Factors affecting the durability of flexible ureteroscopes: An academic center review

Objective: To analyze the factors which affect the durability of the flexible ureteroscope and the causes of scope damage in a single academic center. Material and Method: Between March 2014 and August 2017, 479 flexible ureteroscopic procedures, using 6 flexible ureteroscopes (Olympus model URF-V), were systematically reviewed. Data including indication for procedures, auxiliary device usage, the characteristics of scope damage, and the number of times a scope was used before requiring major repair were gathered. Fisher exact test and Chi-square test were used to evaluate the factors which caused the damage. Results: The major flexible ureteroscopic procedure performed was treatment of renal calculi (81%). The most common auxiliary device used was the Holmium laser (70%). The most common cause of damage requiring repair was working channel leakage (93%). The factor that affected the durability of flexible ureteroscopes was the size of laser fiber. Utilizing laser fiber 200 nm decreased scope damage significantly compared to various other sizes (p-value=0.002 and p-value<0.001). However, the usage of nitinol basket and ureteral access sheath did not affect the durability of flexible ureteroscopes. Conclusion: Large laser fibers are a risk factor for flexible ureteroscope damage. Utilizing small laser fibers during flexible ureteroscopy can decrease scope damage significantly.

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Kesediaan Vaksinasi HPV pada Remaja Putri Ditinjau dari Faktor Orang Tua

Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery) ◽

10.26699/jnk.v7i2.art.p213-222 ◽

2020 ◽

Vol 7 (2) ◽

pp. 213-222

Author(s):

Nonik Ayu Wantini ◽

Novi Indrayani

Keyword(s):

Adolescent Girls ◽

Emotional Support ◽

Parental Support ◽

Hpv Vaccination ◽

Information Support ◽

Bivariate Analysis ◽

P Value ◽

Fisher Exact Test ◽

Chi Square ◽

Cross Sectional

Infeksi HPV dan pre kanker serviks (sel-sel abnormal pada leher rahim yang dapat menyebabkan kanker) telah menurun secara signifikan sejak vaksin HPV digunakan.Cakupan vaksinasi HPV masih rendah di Indonesia.Orang tua adalah pemegang tanggung jawab dan kewajiban utama di dalam penjaminan pemenuhan hak dasar anak untuk mendapatkan vaksinasi. Tujuan penelitian adalah untuk mengetahui faktor yang berhubungan (sikap, kepercayaan, dukungan orang tua) dengan kesediaan vaksinasi pada remaja putri. Jenis penelitian adalah survey analitik dengan pendekatan cross sectional. Penelitian dilaksanakan di SD Muhammadiyah Macanan, Ngemplak dan SMPN 1 Berbah, Sleman pada Mei-Juli 2019. Jumlah sampel 127 remaja putri beserta orang tuanya dipilih dengan accidental sampling. Instrumen kuesioner dan telah dilakukan uji validitas. Analisis bivariat dengan uji chi square (dukungan instrumen, emosional, kepercayaan orang tua) dan uji fisher exact (dukungan informasi dan sikap). Hasil penelitian menunjukkan 92,9% orang tua tidak memberikan dukungan informasi, 85% tidak memberikan dukungan instrumen, 75,6% memberikan dukungan emosional kepada putrinya terkait vaksinasi. Faktor yang berhubungan dengan kesediaan vaksinasi adalah dukungan instrumen (p-value = 0,048). Faktor yang menjadi pertimbangan terbanyak orang tua untuk mengijinkan anaknya di vaksinasi adalah keamanan vaksin (81,1%). Kesimpulan: Ada hubungan dukungan instrumen orang tua dengan kesediaan vaksinasi HPV pada remaja putri. HPV infections and cervical precancers (abnormal cells on the cervix that can lead to cancer) have dropped significantly since HPV vaccine has been in use. HPV vaccination coverage is still low in Indonesia. Parents are the main responsibility and obligation in guaranteeing the fulfillment of the child's basic rights to get a vaccination. The purpose of this study was to determine the related factors (attitudes, beliefs, parental support) with the willingness to participate in HPV vaccination among adolescent girls. This type of the study was analytic survey with cross sectional approach. The study was conducted at SD Muhammadiyah Macanan, Ngemplak and SMPN 1 Berbah, Sleman in May-July 2019. The sample was 127 adolescent girl and their parents selected by accidental sampling. The instrument used questionnaire and already undergone validity test. The bivariate analysis used chi square test (instrument and emotional support, parental trust) and fisher exact test (information support and attitude). The results showed 92.9% of parents did not provide information support, 85% did not provide instrument support, 75.6% provided emotional support to their daughters related to vaccination. Factors related to the willingness of vaccinations were instrument support (p-value = 0.048). The factor that was considered by most parents to allow their children to be vaccinated was vaccine safety (81.1%). Conclusion: There was a correlation between parental instrument support and HPV vaccination willingness of adolescent girls.

