hip and thigh circumferences, have better glucose tolerance, reduced incidence of T2DM and of metabolic syndrome. Insulin resistance (IR) is one of the main culprits in the association between obesity, particularly visceral, and metabolic as well as non-metabolic diseases. In this review we will highlight the current pathophysiological and molecular mechanisms possibly involved in the link between increased VAT, ectopic fat, IR and comorbidities. We will also provide some insights in the identification of these abnormalities. Arq Bras Endocrinol Metab. 2014;58(6):600-9

The antitoxic and protective effects of Curcuma longa and it`s active agent, Curcumin: оverview

2020 ◽  
pp. 66-72
Author(s):  
A. Khisamova ◽  
O. Gizinger
Keyword(s):  
Curcuma Longa ◽  
Physiological Activity ◽  
Active Agent ◽  
Modern Science ◽  
Physical Exertion ◽  
The Body ◽  
Modern World ◽  
Protective Effects ◽  
Daily Stress ◽  
Anti Cancer

In the modern world, where a person is exposed to daily stress, increased physical exertion, the toxic effect of various substances, including drugs. The task of modern science is to find antioxidants for the body. These can be additives obtained both synthetically and the active substances that we get daily from food. Such a striking example is turmeric, obtained from the plant Curcuma longa. Recently, it has been known that curcumin has an antioxidant, anti-inflammatory, anti-cancer effect and, thanks to these effects, plays an important role in the prevention and treatment of various diseases, in particular, from cancer to autoimmune, neurological, cardiovascular and diabetic diseases. In addition, much attention is paid to increasing the biological activity and physiological effects of curcumin on the body through the synthesis of curcumin analogues. This review discusses the chemical and physical characteristics, analogues, metabolites, the mechanisms of its physiological activity and the effect of curcumin on the body.

Adenocarcinoma of the Appendix in Elderly: Diagnostic dilemma

2020 ◽  
Vol 01 ◽  
Author(s):  
Heba Nofal ◽  
Hayder Al-Masari ◽  
Marwan Mohammed Rashed ◽  
Reham Ainawi ◽  
Desh Idnani ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Ct Scan ◽  
Laparoscopic Appendectomy ◽  
Signs And Symptoms ◽  
Morbidity And Mortality ◽  
Diagnostic Dilemma ◽  
Increased Risk

: Acute appendicitis in elderly continue to be a diagnostic dilemma as it raises both the suspicion of malignancy and increased risk of morbidity and mortality. Cancers of the appendix are rare and most of them are found accidentally on appendectomies performed for acute appendicitis. When reviewed, majority of the tumors were carcinoid, adenoma, and lymphoma. Adenocarcinomas of appendix are only 0.08% of all cancers and the treatment remains controversial. This paper presents a case of 75-year-old female presented to emergency (ER) with signs and symptoms mimicking acute appendicitis, laparoscopic appendectomy was planned after a CT scan was done as it was suggesting acute appendicitis. The specimen then was sent foe pathology lab and a diagnosis of adenocarcinoma of the appendix was made.

A Critical Review on Tamaka Shwasa (Bronchial Asthma) - An Ayurvedic View

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Sandip R. Baheti ◽  
Deepa Sharma ◽  
Saroj Devi ◽  
Amit Rai
Keyword(s):  
Bronchial Asthma ◽  
Inflammatory Disease ◽  
Critical Review ◽  
Modern Science ◽  
Modern Medicine ◽  
Chronic Inflammatory Disease ◽  
The Body ◽  
Natural Immunity ◽  
Shortness Of Breath ◽  
Asthma Symptoms

Difficulty in breathing or shortness of breath may be simply termed as Shwasa (Asthma), As per Ayurveda, Shwasa is mainly caused by the Vata and Kapha Doshas. Shwasa is broadly classified into five types in Maha Shwasa (Dyspnoea major), Urdhawa Shwasa (Expiratory Dyspnoea), Chinna Shwasa (Chyne-stroke respiration), Kshudra Shwasa (Dyspnoea minor), Tamaka Shwasa (Bronchial Asthma). In modern science Tamaka Shwasa can be correlated with Asthma, Asthma which is a chronic inflammatory disease of airway. In modern medicine there is no cure for Asthma, symptoms can typically be improved. In Ayurveda, Asthma can be effectively and safely manage the condition without inducing any drug dependency where Pachakarma procedures and use of internal medication detoxifies the body, provides nutrition and increases the elasticity of lung tissue it also develops natural immunity of the body thus decreasing episodic recurrence of the disease.

