scholarly journals Chemotherapy-Induced Peripheral Neurotoxicity in Cancer Survivors: Predictors of Long-Term Patient Outcomes

2021 ◽  
Vol 19 (7) ◽  
pp. 821-828
Author(s):  
Eva Battaglini ◽  
David Goldstein ◽  
Peter Grimison ◽  
Susan McCullough ◽  
Phil Mendoza-Jones ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Cancer Survivors ◽  
Body Mass ◽  
Management Strategies ◽  
Symptom Burden ◽  
Cross Sectional Survey ◽  
Peripheral Neurotoxicity ◽  
Cross Sectional ◽  
Burning Pain ◽  
The Impact

Background: Chemotherapy-induced peripheral neurotoxicity (CIPN) is a major adverse effect of cancer treatment. However, its impact remains poorly understood. This study aimed to investigate the impact associated with CIPN on the lives of cancer survivors. Patients and Methods: A volunteer sample of 986 individuals who had received neurotoxic chemotherapy completed an anonymous, cross-sectional survey. Outcomes assessed included CIPN symptoms, pain, neuropathic pain, quality of life (QoL), physical activity, and comorbid health conditions via the Self-Administered Comorbidity Questionnaire. Results: Respondents had a mean age of 58 years (SD, 10.7), and 83.2% were female. Most were treated for breast (58.9%) or colorectal cancer (13.5%); had received docetaxel (32.7%), paclitaxel (31.6%), or oxaliplatin (12.5%); and had completed treatment 3.6 ± 3.5 years previously. We found that 76.5% of respondents reported current CIPN. Respondents reporting severe CIPN had poorer QoL, more comorbidities, and higher body mass index, and more often received multiple neurotoxic chemotherapies than those with mild CIPN. Respondents who completed the survey ≤1 year after completing chemotherapy did not differ in reported CIPN or pain compared with respondents who completed chemotherapy ≥6 years earlier. However, respondents who completed chemotherapy ≥6 years earlier reported better QoL. Multivariable linear regression analyses revealed predictors of CIPN severity as follows: F(7, 874) = 64.67; P<.001; R2 = 0.34, including pain (β = −0.36; P<.001), burning pain (β = 0.25; P<.001), sex (male sex associated with greater CIPN: β = 0.14; P<.001), years since completing chemotherapy (shorter time associated with greater CIPN; β = −0.10; P<.001), age (β = 0.80; P=.006), number of comorbid conditions (β = 0.07; P=.02), and body mass index (β = 0.07; P=.02). Conclusions: Respondents with a high CIPN symptom burden experienced poorer general health and QoL. Improvements in CIPN may be more likely soon after treatment. However, improvements in QoL may occur over time in those with chronic symptoms. CIPN seems to have lasting impacts on cancer survivors, and understanding risk factors is important to enable the design of further preventive and therapeutic management strategies.

scholarly journals Caffeinated Drinks Intake, Late Chronotype, and Increased Body Mass Index among Medical Students in Chongqing, China: A Multiple Mediation Model

2018 ◽  
Vol 15 (8) ◽  
pp. 1721 ◽  
Author(s):  
Yangchang Zhang ◽  
Yang Xiong ◽  
Jia Dong ◽  
Tingting Guo ◽  
Xiaoman Tang ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Medical Students ◽  
Body Mass ◽  
Cross Sectional Study ◽  
Multiple Mediation ◽  
Depression Anxiety Stress Scale ◽  
Positive Role ◽  
Cross Sectional ◽  
The Impact

