scholarly journals Anti dyslipidemic effect of Ficus Carica Fruit (Fig) on Lipid Profile of Diet Induced Hyperlipidemic Rats

2021 ◽  
Vol 15 (7) ◽  
pp. 1709-1712
Author(s):  
Fouzia Perveen ◽  
Fariha Ahmad Khan ◽  
Zoobia Irum ◽  
Amir Hassan Siddiqui ◽  
Maira Bhatti ◽  
...  
Keyword(s):  
Body Weight ◽  
Cardiovascular Diseases ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Fatal Outcome ◽  
Ficus Carica ◽  
Male Rats ◽  
High Fat ◽  
Standard Drug ◽  
Study Results

Back ground: Hyperlipidaemia, characterized by elevation of one or more lipid types in blood, is a major risk factor for cardiovascular diseases and stroke. Management of hyperlipidaemia is helpful to control the fatal outcome of cardiovascular diseases. This experimental study was done to observe the effects of pulp of Ficus carica fruit on lipid profile in induced hyperlipidemic rats in comparison to atorvastatin. Methodology: The duration of study was 12 weeks. In this study forty male rats were taken and divided into four groups. One group was normal control which was given normal diet throughout study period of 12 weeks. The second group was positive control which was given high fat diet for 12 weeks. The remaining two groups were experimental groups which were given high fat diet for 12 weeks. Hyperlipidaemia was induced after giving high fat diet for first four weeks to the experimental groups. The pulp of Ficus carica fruit and atorvastatin was then added to diet of two experimental groups respectively in addition to high fat diet for the next 8 weeks. Body weight, fasting lipid profile, LDL/HDL ratio and AIP were measured at baseline, 4th, 8th, and 12th week of study. Results: Pulp of Ficus carica fruit significantly improved fasting lipid profile, AIP and LDL/HDL ratio. HDL was also significantly increased. However there was no change in body weight. Conclusion: Ficus carica fruit has marked antihyperlipidemic properties comparable to standard drug atorvastatin. Key words: Hyperlipidaemia, ethanolic extract, pulp, Ficus carica

scholarly journals The Efficacy of Seluang Fish Oil (Rasbora agrotynea) Related Body Weight, Lipid Profile, Adiponectin and Leptin in Wistar Rats-Induced High Fat Diet

2018 ◽  
Vol 2 (2) ◽  
pp. 25-30
Author(s):  
Fatmawati Karim ◽  
Rachmat Hidayat ◽  
Erizka Rivani ◽  
Husnul Khotimah ◽  
Ester G Pansserga
Keyword(s):  
Body Weight ◽  
Fish Oil ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Adiponectin Level ◽  
Male Rats ◽  
Control Group ◽  
High Fat ◽  
Reduce Body Weight

Background Rasbora agrotynea (local name : Seluang ) is a fish native to Sumatera, Malaya and Borneo. This fish has a potential as a local wisdom for supplementation of omega 3 and omega 6. In Sumatera, Seluang fish was used as traditional food.   Aim of Study Aim of this study to explore the efficacy of seluang fish oil in body weight, lipid profile, adiponectin and leptin level in Wistar Rats-Induced High Fat Diet   Methods This study was an experimental study , pre-post test with control group design. The sample in this study was  30 male rats, 8 weeks old, weight 150-200 gram. Rats were given high fat diet and seluang fish oil  at dose of 0,1 , 0,2  and 0,4 mL/200 gr BW/day for 2 weeks. Seluang fish oil was extracted by distilation methods. The results of this study were assayed by SPSS 18.   Results Seluang fish oil 0,4 mL/200 gr BW  was more potent to reduce body weight gain, triglyseride level,  leptin and increase adiponectin level than seluang fish oil 0,1 mL/200 gr BW, 0,2 mL/200 gr BW, negative control and positive control.   Conclusion Seluang fish oil had a potention to reduce body weight, triglyceride, leptin and increase adiponectin level.   Keywords: Seluang fish Oil – body weight- triglyserida – leptin - adiponectin  

scholarly journals The Efficacy of Lerek Fruits (Phrynium maximum)Extract Related Body Weight, Lipid Profile and Leptin in Wistar Rats-Induced High Fat Diet

