LOCAL HYPOXIA AND IMMUNODEFICIENCY. EFFECT OF OBESITY ON REDUCING THE EFFECTIVENESS OF TREATMENT FOR BACTERIAL VAGINOSIS

2022 ◽  
pp. 12-16
Author(s):  
А.М. ЖУКЕМБАЕВА ◽  
М.К. АКИМЖАН ◽  
Н.К. АБТЫХАЛИ ◽  
И.О. АЛИМКУЛ ◽  
А.Б. ДҮЙСЕНБАЙ ◽  
...  
Keyword(s):  
Body Weight ◽  
Bacterial Vaginosis ◽  
Pathological Process ◽  
Vaginal Smears ◽  
Group I ◽  
Alimentary Obesity ◽  
Normal Body Weight ◽  
Quantitative Indicators ◽  
Written Informed Consent

Проведен анализ результатов обследования 143 больных бактериальным вагинозом с учетом наличия у них алиментарного ожирения. Все женщины, принимавшие участие в нашем исследовании, дали письменное информированное согласие на участие в нем. Исследование проводили до начала лечения бактериального вагиноза. В зависимости от наличия алиментарного ожирения больных разделили на 2 группы. В I группу вошли 97 с нормальным весом телом, без признаков алиментарного ожирения. Во II группе у 46 больных отмечалось увеличение массы тела, соответствующее алиментарному ожирению II степени. Критериями для анализа являлись результатами бактериоскопического исследования мазков из влагалища, окрашенных по Грамму и выявления в них количественных показателей «ключевых клеток» и показатели оксиметрии, определение интегративного коэффициента Кслиз%, отражающий содержание кислорода в слизистой оболочке, по отношению к показателям, зарегистрированным на II пальце кисти, позволяющего прогнозировать результативность лечения. Таким образом, на фоне алиментарного ожирения еще до начала лечения интенсивность патологического процесса при бактериальном вагинозе была более выражена, чем без него. При этом локальные гипоксия и иммунодефицит свидетельствовали о риске снижения эффективности лечения The analysis of the results of examination of 143 patients with bacterial vaginosis, taking into account the presence of alimentary obesity, was carried out. All women who took part in our study gave written informed consent to participate in it. The study was carried out before starting treatment for bacterial vaginosis. Depending on the presence of alimentary obesity, the patients were divided into 2 groups. Group I included 97 people with normal body weight, without signs of alimentary obesity. In group II, 46 patients showed an increase in body weight corresponding to alimentary obesity of the II degree. The criteria for the analysis were the results of bacterioscopic examination of vaginal smears stained according to Gram and the identification of quantitative indicators of "key cells" in them and oximetry indicators, determination of the integrative coefficient Cmucous membrane% , reflecting the oxygen content in the mucous membrane, in relation to the indicators recorded on the second finger of the hand, which allows predicting the effectiveness of treatment. Thus, amid alimentary obesity, even before the start of treatment, the intensity of the pathological process with bacterial vaginosis was more pronounced than without it. At the same time, local hypoxia and immunodeficiency indicated the risk of a decrease in the effectiveness of treatment.

scholarly journals PLASMA CONCENTRATION OF ENDOTHELIN-1 IN PATIENTS WITH HYPERTENSION ASSOCIATED WITH OBESITY, DEPENDING ON THE LYS198ASN POLYMORPHISM OF THE ENDOTHELIN-1 GENE

2021 ◽  
Vol 9 (1) ◽  
pp. 87-94
Author(s):  
Yu.O. Smiianova
Keyword(s):  
Body Weight ◽  
Heart Rhythm ◽  
Pathological Process ◽  
Main Group ◽  
Overweight And Obesity ◽  
Control Group ◽  
Endothelin 1 ◽  
Normal Body ◽  
Heart Rhythm Disorders ◽  
Normal Body Weight

