scholarly journals Evaluation of the role of Shodhana (Purification) process in Croton tiglium seeds for reduction of toxic content

2021 ◽  
Vol 12 (3) ◽  
pp. 565-575
Author(s):  
Ajay Kumar Meena ◽  
Poorna Venkataraman ◽  
Ravindra Singh ◽  
Kusuma Ganji ◽  
Murali Krishna C ◽  
...  
Keyword(s):  
Physicochemical Parameters ◽  
Chemical Constituents ◽  
Seed Extract ◽  
Cow Milk ◽  
Purification Process ◽  
Croton Tiglium ◽  
Before And After ◽  
Detoxification Process ◽  
Seed Extracts

In Ayurvedic texts, Jayapala or croton tiglium seeds are well known as khumbini for its toxicity (severe purgative action) and are used for the treatment of constipation after shodhana (detoxification) of the seed with godugdha (cow milk). The oil content of the seeds was responsible for the purgative property, and its reduction enhances its medicinal usage. The presence of Crotonoside or iso-guanosine in seed extract was identified in HPTLC and quantified using high pressure liquid chromatography technique both before and after the purification process of the seed. The phytochemicals and physicochemical parameters of seeds were analyzed to find the level of changes in the processed seeds. The other chemical constituents of the seed extracts are studied using different techniques like HPTLC, HPLC, LC-MS, and GC-MS. The study has revealed that the detoxification process, as per classical texts, has shown an effective depletion in the quantity of crotonoside in processed seeds.

scholarly journals Effect of Cooking Temperature on Biochemical Characteristics, Antioxidant Activity and Antimicrobial Potential of Seed Extracts of Assam, India

2019 ◽  
Vol 16 (2) ◽  
pp. 451-462
Author(s):  
Sony Kumari ◽  
Rabbul Ibne A. Ahad ◽  
Mobina Ahmed ◽  
Dhanapriya Moirangthem ◽  
Drishtirupa Phukan
Keyword(s):  
Seed Extract ◽  
Citrus Limon ◽  
Citrus Fruits ◽  
Citrus Aurantifolia ◽  
E Coli ◽  
Cooking Temperature ◽  
Before And After ◽  
Citrus Maxima ◽  
Citrus Limetta ◽  
Seed Extracts

The present study investigated the effects of cooking temperature on the biochemical characteristics, antioxidant and antimicrobial activity of three different seeds of Citrus fruits (Citrus limon, Citrus limetta, Citrus maxima and Citrus aurantifolia) collected from Assam, India. Total soluble sugar (72 mg/mL) were highest in Citrus maxima hydro 2-propanol seed extract before heating and 50 mg/mL in Citrus limon hydro-methanol, Citrus limetta hydro-methanol and Citrus maxima hydro-methanol seed extract after heating. Total soluble proteins before and after heating were highest 82 mg/mL and 88 mg/mL in Citrus limon 2 propanol seed extract. Free amino acid contents before and after heating were highest (62 µg/mL in Citrus limon hydro-propanol) and (40 µg/mL in Citrus limon hydro-methanol) and free fatty acids were 29.2 µg/mL and 23 µg/mL in Citrus maxima methanol extract, respectively. H2O2 scavenging activity before and after heating were highest in Citrus aurantifolia propanol (59%) and in Citrus limon (67%), respectively. Total antioxidant capacity was found highest in Citrus maxima hydro propanol (92.5%) before heating and in Citrus aurantifolia 2-propanol (65%) after heating. Antimicrobial activity of the seed extracts was studied on B. subtilis, E. coli and P. aeruginosa and minimum inhibitory concentration of the four Citrus fruits was determined. MIC of the different seed extracts was observed for 100% (v/v), 75% (v/v), 50% (v/v) and 25% (v/v) against three test microbes viz. Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli. For Bacillus subtilis, the MIC was found to be at 100%, 100%, 75%, and 75% to the extract of Citrus aurantifolia hydro 2-propanol, Citrus limon methanol, Citrus limetta hydro 2 propanol and Citrus maxima hydro 2-propanol, respectively. For E. coli, the MIC was found to be at 100%, 75%, 100% and 100% for Citrus aurantifolia hydro 2-propanol, Citrus limon hydro 2-propanol, Citrus maxima hydro 2-propanol and Citrus limetta hydro 2 propanol, respectively. For Pseudomonas aeruginosa, the MIC was found to be at 100%, 100%, 75% and 50% for Citrus aurantifolia methanol, Citrus limon methanol, Citrus maxima hydro 2-propanol and Citrus limetta hydro 2 propanol, respectively.