2017 ◽  
Vol 1 (1) ◽  
pp. 8-13
Author(s):  
Radiyati Umi Partan ◽  
Rachmat Hidayat ◽  
Yeni Agustin ◽  
Mgs Irsan Saleh ◽  
Nita Parisa ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Body Weight Gain ◽  
Male Rats ◽  
Control Group ◽  
High Fat ◽  
Fruit Extract ◽  
Reduce Body Weight

Background Phrynium maximum (local name : lerek ) is a plant native to Sumatera, Malaya and Borneo. This plants have a potential as a local wisdom for therapeutics. In Sumatera, Lerek was used as traditional treatment for fever, diarrhea, diabetics and for wound healing.   Aim of Study Aim of this study to explore the efficacy of lerek fruits extract in body weight, lipid profile and leptin level in Wistar Rats-Induced High Fat Diet   Methods This study was an experimental study , pre-post test with control group design. The sample in this study was  30 male rats, 8 weeks old, weight 150-200 gram. Rats were given high fat diet and lerek fruits extract  at dose of 50, 100 and 200 mg/kgBW/day for 2 weeks. Lerek fruits was extracted by infusion methods. The results of this study were assayed by SPSS 18.   Results Lerek fruit extract 100 mg/kgBW  was more potent to reduce body weight gain, triglyseride level and leptin level than lerek fruit extract 50 mg/kgBW, 200 mg.kgBW, negative control and positive control.   Conclusion Lerek fruit extracts had a potention to reduce body weight, triglyceride and leptin level.   Keywords: Lerek fruit extract – body weight- triglyserida - leptin

scholarly journals POTENTIAL OF DUNALIELLA SALINA MICROALGAE TO AMELIORATE HIGH-FAT DIET‑INDUCED OBESITY IN ANIMALS’ RODENT

2018 ◽  
Vol 11 (3) ◽  
pp. 312 ◽  
Author(s):  
Farouk K El-baz ◽  
Hanan F Aly
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Dunaliella Salina ◽  
Body Weight Gain ◽  
Ethanolic Extract ◽  
High Fat ◽  
Related Complication ◽  
Standard Drug ◽  
Reduced Body ◽  
Obese Rats

 Objective: This study was carried out to investigate the potential of Dunaliella salina microalgae to ameliorate obesity induced by high-fat diet (HFD) in male Wistar rats.Methods: Fifty rats weighing 150–160 g were fed HFD for 12 weeks. The rats were randomly divided into five groups of ten rats each. Obese rats were orally administered D. salina ethanolic extract (150 mg/Kg body weight), and orlistat as standard drug (12 mg/Kg body weight), for 6 weeks.Results: Treatment of obese rats with both D. salina and orlistat had a significant effect in reducing body and liver weights as well as visceral fat, inhibiting pancreatic lipase activity, decreased lipid profile, and increased fecal fat and ameliorating liver function enzymes activity, insulin, blood glucose, and leptin levels. Besides, food intake was insignificantly increased as a result of D. salina and orlistat treatments compared with normal control rats.Conclusion: It could be concluded that D. salina rich in β-carotene significantly reduced body weight gain and ameliorated several metabolic pathways implicated in obesity and its related complication. Hence, further intensive study must be carried out to formulate D. Salina extracts to apply as a promising natural anti-obesity nutraceutical drug.

scholarly journals Lactobacillus Rhamnosus Yoba Modulates Serum Cholesterol in Normo-Lipidemic Wistar Rats Fed a High Fat Diet (P20-013-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Adaku Iwueke ◽  
Conrad Miruka ◽  
John Ejekwumadu ◽  
Ronald Kiiza ◽  
Pius Theophilus
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Ldl Cholesterol ◽  
Lactobacillus Rhamnosus ◽  
Hdl Cholesterol ◽  
Male Rats ◽  
Fermented Foods ◽  
Distilled Water ◽  
High Fat

