scholarly journals A Review on Pharmacological Properties and Laboratory Outcomes of Flaxseed Diet (Linum usitatissimum)

2021 ◽  
Vol 70 (1) ◽  
Author(s):  
Kanda Bala Bhavana ◽  
A. Narendra Babu ◽  
J. Naga Lakshmi ◽  
B. Deepthi ◽  
G. Kavya
Keyword(s):  
Linolenic Acid ◽  
Linum Usitatissimum ◽  
Cyclic Peptides ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Soluble Fiber ◽  
Comprehensive Overview ◽  
Therapeutic Benefits ◽  
High Quality Protein ◽  
Prevention And Cure

The current review aimed to provide a comprehensive overview of Bioactive compounds and pharmacological uses, of Linum usitatissimum, and to list its significant therapeutic benefits. From various studies, researchers specified the pharmacological properties of flaxseed. The phytoconstituents like lignan and ? linolenic acid are the richest of flaxseeds. It is also a chief source for soluble fiber, high-quality protein, and antioxidants. Its long trip from old era to the 21st century from being a medication in old age opened the way for a broad populace. Linolenic acid, linoleic acid, lignans, polysaccharides cyclic peptides, alkaloids, cadmium and cyanogenic glycosides were some of the biologically active chemicals and elements. Flaxseed extracts containing lignan or ? linolenic acid were often the focus of biological and clinical research. Some beneficial outcomes for health include decreasing cardiovascular illnesses, atherosclerosis, diabetes, cancer and arthritis, osteoporosis, and autoimmune illnesses, as well as neuroscience. Some Proteins present in flaxseed helps in prevention and cure for cardiovascular disease and reinforce the immune system. This present review focuses briefly on a pharmacological properties and laboratory outcomes of flaxseed diet.

scholarly journals Plant-and Animal-Based Protein Sources for Nutritional Boost of Deep-Fried Dough

2021 ◽  
Vol 5 ◽  
Author(s):  
Ndamulelo Mudau ◽  
Khuthadzo Ramavhoya ◽  
Oluwatoyin O. Onipe ◽  
Afam I. O. Jideani
Keyword(s):  
Linoleic Acid ◽  
Physicochemical Properties ◽  
Linolenic Acid ◽  
Linum Usitatissimum ◽  
Food Production ◽  
Good Choice ◽  
Biologically Active ◽  
Current Interest ◽  
Protein Sources ◽  
Chicken Eggs

Flaxseed (Linum usitatissimum L.) is an oilseed that is used in both industry and food production. Flaxseed contains biologically active compounds including linolenic acid, linoleic acid, and lignans. Flaxseed powder (2.5–10% w/w) and chicken eggs (10–30% v/w) were substituted in cake wheat flour for fried dough (magwinya) production. The physicochemical properties of the fried dough were determined and compared with the control. There was a significant (p < 0.05) increase in moisture, protein, ash, and hardness and a decrease in fat content of fried dough enriched with egg (FDE) and flaxseed powder (FDFX). Enrichment with 30% (v/w) egg and/or 7.5–10% flaxseed powder resulted in higher protein, oil reduction, and ash contents compared with the rest of the products. With the current interest in plant-based protein, flaxseed is a good choice of flour-based snacks for consumers without compromise in nutrition.

Asperugo Procumbens: a Review of Botany, Traditional Uses, Phytochemistry and Pharmacology

2021 ◽  
Vol 15 (10) ◽  
pp. 3092-3095
Author(s):  
Grzegorz Łazarski
Keyword(s):  
Fatty Acids ◽  
Traditional Medicine ◽  
Linolenic Acid ◽  
Pharmacological Study ◽  
Stearidonic Acid ◽  
Pharmacological Properties ◽  
Omega 3 ◽  
Comprehensive Overview ◽  
Traditional Uses ◽  
Wide Range