Background: This paper investigates the problems regarding caffeinated drinks intake, late chronotype, and increased body mass index (BMI) among medical students at a Chinese university. Methods: This cross-sectional study was conducted in 2018 with 616 medical students from Chongqing Medical University in Chongqing, China, whose information were collected by a self-reported questionnaire that included four sections: Demographic characteristics; Caffeinated drinks intake and physical state; Morningness-Eveningness Questionnaire; Depression Anxiety Stress Scale 21. Multiple mediation analyses were conducted to test the impact of late chronotype on increased BMI through caffeinated drinks consumption through two models. Results: The significantly mediated effect of caffeinated drinks consumption was revealed (estimate: −0.01, SE = 0.01, 95% CI [−0.02, −0.01]), and which played a positive role in linking late chronotype (B = −0.01, SE = 0.01, p < 0.001) and increased BMI (B = 1.37, SE = 0.21, p < 0.01), but their significant association did not be found in reversed model. In addition, physical activity and inactivity times demonstrated significant indirect effects in the two models. Conclusions: Interventions should focus on reducing caffeinated drinks intake and sedentary behavior time, enhancing physical activity among medical students.

scholarly journals Body mass index status and peripheral airway obstruction in school-age children: a population-based cohort study

Thorax ◽  
2018 ◽  
Vol 73 (6) ◽  
pp. 538-545 ◽  
Author(s):  
Sandra Ekström ◽  
Jenny Hallberg ◽  
Inger Kull ◽  
Jennifer L P Protudjer ◽  
Per Thunqvist ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Lung Function ◽  
Airway Obstruction ◽  
Body Mass ◽  
Overweight And Obesity ◽  
School Age Children ◽  
Childhood And Adolescence ◽  
Small Airways ◽  
Cross Sectional ◽  
The Impact

BackgroundFew large prospective studies have investigated the impact of body mass index (BMI) on lung function during childhood.MethodsUsing data collected between 2002 and 2013, we analysed associations between BMI status and lung function (assessed by spirometry) from 8 to 16 years, as well as cross-sectional associations with small airway function (impulse oscillometry) at 16 years in the BAMSE cohort (n=2889). At 16 years, cross-sectional associations with local and systemic inflammation were investigated by analysing FENO, blood eosinophils and neutrophils.ResultsOverweight and obesity at 8 years were associated with higher FVC, but lower FEV1/FVC ratio at 8 and 16 years. In boys, but not girls, obesity at 8 years was associated with a further reduction in FEV1/FVC between 8 and 16 years. In cross-sectional analyses, overweight and obesity were associated with higher frequency dependence of resistance (R5–20) and larger area under the reactance curve (AX0.5) at 16 years. Increased blood neutrophil counts were seen in overweight and obese girls, but not in boys. No association was found between BMI status and FENO. Persistent, but not transient, overweight/obesity between 8 and 16 years was associated with higher R5–20 and AX0.5 and lower FEV1/FVC (−2.8% (95% CI −4.1 to −1.2) in girls and −2.7% (95% CI −4.4 to −1.1) in boys) at 16 years, compared with persistent normal weight.ConclusionIn childhood and adolescence, overweight and obesity, particularly persistent overweight, were associated with evidence of airway obstruction, including the small airways.

scholarly journals Urinary Incontinence

AAOHN Journal ◽  
2000 ◽  
Vol 48 (3) ◽  
pp. 112-118 ◽  
Author(s):  
Sheila T. Fitzgerald ◽  
Mary H. Palmer ◽  
Susan J. Berry ◽  
Kristin Hart
Keyword(s):  
Body Mass Index ◽  
Urinary Incontinence ◽  
Working Women ◽  
Working Life ◽  
Full Time ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
University Center ◽  
Occupational Setting ◽  
The Impact

Until recently, the impact of urinary incontinence (UI) on working women, a population generally characterized as healthy, has not been the focus of research. Women employed full time at a large university center participated in a cross sectional survey about UI. Of the 1,113 women surveyed, age 18 and older, 21 % (n = 232) reported UI at least monthly. Incontinent women were significantly older and had a higher body mass index than continent women. Using disposable products, limiting fluids, avoiding caffeinated beverages, using voiding schedules, and keeping extra clothes or underwear were strategies used to manage UI at work. Responses to an open ended question related to the impact of UI on working life included: interference with sleep and resulting fatigue at work, embarrassment, alteration of concentration, and emotional distress. Implications for nurses are discussed in relation to assessment, education, and management of UI in the occupational setting.