To evaluate the clinical efficacy of Palash Mula Arka in Pittaja Netrabhishyanda.

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Yuwaraj D. Kale ◽  
Sarika Choure
Keyword(s):  
Foreign Body ◽  
Modern Science ◽  
Signs And Symptoms ◽  
Burning Sensation ◽  
Trial Group ◽  
Inflammatory Condition ◽  
Conjunctival Hyperemia ◽  
Bacterial Conjunctivitis ◽  
Body Sensation ◽  
Acute Bacterial Conjunctivitis

Abhishyanda is one of the Sarvagata Vyadhi mentioned by Acharya Sushruta. In modern science, signs and symptoms of Netrabhishyanda may be correlated with conjunctivitis, which is the inflammatory condition of conjunctiva. Kavala Dharana, Dhumrapana, Aschyotana, Sechana Putapaka etc. are various suggested regimens in Ayurvedic texts for the treatment of Netrabhishyanda. Considering this effectiveness of Palasha as mentioned by Acharya Sushruta, it is planned to study the use of Palasha Mula Arka Aschyotana in Pittaja Netrabhishyanda. 60 patients having classical signs and symptoms of Pittaja Abhishyanda (Acute Bacterial Conjunctivitis) as per Ayurvedic and modern texts were selected for the study. After completion of therapy, mean Conjunctival hyperemia was reduced to 0.2167 ± 0.4086 in Control and 0.5667 ± 0.5040 in Trial Group. Palasha Mula Arka was found effective in reduction in conjunctival hyperemia, watering and the number of culture colonies, it was also found effective in burning sensation, discharge, foreign body sensation and photophobia.

scholarly journals The Association of Obesity and Liver Enzyme Activities in a Student Population at Increased Risk for Cardiovascular Disease / Veza Između Gojaznosti I Aktivnosti Jetrenih Enzima U Studentskoj Populaciji Sa Povećanim Rizikom Za Nastanak Kardiovaskularnih Bolesti

2013 ◽  
Vol 32 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Emina Čolak ◽  
Dragana Pap ◽  
Nada Majkić-Singh ◽  
Ivana Obradović
Keyword(s):  
Body Mass Index ◽  
Waist Circumference ◽  
Liver Enzyme ◽  
Body Mass ◽  
Statistical Processing ◽  
The Body ◽  
Control Group ◽  
Anthropometric Parameters ◽  
Nonalcoholic Fatty Liver ◽  
Increased Risk

Summary Background: It has been reported that obesity is associated with metabolic syndrome, insulin resistance, cardiovascular risk but also with nonalcoholic fatty liver disease (NAFLD). The prevalence of obesity in children and adolescents is increasing rapidly all over the world. The aim of this study was to analyze the value of liver enzymes: AST, ALT and γGT in a group of obese students in order to establish their correlation to anthropometric parameters such as: BMI (body mass index), WC (waist circumference), HC (hip circumference), and WHR (waist-to-hip ratio) compared to non-obese students who comprised the control group (CG). Methods: In this study, 238 students from the University of Novi Sad of both sexes (126 men and 112 women) with a mean age of 22.32 ± 1.85 years were included. According to the body mass index (BMI) lower and higher than 25 kg/m2 and waist circumference (WC) lower and higher than 94 cm (80 cm for females) the whole group of 238 students was divided into 2 subgroups: the obese group at increased risk for CVD (Group 1) and the group at lower risk for CVD (Group 2). AST, ALT and γGT activities were determined in fasting blood samples. Results: Statistical processing data revealed significantly higher values of AST, ALT and γGT in the group of students with BMI>25 kg/m2, WC>94 cm for males and WC>80 cm for females, HC>108 cm for males and HC>111 cm for females, and WHR>0.90 for males and WHR>0.80 for females (P<0.001). Significant association was established between anthropometric parameters and liver enzyme levels (P<0.0001). Conclusions: Obese students with higher BMI, WC, HC and WHR values have higher liver enzyme activites and a higher chance to develop NAFLD in the future.