Asperugo procumbens is a medicinal plant widely distributed in the world, which is commonly used in the traditional medicine of the Middle East, while currently overlooked in European pharmacopoeias. The aim of the study is to present a comprehensive overview of A. procumbens in botany, traditional medicine, phytochemistry and pharmacology according to the up-to-date data. Scientific literature on the species was collected based on publicly available databases such as: PubMed, Web of Science, Scopus, Google, Google Scholar as well as monographs and PhD theses. In traditional medicine the aerial part of A. procumbens is used for treatment of skin infections, herpes, liver and respiratory tract diseases, to strengthen the heart and the nervous system, and others. Contemporary studies on the pharmacological activity of A. procumbens revealed that it exhibits a wide range of pharmacological properties, including antioxidant, antidepressant, sedative-hypnotic, antibacterial, as well as chemopreventive and antihypertensive properties. Despite many proven medicinal properties, the species does not have a developed phytochemical profile and its chemical composition is very poorly understood. The species is known to contain tannins, flavonoids and phenolics. Only the content of fatty acids is recognised in detail. The species is a good source of omega-3 fatty acids – stearidonic acid (SDA), α-linolenic acid (ALA), and omega-6 fatty acid – γ-linolenic acid (GLA). This article, based on the available literature, highlights the traditional uses, phytochemistry and pharmacological properties of A. procumbens, which may provide a foundation for further pharmacological study as well as clinical application of the species. Keywords: Asperugo procumbens, German madwort, Boraginaceae, traditional uses

scholarly journals Biologically Active Orbitides from the Euphorbiaceae Family

Planta Medica ◽  
2017 ◽  
Vol 84 (09/10) ◽  
pp. 558-567 ◽  
Author(s):  
Suelem Ramalho ◽  
Meri Pinto ◽  
Douglas Ferreira ◽  
Vanderlan Bolzani
Keyword(s):  
Amino Acid ◽  
Secondary Metabolites ◽  
Cyclic Peptides ◽  
Biological Activities ◽  
Biologically Active ◽  
Comprehensive Overview ◽  
Family Based ◽  
Drug Leads ◽  
Different Sources ◽  
Important Progress

AbstractA comprehensive overview of natural orbitides isolated from Euphorbiaceae species and their most relevant biological activities are presented. Euphorbiaceae is a large and diverse family, which comprises about 300 genera, and is known as an important source of medicines and toxins. Several classes of secondary metabolites have been described for this taxon, however, orbitides have been broadly reported in Jatropha and Croton genera. Additionally, the latex is documented as the main source of orbitides in this family. Based on their structural and functional diversity, orbitides present a large variety of biological activities described as cytotoxicity, antimalarial, antibacterial, antifungal, enzymatic inhibition, and immunosuppressive, although the mechanism of action still needs to be further investigated. In recent years, the discovery of bioactive cyclic peptides from different sources has grown exponentially, making them promising molecules in the search for new drug leads. This review also highlights the attempts made by many researchers to organize the orbitides nomenclature and amino acid numbering, as well the important progress recently achieved in the biosynthetic study area.

ASSESSMENT OF TOXICITY OF GERMANIUM COORDINATION COMPOUNDS

2019 ◽  
pp. 16-21
Author(s):  
A. V. Kadomtsevа ◽  
I. V. Zhdanovich ◽  
M. S. Piskunovа ◽  
A. N. Lineva ◽  
A. N. Novikova ◽  
...  
Keyword(s):  
Coordination Compounds ◽  
Organometallic Compounds ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Toxicological Studies ◽  
Methods Of Synthesis ◽  
Promising Area

The synthesis of biologically active coordination compounds and the design on their basis of effective pharmacological preparations is currently the promising area. This paper presents the results of the toxicological studies on digermanium and its complex derivatives. It should be noted that the positive medical properties of organometallic compounds of germanium are confirmed by numerous studies, therefore, the development of the methods of synthesis, as well as investigations of physicochemical and pharmacological properties of these compounds are at the center of attention.

Biologically Active 2,5-Disubstituted-1,3,4-Oxadiazoles

2009 ◽  
Vol 2 (1) ◽  
pp. 390-406
Author(s):  
Harish Rajak ◽  
Murli Dhar Kharya ◽  
Pradeep Mishra
Keyword(s):  
Heterocyclic Compounds ◽  
Medical Literature ◽  
Biological Activities ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Clinical Use ◽  
Synthetic Drugs ◽  
Physiologic Activity ◽  
Pharmacologically Active

There are vast numbers of pharmacologically active heterocyclic compounds in regular clinical use. The presence of heterocyclic structures in diverse types of compounds is strongly indicative of the profound effects such structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic drugs. The 1,3,4-oxadiazole nucleus has emerged as one of the potential pharmacophore responsible for diverse pharmacological properties. Medical Literature is flooded with reports of a variety of biological activities of 2,5-Disubstituted-1,3,4-oxadiazoles. The present work is an attempt to summarize and enlist the various reports published on biologically active 2,5-disubstituted-1,3,4-oxadiazoles.

A Comprehensive Review on Pharmacology and Toxicology of Bioactive Compounds of Lagerstroemia Speciosa (L.) Pers.