Body Mass Index and Association With Caries in School-Aged Children With Orofacial Cleft: A Case-Control Study

2019 ◽  
Vol 57 (2) ◽  
pp. 169-176
Author(s):  
Anna Lena Sundell ◽  
Anna-Karin Nilsson ◽  
Agneta Marcusson ◽  
Carl-Johan Törnhage
Keyword(s):  
Body Mass Index ◽  
Dental Caries ◽  
Body Mass ◽  
Cleft Lip ◽  
Case Control ◽  
Assessment System ◽  
Caries Detection ◽  
Adopted Children ◽  
Cross Sectional ◽  
The Impact

Objective: Data on the association between body mass index (BMI) and dental caries in children with orofacial clefts are sparse. Therefore, studies on the impact of BMI on caries frequency in children with cleft lip and/or palate (CL/P) are of importance. The aim of the current study was to investigate the association between BMI and frequency of dental caries in children with and without CL/P. Height, weight, and BMI in children with CL/P were also compared to controls. Design: This study used a cross-sectional case-control design. Participants: One hundred and thirty-nine 5- and 10-year-old children with CL/P and 299 age-matched controls. Main Outcome Measures: Caries was recorded according to the International Caries Detection and Assessment System. Height and weight were recorded, and BMI was calculated as weight/height2. Results: There was no correlation between BMI and caries frequency. Weight, height, and BMI were significantly lower in all children with CL/P compared to controls. After adjustment for international adoption, only BMI was significantly lower in CL/P children compared to controls. Non-adopted children with CL/P were significantly heavier and longer than adopted children with CL/P. Conclusions: Five- and 10-year-old children with corrected CL/P seemed to have a lower BMI than controls, but there was no association between BMI and caries frequency. Internationally adopted children with CL/P were lighter and shorter than non-adopted CL/P children and controls.

scholarly journals Body Mass Index and Total Symptom Burden in Myeloproliferative Neoplasms Discovery of a U-shaped Association

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2202 ◽  
Author(s):  
Sarah Friis Christensen ◽  
Robyn Marie Scherber ◽  
Nana Brochmann ◽  
Martin Goros ◽  
Jonathan Gelfond ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Myeloproliferative Neoplasms ◽  
Philadelphia Chromosome ◽  
Myeloproliferative Neoplasm ◽  
Symptom Burden ◽  
Normal Weight ◽  
Analysis Of Covariance ◽  
Cross Sectional ◽  
Increased Risk

Elevated body mass index (BMI) is a global health problem, leading to enhanced mortality and the increased risk of several cancers including essential thrombocythemia (ET), a subtype of the Philadelphia-chromosome negative myeloproliferative neoplasms (MPN). Furthermore, evidence states that BMI is associated with the severity of symptom burden among cancer patients. MPN patients often suffer from severe symptom burden. The purpose of this study was to examine whether deviations from a normal BMI in an MPN population are associated with higher symptom burden and reduced quality of life (QoL). A combined analysis of two large cross-sectional surveys, the Danish Population-based Study, MPNhealthSurvey (n = 2044), and the international Fatigue Study (n = 1070), was performed. Symptoms and QoL were assessed using the validated Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF). Analysis of covariance was used to estimate the effects of different BMI categories on symptom scores while adjusting for age, sex, and MPN subtype. A U-shaped association between BMI and Total Symptom Burden was observed in both datasets with significantly higher mean scores for underweight and obese patients relative to normal weight (mean difference: underweight 5.51 (25.8%), p = 0.006; obese 5.70 (26.6%) p < 0.001). This is an important finding, as BMI is a potentially modifiable factor in the care of MPN patients.

scholarly journals Sex Differences in the Influence of Sleep on Body Mass Index and Risk of Metabolic Syndrome in Middle-Aged Adults

