Modeling of the Dec 24, 2018 eruptive intrusion at Etna volcano by data of multi-disciplinary continuous deformation networks (CGPS, borehole strainmeters and tiltmeters)

2020 ◽  
Author(s):  
Marco Aloisi ◽  
Alessandro Bonaccorso ◽  
Flavio Cannavò ◽  
Gilda Currenti ◽  
Salvatore Gambino
Keyword(s):  
High Rate ◽  
Flank Eruption ◽  
Etna Volcano ◽  
Complete Model ◽  
Complementary Information ◽  
Eruptive Fissure ◽  
Continuous Deformation ◽  
Complex Process ◽  
Reliable Model ◽  
Different Types

<p>In the previous EGU 2019 we presented the different data acquired by the multi-disciplinary deformation networks during the eruption of Etna on 24 December 2018, when the volcano was suddenly penetrated by a violent dyke intrusion. An eruptive fissure opened and continued to propagate southward for more than 10 hours. The situation created the fear of possible serious consequences of feeding a lava flow even at medium-low altitudes, therefore potentially hazardous for the villages and infrastructures located there. However, the propagation stopped and lava flows finished on 25 December.</p><p>In this updated study we present the effort made to model the complex eruptive process characterized by two attempts of intrusion. We inferred a first dyke starting from the sea level depth with an increasing of its dimension in the shallower part. Successively and until the early hours of 25 December, we revealed a second attempt of intrusion characterized by a dyke with a powerful opening with respect to the first dyke but that, fortunately, did not reach the free surface. We describe how different types of continuous deformation data provide complementary information on the ongoing process allowing us to model the fast intrusive process. In particular, the high-precision borehole instruments (strainmeters and tiltmeters) provided a robust early warning; the displacement field measured by high-rate GPS allowed obtaining an early but also reliable model of the source. Finally, the integration of all the continuous data constrained a more detailed and complete model and its time evolution able to represent the complex process leading to this flank eruption.</p><p> </p>

Research on Quick Superplastic Forming for Aluminium Alloy Sheet

2012 ◽  
Vol 735 ◽  
pp. 301-306 ◽  
Author(s):  
Hai Jian Liang ◽  
Xiao Wei Wu ◽  
Yong Wang ◽  
Quan Lin Jin ◽  
Zhao Li Ma ◽  
...  
Keyword(s):  
Mass Production ◽  
Simulation Experiment ◽  
Hot Stamping ◽  
Superplastic Forming ◽  
Alloy Sheet ◽  
High Rate ◽  
Hot Forming ◽  
Forming Technology ◽  
Complex Process ◽  
Better Than

This article describes the high rate superplastic forming. The high rate superplastic forming technology is a new complex process,which integrates hot stamping and superplastic forming .It has feature of rapidity of the hot stamping and character of excellent formability of the superplastic forming.We obtained the best proportion of the hot forming and the superplastic forming through simulation experiment, and formed a car’s abonnet by applying the proportion.Compared with the high rate superplastic forming,the forming quality is better than that of hot forming. and the forming time is less than that of superplastic forming. Result shows that ,the high rate superplastic forming technology can meet the requirements for mass production.

scholarly journals Lysyl Oxidase Mechanisms to Mediate Gastrointestinal Cancer Progression

2020 ◽  
pp. 1-10
Author(s):  
Ahmadshah Farhat ◽  
Gordon A. Ferns ◽  
Korosh Ashrafi ◽  
Mohammad-Hassan Arjmand
Keyword(s):  
Cancer Progression ◽  
Extracellular Enzymes ◽  
Lysyl Oxidase ◽  
Ecm Remodeling ◽  
Complex Process ◽  
High Prevalence ◽  
Different Types ◽  
Fibrotic Diseases ◽  
Gi Cancers ◽  
Improvement In Survival

<b><i>Background:</i></b> Malignancy is a complex process resulting from different changes such as extracellular matrix (ECM) remodeling and stiffness. One of the important enzymes that contribute to ECM remodeling is lysyl oxidase (Lox) that is overexpressed in different types of human cancers. Because of the high prevalence and poor survival of gastrointestinal (GI) malignancies in this review, we discuss the association between Lox activity and the progression of GI cancers. Lox proteins are a group of extracellular enzymes that catalyzed the cross-linking of collagen and elastin, so they have important roles in the control of structure and homeostasis of ECM. Abnormal activation and expression of the Lox family of proteins lead to changes in the ECM toward increased rigidity and fibrosis. Stiffness of ECM can contribute to the pathogenesis of cancers. <b><i>Summary:</i></b> Dysregulation of Lox expression is a factor in both fibrotic diseases and cancer. ECM stiffness by Lox overactivity creates a physical barrier against intratumoral concentration of chemotherapeutic drugs and facilitates cancer inflammation, angiogenesis, and metastasis. <b><i>Key Message:</i></b> Because of the roles of Lox in GI cancers, development targeting Lox protein isotypes may be an appropriate strategy for treatment of GI cancers and improvement in survival of patients.

