Capsicum Seeds as a Source of Bioactive Compounds: Biological Properties, Extraction Systems, and Industrial Application

Given the health-beneficial properties of compounds from hop, there is still a growing trend towards developing successful extraction methods with the highest yield and also receiving the products with high added value. The aim of this study was to develop efficient extraction method for isolation of bioactive compounds from the Polish “Marynka” hop variety. The modified two-step supercritical fluid extraction allowed to obtain two hop samples, namely crude extract (E1), composed of α-acids, β-acids, and terpene derivatives, as well as pure xanthohumol with higher yield than that of other available methods. The post-extraction residues (R1) were re-extracted in order to obtain extract E2 enriched in xanthohumol. Then, both samples were subjected to investigation of their antibacterial (anti-acne, anti-caries), cytotoxic, and anti-proliferative activities in vitro. It was demonstrated that extract (E1) possessed more beneficial biological properties than xanthohumol. It exhibited not only better antibacterial activity against Gram-positive bacteria strains (MIC, MBC) but also possessed a higher synergistic effect with commercial antibiotics when compared to xanthohumol. Moreover, cell culture experiments revealed that crude extract neither inhibited viability nor divisions of normal skin fibroblasts as strongly as xanthohumol. In turn, calculated selectivity indexes showed that the crude extract had from slightly to significantly better selective anti-proliferative activity towards cancer cells in comparison with xanthohumol.

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Formation of Amphiphilic Molecules from the Most Common Marine Polysaccharides, toward a Sustainable Alternative?

Molecules ◽

10.3390/molecules26154445 ◽

2021 ◽

Vol 26 (15) ◽

pp. 4445

Author(s):

Tiphaine Wong ◽

Lorette Brault ◽

Eric Gasparotto ◽

Romuald Vallée ◽

Pierre-Yves Morvan ◽

...

Keyword(s):

Fatty Acid ◽

Carboxylic Acid ◽

Bioactive Compounds ◽

Biological Properties ◽

Cross Linking ◽

Structural Modifications ◽

Chemical Structures ◽

Amphiphilic Molecules

Marine polysaccharides are part of the huge seaweeds resources and present many applications for several industries. In order to widen their potential as additives or bioactive compounds, some structural modifications have been studied. Among them, simple hydrophobization reactions have been developed in order to yield to grafted polysaccharides bearing acyl-, aryl-, alkyl-, and alkenyl-groups or fatty acid chains. The resulting polymers are able to present modified physicochemical and/or biological properties of interest in the current pharmaceutical, cosmetics, or food fields. This review covers the chemical structures of the main marine polysaccharides, and then focuses on their structural modifications, and especially on hydrophobization reactions mainly esterification, acylation, alkylation, amidation, or even cross-linking reaction on native hydroxyl-, amine, or carboxylic acid functions. Finally, the question of the necessary requirement for more sustainable processes around these structural modulations of marine polysaccharides is addressed, considering the development of greener technologies applied to traditional polysaccharides.

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Bioactive Compounds in Salicornia patula Duval-Jouve: A Mediterranean Edible Euhalophyte

Foods ◽

10.3390/foods10020410 ◽

2021 ◽

Vol 10 (2) ◽

pp. 410

Author(s):

Irene Sánchez-Gavilán ◽

Esteban Ramírez ◽

Vicenta de la Fuente

Keyword(s):

Fatty Acids ◽

Bioactive Compounds ◽

Mediterranean Area ◽

Biological Properties ◽

Total Phenolic ◽

Tinto River ◽

New Findings ◽

High Concentrations ◽

Salicornia Patula ◽

First Time

Many halophytes have great nutritional and functional potential, providing chemical compounds with biological properties. Salicornia patula Duval-Jouve is a common euhalophyte from saline Mediterranean territories (Spain, Portugal, France, and Italy). In the present work we quantified for the first time the bioactive compounds in S. patula (total phenolic compounds and fatty acids), from Iberian Peninsula localities: littoral-coastal Tinto River basin areas (southwest Spain, the Huelva province), and mainland continental territories (northwest and central Spain, the Valladolid and Madrid provinces). Five phenolic acids including caffeic, coumaric, veratric, salicylic, and transcinnamic have been found with differences between mainland and coastal saltmarshes. S. patula contain four flavonoids: quercetin-3-O-rutinoside, kaempferol/luteolin, apigenin 7-glucoside, and pelargonidin-3-O-rutinoside. These last two glycosylated compounds are described for the first time in this genus of Chenopodiaceae. The fatty acid profile described in S. patula stems contains palmitic, oleic, and linoleic acids in high concentrations, while stearic and long-chain fatty acids were detected in low amounts. These new findings confirm that S. patula is a valuable source of bioactive compounds from Mediterranean area.