2020 ◽  
Vol 06 ◽  
Author(s):  
Surya Kant Tripathi ◽  
Sunayna Behera ◽  
Munmun Panda ◽  
Gokhan Zengin ◽  
Bijesh K. Biswal
Keyword(s):  
Molecular Mechanisms ◽  
Biological Activities ◽  
Health Benefit ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Lagerstroemia Speciosa ◽  
Novel Drugs ◽  
Corosolic Acid ◽  
Current Article ◽  
Preclinical And Clinical Studies

Background: Lagerstroemia speciosa (L.) Pers is one of the most valuable plants due to its ornamental and pharmacological relevance. It is known for its anti-diabetic activity with proved potent blood sugar-lowering activity. The anti-diabetic activity is due to presence of its biologically active component corosolic acid. Moreover, L. speciosa and its novel purified compounds are also well-known for its several biological activities with beneficial health benefit on the human being. Objectives: This review provides a summary of pharmacokinetics, toxicity, and pharmacological properties of L. speciosa and its purified phytochemicals which may help researchers for building up new researches in near future. Methods: The current article is prepared by collecting through various online and offline databases. Preliminary source of study and data collection for outlining the review was research articles and reviews that have been already published by many reputed publishers, including Springer, Elsevier, Taylor & Francis imprints, BMC, Willy, The Norwegian Academy of Science and Letters, Environmental health prospective (EHP), and PLOS One. Result: The available studies results suggested that the L. speciosa and its phytochemicals showed antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiviral, anti-obesity, and cardio-protective activities. Pharmacokinetic stud-ies suggested the low bioavailability of its purified compounds. However, nano-encapsulation can improve the bioavaila-bility related issue and effectively potentiate the medicinal properties of its constituents. Conclusion: Considering the worthy pharmacological properties, L. speciosa is considered as a potent source of several novel drugs. Though, still preclinical and clinical studies are needed to reveal the targets, molecular mechanisms, bioavail-ability, and toxicity of its constituents.

scholarly journals Green synthesis of silver nanoparticles: Characterization and its potential biomedical applications

2021 ◽  
Vol 10 (1) ◽  
pp. 412-420
Author(s):  
Mona S. Alwhibi ◽  
Dina A. Soliman ◽  
Manal A. Awad ◽  
Asma B. Alangery ◽  
Horiah Al Dehaish ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Aloe Vera ◽  
Inhibition Zone ◽  
Biologically Active ◽  
Noble Metal Nanoparticles ◽  
Biological Synthesis ◽  
Ag Nps ◽  
Mouse Melanoma ◽  
Therapeutic Benefits ◽  
Vis Spectroscopy

Abstract In recent times, research on the synthesis of noble metal nanoparticles (NPs) has developed rapidly and attracted considerable attention. The use of plant extracts is the preferred mode for the biological synthesis of NPs due to the presence of biologically active constituents. Aloe vera is a plant endowed with therapeutic benefits especially in skincare due to its unique curative properties. The present study focused on an environmental friendly and rapid method of phytosynthesis of silver nanoparticles (Ag-NPs) using A. vera gel extract as a reductant. The synthesized Ag-NPs were characterized by transmission electron microscopy (TEM), UV-Vis spectroscopy, Fourier transform infrared (FTIR), and dynamic light scattering (DLS). TEM micrographs showed spherical-shaped synthesized Ag-NPs with a diameter of 50–100 nm. The UV-Vis spectrum displayed a broad absorption peak of surface plasmon resonance (SPR) at 450 nm. The mean size and size distribution of the formed Ag-NPs were investigated using the DLS technique. Antibacterial studies revealed zones of inhibition by Ag-NPs of A. vera (9 and 7 mm) against Pseudomonas aeruginosa and Escherichia coli, respectively. Furthermore, the antifungal activity was screened, based on the diameter of the growth inhibition zone using the synthesized Ag-NPs for different fungal strains. Anticancer activity of the synthesized Ag-NPs against the mouse melanoma F10B16 cell line revealed 100% inhibition with Ag-NPs at a concentration of 100 µg mL−1. The phytosynthesized Ag-NPs demonstrated a marked antimicrobial activity and also exhibited a potent cytotoxic effect against mouse melanoma F10B16 cells. The key findings of this study indicate that synthesized Ag-NPs exhibit profound therapeutic activity and could be potentially ideal alternatives in medicinal applications.