Larvicidal activity of ethanolic leaf and seed extract of Croton tiglium against Aedes aegypti

2021 ◽  
Vol 4 (2) ◽  
pp. 28-31
Author(s):  
Parbin Iraqui ◽  
Keyword(s):  
Aedes Aegypti ◽  
Larvicidal Activity ◽  
Mosquito Larva ◽  
Seed Extract ◽  
Leaf Extracts ◽  
Croton Tiglium ◽  
Soxhlet Apparatus ◽  
Percent Mortality ◽  
Harmful Effects ◽  
Seed Extracts

Aim and objectives: Mosquitoes are the transmitters of serious human diseases that cause millions of deaths every year. The use of synthetic insecticides causes harmful side effects to the environment and human health. So a natural alternative way is needed to solve this problem. Extracts from the various parts of plants like leaves, seeds, barks and roots can be used to control mosquitoes. This study aims to evaluate the larvicidal activity of ethanolic seed and leaf extracts of a traditionally used medicinal plant Croton tiglium, against Aedes aegypti, the vector of dengue fever. Material and methods: In this study, extracts from the dried leaf and seed powder of the Croton tiglium plant were extracted using ethanol in a soxhlet apparatus. Different concentrations were prepared from the extracts. Third instar larvae of Aedes aegypti were collected from the mosquito culture laboratory of the Life Sciences Department of Dibrugarh University. Prepared concentrations of the extracts were tested against the larvae of Aedes aegypti to evaluate the larvicidal activity by calculating percent mortality. Result: The ethanolic leaf and seed extracts of the selected plant were found effective against the larvae of Aedes aegypti. The 250 ppm concentration of both leaf and seed extracts showed the highest mortality of mosquito larva. The seed extract of this plant was found more effective in killing mosquito larva. Conclusion: From the study, it can be concluded that the ethanolic leaf and seed extracts of Croton tiglium possess larvicidal activity against Aedes aegypti. Hence, it could be useful in controlling mosquitoes without any harmful effects. However, further study and investigation will be needed to isolate and characterize bioactive components from this plant with larvicidal activity and the development of drugs for dengue from the components

scholarly journals Anti-inflammatory role of papaya seed extracts in inhibiting osteoclastogenesis of rats with Periodontitis

2019 ◽  
Vol 4 (2) ◽  
pp. 95
Author(s):  
Ratih Pusporini ◽  
Ahmad Basori ◽  
Agung Krismariono
Keyword(s):  
Wistar Rats ◽  
Alveolar Bone ◽  
Seed Extract ◽  
Control Group ◽  
Mandibular Incisor ◽  
Male Wistar Rats ◽  
Anti Inflammatory ◽  
Papaya Seed ◽  
Seed Extracts

Some previous studies mentioned that papaya seed extract has anti-inflammatory activity because it contains polyphenols including phenolic and flavonoid acids. Polyphenols of the papaya seed extracts are known to inhibit the severity of periodontitis. It can prevent the release of excessive osteoclastogenesis which may promote bone resorption aggravating periodontitis. Hence, this study aims to determine the role of papaya seed extract in reducing the number of osteoclasts in rats with periodontitis. Twenty-eight male Wistar rats were divided into 4 groups of induced periodontitis using lipopolisakarida (LPS) Porphyromonas gingivalis (P. Gingivalis) and followed by wire ligature in “8” placed around the mandible mandibular incisor. The first group was given standard food without any papaya extract, while each rat in three other groups with periodontitis (P2, P3, P4) was given with Papaya seed extracts of 200 mg/kgBW, 300 mg/kgBW, and 400 mg/kgBW. Seven rats in one group were not induced by periodontitis and were fed with standard food as a control group. On the 30th day, the rat was sacrificed, and its transverse pieces of alveolar bone around the mandibular incisor were stained with Hematoxylin-Eosin. The data analyzed by one way ANOVA indicated a significant result. Thus, it is conclusive that extract of papaya seed ethanol inhibited osteoclastogenesis in Wistar rats induced with periodontitis.