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The synthesis and characterization of some new diazoamino derivatives

Chemical Industry and Chemical Engineering Quarterly ◽

10.2298/ciceq090918013m ◽

2010 ◽

Vol 16 (1) ◽

pp. 89-95

Author(s):

Mihaela Mocanu

Keyword(s):

1H Nmr ◽

Bioactive Compounds ◽

Elemental Analysis ◽

Analysis Data ◽

Biological Properties ◽

Synthesis And Characterization ◽

Elemental Analysis Data ◽

Spectral Measurements ◽

Inflammatory Processes

The sulfonamidic moiety is much encountered in structures of bioactive compounds. In the present paper the studies on the sulfonamidated aryloxyalkylcarboxylic acids are extended by their attaching on certain substrata able to confer some special biological properties to the final products, such as anti-tumor and antioxidant actions useful in treating inflammatory processes, ulcer, convulsions and diabetes, as well as a herbicidal action. The stepwise syntheses of the sulfonamidated aryloxyalkylcarboxylic acid derivatives and their characterization by elemental analysis data and IR, 1H-NMR and UV-Vis spectral measurements are described. The newly obtained compounds could show potential pharmaceutical and herbicide properties.

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Exploitation of Agro-Industrial Waste as Potential Source of Bioactive Compounds for Aquaculture

Foods ◽

10.3390/foods9070843 ◽

2020 ◽

Vol 9 (7) ◽

pp. 843

Author(s):

Nayely Leyva-López ◽

Cynthia E. Lizárraga-Velázquez ◽

Crisantema Hernández ◽

Erika Y. Sánchez-Gutiérrez

Keyword(s):

Bioactive Compounds ◽

Industrial Waste ◽

Biological Activities ◽

Biological Effects ◽

Food Additives ◽

Well Being ◽

Biological Properties ◽

Industrial Wastes ◽

Added Value ◽

Bodies Of Water

The agroindustry generates a large amount of waste. In postharvest, food losses can reach up to 50%. This waste represents a source of contamination of soil, air, and bodies of water. This represents a problem for the environment as well as for public health. However, this waste is an important source of bioactive compounds, such as phenolic compounds, terpenes, and β-glucans, among others. Several biological activities have been attributed to these compounds; for example, antioxidant, antimicrobial, gut microbiota, and immune system modulators. These properties have been associated with improvements in health. Recently, the approach of using these bioactive compounds as food additives for aquaculture have been addressed, where it is sought that organisms, in addition to growing, preserve their health and become disease resistant. The exploitation of agro-industrial waste as a source of bioactive compounds for aquaculture has a triple objective—to provide added value to production chains, reduce pollution, and improve the well-being of organisms through nutrition. However, to make use of the waste, it is necessary to revalue them, mainly by determining their biological effects in aquaculture organisms. The composition of bioactive compounds of agro-industrial wastes, their biological properties, and their application in aquaculture will be addressed here.

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The Role of Fruit by-Products as Bioactive Compounds for Intestinal Health

Foods ◽

10.3390/foods9111716 ◽

2020 ◽

Vol 9 (11) ◽

pp. 1716

Author(s):

Mohamed Aymen Chaouch ◽

Stefania Benvenuti

Keyword(s):

Bioactive Compounds ◽

Biological Properties ◽

Intestinal Function ◽

Gut Flora ◽

Good Source ◽

Fruit Processing ◽

Negative Environmental Impact ◽

Significant Chemical ◽

By Products

The fruit processing industry generates large amounts of wastes (pomace, seeds, peels) that causes negative environmental impact with considerable treatment expenses. Nevertheless, various studies demonstrated that these by-products are still rich in bioactive compounds, especially dietary fibres and phenolic compounds, thus leading to significant chemical, physical and biological properties. These characteristics make fruits by-products a good source for new supplements in food products having important effect on intestinal function. Thus, the aim of this review is to evaluate the different bioactive compounds isolated from fruit by-products and to analyse their application in various formulations for the food and nutraceutical industries. In consideration of the biological properties of these compounds, their role in the functioning and action on intestine and gut flora was discussed.

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Extracellular Enzymes and Bioactive Compounds from Antarctic Terrestrial Fungi for Bioprospecting

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17186459 ◽

2020 ◽

Vol 17 (18) ◽

pp. 6459

Author(s):

Laura Zucconi ◽

Fabiana Canini ◽

Marta Elisabetta Temporiti ◽

Solveig Tosi

Keyword(s):

Bioactive Compounds ◽

Extracellular Enzymes ◽

Biological Properties ◽

Metabolic Potential ◽

Functional Roles ◽

Antarctic Soils ◽

Terrestrial Fungi ◽

The Antarctic ◽

Abiotic Environmental Factors

Antarctica, one of the harshest environments in the world, has been successfully colonized by extremophilic, psychrophilic, and psychrotolerant microorganisms, facing a range of extreme conditions. Fungi are the most diverse taxon in the Antarctic ecosystems, including soils. Genetic adaptation to this environment results in the synthesis of a range of metabolites, with different functional roles in relation to the biotic and abiotic environmental factors, some of which with new biological properties of potential biotechnological interest. An overview on the production of cold-adapted enzymes and other bioactive secondary metabolites from filamentous fungi and yeasts isolated from Antarctic soils is here provided and considerations on their ecological significance are reported. A great number of researches have been carried out to date, based on cultural approaches. More recently, metagenomics approaches are expected to increase our knowledge on metabolic potential of these organisms, leading to the characterization of unculturable taxa. The search on fungi in Antarctica deserves to be improved, since it may represent a useful strategy for finding new metabolic pathways and, consequently, new bioactive compounds.

