scholarly journals ĀKĀRAKARA AS DERMAL ANAESTHETIC

2021 ◽  
Vol 9 (11) ◽  
pp. 2764-2768
Author(s):  
Bhavya K.G ◽  
George M. J
Keyword(s):  
Medical Science ◽  
Ethanolic Extract ◽  
Local Anaesthetics ◽  
Herbal Extracts ◽  
Topical Anaesthetic ◽  
Painful Procedure ◽  
Anaesthetic Agents ◽  
Surgical Field ◽  
Topical Anaesthetics

Nowadays, the role of local anaesthesia in the surgical field is highly appraisable. Local anaesthetics are the drugs that produce a loss of sensation over the localised areas without producing a loss of consciousness. Humans have been using various methods to block pain for thousands of years. Controlling pain during the śhastrakarma in śalyatantra has been always challenging. There has been the introduction of various methods of local anaesthetics since the origin of medical science, topical anaesthetics being one of them. Studies have been conducted to discover novel anaesthetic agents by various scholars. Herbal extracts do not stand far in the pathway of this search. Owing to these discoveries, 30% ethanolic extract gel of Ākārakara (Spilanthes calva DC.) is selected here as a topical anaesthetic to evaluate the efficacy in facilitating the management of warts by a painful procedure agnikarma. Keywords: Dermal anaesthetic, Ākārakara, Spilanthol

scholarly journals An Experimental Study of Ethanolic Extract of Myristica fragrans in Morphine Dependence

2016 ◽  
Vol 15 (2) ◽  
pp. 224-229 ◽  
Author(s):  
Imran Zaheer ◽  
Syed Ziaur Rahman ◽  
Rahat Ali Khan ◽  
Mehtab Parveen
Keyword(s):  
Medical Science ◽  
Ethanolic Extract ◽  
Study Groups ◽  
Morphine Dependence ◽  
Control Group ◽  
Albino Rats ◽  
Abstinence Syndrome ◽  
Myristica Fragrans ◽  
Wistar Albino Rats

Objective: To evaluate the role of ethanolic extract of Myristica fragrans in morphine dependence. Methods: Wistar albino rats were made moderate and severe grade morphine dependence by administering morphine sulphate in dose of 10 mg /kg (i.p.), twice daily for 4 days and by increasing doses of 10-100 mg/kg (i.p.), twice daily for 7 days, respectively. The signs of spontaneous abstinence syndrome were recorded 12 hours in both studies after the last dose of morphine for 30 minutes and quantified by ‘counted’ and ‘checked’ signs. Ethanolic extract of Myristica fragrans (EEMF) was administered p.o. in different regimen: (a) EEMF 200 mg/kg along with morphine twice daily for 4 days and 7 days in moderately and severely induced morphine dependence group, respectively. (b) EEMF 400 mg/kg (p.o.), single dose10 hours after the last dose of morphine in both moderately and severely induced morphine dependence rats.Result: Oral administration of EEMF in both study groups caused significant reduction in the scores of counted and checked signs of morphine abstinence syndrome as compared to active morphine control group. The reduction was significantly more in regimen ‘a’ as compared to regimen ‘b’.Conclusion: Ethanolic extract of Myristica fragrans seed significantly reduced the mean scores of various’counted signs’ and ‘checked signs’ of morphine withdrawal syndrome and might give a solution as a substitute therapy in morphine de-addiction.Bangladesh Journal of Medical Science Vol.15(2) 2016 p.224-229

scholarly journals INSIGHTS INTO THE ROLE OF MORUS ALBA IN REVERSING OBESITY-ASSOCIATED HEPATIC STEATOSIS AND RELATED METABOLIC DISORDER IN RATS

2016 ◽  
pp. 231
Author(s):  
Hanaa H. Ahmed ◽  
Fatehya M Metwally ◽  
Hend Rashad ◽  
Asmaa M Zaazaa
Keyword(s):  
Insulin Resistance ◽  
Hepatic Steatosis ◽  
Metabolic Disorder ◽  
Ethanolic Extract ◽  
Treated Group ◽  
Morus Alba ◽  
The Other ◽  
Obese Group ◽  
Control Group