scholarly journals Isolation, Structure Elucidation, and Biological Activity of a New Alkaloid from Zanthoxylum rhetsa

2011 ◽  
Vol 6 (11) ◽  
pp. 1934578X1100601
Author(s):  
Karsten Krohn ◽  
Stephan Cludius-Brandt ◽  
Barbara Schulz ◽  
Mambatta Sreelekha ◽  
Pottachola Mohamed Shafi
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Medicinal Plant ◽  
Plant Extract ◽  
Structure Elucidation ◽  
Biologically Active ◽  
Reduction Product ◽  
Pharmacological Properties ◽  
Evergreen Tree

Several biologically active alkaloids (1-4, 6), including a new quinazoline-6-carboxylic acid (1), were isolated from the medicinal plant Zanthoxylum rhetsa, an evergreen tree, native to subtropical areas. Whereas the pharmacological properties of the plant extract and single constituents have been widely tested, we now show that all of the metabolites have antialgal activities, all but 6 are antibacterial, and 6 and the reduction product 5 (derived from 4) are also antifungal.

scholarly journals Betanin: a promising molecule for biomedical applications

2020 ◽  
Vol 10 (3) ◽  
pp. 5392-5399
Keyword(s):  
Positive Impact ◽  
Pharmaceutical Products ◽  
Free Radical Scavenger ◽  
Biologically Active ◽  
New Drugs ◽  
Radical Scavenger ◽  
Therapeutic Effects ◽  
Pharmacological Properties ◽  
Natural Colorant ◽  
Anti Oxidant

Plants with medicinal properties possess beneficial influences on health and disease. Different plant parts and extracts carry valuable active ingredients with pharmacological properties that lead to developing new drugs. Terminalia bellirica is among those plants that have been formulated as pharmaceutical products. This is attributed to its biologically active phenolics and tannins exhibiting analgesic, anti-hypertensive, anti-microbial, anti-diabetic, anti-oxidant, as well as, other pharmacological properties. Beetroot has been shown to be rich in nitrates with a positive impact on the cardiovascular system. Beetroot contains a number of useful ingredients as the free-radical scavenger ascorbic acid, the anti-inflammatory flavonoids and the anti-oxidant carotenoids. Moreover, beetroot is rich in the natural colorant betalains that are further classified into betacyanins and betaxanthins. Betanin, is one of the major constituents of beetroots that have been postulated to possess significant beneficial therapeutic effects in a number of conditions and diseases. However, several studies have demonstrated the relatively poor bioavailability of betanin upon oral administration. In the current review we aim to highlight some of the latest researches dealing with the therapeutic properties of betanin in different disease conditions, the possible mechanistic pathways beyond such beneficial effects and plausible strategies capable of enhancing its stability and bioavailability.

scholarly journals Senna leaves: component composition, pharmacological properties, standardization

2021 ◽  
Vol 24 (2) ◽  
pp. 53-65
Author(s):  
Anna A. Romanyuk ◽  
Dmitry V. Moiseev
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Component Composition ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Anthracene Derivatives ◽  
The Russian Federation ◽  
The Republic ◽  
Active Substances

Objective: generalization and analysis of scientific data on the component composition, pharmacological properties and standardization of senna leaves. Materials and methods. The article provides an overview of scientific publications in the journals of the search platforms Scopus and PubMed, as well as the databases of the Russian Science Citation Index. The analysis of the range of herbal medicinal products was carried out according to the data of the State Registers of Medicines of the Republic of Belarus, the Russian Federation and the Republic of Kazakhstan using content analysis, comparison and generalization of data. Results. In addition to the laxative effect, determined by the presence of anthracene derivatives in senna leaves, the complex of their biologically active substances has antimicrobial, hypoglycemic, antioxidant, antifungal and antitumor effects. Also, the chemical composition of the plant is represented by fatty acids, triglycerides, flavonoids, macro- and microelements. The analysis of medicinal herbal preparations based on senna leaves registered in the Russian Federation, the Republic of Belarus and the Republic of Kazakhstan has been carried out. The differences in the methods of their standardization, given in the normative documentation on quality, have been revealed. The scientific experience of using the method of high performance liquid chromatography for the determination of anthracene derivatives in senna leaves is generalized. Conclusion. The complex of biologically active substances of senna leaves exhibits various pharmacological effects, which, possibly, will expand the range of combined preparations based on them. The use of a modern and selective method of high-performance liquid chromatography in the analysis of senna leaves is a very promising direction in the field of standardization of this type of medicinal plant material.

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