Modeling a multi-layered blockchain framework for digital services that governments can implement

2021 ◽  
pp. 1-13
Author(s):  
Fernando Rebollar ◽  
Rocío Aldeco-Perez ◽  
Marco A. Ramos
Keyword(s):  
Statistical Analysis ◽  
General Population ◽  
Information Security ◽  
High Rate ◽  
The Internet ◽  
Sufficient Information ◽  
Electronic Network ◽  
Digital Services ◽  
Different Types ◽  
Cryptographic Techniques

The general population increasingly uses digital services, meaning services which are delivered over the internet or an electronic network, and events such as pandemics have accelerated the need of using new digital services. Governments have also increased their number of digital services, however, these digital services still lack of sufficient information security, particularly integrity. Blockchain uses cryptographic techniques that allow decentralization and increase the integrity of the information it handles, but it still has disadvantages in terms of efficiency, making it incapable of implementing some digital services where a high rate of transactions are required. In order to increase its efficient, a multi-layer proposal based on blockchain is presented. It has four layers, where each layer specializes in a different type of information and uses properties of public blockchain and private blockchain. An statistical analysis is performed and the proposal is modeled showing that it maintains and even increases the integrity of the information while preserving the efficiency of transactions. Besides, the proposal can be flexible and adapt to different types of digital services. It also considers that voluntary nodes participate in the decentralization of information making it more secure, verifiable, transparent and reliable.

scholarly journals The genetics of amelogenesis imperfecta: a review of the literature

2005 ◽  
Vol 13 (3) ◽  
pp. 212-217 ◽  
Author(s):  
Maria Cristina Leme Godoy dos Santos ◽  
Sergio Roberto Peres Line
Keyword(s):  
Autosomal Recessive ◽  
Autosomal Dominant ◽  
Dental Enamel ◽  
Matrix Proteins ◽  
Specific Gene ◽  
Enamel Formation ◽  
Complex Process ◽  
Different Types ◽  
Kallikrein 4

A melogenesis imperfecta (AI) is a group of inherited defects of dental enamel formation that show both clinical and genetic heterogeneity. Enamel findings in AI are highly variable, ranging from deficient enamel formation to defects in the mineral and protein content. Enamel formation requires the expression of multiple genes that transcribes matrix proteins and proteinases needed to control the complex process of crystal growth and mineralization. The AI phenotypes depend on the specific gene involved, the location and type of mutation, and the corresponding putative change at the protein level. Different inheritance patterns such as X-linked, autosomal dominant and autosomal recessive types have been reported. Mutations in the amelogenin, enamelin, and kallikrein-4 genes have been demonstrated to result in different types of AI and a number of other genes critical to enamel formation have been identified and proposed as candidates for AI. The aim of this article was to present an evaluation of the literature regarding role of proteins and proteinases important to enamel formation and mutation associated with AI.

scholarly journals Number of cases of type 1 and 2 diabetes diagnosed in Amapá between 2007 and 2012

2020 ◽  
pp. 18-26
Author(s):  
Kauê de Melo Souza ◽  
Lucas Facco ◽  
Amanda Alves Fecury ◽  
Maria Helena Mendonça de Araújo ◽  
Euzébio de Oliveira ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Genetic Factors ◽  
Sedentary Lifestyle ◽  
High Rate ◽  
Main Risk Factor ◽  
Food Education ◽  
Different Types

Diabetes mellitus is a succession of different types of disorders in metabolism that are characterized by causing a high rate of blood sugar. Because it is a disease with genetic factors type 1 diabetes has as main risk factor heredity, while type 2 diabetes besides these factors, includes obesity, high blood pressure, poor food education and advancing age. This study aims to show the number of cases of type 1 and 2 diabetes diagnosed in Amapá with the variables gender, age group, sedentary lifestyle, overweight, smoking, between 2007 and 2012. The data for the research were taken from the computer department of SUS, DATASUS (http://datasus.saude.gov.br). Type 1 and 2 diabetes mellitus (DM1 and DM2) are diseases that are tied to disturbances in production or in the efficient use of insulin. Smoking, as well as sedentary lifestyle and overweight are important risk factors for the development of DM2. Type 2 diabetes mellitus provides the development of various organic nerve lesions. In addition, DM2, through its chronicity, enables the development of retinopathies, nephropathies and other conditions negative to the individual’s health.