<p>ABSTRACT<br />Objective: The goal of the present study was to examine the viability of Morus alba (M. alba) ethanolic extract in repression of obesity-associated<br />hepatic steatosis and related metabolic disorder; dyslipidemia, hyperinsulinemia, and glycemic status.<br />Methods: Adult female albino rats were randomly assigned into four groups, eight rats each as follows: Group (1) control group received standard<br />rodent diet for 24 weeks. The other three groups administered high cholesterol diet for 12 weeks and served as obese group, M. alba-treated group,<br />and simvastatin-treated group.<br />Results: The current results showed an increment in thoracic circumference (TCX) and abdominal circumferences (AC) as well as body mass index<br />(BMI) in obese group. In addition, dyslipidemia, hyperinsulinemia, hyperglycemia, and insulin resistance have been elucidated in obese group.<br />Moreover, hepatic malondialdehyde (MDA), nitric oxide (NO), serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and bilirubin<br />values were significantly increased in obese groups versus control group. On the other hand, administration of ethanolic extract of Morus alba or<br />simvastatin could significantly lessen BMI and in addition to improve dyslipidemia in obese group. Glucose, insulin levels, and insulin resistance value<br />in serum samples demonstrated a significant reduction in obese group upon treatment with M. alba ethanolic extract or simvastatin. Furthermore,<br />noticeable depletion in hepatic MDA, NO contents, serum ALT, AST activities, and serum bilirubin level was recorded as a result of treatment with<br />either ethanolic extract of M. alba or simvastatin. Histopathological examination of liver tissue showed ballooning degeneration in the hepatocytes<br />(hepatic steatosis) associated with inflammatory cells penetration in portal zone in obese group. Meanwhile, the treatment of obese groups with<br />ethanolic extract of M. alba or simvastatin was found to restore the structural organization of the liver.<br />Conclusion: The present findings provide a novel aspect for understanding of the role of M. alba against obesity-associated liver diseases and related<br />metabolic disorder. The mechanisms underlying these effects seem to depend on the hypolipidemic potential, anti-inflammatory property, and<br />antioxidant activity of its phytochemicals.<br />Keywords: Obesity, Morus alba, Dyslipidemia, Hyperinsulinemia, Hyperglycemia, Hepatic steatosis.</p>

The plague in Moscow in 1771 and a new coronavirus infection: what they have in common

2021 ◽  
pp. 62-77
Author(s):  
Leonid Anatolievich Denisov ◽  
Mikhail Sergeevich Pakhomov
Keyword(s):  
Mental Health ◽  
Health Care ◽  
Effective Treatment ◽  
Medical Science ◽  
Historical Event ◽  
Prevention Measures ◽  
Physical And Mental Health ◽  
Coronavirus Infection ◽  
The City

The article is devoted to a historical event that occurred 250 years ago in Moscow. The authors draw analogies between the plague epidemic and the current situation associated with a new coronavirus infection, and note what unites these events. It shows the dedicated work of doctors in the conditions of complete ambiguity of the causes and spread of these infections, in the absence of effective treatment methods, what was the behavior of the population, how prevention measures were developed, and what is the role of the authorities of Moscow and St. Petersburg in the fight. How the state of medical science and the level of health care, referred to by economists as the non — material sphere, can affect the physical and mental health of the population and the economic situation of the city, country and the whole World.

PROTECTIVE ROLE OF FICUS RACEMOSA IN DIABETES INDUCED NEUROPATHY: STRUCTURAL AND FUNCTIONAL EVIDENCES

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (11) ◽  
pp. 58-60
Author(s):  
N Solanki ◽  
◽  
S. K Bhavsar
Keyword(s):  
Sciatic Nerve ◽  
Diabetic Neuropathy ◽  
Ethanolic Extract ◽  
Protective Role ◽  
Diabetic Rats ◽  
Dependent Manner ◽  
Traditional System ◽  
Ficus Racemosa ◽  
Dose Dependent

Ficus racemosa is used in traditional system of medicine for various health problems and diseases, and is commonly known as Gular fig. The main objective was to study its effects against streptozotocin induced diabetic neuropathy by structural and functional marker. Investigation of diabetic neuropathy was carried out through functional and structural assessment in streptozotocin induced in diabetic rats. Diabetic rats were treated for 28 days in dose dependent manner of Ficus racemosa aqueous extract (250 mg/kg and 500 mg/kg) and ethanolic extract (200 mg/kg and 400 mg/kg). Study showed marked protection observed by Ficus racemosa in hippocampus region of brain and sciatic nerve tissues. Ficus racemosa treatment showed improvement in functional and structural markers, which strongly suggest its protective role in diabetic neuropathy.

scholarly journals Irrational use of Eucalyptus oil in dentistry: a case report

1970 ◽  
Vol 10 (2) ◽  
pp. 121-124
Author(s):  
RS Shishir ◽  
C Renita ◽  
AR Kumuda ◽  
BG Subhas
Keyword(s):  
Case Report ◽  
Medical Science ◽  
Herbal Medicines ◽  
Dental Pain ◽  
Rural India ◽  
Herbal Drug ◽  
Self Medication ◽  
Eucalyptus Oil ◽  
Acacia Catechu