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The effect of Gokshura Churna over Tilanalakshara Yoga in the management of Mutrashmari - A Randomized Comparative Clinical Study

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.v3i5.13811 ◽

2018 ◽

Vol 3 (5) ◽

Author(s):

Dr. Anil M. Sanshi ◽

Dr.Pallavi A. Hegde

Keyword(s):

Abdominal Pain ◽

Renal Calculi ◽

Renal Calculus ◽

P Value ◽

Standard Group ◽

Standard Drug ◽

Female Ratio ◽

Comparative Clinical Study ◽

Group B ◽

Trial Drug

Background: Mutrashmari is a stone like structure anywhere in the Mutravaha Srothas which can be compared with renal calculi and one among the Astamahagada, clinical features as renal angle pain, haematuria, pyuria and dysuria. Peak age is 3rd to 5th decade while majority of patients report regarding onset of disease in 2nd decade of life and male to female ratio is 3:1. Objectives: To compare the effect of Gokshura Churna over Tilanalakshara Yoga in the management of Mutrashmari with special reference to Renal calculi. Materials and Methods: 30 patients were selected on the basis of inclusion criteria and divided into 2 groups with 15 patients in each group by chit method. Group A was treated with standard drug Tilanalakshara Yoga and Group B was traeted with trial drug Gokshura Churna. Results: It was found that standard group reduced the abdominal pain by 85.1%, dysuria by 89.4%, renal angle tenderness 88.4%, haematuria 100%, pyuria 100%, size of renal calculus 41.9% by 21st day of treatment. In study group it was observed that abdominal pain reduced by 92%, dysuria 96.1%, renal angle tenderness 91.6%, haematuria 100%, pyuria 100% and size of renal calculus 48.5% by 21st day of treatment. Conclusion: This assessment showed Gokshura Churna had significant result over Tilanala Kshara Yoga in both subjective and objective parameters with P value less than 0.0001.

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1412. The utility of respiratory viral panel testing for nosocomial fever in the neonatal intensive care unit

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa439.1594 ◽

2020 ◽

Vol 7 (Supplement_1) ◽

pp. S713-S713

Author(s):

Carlo Fopiano Palacios ◽

Eric Lemmon ◽

James Campbell

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Linear Regression ◽

Length Of Stay ◽

Neonatal Intensive Care Unit ◽

Neonatal Intensive Care ◽

P Value ◽

Fisher Exact Test ◽

The Mean ◽

Pcr Test

Abstract Background Patients in the neonatal intensive care unit (NICU) often develop fevers during their inpatient stay. Many neonates are empirically started on antibiotics due to their fragile clinical status. We sought to evaluate whether the respiratory viral panel (RVP) PCR test is associated with use of antibiotics in patients who develop a fever in the NICU. Methods We conducted a retrospective chart review on patients admitted to the Level 4 NICU of the University of Maryland Medical Center from November 2015 to June 2018. We included all neonates who developed a fever 48 hours into their admission. We collected demographic information and data on length of stay, fever work-up and diagnostics (including labs, cultures, RVP), and antibiotic use. Descriptive statistics, Fisher exact test, linear regression, and Welch’s ANOVA were performed. Results Among 347 fever episodes, the mean age of neonates was 72.8 ± 21.6 days, and 45.2% were female. Out of 30 total RVP samples analyzed, 2 were positive (6.7%). The most common causes of fever were post-procedural (5.7%), pneumonia (4.8%), urinary tract infection (3.5%), meningitis (2.6%), bacteremia (2.3%), or due to a viral infection (2.0%). Antibiotics were started in 208 patients (60%), while 61 neonates (17.6%) were already on antibiotics. The mean length of antibiotics was 7.5 ± 0.5 days. Neonates were more likely to get started on antibiotics if they had a negative RVP compared to those without a negative RVP (89% vs. 11%, p-value < 0.0001). Patients with a positive RVP had a decreased length of stay compared to those without a positive RVP (30.3 ± 8.7 vs. 96.8 ± 71.3, p-value 0.01). On multivariate linear regression, a positive RVP was not associated with length of stay. Conclusion Neonates with a negative respiratory viral PCR test were more likely to be started on antibiotics for fevers. Respiratory viral PCR testing can be used as a tool to promote antibiotic stewardship in the NICU. Disclosures All Authors: No reported disclosures