Endothelial dysfunction is considered one of the main mechanisms for the further development of arterial hypertension (AH) and its complications, and endothelin-1 (ЕТ-1) plays one of the key roles in this process. Endothelium is drawn into the pathological process at the earliest stages of AH development. ЕТ-1 is currently considered as a marker and predictor of the stage and consequences of AH, chronic heart failure (CHF), coronary heart disease (CHD), in particularly, acute myocardial infarction (MI), heart rhythm disorders, pulmonary hypertension, atherosclerotic vascular injury, target vascular disorders. One factor that may influence the level of ЕТ-1 is the endothelin-1 gene Lys198Asn polymorphism, which is considered by many researchers as a possible genetic marker of AH. However, the effect of this polymorphism on the level of plasma ЕТ-1 level in patients with AH of varying severity in Ukraine is understudied. The basis of this work were the materials of a complete examination of 160 patients with a verified diagnosis of AH I, stage II of 1, 2, 3 degrees (main group) and 110 apparently healthy persons (control group). Patients of the main group were divided into three subgroups: 1st group ­– 75 patients with normal body weight; 2nd group – 48 overweight patients; 3rd group – 37 patients with alimentary obesity. In obese patients, the waist circumference in women was around 103 (96–115) cm, and in men – 108 (105–116) cm, which indicates an abdominal type of obesity in these patients. As a result of the study, it was found that the level of ЕТ-1 is higher in patients with AH who suffer with overweight and obesity as compared with patients with AH and normal body weight. Also, the peptide level depends on the genotype of patients and is higher in AH patients with the genotype Asn198Asn and Lys198Asn as compared to carriers of the genotype Lys198Lys.

scholarly journals Dynamics of Body Type Indicators of Adult Women Under the Influence of Aqua Fitness

2021 ◽  
Vol 21 (2) ◽  
pp. 129-135
Author(s):  
Karyna Pirohova ◽  
Оlha Мyкytchyk ◽  
Sergiy Afanasiev ◽  
Olena Omelchenko ◽  
Tetiana Sydorchuk ◽  
...  
Keyword(s):  
Body Weight ◽  
The Body ◽  
Rank Test ◽  
Adult Women ◽  
Body Type ◽  
Obesity Class ◽  
Signed Rank ◽  
Signed Rank Test ◽  
Normal Body Weight

The study purpose was to determine the effectiveness of a differentiated approach to aqua fitness classes with women of the first period of adulthood. Materials and methods. 30 adult women, whose average age was 30.57 years, took part in the study. The study was conducted during 2019-2020. Anthropometric measurements included body length, body weight, chest, shoulder, calf, thigh, waist, buttocks and wrist circumferences. To determine the overweight we calculated the body mass index. Measurements were taken at the end of each mesocycle of wellness training. Statistical analysis covered determination of mean, standard deviation, reliability of the differences (Wilcoxon signed-rank test). Results. The effectiveness of a differentiated approach to aqua fitness classes was proven by improvement of women’s body type. By the end of the study, there were no women with obesity class II and underweight. The number of women with obesity class I decreased by 3.33%. The number of women with normal body weight increased by 13.37%. Conclusions. The implementation of a differentiated approach to aqua fitness classes with adult women has significantly corrected their body proportions. This allows recommending a differentiated approach according to a body type to implement into aqua fitness classes.

INTESTINAL MICROFLORA ON THE BACKGROUND OF BACTERIAL VAGINOSIS ON VULVOVAGINAL CANDIDIASIS IN OVERWEIGHT AND OBESE WOMEN

2021 ◽  
Vol 74 (10) ◽  
pp. 2482-2488
Author(s):  
Karine A. Hasparian ◽  
Valentina K. Kondratiuk ◽  
Olha V. Trokhymovych ◽  
Kateryna O. Kondratiuk ◽  
Iryna M. Nikitina ◽  
...  
Keyword(s):  
Body Weight ◽  
Bacterial Vaginosis ◽  
Intestinal Microbiota ◽  
Intestinal Microflora ◽  
Overweight And Obesity ◽  
Vulvovaginal Candidiasis ◽  
Intestinal Microbiome ◽  
Excess Body Weight ◽  
Obese Women