Child and Adolescent Suicides in Bosnia and Herzegovina Before and After the War (1992–1995)

Crisis ◽  
2010 ◽  
Vol 31 (3) ◽  
pp. 160-164 ◽  
Author(s):  
Almir Fajkic ◽  
Orhan Lepara ◽  
Martin Voracek ◽  
Nestor D. Kapusta ◽  
Thomas Niederkrotenthaler ◽  
...  
Keyword(s):  
Bosnia And Herzegovina ◽  
Age Differences ◽  
Suicide Risk ◽  
Child And Adolescent ◽  
Youth Suicide ◽  
Southeastern Europe ◽  
Suicide Rates ◽  
Before And After ◽  
Sex And Age Differences

Background: Evidence on youth suicides from Southeastern Europe is scarce. We are not aware of previous reports from Bosnia and Herzegovina, which experienced war from 1992 to 1995. Durkheim’s theory of suicide predicts decreased suicide rates in wartime and increased rates afterward. Aims: To compare child and adolescent suicides in Bosnia and Herzegovina before and after the war. Methods: Data on youth suicide for prewar (1986–90) and postwar (2002–06) periods were analyzed with respect to prevalence, sex and age differences, and suicide methods. Suicide data from 1991 through 2001 were not available. Results: Overall youth suicide rates were one-third lower in the postwar than in the prewar period. This effect was most pronounced for girls, whose postwar suicide rates almost halved, and for 15–19-year-old boys, whose rates decreased by about a one-fourth. Suicides increased among boys aged 14 or younger. Firearm suicides almost doubled proportionally and were the predominant postwar method, while the most common prewar method had been hanging. Conclusions: The findings from this study indicate the need for public education in Bosnia and Herzegovina on the role of firearm accessibility in youth suicide and for instructions on safe storage in households. Moreover, raising societal awareness about suicide risk factors and suicide prevention is needed.

Strategic Role of Zakat in Multidimensional Quality of Life in Sijunjung, Indonesia

2018 ◽  
Vol 15 (1) ◽  
pp. 55-72
Author(s):  
Herlin Hamimi ◽  
Abdul Ghafar Ismail ◽  
Muhammad Hasbi Zaenal
Keyword(s):  
Quality Of Life ◽  
Positive Impact ◽  
Wealth Distribution ◽  
Absolute Poverty ◽  
Before And After ◽  
The Status ◽  
Being There ◽  
The Impact

Zakat is one of the five pillars of Islam which has a function of faith, social and economic functions. Muslims who can pay zakat are required to give at least 2.5 per cent of their wealth. The problem of poverty prevalent in disadvantaged regions because of the difficulty of access to information and communication led to a gap that is so high in wealth and resources. The instrument of zakat provides a paradigm in the achievement of equitable wealth distribution and healthy circulation. Zakat potentially offers a better life and improves the quality of human being. There is a human quality improvement not only in economic terms but also in spiritual terms such as improving religiousity. This study aims to examine the role of zakat to alleviate humanitarian issues in disadvantaged regions such as Sijunjung, one of zakat beneficiaries and impoverished areas in Indonesia. The researcher attempted a Cibest method to capture the impact of zakat beneficiaries before and after becoming a member of Zakat Community Development (ZCD) Program in material and spiritual value. The overall analysis shows that zakat has a positive impact on disadvantaged regions development and enhance the quality of life of the community. There is an improvement in the average of mustahik household incomes after becoming a member of ZCD Program. Cibest model demonstrates that material, spiritual, and absolute poverty index decreased by 10, 5, and 6 per cent. Meanwhile, the welfare index is increased by 21 per cent. These findings have significant implications for developing the quality of life in disadvantaged regions in Sijunjung. Therefore, zakat is one of the instruments to change the status of disadvantaged areas to be equivalent to other areas.

