scholarly journals Nutritional approach in the prevention and treatment of knee osteoarthritis: a systematic review

2021 ◽  
Vol 14 (4) ◽  
Author(s):  
Juracy Barbosa Santos ◽  
Lanussy Rassi Mangili ◽  
Mylene Rassi Mangili ◽  
Isabela Rassi Mangili ◽  
Durval Ribas Filho
Keyword(s):  
Knee Osteoarthritis ◽  
Dietary Intervention ◽  
Time Frame ◽  
Vital Role ◽  
Joint Disease ◽  
Loss Of Function ◽  
Socioeconomic Impacts ◽  
Knee Oa ◽  
Treatment And Prevention ◽  
Prevention And Treatment

Osteoarthritis (OA) is the most prevalent joint disease, considered the rheumatic condition with the greatest consequences in terms of socioeconomic impacts, especially knee osteoarthritis since it makes walking difficult. To date, there is no cure for OA, so available treatments aim to reduce symptoms such as pain and inflammation, maintain joint mobility, and limit the loss of function. As OA has a known inflammatory component, it is believed that nutrition can play a vital role in the prevention and ongoing management of OA. This article aims to analyze the available evidence in the prevention and treatment of knee OA with a dietary intervention that may play a potential role in the management of the disease. To carry out this literature review, articles were searched in the Scielo, Pubmed, and Bireme databases with the time frame of the last 10 years. The results showed that some nutrients, vitamins, and antioxidants are widely discussed in the literature in the treatment and prevention of the disease. Management of free radicals is necessary and the influence of nutrients and diet on cartilage and OA metabolism may represent a long-term adjuvant alternative in the treatment of patients with knee OA. Effects of dietary modifications on lipid and cholesterol profiles, adequate vitamin levels, and weight reduction in obese patients may influence the course of the disease.

scholarly journals Small Noncoding RNAs in Knee Osteoarthritis: The Role of MicroRNAs and tRNA-Derived Fragments

2021 ◽  
Vol 22 (11) ◽  
pp. 5711
Author(s):  
Julian Zacharjasz ◽  
Anna M. Mleczko ◽  
Paweł Bąkowski ◽  
Tomasz Piontek ◽  
Kamilla Bąkowska-Żywicka
Keyword(s):  
Knee Osteoarthritis ◽  
Noncoding Rnas ◽  
Pathological Process ◽  
Joint Disease ◽  
Limited Information ◽  
Genetic Changes ◽  
Small Noncoding Rnas ◽  
Knee Oa ◽  
Cartilage Homeostasis

Knee osteoarthritis (OA) is a degenerative knee joint disease that results from the breakdown of joint cartilage and underlying bone, affecting about 3.3% of the world's population. As OA is a multifactorial disease, the underlying pathological process is closely associated with genetic changes in articular cartilage and bone. Many studies have focused on the role of small noncoding RNAs in OA and identified numbers of microRNAs that play important roles in regulating bone and cartilage homeostasis. The connection between other types of small noncoding RNAs, especially tRNA-derived fragments and knee osteoarthritis is still elusive. The observation that there is limited information about small RNAs different than miRNAs in knee OA was very surprising to us, especially given the fact that tRNA fragments are known to participate in a plethora of human diseases and a portion of them are even more abundant than miRNAs. Inspired by these findings, in this review we have summarized the possible involvement of microRNAs and tRNA-derived fragments in the pathology of knee osteoarthritis.

scholarly journals Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Feifan Lu ◽  
Pei Liu ◽  
Qidong Zhang ◽  
Weiguo Wang ◽  
Wanshou Guo
Keyword(s):  
Knee Osteoarthritis ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Case Control ◽  
Joint Disease ◽  
Cochrane Library ◽  
Case Control Studies ◽  
Knee Oa ◽  
Statistical Heterogeneity ◽  
Bone Changes