Abstract Objectives The study was aimed at assessing the effects of Lactobacillus rhamnosus yoba on the serum lipid profile and body weight of male Wistar rats fed a high fat diet. Methods 20 seven week old male rats weighing between 120 g and 180 g were used for the study and divided into 4 groups of 5 rats each. The control group was fed normal mice pellets and distilled water, while the other groups were fed mice pellets supplemented with 3% cholesterol and 2% saturated fat in addition to any of distilled water, Lactobacillus rhamnosus yoba or Norvastatin respectively. The body weight was measured at the start of the study and after 2 weeks while serum parameters were measured after 8 weeks. Data was analyzed using SPSS Version 20. ANOVA and Tukey's tests determined significant differences in means at 95% confidence interval. Results Lactobacillus rhamnosus yoba significantly (P < 0.005) modulated weight gain, serum total cholesterol and triglycerides when compared to the control. Similarly, LDL-cholesterol was significantly modulated (P < 0.005) while HDL-cholesterol was significantly enhanced (P < 0.005) when compared to the control. Conclusions The ability of Lactobacillus rhamnosus yoba to elevate HDL cholesterol and modulate LDL-cholesterol without the side effects of statins makes it a potential functional food. In line with the findings, the present study justifies the use of Lactobacillus rhamnosus yoba as a probiotic in fermented foods. Funding Sources NA.

Evaluation of anti-obesity activity of Thespesia populnea (L.) and flavonoid isolated quercetin on high fat diet –induced obese rats

2016 ◽  
Vol 2 (1) ◽  
pp. 46 ◽  
Author(s):  
Gandhimathi Retnasamy ◽  
Sreedevi Adikay
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Tween 80 ◽  
Coronary Risk ◽  
High Fat ◽  
Thespesia Populnea ◽  
Risk Indices ◽  
Obese Rats

The anti-obesity activity of ethanol extract of the stem bark of Thespesia populnea L., (EETP) was evaluated in High Fat Diet (HFD) induced obese rats and flavonoid isolated of Quercetin was characterized. Acute oral toxicity studies revealed that EETP is safe up to 2000mg/kg and doses were selected. Six groups of rats were used and administered orally with vehicle 0.2ml of 1% tween 80 (normal control), fed on HFD+0.2ml of 1% tween 80 (negative control), fed on HFD+EETP (100, 200 & 400 mg/kg) and fed on HFD+ Orlistat 50 mg/kg (positive control), for 40 days respectively. The body rectal temperature, food intake, Lee index and body weight of the animals were recorded and the whole brain was dissected out for estimation of serotonin on day 41. The blood samples were collected by cardiac puncture and used for the estimation of lipid profile. The atherogenic and coronary risk indices were calculated from lipid profile. Obese rats pretreated with EETP or Orlistat exhibited significant increase in body rectal temperature and decrease in food intake, Lee index and body weight of the animals. Moreover, the tested extracts showed beneficial effects on brain serotonin, lipid profile, atherogenic and coronary risk indices in rats. In conclusion, EETP exerts potential anti-obesity activity that could be partly attributed to its flavonoid Quercetin and other bioactive phytoconstituents.

scholarly journals TO EVALUATE THE ANTI-ATHEROSCLEROTIC POTENTIAL OF QUERCETIN IN ALLOXANINDUCED DIABETIC RATS FED WITH HIGH-FAT DIET

2018 ◽  
Vol 11 (3) ◽  
pp. 379
Author(s):  
Biplav S ◽  
Sindhura G ◽  
Shivalinge Gowda K P
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Group Iv ◽  
Lipoprotein Cholesterol ◽  
Histopathological Study ◽  
High Fat ◽  
Group Iii

 Objective: The main aim of the present study is concerned with the evaluation of anti-atherosclerotic potential of quercetin in alloxan-induced diabetic rats fed with high-fat diet (HFD).Methods: Atherosclerosis (AS) is the major cause for many of the cardiovascular disease, and it is accelerated in the presence of diabetes mellitus and causes profound alterations in the lipid profile. The method used for the induction of AS was using HFD for 60 days. In this study, rats were divided into four groups (n=6). Group I served as normal control, Group II alloxan (120 mg/kg b.w i.p)-treated diabetic rats, Group III received quercetin (50 mg/ kg b.w p.o), and Group IV received atorvastatin (10 mg/kg b.w p.o) along with alloxan (120 mg/kg b.w i.p) on the 1st day of the days of the study period. AS was induced in Group II, Group III, and Group IV rats by feeding them with HFD from the 1st day to 60th day. The body weight, feed intake was measured daily. The blood was withdrawn from retro-orbital plexus, and the serum was used for the estimation of lipid profile (total cholesterol [TC], triglycerides [TGs], low-density lipoprotein cholesterol [LDL-C], very LDL-C [VLDL-C], and high-density lipoprotein cholesterol [HDL-C]). After scarification under overdose of ketamine, the histopathological study of aorta was carried out.Results: The results showed that the quercetin-treated rats showed a decrease in body weight gain, decreased levels of TC, TGs, LDL-C, and VLDL-C, and increased levels of HDL-C were observed in Group III rats when compared to alloxan-induced diabetic rats fed with HFD (Group III). The histopathological study of aorta showed no development of plaques and of foam cells.Conclusion: From this study, it can be calculated that quercetin has anti-atherosclerotic activity as it significantly altered overall lipid profile in diabetic rats fed with HFD. This activity may be attributed to its antioxidant, inhibition of HMG-CoA reductase activity of quercetin.