Grape Seeds Extract as Brain Food: A Review

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Souad El Gengaihi ◽  
Doha H. Abou Baker
Keyword(s):  
Antioxidant Activities ◽  
Complex Mixture ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Amyloid Peptide ◽  
Grape Seeds ◽  
Potential Benefits ◽  
Reduced Risk

Interest in the biological role of bioactive compounds present in medicinal herbs has increased over the last years. Of particular interest are plants that have an anti-Alzheimer activities. Several plants can be useful for Alzheimer (AD) management. Such as these which have anti-inflammatory activity, acetylcholinesterase (AChE) inhibitory action, antiapoptotic, slow the aggregation of amyloid peptide and antioxidant activities. Grape seed extract (GSE) is a complex mixture of several compounds, mostly represented by polyphenols and flavonoids. Their consumption is safe and is recognized to exert several health benefits. GS flavonoids have been associated with the reduced risk of chronic diseases, we present some findings on the potential benefits of GSE for the treatment of AD.

SUBLINGUAL VITAMIN D3 DRUG THERAPY IN VITAMIN D DEFICIENCY PATIENTS AT PRAVARA RURAL HOSPITAL

2019 ◽  
pp. 18-20
Author(s):  
Sanjeeva Kumar Goud T ◽  
Rahul Kunkulol
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Significant Difference ◽  
Before And After

The present study was aimed to study the effect of Sublingual Vitamin D3 on Serum Vitamin D level in Vitamin D deficiency patients. This was a cross-sectional and interventional study. All the Vitamin D deficiency patients of age 18-60years and either gender, willing to participate in the study were included. Patients who had greater than 20 ng/ml were excluded from the study. The total number of participants in our study was 200, out of these 111 males and 89 females, the mean age in our study was 51.07 ± 7.39Yrs. All volunteers were given sublingual vitamin D3 (60,000IU) in six doses every fifteen days of follow up for 3 months. The subject’s serum 25(OH)D levels were estimated before and after the treatment of sublingual vitamin D3. There was a statistically significant difference in serum vitamin D3 level before 16.61±6.71 ng/ml and after 35.80±7.80 ng/ml after treatment with Sublingual Vitamin D3. Six doses of 60,000IU of Vitamin D3 sublingual route having improved the role of serum 25(OH)D levels in the treatment of Vitamin D3 deficiency patients.Keywords: Vitamin D3; Sublingual route

Arthroscopy in Arthrosis: Is It Worth it? A case Presentation

2018 ◽  
Vol 69 (8) ◽  
pp. 2232-2235
Author(s):  
Marius Moga ◽  
Mark Edward Pogarasteanu ◽  
Antoine Edu
Keyword(s):  
Clinical Status ◽  
Loose Body ◽  
Point Of View ◽  
The Other ◽  
Joint Range Of Motion ◽  
Objective Evidence ◽  
Before And After ◽  
Total Knee ◽  
Joint Range

The role of arthroscopy in incipient and mild arthrosis, even combined with proximal tibial ostetomy, is well known and well documented. On the other hand, its role in the treatment of advanced arthrosis of the large joints, especially the knee, is a subject of controversy. The proponents of the use of arthroscopy in advanced arthrosis claim that meniscectomy, synovectomy, ostophytectomy, chondral lesion stabilization, arthroscopic release, plica and loose body removal greatly improve the quality of life for most patients, especially if followed by the use of viscoelastic injection, by diminishing pain and improving joint range of motion. The opponents claim that, even though the advantages are clear in the cases that refuse arthroplasty, in all the other cases the surgical indication should be total knee arthroplasty, as the clinical relief is temporary, but with all the risks of a surgical intervention. We have conducted an overview of the recent literature, in order to find objective evidence to sustain either point of view. We focused on articles published that included an objective measurement of before and after clinical status through clinical scores and objective measurements. We also focused on the follow-up period and on the evolution of the pathology after arthroscopy.