Abstract Background Knee osteoarthritis is a joint disease which is characterized by degeneration of articular cartilage and subsequent subchondral bone changes. Polymorphisms of IL-17A/F gene were the recognized candidate genes associated with knee osteoarthritis risk although the results were conflicting. The aim of this study was to determine whether IL-17A(rs2275913) and IL-17F(rs763780) polymorphisms confer susceptibility to knee osteoarthritis. Method Literature search was performed in PubMed, Medline, Cochrane Library, Web of science, Embase, and Google Scholar (last search was updated on June 20, 2019), and assessing this association was performed by calculating odds ratios with 95% confidence intervals. Statistical heterogeneity was quantitatively evaluated by using the Q statistic with its p value and I2 statistic. Result Six case-control based studies were included involving IL-17A(rs2275913) (2134 cases and 2306 controls) and IL-17F(rs763780) (2134 cases and 2426 controls). The overall analysis suggested that the A allele of the rs2275913 polymorphism, and the C allele of the rs763780 polymorphism in the IL-17 gene may increase the risk of OA. However, subgroup analysis revealed that no association between IL-17A(rs2275913) gene and knee OA risk was found in Caucasian population. Conclusions This meta-analysis revealed that the IL-17A(rs2275913) gene polymorphisms may increase the risk of knee OA in Asians, and the IL-17F(rs763780) gene polymorphisms may increase the risk of knee OA both in Asians and Caucasians. However, because of the limitations of the present study, additional larger studies are needed to confirm our findings in the future.

scholarly journals Divergent Mononuclear Cell Participation and Cytokine Release Profiles Define Hip andKnee Osteoarthritis

2019 ◽  
Vol 8 (10) ◽  
pp. 1631 ◽  
Author(s):  
Grieshaber-Bouyer ◽  
Kämmerer ◽  
Rosshirt ◽  
Nees ◽  
Koniezke ◽  
...  
Keyword(s):  
T Cells ◽  
Knee Osteoarthritis ◽  
Mononuclear Cell ◽  
Synovial Membrane ◽  
Mononuclear Cells ◽  
Immune Cell ◽  
Joint Disease ◽  
Cytokine Release ◽  
Knee Oa ◽  
Release Profiles

Osteoarthritis (OA) is a progressive joint disease driven by a blend of inflammatory and biomechanical processes. Studies using human samples to understand inflammatory mechanisms in OA frequently recruit OA patients with different affected joints, even though recent evidence indicates that OA is a heterogeneous disease which only culminates in a common end point. Differences in age of onset and the dynamics of disease progression suggest that different joints may represent different disease entities, thereby diluting the discovery potential in a combined analysis. We hypothesized that different OA joints may also differ in immunopathology within the synovium. To investigate this hypothesis, we profiled the immune cell contribution (flow cytometry) and cytokine release profiles (ELISA) in purified synovial membrane mononuclear cells from 50 patients undergoing either hip (n = 34) or knee (n = 16) replacement surgery. Unsupervised computational approaches were used for disease deconstruction. We found that hip and knee osteoarthritis are not identical in respect to the inflammatory processes that take place in the synovial membrane. Instead, we report that principally CD14+ macrophages are expanded fourfold in the synovial membrane of patients with knee OA compared to hip OA, with a trend to higher expression in CD8+ T cells, while CD4+ T cells, B cells, and NK cells were found at comparable quantities. Upon isolation and culture of cells from synovial membrane, isolates from hip OA released higher concentrations of Eotaxin (CCL11), G-CSF, GM-CSF, INF-γ, IP-10 (CXCL10), TNF-α, MIP-1α (CCL3), MIP-1β (CCL4), IL-4, IL-10, IL-17, and lower concentrations of stem cell factor (SCF), thereby highlighting the difference in the nature of hip and knee osteoarthritis. Taken together, this study establishes hip and knee OA as immunologically distinct types of OA, and creates a resource of the cytokine expression landscape and mononuclear cell infiltration pattern of patients with hip and knee osteoarthritis.

scholarly journals Serum Metabolites as Potential Biomarkers for Diagnosis of Knee Osteoarthritis

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Qingmeng Zhang ◽  
Heng Li ◽  
Zhendong Zhang ◽  
Fan Yang ◽  
Jiying Chen
Keyword(s):  
Knee Osteoarthritis ◽  
Metabolic Profile ◽  
Elderly Population ◽  
The Elderly ◽  
Ultra Performance Liquid Chromatography ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Healthy Controls ◽  
Knee Oa ◽  
Potential Biomarkers