scholarly journals Effect of Citrus Limon Essential Oil on Lipid Profile and Obesity in Wistar Rats

2021 ◽  
pp. 1-5
Author(s):  
Souhaila Benchaoui ◽  
Meriem Gueracheha ◽  
Asma Boutebsou
Keyword(s):  
Body Weight ◽  
Essential Oil ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Intraperitoneal Administration ◽  
Female Rats ◽  
Abdominal Circumference ◽  
Citrus Limon ◽  
Standard Diet ◽  
High Fat

Obesity causes many pathologies; no therapeutic axis has provided an effective solution to this problem. The use of herbal medicine with healthy food and physical activity is recommended, and essential oils are the best known of these natural substances. The objective of this study is to evaluate the effect of Citrus limon essential oil on body weight and lipid profile. The plant material is the lemon; the extraction method is hydrodistillation. The experiment lasted 20 days and involved 15 female rats (2 to 3 months old) weighing between 160g and 230g. The rats were divided into 3 groups: the first receiving a standard diet, the second receiving a high-fat diet, and the third receiving a high-fat diet and treated with essential oil. The extraction yield is 1.69%. The physicochemical characteristics comply with AFNOR. This study shows that a high-lipid diet induces obesity characterized by hyperlipidemia. Intraperitoneal administration of the essential oil caused a decrease in body weight, abdominal circumference, plasma total cholesterol, and triglycerides and an increase in HDL-cholesterol. Considering this study, we found that lemon essential oil has beneficial effects on metabolic alterations. Its inclusion in the diet may help improve the metabolic profile and reduce the incidence of obesity and its long-term complications.

scholarly journals Effects of Prebiotics, Probiotics, and Synbiotics on the Bodyweight, Blood Glucose, Triglyceride and TNF-α of Diet-induced Obesity Rats

2020 ◽  
Vol 4 (2) ◽  
pp. 247
Author(s):  
Lenny Octavia ◽  
Soebagijo Adi Soelistijo ◽  
Agung Dwi Wahyu Widodo
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
High Fat Diet ◽  
Short Chain Fatty Acids ◽  
The Body ◽  
Male Rats ◽  
Acid Oxidation ◽  
Low Grade ◽  
High Fat ◽  
Tnf Α

Abstract  High-fat diet leads to obesity-associated chronic low-grade inflammation. Prebiotics, probiotics, and synbiotics produced short-chain fatty acids (SCFA), bonded to G protein-coupled receptors (GPR)-41 and GPR-43 decreased triglyceride deposits in adipocytes and liver, decreased fatty acid oxidation, increased glucose regulation and insulin sensitivity thus reduced the risk of obesity and metabolic syndrome. This study conducted in order to evaluate the effects of prebiotics, probiotics, and synbiotics on the body weight, blood glucose, triglyceride, and TNF-α used rats model, which were fed by a high-fat diet. Thirty-eight 6-8 weeks old male rats were fed by high-fat diet for three weeks, then rats were randomly divided into four groups, high-fat diet (HFD), a high fat diet with prebiotics supplementation (HFD+ PRE), a high fat diet with probiotics supplementation (HFD+PRO), and high-fat diet with synbiotics supplementation (HFD+SYN) for three weeks. Blood samples and body weight were measured at the third and sixth week. There was no effect of prebiotics, probiotics, and synbiotics on body weight, triglyceride levels, blood glucose, and TNF-α in rats fed a high-fat diet compared to control. These results suggested that supplementations gave inconsistent results with other studies and needed further researches.Keywords             : high fat diet, prebiotics, probiotics, synbiotics, meta-inflammationCorrespondence   : [email protected]

scholarly journals Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats

2015 ◽  
Vol 21 (3) ◽  
Author(s):  
María J. Ríos-Lugo ◽  
Vanesa Jiménez-Ortega ◽  
Pilar Cano-Barquilla ◽  
Pilar Fernández Mateos ◽  
Eduardo J. Spinedi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Body Weight ◽  
Feeding Behavior ◽  
High Fat Diet ◽  
Control Diet ◽  
Male Rats ◽  
Mrna Levels ◽  
High Fat ◽  
Medial Basal Hypothalamus ◽  
Group I