scholarly journals Life Course Predictors of Allostatic Load Among LGBTQ Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 735-735
Author(s):  
Charles Hoy-Ellis ◽  
Hyun Kim ◽  
Karen Fredriksen Goldsen
Keyword(s):  
Older Adults ◽  
Life Course ◽  
Interpersonal Violence ◽  
Allostatic Load ◽  
Identity Management ◽  
The Body ◽  
Linear Regression Models ◽  
Psychophysiological Stress ◽  
Increased Risk ◽  
Wear And Tear

Abstract LGBTQ older adults are at significantly increased risk for poor mental and physical health, likely consequential to lifelong bias. Allostatic load (AL), the net effect of “wear and tear” on the body resulting from repeated, chronic over-activation of the psychophysiological stress response system. Utilizing the Health Equity Promotion Model, the aim of this study was to test potential life course predictors of AL, including interpersonal violence, legal marriage, and identity management in a sample of LGBTQ adults 50 to 97 years of age (n=317). Results from a series of hierarchical linear regression models showed that adult physical abuse and late identity disclosure for those who had been in an opposite-sex marriage predicted higher AL in this sample of LGBTQ older adults, indicating need for increased research on bias over the life course as contributory to AL and biopsychosocial dysfunction among LGBTQ older adults.

scholarly journals Timing of Bisphosphonate Initiation After Fracture: What Does the Data Really Say?

2020 ◽  
Vol 11 ◽  
pp. 215145932098036
Author(s):  
David W. Barton ◽  
C. Taylor Smith ◽  
Amit S. Piple ◽  
Sterling A. Moskal ◽  
Jonathan J. Carmouche
Keyword(s):  
Fracture Healing ◽  
Clinical Studies ◽  
Osteoporosis Treatment ◽  
The Body ◽  
Non Union ◽  
Increased Risk ◽  
Level I ◽  
Timing Of Initiation ◽  
The Impact ◽  
Published Research

Introduction: Osteoporosis is often not clinically recognized until after a fracture occurs. Individuals who have 1 fracture are at increased risk of future fractures. Prompt initiation of osteoporosis treatment following fracture is critical to reducing the rate of future fractures. Antiresorptives are the most widely used class of medications for the prevention and treatment of osteoporosis. Many providers are hesitant to initiate antiresorptives in the acute post-fracture period. Concerns include interference with bone remodeling necessary for successful fracture healing, which would cause increased rates of non-union, malunion, and refracture. While such concerns should not extend to anabolic medications, physicians may also hesitate to initiate anabolic osteoporosis therapies due to high cost and/or lack of familiarity. This article aims to briefly review the available data and present a digestible narrative summary to familiarize practicing orthopaedic surgeons with the essential details of the published research on this topic. Results: The results of 20 clinical studies and key pre-clinical studies related to the effect of anti-resorptive medications for osteoporosis on fracture healing are summarized in the body of this narrative review. Discussion & Conclusions: While few level I studies have examined the impact of timing of initiation of osteoporosis medications in the acute post-fracture period, the few that have been published do not support these concerns. Specifically, data from level I clinical trials indicate that initiating bisphosphonates as early as 2 weeks post-fracture does not increase rates of non-union or malunion. By reviewing the available data, we hope to give clinicians the confidence to initiate osteoporosis treatment promptly post-fracture.

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