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Synergistic effect of genetic polymorphisms in TLR6 and TLR10 genes on the risk of pulmonary tuberculosis in a Moldavian population

Innate Immunity ◽

10.1177/17534259211029996 ◽

2021 ◽

pp. 175342592110299

Author(s):

Alexander Varzari ◽

Igor V. Deyneko ◽

Elena Tudor ◽

Harald Grallert ◽

Thomas Illig

Keyword(s):

Pulmonary Tuberculosis ◽

Interaction Analysis ◽

P Value ◽

Fisher Exact Test ◽

Snp Analysis ◽

Nucleotide Polymorphism ◽

Single Nucleotide ◽

Exact Test ◽

Pulmonary Tb ◽

The Republic

Polymorphisms in genes that control immune function and regulation may influence susceptibility to pulmonary tuberculosis (TB). In this study, 14 polymorphisms in 12 key genes involved in the immune response ( VDR, MR1, TLR1, TLR2, TLR10, SLC11A1, IL1B, IL10, IFNG, TNF, IRAK1, and FOXP3) were tested for their association with pulmonary TB in 271 patients with TB and 251 community-matched controls from the Republic of Moldova. In addition, gene–gene interactions involved in TB susceptibility were analyzed for a total of 43 genetic loci. Single nucleotide polymorphism (SNP) analysis revealed a nominal association between TNF rs1800629 and pulmonary TB (Fisher exact test P = 0.01843). In the pairwise interaction analysis, the combination of the genotypes TLR6 rs5743810 GA and TLR10 rs11096957 GT was significantly associated with an increased genetic risk of pulmonary TB (OR = 2.48, 95% CI = 1.62–3.85; Fisher exact test P value = 1.5 × 10−5, significant after Bonferroni correction). In conclusion, the TLR6 rs5743810 and TLR10 rs11096957 two-locus interaction confers a significantly higher risk for pulmonary TB; due to its high frequency in the population, this SNP combination may serve as a novel biomarker for predicting TB susceptibility.

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Abstract TP20: Longer Procedural Times Are Independently Associated with Symptomatic Intracranial Hemorrhage in Large Vessels Occlusion Stroke Patients Undergoing Thrombectomy

Stroke ◽

10.1161/str.44.suppl_1.atp20 ◽

2013 ◽

Vol 44 (suppl_1) ◽

Author(s):

Omar Kass-Hout ◽

Tareq Kass-Hout ◽

Michael R. Frankel ◽

Fadi Nahab ◽

Samir R. Belagaje ◽

...

Keyword(s):

Functional Outcomes ◽

Infarct Volume ◽

P Value ◽

Procedure Time ◽

Entire Cohort ◽

Radiographic Outcomes ◽

Academic Center ◽

Procedural Time ◽

Symptomatic Intracranial Hemorrhage

Background and Purpose: Time to reperfusion is an essential factor in determination of outcomes in (AIS). We sought to establish the effect of the procedural time on the clinical and radiographic outcomes of AIS patients undergoing intra-arterial therapy. Methods: Retrospective review of a prospectively collected database of endovascularly treated large vessel AIS in a large academic center. Data from all consecutive patients who underwent mechanical thrombectomy from September 2010 to July 2012 were analyzed. The variable of interest was procedural time (defined as time from groin puncture to end of procedure). Outcome measures included the rates of symptomatic intracebral hemorrhage (sICH, defined as any parenchymal hematoma e.g. PH-1/PH-2), final infarct volume, 90-day mortality, and independent functional outcomes (modified Rankin Scale, mRS 0-2) at 90 days. Results: The entire cohort included 242 patients with a mean age of 65.5+/- 14.2 and median baseline NIHSS 20. Of the patients 49.38% were females. The median ASPECTS score was 8. The mean procedure time was significantly shorter in patients with good outcome (86.73 vs. 73.13 respectively, P-value: 0.0228). However, after controlling for ASPECTS score, type of retrieval device, TICI score, volume of infarct, interval from symptoms onset to puncture, and co-morbidities, this association did not prove to be significant (P-value = 0.7101). Patients with SICH had significantly higher mean procedure time than patients without SICH (79.65 vs. 104.5 respectively; P-value: 0.0319) which remained significant when controlling to the previous factors (OR = 0.974 with a 95 % CI of (0.957, 0.991). There was no correlation between the volume of infarction and the procedure time (r = 0.10996, P-value: 0.0984). There was no association between procedure time and 90-day mortality (77.8 vs. 88.2 minutes in survivals vs. deaths respectively; P-value: 0.0958). Conclusion: Our data support an association between the risk of SICH and a longer procedure time while no definite association between procedural times and the final infarction volume or long-term functional outcomes was found after adjustment for multiple imbalances.