AbstractPrevious studies indicate that the administration of melatonin caused body weight and abdominal visceral fat reductions in rodent models of hyperadiposity. The objective of the present study performed in high-fat fed rats was to evaluate the activity of melatonin on gene expression of some medial basal hypothalamus (MBH) signals involved in feeding behavior regulation, including neuropeptide Y (NPY), proopiomelanocortin (POMC), prolactin-releasing peptide (PrRP), leptin- and insulin-receptors (R) and insulin-R substrate (IRS)-1 and -2. Blood levels of leptin and adiponectin were also measured.Adult Wistar male rats were divided into four groups (n=16 per group): (i) control diet (3% fat); (ii) high-fat (35%) diet; (iii) high-fat diet+melatonin; (iv) control diet+melatonin. Rats had free access to high-fat or control chow and one of the following drinking solutions: (a) tap water; (b) 25 μg/mL of melatonin.After 10 weeks, the high-fat fed rats showed augmented MBH mRNA levels of NPY, leptin-R, PrRP, insulin-R, IRS-1 and IRS-2. The concomitant administration of melatonin counteracted this increase. Feeding of rats with a high-fat diet augmented expression of the MBH POMC gene through an effect insensitive to melatonin treatment. The augmented levels of circulating leptin and adiponectin seen in high-fat fed rats were counteracted by melatonin as was the augmented body weight: melatonin significantly attenuated a body weight increase in high-fat fed rats without affecting chow or water consumption. Melatonin augmented plasma leptin and adiponectin in control rats.The results indicate that an effect on gene expression of feeding behavior signals at the central nervous system (CNS) may complement a peripheral rise of the energy expenditure produced by melatonin to decrease body weight in high-fat fed rats.

Effects of combined glucocorticoid/mineralocorticoid receptor modulation (CORT118335) on energy balance, adiposity, and lipid metabolism in male rats

2019 ◽  
Vol 317 (2) ◽  
pp. E337-E349
Author(s):  
Elizabeth T. Nguyen ◽  
Sarah Berman ◽  
Joshua Streicher ◽  
Christina M. Estrada ◽  
Jody L. Caldwell ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
The Body ◽  
Male Rats ◽  
Chow Diet ◽  
High Fat ◽  
Receptor Modulation

Psychological stress and excess glucocorticoids are associated with metabolic and cardiovascular diseases. Glucocorticoids act primarily through mineralocorticoid (MR) and glucocorticoid receptors (GR), and compounds modulating these receptors show promise in mitigating metabolic and cardiovascular-related phenotypes. CORT118335 (GR/MR modulator) prevents high-fat diet-induced weight gain and adiposity in mice, but the ability of this compound to reverse obesity-related symptoms is unknown. Adult male rats were subcutaneously administered CORT118335 (3, 10, or 30 mg/kg) or vehicle once daily. A 5-day treatment with CORT118335 at 30 mg/kg induced weight loss in rats fed a chow diet by decreasing food intake. However, lower doses of the compound attenuated body weight gain primarily because of decreased calorific efficiency, as there were no significant differences in food intake compared with vehicle. Notably, the body weight effects of CORT118335 persisted during a 2-wk treatment hiatus, suggesting prolonged effects of the compound. To our knowledge, we are the first to demonstrate a sustained effect of combined GR/MR modulation on body weight gain. These findings suggest that CORT118335 may have long-lasting effects, likely due to GR/MR-induced transcriptional changes. Prolonged (18 days) treatment of CORT118335 (10 mg/kg) reversed body weight gain and adiposity in animals fed a high-fat diet for 13 wk. Surprisingly, this occurred despite a worsening of the lipid profile and glucose homeostasis as well as a disrupted diurnal corticosterone rhythm, suggesting GR agonistic effects in the periphery. We conclude that species and tissue-specific targeting may result in promising leads for exploiting the metabolically beneficial aspects of GR/MR modulation.

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