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Applying Seaweed Compounds in Cosmetics, Cosmeceuticals and Nutricosmetics

Marine Drugs ◽

10.3390/md19100552 ◽

2021 ◽

Vol 19 (10) ◽

pp. 552

Author(s):

Lucía López-Hortas ◽

Noelia Flórez-Fernández ◽

Maria D. Torres ◽

Tania Ferreira-Anta ◽

María P. Casas ◽

...

Keyword(s):

Bioactive Compounds ◽

Algal Blooms ◽

Low Cost ◽

Wide Distribution ◽

Biological Properties ◽

Waste Streams ◽

Patent Literature ◽

Renewable Material ◽

Technical Features ◽

Skin Care Products

The interest in seaweeds for cosmetic, cosmeceutics, and nutricosmetics is increasing based on the demand for natural ingredients. Seaweeds offer advantages in relation to their renewable character, wide distribution, and the richness and versatility of their valuable bioactive compounds, which can be used as ingredients, as additives, and as active agents in the formulation of skin care products. Bioactive compounds, such as polyphenols, polysaccharides, proteins, peptides, amino acids, lipids, vitamins, and minerals, are responsible for the biological properties associated with seaweeds. Seaweed fractions can also offer technical features, such as thickening, gelling, emulsifying, texturizing, or moistening to develop cohesive matrices. Furthermore, the possibility of valorizing industrial waste streams and algal blooms makes them an attractive, low cost, raw and renewable material. This review presents an updated summary of the activities of different seaweed compounds and fractions based on scientific and patent literature.

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Isolation and Partial Purification of Bioactive Compounds from Sponge Sigmadocia Fibulata (Schmidt) Collected from West Coast of Mumbai, India

Biomedical & Pharmacology Journal ◽

10.13005/bpj/2269 ◽

2021 ◽

Vol 14 (3) ◽

pp. 1675-1684

Author(s):

Bhadekar N. S ◽

Zodape G.V

Keyword(s):

Bioactive Compounds ◽

West Coast ◽

Acid Methyl Ester ◽

Biological Properties ◽

Partial Purification ◽

Acid Metabolite ◽

Fatty Acid Metabolite ◽

Plant Metabolite ◽

Pharmaceutical Properties ◽

Layer Chromatography

The sponge Sigmadocia fibulata (Schmidt) was collected during low tides from West Coast of Mumbai. Crude extract was obtained by taking 10 gram of sponge samples in10 ml of methanol. The preparative TLC (Thin Layer Chromatography) was performed by using Toluene: Ethyl acetate: Diethylamine (7:2:1) (v/v). The isolated compounds were subjected to GC-MS and FTIR analysis. The structural properties of bio active compounds were determined.From the structural determination it was confirmed that S. fibulata contains bioactive compounds as Triacontanoic acid, methyl ester – (Skin irritant), Hexadecanoic acid, 2- hydroxyl- (hydroxymethyl) ethyl ester – (Fatty acid, Metabolite and Irritant) and 2-Nitro-1, 3-bis-oclyoxy-benzene, (A natural product found in Neolitsea daibuensis. It has a role as a plant metabolite and an algal metabolite). From their biological properties it was confirmed that S. fibulata contains bio active compound, which has biomedical and pharmaceutical properties.

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Characterization of Andean Blueberry in Bioactive Compounds, Evaluation of Biological Properties and in vitro Bioaccessibility

10.20944/preprints202009.0055.v1 ◽

2020 ◽

Author(s):

Nieves Baenas ◽

Jenny Ruales ◽

Diego A. Moreno ◽

Daniel Alejandro Barrio ◽

Carla M. Stinco ◽

...

Keyword(s):

Antioxidant Capacity ◽

Bioactive Compounds ◽

Biological Activities ◽

In Vitro Digestion ◽

Biological Properties ◽

Wide Range ◽

Zebrafish Embryogenesis

Andean blueberries are wild berries grown and consumed in Ecuador which contain high values of bioactive compounds, mainly anthocyanins, with powerful antioxidant activity. The aim of this study was to evaluate the profile and contents of (poly)phenols and carotenoids in Andean blueberry by HPLC-DAD-MSn and determine a wide range of its biological activities. The antioxidant capacity of this fruit was evaluated in vitro by three different methods and in vivo using the zebrafish animal model, also the toxicity effect was determined by the zebrafish embryogenesis test. Besides, the antimicrobial activity and the capacity of Andean blueberry to produce hemagglutination in blood cells were evaluated. Finally, the bioaccessibility of (poly)phenols and related antioxidant capacity were determined in the different phases of an in vitro digestion. The global results indicated no toxicity of Andean blueberry, weakly bacteriostatic activity, and high contents of anthocyanins and antioxidant capacity, which were partially bioaccesible in vitro (~ 50 % at the final intestinal step), contributing to the knowledge of its health benefits for consumers and its potential use in the food and pharmaceutical industry as functional ingredient.

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