Knee osteoarthritis (OA) is a highly prevalent chronic degenerative joint disease that mainly affects the elderly population. The aim of this study was to investigate serum signature metabolites as potential biomarkers for early diagnosis of knee OA. Global serum metabolic profiles of 40 patients with knee OA and 20 healthy controls (HC) were analyzed by ultra-performance liquid chromatography coupled to mass spectrometry. An OA-specific metabolic profile was established that can clearly discriminate patients with OA from HCs. Fourteen metabolites that are involved in the metabolism of amino acids, purine, energy, glycolysis, fatty acids, and lipids were significantly altered in patients with OA compared to HCs. These metabolites could be potentially used as biomarkers for the diagnosis of knee OA.

scholarly journals Combined therapies with exercise, ozone and mesenchymal stem cells improve the expression of HIF1 and SOX9 in the cartilage tissue of rats with knee osteoarthritis

2020 ◽  
Vol 107 (2) ◽  
pp. 231-242
Author(s):  
Sara Asadi ◽  
Parvin Farzanegi ◽  
Mohammad Ali Azarbayjani
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Knee Osteoarthritis ◽  
Combined Therapy ◽  
Hypoxia Inducible Factor ◽  
Degenerative Joint Disease ◽  
Exercise Group ◽  
Joint Disease ◽  
Cartilage Tissue ◽  
Knee Oa

AbstractPurposeKnee osteoarthritis (OA) is a common type of degenerative joint disease which decreases the quality of life. Sex-determining region Y box 9 (SOX9) and hypoxia-inducible factor-1 (HIF1) are considered as the key regulators of OA. We investigated the effect of combined therapies with mesenchymal stem cells (MSCs), ozone (O3) and exercise training on SOX9 and HIF1 expression in the cartilage of rats with knee OA.MethodsKnee OA was induced by surgical method. OA rats were divided into model, MSCs, ozone, exercise, MSCs + ozone, MSCs + exercise, ozone + exercise and MSCs + ozone + exercise groups. Rats in the MSCs group received intraarticular injection of 1 × 106 cells/kg. Rats in the ozone group received O3 at the concentration of 20 μg/mL, once weekly for 3 weeks. Rats in the exercise group were trained on rodent treadmill three times per week. 48 hours after the programs, cartilage tissues were isolated and the expression of SOX9 and HIF1 was determined using Real-Time PCR.ResultsSignificant differences were found in the expression of SOX9 and HIF1 between groups (P < 0.0001). Although combined therapies with exercise, MSCs and O3 significantly increased the expression of SOX9 and HIF1 in the cartilage tissue of rats with knee OA, combination of exercise with O3 was significantly more effective compared to the other combined therapies (P < 0.001).ConclusionsCombined therapy with exercise, MSCs and O3 significantly increased the expression of SOX9 and HIF1 genes in the cartilage of rats with knee OA; however, exercise + O3 was significantly more effective.

Relation between Vitamin D deficiency and the Occurrence of Knee Osteoarthritis and Its Severity

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Eman Ahmed Hafez ◽  
Noran Osama Ahmed El-Azizi ◽  
Naglaa Affify Mohammed ◽  
Abdelnasser Fetouh Eisa Ahmed
Keyword(s):  
Vitamin D ◽  
Articular Cartilage ◽  
Knee Osteoarthritis ◽  
Vitamin D Deficiency ◽  
Pain Score ◽  
Cartilage Damage ◽  
Critical Role ◽  
Joint Disease ◽  
P Value ◽  
Knee Oa