The aim of our work was to study the intestinal microbiome in obese women and further develop differentiated patterns of exposure to the intestinal microbiota to improve metabolism and reduce excess weight. Materials and methods: Surveyed 120 overweight and obese women. For comparison, 60 women without overweight and obesity were examined. Group I – women with vulvovaginal candidiasis and overweight and obesity (60 women); group II – women with vulvovaginal candidiasis without overweight and obesity (30 women); group III – women with bacterial vaginosis and overweight and obesity (60 women); ІV – women with bacterial vaginosis without overweight and obesity (30 women). The study of the intestinal microbiocenosis included the determination of the species and quantitative composition of the microflora. Quantitative indicators of intestinal microflora were studied by seeding 1 ml from each dilution on differential diagnostic media: Endo, Ploskireva, ICA (bismuth – agar sulfide) to detect pathogenic enterobacteria; ZhSA (yellow – salt agar) for determination of staphylococci. To study the hemolytic activity of bacteria was used agar with 5% erythrocyte content of sheep. The presence of bifidobacteria in the test material was studied on Blaurok medium, and lactobacilli – on MRS medium. Statistical analysis of the obtained research results was performed using standard computer packages “Data Analysis” Microsoft Excel for Windows 2002. Results: Based on the results of studies, we can summarize the nature of changes in the intestinal microbiome on the background of vulvovaginal candidiasis and bacterial vaginosis in women with overweight and obesity. In all women with excess body weight and obesity, intestinal microflora disorders have been registered, which are characterized by the replacing the lactobacilli and bifidum bacteria to opportunistic pathogens. A significant increase in Firmicutes phylum microorganisms and a significant decrease in Bacteroidetes phylum were found. The obtained data prove that changes in the species composition of the intestinal microbiota play an important role in the pathogenesis of obesity. Conclusions: The results indicate the feasibility of monitoring the intestinal microbiota in women with vulvovaginal candidiasis and bacterial vaginosis, especially in the presence of excess body weight and obesity to determine the degree of violations of its components, and timely correction of the detected changes.

scholarly journals An experimental study of albino rats fed on Nigella sativa and aspirin for four weeks duration: determination of coagulation profile

2016 ◽  
Vol 10 (2) ◽  
Author(s):  
Akhtar Munir ◽  
Muhammad Tayyib ◽  
Muhammad Farooq ◽  
Muhammad Mashraf ◽  
Anjum Rashid ◽  
...  
Keyword(s):  
Experimental Study ◽  
Body Weight ◽  
Nigella Sativa ◽  
Control Group ◽  
Albino Rats ◽  
Clot Retraction ◽  
Blood Samples ◽  
Synthetic Diet ◽  
Group I

Ninety albino rats were selected and were divided into six groups on the basis of different diets given. Control group (I) was fed on synthetic diet and experimental groups (IIA, IIB, IIC, IID and IIE) were fed on 1 mg aspirin, 15mg, 30 mg, 45 mg Nigella Sativa per kg body weight respectively while HE was given 30 mg NS and 1 mg aspirin/kg body wt. Blood samples were collected by heart puncture and Coagulation parameters were done. BT was prolonged in groups taking aspirin only. APTT was reduced significantly in groups taking different concentration of NS when compared with control. Percentage of clot retraction was weak significantly in groups taking aspirin only when comparing with other groups.