scholarly journals Enhancement and assessment of students’ systems thinking skills by application of systemic synthesis questions in the organic chemistry course

2016 ◽  
Vol 81 (12) ◽  
pp. 1455-1471 ◽  
Author(s):  
Tamara Hrin ◽  
Dusica Milenkovic ◽  
Mirjana Segedinac ◽  
Sasa Horvat
Keyword(s):  
Organic Chemistry ◽  
Systems Thinking ◽  
Higher Order Thinking ◽  
Thinking Skills ◽  
Assessment Tools ◽  
School Students ◽  
Complex Dimension ◽  
Complex Process ◽  
Different Types ◽  
Teaching Learning

Many studies in the field of science education have emphasized the fact that systems thinking is a very important higher-order thinking skill which should be fostered during classes. However, more attention has been dedicated to the different ways of systems thinking skills assessment, and less to their enhancement. Taking this into consideration, the goal of our study was not only to validate secondary school students? systems thinking skills, but also to help students in the complex process of their development. With this goal, new instructional and assessment tools - systemic synthesis questions [SSynQs], were constructed, and an experiment with one experimental (E) and one control (C) group was conducted during organic chemistry classes. Namely, the instructional teaching/learning method for both E and C groups was the same in processing the new contents, but different on classes for the revision of the selected organic chemistry contents. The results showed that students exposed to the new instructional method (E group) achieved higher performance scores on three different types of systems thinking than students from the C group, who were taught by the traditional method. The greatest difference between the groups was found in the most complex dimension of systems thinking construct - in the II level of procedural systems thinking. Along with this dimension, structural systems thinking and I level of procedural systems thinking were also observed.

New trends in chromosomal investigation in children with cardiovascular malformations

2004 ◽  
Vol 14 (6) ◽  
pp. 622-629 ◽  
Author(s):  
Ruth Schellberg ◽  
Gesa Schwanitz ◽  
Lutz Grävinghoff ◽  
Rolf Kallenberg ◽  
Detlef Trost ◽  
...  
Keyword(s):  
Chromosomal Aberrations ◽  
In Situ Hybridisation ◽  
High Rate ◽  
Diagnostic Approach ◽  
Fluorescence In Situ Hybridisation ◽  
Cardiovascular Malformations ◽  
Genetic Investigation ◽  
Different Types ◽  
Cardiovascular Defects

We investigated a group of 376 children, seen over a period of 7 years with different types of congenital cardiovascular defects, to assess the presence of chromosomal aberrations. The diagnostic approach, achieved in 3 consecutive steps, revealed conventional chromosomal aberrations in 30 of the patients (8%) excluding trisomies 13, 18, 21. Fluorescence in situ hybridisation for microdeletions showed 51 microdeletions (15%), with 43 patients having deletions of 22q11.2, 7 patients with deletion of 7q11.23, and 1 patient with deletion of 4p16.3. In 23 patients with additional clinical abnormalities, we carried out a subtelomeric screening. This revealed, in two cases (9%), different subtelomeric aberrations, namely deletions of 1p and of 1q. Thus, subtelomeric screening proved to be a very valuable as a new diagnostic approach. Our approach to genetic investigation in three phases makes it possible to detect a high rate of pathologic karyotypes in patients with congenital cardiovascular malformations, thus guaranteeing more effective genetic counselling of the families, and a more precise prognosis for the patient.

The Birth and Death of a Neuron

The Neuron ◽  
2015 ◽  
pp. 329-352
Author(s):  
Irwin B. Levitan ◽  
Leonard K. Kaczmarek
Keyword(s):  
Nervous System ◽  
Transcription Factors ◽  
Bone Morphogenetic Proteins ◽  
Mitochondrial Membrane ◽  
Brain Regions ◽  
High Rate ◽  
Outer Mitochondrial Membrane ◽  
Programmed Death ◽  
Different Types ◽  
Specific Neuron