Abstract Background Vitamin D is important to normal bone and cartilage metabolism. Insufficient concentrations of vitamin D adversely affect calcium metabolism, osteoblastic activity, matrix ossification, bone density, and articular cartilage turnover. Osteoarthritis (OA) is a degenerative joint disease involving the cartilage and many of its surrounding tissues. In addition to damage and loss of articular cartilage, there is remodelling of subarticular bone, osteophyte formation, ligamentous laxity, weakening of periarticular muscles, and, in some cases, synovial inflammation. Pain is the major clinical symptom in knee OA joint. Objective To estimate a relation between Vit.D deficiency and the severity of knee osteoarthritis. Patients and Methods This study was a cross sectional study conducted on ninety (90) patients diagnosed (aged 40-55 years old) with knee osteoarthritis according to according to American college of rheumatology (ARC) criteria 2016 for diagnosis of OA. Patients were recruited from the Rheumatology Outpatient Clinic and Internal Medicine and Rheumatology Department at Ain Shams University Hospitals. Results Our studied cases show that VAS pain score ranges from 3–7 with a mean 4.70 ± 0.93 and median 4. As regard pain domini of WOMAC, it had significant relation with Vit D significant (p value = 0.007) while VAS Pain Score not significant related to Vit D (p value = 0.121). In current study, the correlation between stiffness and Vit D is statistically significant (p value =0.001), the correlation between physical function and Vit D is statistically significant (p value = 0.001), the correlation between WOMAC score and Vit D was statistically significant (p value = 0.001) As regard relation between Vit. D and X-Ray Kellgran-Lawrence system, it was significant in grade 1and grade 3. But it was non-significant n grade 2 &4. Conclusion This study has demonstrated a significant association between knee OA and vitamin D deficiency and corresponding with the development of knee cartilage damage. As Low levels of vitamin D may not play a critical role in OA pathogenesis and progression.

scholarly journals The Role of Platelet Rich Plasma in the Treatment Algorithm of Knee Osteoarthritis

2017 ◽  
pp. 63-69
Author(s):  
George Chang Chien
Keyword(s):  
Hyaluronic Acid ◽  
Knee Osteoarthritis ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Treatment Algorithm ◽  
Recovery Process ◽  
Joint Disease ◽  
Treatment Modalities ◽  
Surgical Approaches ◽  
Knee Oa

Osteoarthritis (OA) is a progressive joint disease associated with both mechanical and biologic abnormalities of the articular cartilage and subchondral bone. In normal cartilage, a delicate balance exists between matrix synthesis and degradation; in OA, however, cartilage degradation exceeds synthesis. Treatment modalities include nonpharmacological, pharmacological, and surgical approaches. Intrarticular platelet rich plasma (PRP) has emerged as promising treatment for early stages of knee OA. PRP is an autologous blood product defined as a volume of plasma that has a supraphysiologic platelet count. PRP can accelerate the physiological recovery process, relieve pain, and contains anti-inflammatory and anti-bacterial activity. Although the mechanisms for these complex interactions are not completely understood, they are attributed to the more than 30 bioactive proteins contained in the alpha granules of platelets including growth factors and proteins, such as fibrin, fibronectin, vitronectin and thrombospondin. Several studies now have demonstrated that intraarticular PRP injections are safe and effective treatment to reduce pain and improve quality of life through increased function in knee OA. The available literature suggests that PRP is a better option than hyaluronic acid for many knee OA patients. We identified 12 comparative studies that demonstrated superiority of PRP as compared to hyaluronic acid for knee OA. Considering what is known about the deleterious effects of local anesthetic and corticosteroids on soft tissue health, it may be time for a shift in the knee OA treatment algorithm to favor early intervention for regenerative therapies including platelet rich plasma. Key words: Platelet rich plasma, hyaluronic acid, knee pain, knee osteoarthritis, arthritis, chondrotoxicity

scholarly journals Effects of photobiomodulation and a physical exercise program on the expression of inflammatory and cartilage degradation biomarkers and functional capacity in women with knee osteoarthritis: a randomized blinded study

2021 ◽  
Vol 61 (1) ◽  
Author(s):  
Patricia Gabrielli Vassão ◽  
Ana Carolina Flygare de Souza ◽  
Raquel Munhoz da Silveira Campos ◽  
Livia Assis Garcia ◽  
Helga Tatiana Tucci ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Knee Osteoarthritis ◽  
Functional Capacity ◽  
Exercise Program ◽  
Cartilage Degradation ◽  
Post Treatment ◽  
Joint Disease ◽  
Control Group ◽  
Knee Oa ◽  
And Cartilage