DETERMINATION OF ADOLESCENT FOOD HABITS ON THE BASIS OF AGE, HEIGHT AND WEIGHT

2018 ◽  
Vol 24 (2) ◽  
Author(s):  
ALBHA TIWARI ◽  
VIMLESH KUMAR TIWARI
Keyword(s):  
Body Weight ◽  
Fast Food ◽  
Food Habits ◽  
Age Groups ◽  
Normal Body ◽  
Lower Body Weight ◽  
Significant Difference ◽  
Normal Body Weight ◽  
Difference Body

Significant differences between nutritional and fast food habits were observed at the 13-15 years and 16-18 years age groups of boys and girls respectively. The girls in the age group and boys had non-significant difference. Body weight showed non-significant difference for fast food and nutritional diet for boys and girls. Body weight of boys increased by 8.90% over normal body weight of 13-15 years. Lower body weight was observed in 16-18 boys adolescent and 13-15 years and 16-18 years girls where body weight was lower than normal body weight. Fast food did not affect in the enhancement of body weight. Nutritional food had significant role in boy weight increase in both age groups.

THE NEGATIVE IMPACT OF ALIMENTARY OBESITY ON THE STATE OF LOCAL IMMUNITY OF THE VAGINAL MUCOSA AND THE EFFECTIVENESS OF THE THERAPY OF BACTERIAL VAGINOSIS

2022 ◽  
pp. 8-12
Author(s):  
А.М. ЖУКЕМБАЕВА ◽  
Б.Н. АСАН ◽  
А.Т. АБЫЛГАЗИЕВА ◽  
А.А. АЙТБАЙ ◽  
И.Г. МУРАТХАН ◽  
...  
Keyword(s):  
Bacterial Vaginosis ◽  
Negative Impact ◽  
The State ◽  
Vaginal Mucosa ◽  
Local Immunity ◽  
Pronounced Increase ◽  
Group I ◽  
Alimentary Obesity ◽  
Grade Ii ◽  
Group Ii

Проведен анализ результатов стандартного лечения бактериального вагиноза у 143 больных с учетом наличия у них алиментарного ожирения. Все женщины, принимавшие участие в нашем исследовании, дали письменное информированное согласие на участие в нем. Лечение БВ проводилось по общепринятой методике метронидазолом и клиндамицином. В зависимости от наличия алиментарного ожирения больных бактериальным вагинозом разделили на 2 группы. В I группу вошли 97 без алиментарного ожирения. Во II группе у 46 больных отмечалось увеличение массы тела, соответствующее алиментарному ожирению II степени. Исследования проводили до начала лечения и через 14 суток после его завершения. Сравнительный анализ результатов лечения БВ в исследуемых группах показал, что на фоне АО II степени отмечались достоверно более выраженные увеличение количества «ключевых клеток» (P<0,05) и смещение pH в щелочную сторону (P<0,05) во II группе. При этом эффективность лечения у больных II группы, где отмечалось алиментарное ожирение II степени была достоверно меньше, чем в I (P<0,05), что свидетельствовало о негативном влиянии алиментарного ожирения на состояние локального иммунитета слизистой оболочки влагалища и результативность проводимой терапии бактериального вагиноза. The results of standard treatment of bacterial vaginosis in 143 patients were analyzed, taking into account the presence of alimentary obesity in them. All the women who took part in our study gave written informed consent to participate in it.BV was treated according to the generally accepted method with metronidazole and clindamycin. Depending on the presence of alimentary obesity, patients with bacterial vaginosis were divided into 2 groups. Group I included 97 people without alimentary obesity. In group II, 46 patients had an increase in body weight corresponding to alimentary obesity of the II degree. Studies were conducted before the start of treatment and 14 days after its completion. A comparative analysis of the results of BV treatment in the study groups showed that against the background of grade II AO, there was a significantly more pronounced increase in the number of "key cells" (P<0.05) and a pH shift to the alkaline side (P<0.05) in group II. At the same time, the effectiveness of treatment in group II patients with grade II alimentary obesity was significantly less than in group I (P<0.05), which indicated a negative effect of alimentary obesity on the state of local immunity of the vaginal mucosa and the effectiveness of the therapy of bacterial vaginosis.