Study of Possible Relation between Fasting Plasma Glucagon, Gestational Diabetes and Development of Type 2 DM

2020 ◽  
Vol 16 (2) ◽  
pp. 148-155 ◽  
Author(s):  
Ashraf Okba ◽  
Salwa Seddik Hosny ◽  
Alyaa Elsherbeny ◽  
Manal Mohsin Kamal
Keyword(s):  
Gestational Diabetes ◽  
Pregnant Women ◽  
Post Partum ◽  
Plasma Glucagon ◽  
Type 2 Dm ◽  
Fasting Plasma ◽  
Before And After ◽  
Two Phases

Background and Aims: Women who develop GDM (gestational diabetes mellitus) have a relative insulin secretion deficiency, the severity of which may be predictive for later development of diabetes. This study aimed to investigate the role of fasting plasma glucagon in the prediction of later development of diabetes in pregnant women with GDM. Materials and Methods: The study was conducted on 150 pregnant women with GDM after giving informed oral and written consents and being approved by the research ethical committee according to the declaration of Helsinki. The study was conducted in two phases, first phase during pregnancy and the second one was 6 months post-partum, as we measured fasting plasma glucagon before and after delivery together with fasting and 2 hour post-prandial plasma sugar. Results: Our findings suggested that glucagon levels significantly increased after delivery in the majority 14/25 (56%) of GDM women who developed type 2 DM within 6 months after delivery compared to 6/20 (30%) patients with impaired fasting plasma glucose (IFG) and only 22/105 (20%) non DM women, as the median glucagon levels were 80,76, 55, respectively. Also, there was a high statistical difference between fasting plasma glucagon post-delivery among diabetic and non-diabetic women (p ≤ 0.001). These results indicated the useful role of assessing fasting plasma glucagon before and after delivery in patients with GDM to predict the possibility of type 2 DM. Conclusion: There is a relatively high glucagon level in GDM patients, which is a significant pathogenic factor in the incidence of subsequent diabetes in women with a history of GDM. This could be important in the design of follow-up programs for women with previous GDM.

A Review on Ethnobotanical, Phytochemical, Pharmacological and Traditional Aspects of Indigenous Indian Herb Trachyspermum ammi (L)

2020 ◽  
Vol 6 (3) ◽  
pp. 172-187 ◽  
Author(s):  
Nikita Saraswat ◽  
Neetu Sachan ◽  
Phool Chandra
Keyword(s):  
Chemical Constituents ◽  
Collective Data ◽  
Trachyspermum Ammi ◽  
Present Information ◽  
Gastrointestinal Problems ◽  
Vedic Literature ◽  
Key Terms ◽  
Phytochemical Studies ◽  
Near Future

Introduction and Ethnopharmacological relevance: In the Indian Vedic literature, Charakasamhita and Sushritasamhita, the Ajwain is known as Bhootika and in the charaksamhita commentaries, it is termed as Yavanika. The medicinal role of Ajwain fruit is claimed to be very important in the treatment of many ailments in humans. The plant Trachyspermum ammi Linn. is a grassy, aromatic annual plant, which falls in the family Umbelliferae. This plant is grown in India, Iran, Pakistan, Egypt, etc. for its medicinal benefits. Tribals of India use it for the treatment of diarrhea, arthritis, colic and gastrointestinal problems. In the traditional preparations, Indian Vaidya guru’s (Ayurveda Guru’s), the ajwain extract is used as “Admoda Arka”. The Ayurveda doctors, hakims and Vaidya gurus recommend ajwain for treating headaches, cold, flu and even during painful menstrual periods. Aim of the Study: The review paper has compiled the researches conducted on Trachyspermum ammi, which will help in presenting a collective data of the authentic researches conducted on the plant worldwide. It will also present information about the phytoconstituents which can be useful for building up new researches in near future. Materials and Methods: This paper has been prepared by collecting all the information available on the following platforms and the papers were searched from 1975 to 2019. The databases and electronic journals were well searched including Wiley, Springer link, Google Scholar, Science Direct, Pubmed. The key terms used for the search were Ajwain, C. copticum, Trachyspermum ammi and other synonyms of the plant. The search was also done by the names of chemical constituents present in the plant and the pharmacological effect of the plant. Results: The multiple uses of T. ammi are due to the active constituents present in it. As per the phytochemical studies on the fruits of T. ammi, the presence of various phytoconstituents has been found such as saponins, flavonoids, alkaloids, glycosides, fixed oils, thymenes, cumenes, tannins, amino acids, p-cymene, c-terpinene, steroids, etc. Conclusions: This paper is focused on presenting a detailed review on the literature, pharmacological properties, physicochemical studies and the newest researches on the plant. In this paper, we have also compiled the traditional uses of the herb used by Indian peopleon recommendations from their Hakims, Vaidya and use of the herbs by many tribes all across India and Pakistan.

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