Use of herbal medicaments for dental pain is a practice still followed in some parts of rural India. Most often these herbal medicines are readily available to the rural without the prescription from an authorized practitioner. Eucalyptus oil is one such herbal drug which is widely used for a number of ailments. An unusual and a rare case of chemical injury secondary to the use of eucalyptus oil has been presented here. We have also described the management of the injury with herbal medication. This case report tends to highlights the dangers of self medication and also stresses on the role of herbal medications in dentistry. Keywords: Eucalyptus oil; chemical ulcers; acacia catechu; dentistry. DOI: http://dx.doi.org/10.3329/bjms.v10i2.7807 Bangladesh Journal of Medical Science Vol.10 No.2 Apr’11 pp.121-124

scholarly journals The Royal Portuguese Cabinet of Reading: a space for medical science in the 19th century

Almanack ◽  
2016 ◽  
pp. 241-286
Author(s):  
Monique de Siqueira Gonçalves ◽  
Tânia Bessone
Keyword(s):  
19Th Century ◽  
Medical Science ◽  
Target Audience ◽  
Relative Importance ◽  
Science Field ◽  
The 19Th Century ◽  
General Collection

Abstract: This work presents an analysis on the role of the Royal Portuguese Cabinet of Reading during the second half of the 19th century regarding the collection and safekeeping of medical science books. By analyzing the books contained in the 1906 catalog by Ramiz Galvão (consisting of the institution's collection since 1837), we intend to understand the relative importance of the medical science collection found in the general collection of the Royal Portuguese Cabinet of Reading, and whether it was updated and relevant amidst the constitution of Brazil's medical science field. It is also intended to discover the preponderant idiom among its works and at which target audience they were aimed at, therefore, whether its guard matched the institution's outline of lusophone culture preservation.

scholarly journals Protective Role of Agrimonia eupatoria L. in Heavy Metal Induced Nephrotoxicity

2018 ◽  
Vol 62 (2) ◽  
pp. 13-18
Author(s):  
D. Marcinčáková ◽  
M. Falis ◽  
P. Schusterová ◽  
P. Váczi ◽  
S. Marcinčák ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Potassium Dichromate ◽  
Ethanolic Extract ◽  
Protective Role ◽  
Rabbit Kidney ◽  
Cell Adherence ◽  
Metal Compounds ◽  
Sulfate Heptahydrate ◽  
Chloride Dihydrate

Abstract The aim of this study was to evaluate the potential protective role of Agrimonia eupatoria L. in heavy metal induced nephrotoxicity. Rabbit kidney epithelial cells (RK13) were used as the model cell line. They were exposed to three different heavy metal compounds: cadmium chloride dihydrate CdCl2.2H2O (15 and 20 mg.l−1), potassium dichromate K2Cr2O7 (1, 10 mg.l−1), and zinc sulfate heptahydrate ZnSO4.7H2O (50, 150 mg.l−1) simultaneously with agrimony (ethanolic extract, 100 mg.l−1). The cell response was recorded using the xCELLigence system or real-time cell analysis (RTCA) as a cell index (CI) and expressed as cell adherence (%) compared to control cells without treatment. The potential nephroprotective effects were recorded in cells treated with chromium (1 a 10 mg.l−1) and agrimony, where the cell adherence increased from 95.11 ± 11.25 % and 7.24 ± 0.33 % to 103.26 ± 1.23 % and 68.54 ± 4.89 % (P < 0.05) respectfully and also with a combination of agrimony and zinc (150 mg.l−1), where the adherence increased from 57.45 ± 1.98 % to 95.4 ± 6.95 %. During the cell exposure to cadmium in combination with agrimony, the protective effect was not recorded; the adherence of cells was even decreased (P < 0.05).

scholarly journals To study the role of guduchyadi kashaya on viral diseases.

2020 ◽  
Vol 8 (05) ◽  
Author(s):  
Akshay Vaidya
Keyword(s):  
Wound Healing ◽  
Side Effects ◽  
Medicinal Plants ◽  
Broad Spectrum ◽  
Viral Infections ◽  
Modern Science ◽  
Viral Diseases ◽  
Diverse Group ◽  
Herbal Extracts

Viral infections remain major “worldwide” cause of morbidity and mortality.  Herbal extracts or wholesome drugs have been in use for medicinal purposes since ancient time and are known for their antiviral properties and more tolerable side effects. Thus, naturally based pharmacotherapy is a proper alternative for treating viral diseases. Hence this article describes potential antiviral properties of medicinal plants against diverse group of viruses and suggests screening the potential of plants possessing broad spectrum anti-viral effects against viral diseases. Guduchyadi Kwath is a polyherb ayurvedic preparation useful in various diseases. It is useful in pitta vikar, shleshma vikar, Jwara, Chardi, Daha, Trushna, and Agnimandya1. According to modern science it showed anti-inflammatory, antioxidant, antibacterial, antiviral, antimalarial, hepatoprotective, wound healing and immune-modulatory action. The study is aim to the effect of “Guduchyadi kashaya” on viral diseases.

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