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Single-use versus reusable flexible ureteroscopes: a comprehensive cost-analysis decision model

Revista de Medicina ◽

10.11606/issn.1679-9836.v97i3p323-333 ◽

2018 ◽

Vol 97 (3) ◽

pp. 323-333

Author(s):

Giovanni Scala Marchini ◽

Fábio César Miranda Torricelli ◽

Manoj Monga ◽

Carlos Alfredo Batagello ◽

Fábio Carvalho Vicentini ◽

...

Keyword(s):

Cost Effectiveness ◽

Case Series ◽

Final Analysis ◽

Flexible Ureteroscopy ◽

Complication Rates ◽

Ureteral Access Sheath ◽

Flexible Scope ◽

Surgical Costs ◽

Single Use ◽

The Cost

Purpose: The significant improvements in flexible ureterorenoscopes have made flexible ureteroscopy the main treatment modality to target upper urinary pathologies. The purpose of this study was to critically evaluate all literature concerning the cost-effectiveness of flexible ureteroscopy comparing single-use with reusable scopes. Methods: A systematic online literature review was performed in PubMed, Embase and Google Scholar databases. Two separate urologists (GSM and FCT) performed the online search and reviewed all papers considered suitable and relevant for this analysis. Because of the paucity of high quality publications, not only prospective assessments but also case control and case series studies were included in the final analysis. All factors potentially affecting surgical costs or clinical outcomes were considered in the analysis. Results: 741 studies with the previously elected terms were found. Of those, 18 were duplicated and 77 were not related to urology procedures and were excluded. Of the remaining 646 studies, 59 published between 2000 and 2018 were considered of relevance to the pre-defined queries and were selected for further analysis. Stone free and complication rates were similar between single-use and reusable scopes. In special, urinary tract infection rate following flexible ureteroscopy is not inferior if a single-use device is used instead of a reusable scope. Operative time was in average 20% shorter if a digital scope was used, single-use or not. There is a suggestion that the learning curve is shorter with single-use devices but this is not consistent in the literature. Surgeon expertise impacts the longevity of the flexible scope. Reusable digital scopes seem to last longer than optic ones, though scope longevity is very variable worldwide. New scopes usually last three to four times more than refurbished ones and single-use ureterorenoscopes have good resilience throughout long cases. Both sterilization method and cleaning process impact scope longevity, the best results being achieved with Cidex and a dedicated nurse to take care of the sterilization process. The main factors that negatively impact device longevity regarding patient and disease are lower pole pathologies, large stone burden and non-use of a ureteral access sheath. Conclusions: The cost-effectiveness of a flexible ureteroscopy program is dependent of several aspects that must be considered when deciding whether to choose between a single-use and a reusable ureterorenoscope. Disposable devices are already a reality and will progressively become the standard as manufacturing price falls significantly.

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Analisis faktor kejadian wasting pada anak balita 12-59 bulan di Puskesmas Bulili Kota Palu: Studi cross sectional

AcTion Aceh Nutrition Journal ◽

10.30867/action.v6i2.345 ◽

2021 ◽

Vol 6 (2) ◽

pp. 111

Author(s):

Hepti Muliyati ◽

Menis Mbali ◽

Hadidja Bando ◽

Riana Pangestu Utami ◽

Opyn Mananta

Keyword(s):