ROLE OF BODY WEIGHT AND BODY FIGURE IN THE DETERMINATION OF ADOLESCENT FOOD HABITS

2019 ◽  
Vol 25 (1) ◽  
Author(s):  
ALBHA TIWARI ◽  
VIMLESH KUMAR TIWARI
Keyword(s):  
Body Weight ◽  
Fast Food ◽  
Food Habits ◽  
Age Groups ◽  
Normal Body ◽  
Lower Body Weight ◽  
Significant Difference ◽  
Normal Body Weight

Body weight showed non-significant difference for fast food and nutritional diet for 13-15 years old boys and girls adolescents. Body weight of boy’s adolescent increased over normal body weight of 13-15 years. Whereas, lower body weight was observed in 16-18 boys adolescent and 13-15 years and 16-18 years girls where body weight was lower than normal body weight. The general body figure of boys and girls adolescent have nutritional diet except fast food and nutritional food habits in girls of 13-15 yrs and 16-18 yrs girls of nanus body figure respectively. Interestingly, girls of 13-15 yrs, had fast food in diet whose body figure was midget. The t-test indicated that boys and girls body figure had highly significant differences in their food habits in both age groups 13-15 yrs and 16-18 yrs.

scholarly journals FEATURES OF APOPTOSIS, FORMATION OF MEMBRANE-RELEASED MICROPARTICLES AND CYTOKINES PRODUCTION IN CASE OF LYMPHOCYTE DAMAGE IN SYNTROPY OF BRONCHIAL ASTHMA AND OBESITY IN YOUNG PATIENTS

2019 ◽  
Vol 1 (71) ◽  
pp. 16-22
Author(s):  
Ирина Соловьева ◽  
Irina Soloveva ◽  
Ирина Демко ◽  
Irina Demko ◽  
Елена Собко ◽  
...  
Keyword(s):  
Body Weight ◽  
Bronchial Asthma ◽  
Peripheral Blood ◽  
Cell Damage ◽  
Young Patients ◽  
Tnf Α ◽  
Pathogenetic Factor ◽  
Normal Body Weight ◽  
Functional Examination

The aim of the research was to study the characteristics of apoptosis, membrane-released microparticles (MRM) formation and cytokines production in case of lymphocyte damage in young patients with bronchial asthma, depending on body mass index. 224 people were examined. In all the patients there was done an assessment of the excessive weight and determination of obesity degree as well as clinical and functional examination; there was performed a determination of cytokines and adipokines; the lymphocytes were separated from the peripheral blood. The number of apoptotic cells was estimated in accordance with the standard protocol; the number of MRM was counted. It was found out that in case of bronchial asthma and obesity syntropy, even at a young age, more often there are patients with moderate and severe clinical course; besides, the severity of bronchial-obstructive syndrome in patients of this group is more significant with the tendency to decrease in FEV1 and FEV1/FVC. In the group of young patients with obesity combined with bronchial asthma in the peripheral blood there was imbalance of both adipokines and cytokines, characterized by evident increase in the levels of pro-inflammatory leptin, IL-4, IL-6, TNF-α, and the decrease in potential body weight regulator IL-15, and at the same time low levels of anti-inflammatory adiponectin. In patients with obesity, the percentage of cells in apoptosis was significantly lower compared to both those in control with obesity and patients with normal body weight. The number of MRM, as cell damage indicator, significantly increased in the group with obesity. It can be assumed that the imbalance of cytokines, adipokines and mechanisms of programmed cell death is a possible pathogenetic factor in asthma and obesity syntropy.

Evaluation of unconventional poultry feed in broilers

2019 ◽  
Vol 17 (1) ◽  
Keyword(s):  
Body Weight ◽  
Treatment Group ◽  
Blood Meal ◽  
Feed Consumption ◽  
Trial Period ◽  
Feed Ingredients ◽  
Treatment Groups ◽  
Broiler Production ◽  
Group I ◽  
Unconventional Feed