The development of the nervous system requires the participation of a variety of factors that influence neuronal determination, proliferation, migration, and differentiation. The earliest steps in the formation of a neuron involve the actions of factors such as the bone morphogenetic proteins and neural inducers. Acting on cells that still have the potential to develop into many different types of cells, these factors control the synthesis of transcription factors and determine whether the complement of genes that becomes activated corresponds to those required for building a neuron. The birth of new neurons occurs at a high rate early in development, but in some brain regions persists in adults. The normal formation of the nervous system also requires the programmed death of many neurons. Decisions as to whether a specific neuron survives or perishes during development are made by factors that control the permeability of the outer mitochondrial membrane.

scholarly journals A novel nerve transection and repair method in mice: histomorphometric analysis of nerves, blood vessels, and muscles with functional recovery

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jung Il Lee ◽  
Anagha A. Gurjar ◽  
M. A. Hassan Talukder ◽  
Andrew Rodenhouse ◽  
Kristen Manto ◽  
...  
Keyword(s):  
Muscle Atrophy ◽  
Functional Recovery ◽  
Functional Outcomes ◽  
Nerve Transection ◽  
Histomorphometric Analysis ◽  
Sciatic Nerve Transection ◽  
Functional Deficit ◽  
Reliable Model ◽  
Different Types ◽  
Branching Index

AbstractPeripheral nerve transection is associated with permanent functional deficit even after advanced microsurgical repair. While it is difficult to investigate the reasons of poor functional outcomes of microsurgical repairs in humans, we developed a novel pre-clinical nerve transection method that allows reliable evaluation of nerve regeneration, neural angiogenesis, muscle atrophy, and functional recovery. Adult male C57BL/6 mice were randomly assigned to four different types of sciatic nerve transection: Simple Transection (ST), Simple Transection & Glue (TG), Stepwise Transection and Sutures (SU), and Stepwise Transection and Glue (STG). Mice were followed for 28 days for sciatic function index (SFI), and sciatic nerves and hind limb muscles were harvested for histomorphological and cellular analyses. Immunohistochemistry revealed more directional nerve fiber growth in SU and STG groups compared with ST and TG groups. Compared to ST and TG groups, optimal neural vessel density and branching index in SU and STG groups were associated with significantly decreased muscle atrophy, increased myofiber diameter, and improved SFI. In conclusion, our novel STG method represents an easily reproducible and reliable model with close resemblance to the pathophysiological characteristics of SU model, and this can be easily reproduced by any lab.

scholarly journals Micropropagation’s Complete Protocol of Red Araçá (Psidium cattleianum, Myrtaceae) from Germinated Seeds in vitro

2018 ◽  
Vol 10 (2) ◽  
pp. 234
Author(s):  
Cassio G. Freire ◽  
João P. P. Gardin ◽  
Cesar M. Baratto ◽  
Renato L. Vieira ◽  
Simone S. Werner
Keyword(s):  
Food Production ◽  
High Rate ◽  
Nodal Segments ◽  
Ms Medium ◽  
Brazilian Atlantic Forest ◽  
Psidium Cattleianum ◽  
Different Types ◽  
In Vitro Establishment ◽  
Germinated Seeds

Red Araçá’s (Psidium cattleianum) micropropagation processes have shown enormous potential both in terms of research and as a sustainable native resource to be used in the areas of food production, ecology, and pharmacology. Currently, however, despite that potential, research efforts involving this myrtaceae, native to the Brazilian Atlantic Forest, have been scarce. With that in mind, this study set out to establish micropropagation techniques that would allow the development of a feasible protocol to be used with Red Araçá, achieving its mircropropagation from in vitro germinated seeds. Different types of explants were tested for in vitro establishment. For the multiplication of nodal segments, different concentrations of BAP and IAA combinations were tested in an MS medium. Using the same medium, different concentrations of ampicillin were applied in order to determine its influence on the decontamination of the apical segments. The BAP and IAA combinations were also used to test their effects on the in vitro explants’ development and rooting. During pre-acclimatization, survival of in vitro rooted plants was tested in a nebulizer chamber, using a commercial substrate and that same substrate mixed with washed sand (1:1). In essence, it was indeed possible to develop a complete protocol for the micropropagation of the Red Araçá from seedlings obtained by in vitro germination. The in vitro introduction of the Red Araçá was rather efficient, independently of the type of explants used. As the BAP and IAA concentrations increased, so did the in vitro seedlings’ development (7 leaves explant-1) and rooting (67%). Additionally, the in vitro rooted plants exhibited a high rate of survival (80%) in the pre-acclimatization phase, independently of the substrate used.

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