Public Health ◽

Birth Weight ◽

Low Birth Weight ◽

Public Health Problem ◽

Sampling Technique ◽

P Value ◽

Fisher Exact Test ◽

Important Public Health Problem ◽

Cross Sectional ◽

Exact Test

Wasting on children is an important public health problem because of its considerable impact on their health and growth. This problem could lead to iron deficiency which could induce infection disease and probably lower a child’s intelligence as a long-term effect. This study aimed to analyze factors related to wasting on 12-59 months children in Bulili Public Health Center (PHC), Palu City. The analytical descriptive study designed with a cross-sectional approach was applied in this study. One hundred and twenty-one subject was selected from 283 children with purposive sampling technique. Data were analyzed with chi-square and Fisher exact test with significant (p < 0,05). The result showed that most children with low birth weight experienced wasting with a p-value = 0,000. Most of the children from higher-income families did not experience wasting with a p-value = 0,004. Most children who didn’t receive breastfeeding milk did not experience wasting with a p-value = 0,958. This study concluded a correlation between low birth weight and income to wasting, but breastfeeding practice was not related.

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The correlation between IL-10 expression and histopathological type in nasopharynx carcinoma patients

Oto Rhino Laryngologica Indonesiana ◽

10.32637/orli.v50i1.353 ◽

2020 ◽

Vol 50 (1) ◽

pp. 52

Author(s):

Hamita Hamita ◽

Muhtarum Yusuf ◽

Manshur Shidiq Wiyadi

Keyword(s):

Nasopharyngeal Carcinoma ◽

Polyclonal Antibody ◽

Therapy Response ◽

P Value ◽

Fisher Exact Test ◽

Type I ◽

Cross Sectional ◽

Positive Expression ◽

Rabbit Polyclonal Antibody ◽

Histopathological Type

Background: Nasopharyngeal carcinoma (NPC) is a malignancy originated from nasopharyngeal epithelial cells. NPC therapy response could be predicted from histopathological type, but some patients with the same histopathological type, showed a different therapy response. Interleukin (IL)-10 expression is expected to be able to predict a better response of therapy in NPC patients. Purpose: To find out the correlation between IL-10 expression and histopathological type in NPC patients. Method: An analytic observational study with cross sectional approach towards 33 samples taken from the Oncology Polyclinic of Outpatient Unit of Otorhinolaryngology Head and Neck Surgery Department, Dr. Soetomo General Hospital. Formalin-fixed paraffin-embedded biopsy specimens were obtained. The IL-10 expression was studied with immunohistochemistry using rabbit polyclonal antibody Anti IL-10. Assessment of the staining used Allred scale. The Fisher exact test was utilized to determine the correlation of IL-10 expression and histopathological type of NPC, with p value = 0.05. Result: The result of IL-10 expression in NPC patients with histopathological WHO type I NPC obtained 1 sample (8.3%) with strong positive expression and 2 samples (9.5%) with weak positive expression. In patients with histopathological WHO type II NPC obtained 2 samples (16.7%) with strong positive expression and 12 samples (57.1%) with weak positive expression. In patients with histopathological WHO type III NPC obtained 9 samples (75%) with strong expression and 7 samples (33.3%) with weak positive expression. Conclusion: There was moderate positive correlation between IL-10 expression and histopathological type in NPC patients.Keywords: nasopharyngeal carcinoma, IL-10 expression, histopathological type ABSTRAK Latar belakang: Karsinoma nasofaring (KNF) adalah suatu keganasan yang berasal dari epitel nasofaring. Respon terapi KNF selama ini dapat dinilai berdasarkan tipe histopatologi, namun pada kenyataannya penderita KNF dengan tipe histopatologi sama dapat menunjukkan respon terapi berbeda. Pemeriksaan ekspresi interleukin (IL)-10 diharapkan dapat memberikan prediksi lebih baik mengenai respon terapi pada penderita KNF. Tujuan: Mengetahui hubungan antara ekspresi IL-10 dengan tipe histopatologi pada penderita KNF. Metode: Penelitian observasional analitik dengan pendekatan cross sectional pada 33 sampel yang diperoleh dari Poliklinik Onkologi Unit Rawat Jalan, Departemen THTBedah Kepala Leher, RSUD Dr Soetomo. Ekspresi IL-10 diperiksa dari blok parafin dengan teknik pemulasan imunohistokimia menggunakan rabbit polyclonal antibody Anti IL-10. Ekspresi IL-10 dinilai dengan menggunakan skala Allred. Uji Fisher exact digunakan untuk menentukan korelasi antara ekspresi IL-10 dan tipe histopatologi KNF, dengan p = 0,05. Hasil: Ekspresi IL-10 pada KNF WHO tipe I didapatkan ekspresi positif kuat 1 penderita (8,3%) dan ekspresi positif lemah 2 penderita (9,5%). Hasil ekspresi IL-10 pada KNF WHO tipe II didapatkan ekspresi positif kuat 2 penderita (16,7%) dan ekspresi positif lemah 12 penderita (57,1%). Hasil ekspresi IL-10 pada KNF WHO tipe III 9 penderita (75%) dengan ekspresi positif kuat dan 7 penderita (33,3%) dengan ekspresi positif lemah. Kesimpulan: Didapatkan korelasi positif sedang antara ekspresi IL-10 dan tipe histopatologi pada penderita KNF