Background: Commercial broiler is a rapidly growing sector in Bangladesh. The broilers are supplied with the balanced ration prepared from a number of ingredients which are not available uniformly throughout the years. On the other hands, manufactured feeds are costly and inconvenient for the rural farmers. This study is undertaken to use unconventional feed ingredients aiming to decrease the broiler production cost. Method: A total of ninety-nine day- old broiler chicks (Hubbard) of either sex were used in this study in 3 treatment groups to assess processed unconventional feed item (shoti, blood meal, poultry dropping and molasses) on growth and profitability upon rearing for 60 days. Broilers were reared in dip litter system and were fed ad libitum on conventional and unconventional diet dividing into 3 treatment diets namely, treatment diet 1 (T1: Conventional as control), treatment diet 2 (T2: unconventional with blood meal and shoti), and treatment diet 3 (T3: unconventional with blood meal, shoti, poultry droppings and molasses) throughout the trial period. Treatment group 1 (T1) was used as control. Results: Broilers fed on control diet (conventional feed) achieved higher (P<0.01) body weight, while the broilers offered diets with the highest amount of unconventional feed had the lowest body weight. Increased (P<0.01) feed intake was observed during 21days and 49 days of age when broilers fed diets with the supplementation, but no significant differences were found among the groups in terms of feed consumption during 33 day of age. FCR differed significantly (P<.01) throughout the trial period with the broilers fed diets without supplementation of unconventional feed item had the superior FCR than the others. Mortality rate was 6.06%,9.09%, and 9.09% in treatment group I, treatment group II, and treatment group III respectively while live weights, feed conversion and feed consumption was unaffected by all the dietary groups with/without incorporation of unconventional feed item up to day 60 days of age. Statistically significant (P<0.01) decreased live weight was observed among the treatment groups in 60-day-old birds. Productivity and cost-benefit analysis were performed. Conclusion: Use of unconventional feed ingredients in broiler production greatly reduces the feed cost with little hampering the growth rate and hence, it is profitable for the farmers.

Adaptive changes of the hair coat of the horses of zabaykalsky aborigenous breed

2019 ◽  
Vol 49 (4) ◽  
pp. 101-105 ◽  
Author(s):  
G. M. Shkyratova ◽  
B. Z. Bazaron ◽  
T. N. Khamiruev ◽  
S. M. Dashinimaev
Keyword(s):  
Seasonal Changes ◽  
Climatic Conditions ◽  
Skin Thickness ◽  
Summer Period ◽  
Hair Coat ◽  
Skin Fold ◽  
Winter Grazing ◽  
Shoulder Blade ◽  
Quantitative Indicators

The seasonal changes in the skin thickness and structure of the horses’ coat, as signs of adaptation to environmental factors, were studied. The experiment was carried out with the livestock kept in a herd using winter-grazing technology without additional feedings in the climatic conditions of the Trans-Baikal Territory. The objects of the research were adult mares of Zabaikalsky breed of horses of the same age, class and fatness. The studies were carried out in the middle of each season (May, July, October, February). The length of the coat was measured with a caliper, the coat itself with the determination of the ratio of hair (fl uffy hair, heterotype hair and coarse hair) and the thickness of the skin fold were measured in accordance with the approved methodological recommendations. The minimum skin thickness in winter was detected in mares on the back and shoulder blade – 4.3 and 4.4 mm, the maximum – on the side and thigh – 4.5 4.6 mm. When compared with the summer period, the increase on the side was 0.8 mm, whereas on the back, shoulder blade and thigh – 0.4 mm (p ≤ 0,001). In spring, thickening of the skin was noted within 0.1-0.3 mm in the same topographic areas, compared to autumn. The quantitative indicators of the coat changed depending on the season of the year. In winter, the coat contained more fl uffy hair (23.10%), and less coarse hair (68.24%), in summer there was a lower content of fl uffy hair (4.33%), but more coarse hair (94.01%.) Sharp seasonal changes were noted with regard to the length of the hair. The longest hair was found in winter and spring – 4.96 and 4.26 cm, whereas the shortest – in summer and autumn – 0.94 and 1.90 cm, respectively.

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