Abstract Background The knee osteoarthritis (OA) is a joint disease characterized by degradation of articular cartilage that leads to chronic inflammation. Exercise programs and photobiomodulation (PBM) are capable of modulating the inflammatory process of minimizing functional disability related to knee OA. However, their association on the concentration of biomarkers related to OA development has not been studied yet. The aim of the present study is to investigate the effects of PBM (via cluster) with a physical exercise program in functional capacity, serum inflammatory and cartilage degradation biomarkers in patients with knee OA. Methods Forty-two patients were randomly allocated in 3 groups: ESP: exercise + sham PBM; EAP: exercise + PBM and CG: control group. Six patients were excluded before finished the experimental period. The analyzed outcomes in baseline and 8-week were: the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) and the evaluation of serum biomarkers concentration (IL-1β, IL-6, IL-8, IL-10 e TNF-α, and CTX-II). Results An increase in the functional capacity was observed in the WOMAC total score for both treated groups (p < 0.001) and ESP presents a lower value compared to CG (p < 0.05) the 8-week post-treatment. In addition, there was a significant increase in IL-10 concentration of EAP (p < 0.05) and higher value compared to CG (p < 0.001) the 8-week post-treatment. Moreover, an increase in IL-1β concentration was observed for CG (p < 0.05). No other difference was observed comparing the other groups. Conclusion Our data suggest that the physical exercise therapy could be a strategy for increasing functional capacity and in association with PBM for increasing IL-10 levels in OA knee individuals. Trial registration: ReBEC (RBR-7t6nzr).

Feasibility and acceptability of instructions of daily care in overweight and obese knee osteoarthritis participants

2021 ◽  
Vol 17 ◽  
Author(s):  
Muhammad Tariq Rafiq ◽  
Mohamad Shariff A Hamid ◽  
Eliza Hafiz ◽  
Farid Ahmad Chaudhary ◽  
Muhammad Irfan Khan
Keyword(s):  
Knee Osteoarthritis ◽  
Controlled Trial ◽  
Weight Bearing ◽  
Joint Disease ◽  
Control Group ◽  
P Value ◽  
Open Label ◽  
Timed Up And Go ◽  
Knee Oa ◽  
Daily Care

Introduction: Knee osteoarthritis (OA) is a weight-bearing joint disease and more common in the overweight and obese persons. The objective of the study was to assess the feasibility and acceptability of instructions of daily care (IDC) on pain, mobility and body mass index (BMI) among knee OA participants who are overweight or obese. Material and Method: The study was an open-label randomized controlled trial of six-weeks. Forty overweight and obese participants with knee OA were randomly divided into two groups by a computer-generated number. The participants in the Instruction Group (IG) were provided with leaflets explaining IDC for the duration of six-weeks. Both groups were instructed to take low doses of the non-steroid anti-inflammatory drug (NSAIDs) on alternate days. The outcome measures were pain, mobility and BMI. The feasibility and acceptability of knee pain and mobility were assessed using a questionnaire designed by experts in rehabilitation. Results: Participants in the IG reported more statistically significant pain relief as assessed by the Western Ontario and McMaster Universities Osteoarthritis Index score (p=0.001) and improvement in mobility (p=0.000) assessed by the Timed Up and Go test score after six weeks compared to the Control Group (CG). Both groups did not demonstrate any significant change in BMI (p-value > 0.05), The results of descriptive statistics showed a significantly higher satisfaction score to participants who received a combination of IDC and NSAIDs, indicating an acceptable intervention. Conclusion: The IDC are effective and acceptable in terms of improving pain and mobility and should be recommended as the usual care of treatment.

scholarly journals Treatment and Prevention of Osteoarthritis through Exercise and Sports

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Victor Valderrabano ◽  
Christina Steiger
Keyword(s):  
Pain Relief ◽  
Muscle Function ◽  
Symptomatic Treatment ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Joint Function ◽  
Treatment And Prevention ◽  
High Prevalence ◽  
Strengthening Exercises ◽  
Prevention And Treatment

Osteoarthritis (OA) is a degenerative joint disease with a high prevalence among older people. To date, the pathogenesis of the disease and the link between muscle function and OA is not entirely understood. As there is no known cure for OA, current research focuses on prevention and symptomatic treatment of the disorder. Recent research has indicated that muscle weakness precedes the onset of OA symptoms. Furthermore, several studies show a beneficial effect of land-based aerobic and strengthening exercises on pain relief and joint function. Therefore, current research focuses on the possibility to employ exercise and sports in the prevention and treatment of OA.

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