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Plasma miR-126 levels and its genomic polymorphism SNP rs4636297 in Type 2 diabetes

Asia Pacific Journal of Molecular Biology and Biotechnology ◽

10.35118/apjmbb.2020.028.1.03 ◽

2020 ◽

pp. 27-33

Author(s):

Monireh Rezai ◽

Shirin Shahbazi ◽

Nasrin Mansournia

Keyword(s):

Gene Expression ◽

Type 2 Diabetes ◽

Diabetic Complications ◽

Odds Ratio ◽

Software Tool ◽

Diabetic Complication ◽

P Value ◽

Fisher Exact Test ◽

Genomic Polymorphism

Since the variation of microRNAs expression has been described in type2 diabetes, we aimed to evaluate the plasma levels of miR-126 with known roles in the angiogenesis. Genomic polymorphism of miR-126 (SNP rs4636297) was also assessed as it is involved in the processing of pri-miR-126 to mature microRNA.Genotyping of the SNP rs4636297 was carried out by PCR-RFLP using HaeII enzyme. Real-time PCR assay was applied to assess miR-126 expression, which the fold change in gene expression was calculated by the Relative Expression Software Tool (REST). Data analysis was performed using exact-like logistic regression, Fisher exact test and the elrm package with the R software. Our data indicated that the group with BMI greater than 30 was at greater risk of diabetes (odds ratio=14.4, p value=0.00), compared with the BMI=19-25. The mean fold decrease in miR-126 gene expression in diabetic samples relative to normal samples was 0.653 (95% confidence interval: 0.012 - 18.765). All patients with the lowest levels of miR-126, had experienced diabetic complications. Considering the AA genotype as the reference, the odds ratio of diabetic complications for the GG and AG genotype were 1.2 and 1.43, respectively. miR-126 is one of the key factors in predisposition to diabetes and diabetic complication. Since the lowest expression of miR-126 leads to the diabetic complications it can be concluded that genetic predisposing factors should be considered in the management and treatment of Type 2 diabetes.

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Innovative Method of Using Endoscope in Postoperative Canal Wall Down Mastoid Cavity

Journal of Nepal Medical Association ◽

10.31729/jnma.3628 ◽

2018 ◽

Vol 56 (211) ◽

pp. 650-653 ◽

Cited By ~ 1

Author(s):

Meera Bista ◽

Nayan Bahadur Mahato ◽

Deepak Regmi

Keyword(s):

Study Data ◽

Mastoid Cavity ◽

P Value ◽

Fisher Exact Test ◽

Wide Field ◽

Canal Wall ◽

Cross Sectional ◽

Significant Difference ◽

Canal Wall Down ◽

Mastoid Surgery

Introduction: Poor access to the difficult areas in the middle ear and mastoid cavity is considered as the major reason for failure in mastoid surgery. Wide field visibility, visualization of nooks and corners by an endoscope could contribute to better clinical control of the disease in these patients that cannot be accessed by the operating microscope. Methods: This was a descriptive cross-sectional study, done in Kathmandu Medical College from January to June 2017. Thirty two patients were included in the study. Data collection was done by convenient sampling. Statistical analysis was done by Chi square test and Fisher Exact test, P value of <0.005 was considered statistically significant. Results: The study revealed that exposure benefit with an endoscope in canal wall down mastoid surgery was significantly better than with a microscope (P value of 0.034). The level of complete clearance and level of difficulty in cleaning with the help of a microscope compared to endoscope did not show a significant difference with P value of 0.288 and 0.652 obtained by Fisher extract test respectively. After microscopic removal of materials from the mastoid cavity, 22 (68.8%) which is more than half of cases had remaining materials in the cavity which was removed by endoscope completely. Conclusions: Outcome will make the ENT surgeons aware of use of endoscopy in post mastoid follow up cases to give better results and make the surgeon much more successful in his/her endeavor to eradicate the disease.

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