Healthcare ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 561
Author(s):  
Hyun-E Yeom ◽  
Jungmin Lee
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Cross Sectional Study ◽  
Poor Sleep ◽  
Middle Aged ◽  
Cross Sectional ◽  
Aged People ◽  
Middle Aged Adults ◽  
The Impact

Poor sleep and obesity are intimately related to cardiovascular diseases. We aimed to examine whether the influence of sleep and body mass index (BMI) on the risk of metabolic syndrome (MetS) differed by sex in middle-aged people. It is a cross-sectional study of 458 Korean participants who completed self-administered surveys; the data were analyzed using the PROCESS macro for SPSS. We found that both sleep and BMI were significant predictors of MetS risk in women, particularly by the role of BMI connecting the impact of sleep to MetS risk. However, the association was not found in men, showing that BMI, but not sleep, was a significant predictor of MetS. This sex-related difference was due to different relationships between sleep and BMI, indicating that BMI was more dependent on sleep quality for women than for men. Therefore, a sex-specific approach to decrease the risk of MetS is warranted.

scholarly journals Which body mass index is best associated with risk of diabetes mellitus and hypertension in a Japanese-Brazilian population?

2007 ◽  
Vol 23 (2) ◽  
pp. 297-304 ◽  
Author(s):  
Rosana Farah Simony ◽  
Suely Godoy Agostinho Gimeno ◽  
Sandra Roberta Gouveia Ferreira ◽  
Laércio Joel Franco
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Body Mass ◽  
Sensitivity And Specificity ◽  
Population Based ◽  
Cross Sectional Study ◽  
Odds Ratios ◽  
Cross Sectional ◽  
Japanese Brazilians ◽  
The Impact

The objective of this study was to evaluate the impact of different body mass index (BMI) ranges associated with the risk of diabetes and hypertension in Japanese-Brazilians. This cross-sectional study was based on data from 1,330 Japanese-Brazilians > 30 years of age who participated in a population-based survey on the prevalence of diabetes mellitus and associated diseases. Glucose tolerance status was classified according to WHO criteria and blood pressure levels according to the VI-JNC. Odds ratios for diabetes and hypertension were calculated for different BMI ranges; for different BMIs, sensitivity and specificity for percentiles 25, 50, 75, 90 and 95 were obtained. Increased odds ratios for diabetes mellitus and hypertension were observed with BMI values > 25kg/m². The 50th percentile corresponded to the highest sensitivity and specificity for the identification of risk for both diseases. Our results suggest that BMI values proposed by WHO should also be useful for this group of Japanese descendants in the assessment of risk for DM and hypertension.

scholarly journals Prevalence, Awareness, Treatment, and Control of Hypertension among Chinese First-Generation Migrants and Italians in Prato, Italy: The CHIP Study

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Pietro A. Modesti ◽  
Maria Calabrese ◽  
Ilaria Marzotti ◽  
Hushao Bing ◽  
Danilo Malandrino ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
First Generation ◽  
Primary Outcome Measure ◽  
Cross Sectional Survey ◽  
Antihypertensive Medications ◽  
Cross Sectional ◽  
Parental History ◽  
Chinese Migrants ◽  
First Generation Migrants

Data on health needs of Chinese living in the South of Europe are lacking. To compare prevalence, awareness, treatment, control, and risk factors for hypertension between Chinese migrants and Italian adults, a sample of 1200 first-generation Chinese migrants and 291 native Italians aged 35–59 years living in Prato (Italy) was recruited in a community-based participatory cross-sectional survey. Primary outcome measure was hypertension, diagnosed for blood pressure values ≥ 140/90 mmHg or current use of antihypertensive medications. Associations with exposures (including age, gender, body mass index, waist, education level, total cholesterol, and triglycerides) were examined using logistic regression. When compared with Italians, Chinese had higher hypertension prevalence (27.2% versus 21.3%,p<0.01), with comparable levels of awareness (57.4% and 48.4%) but lower treatment rates (70.6% and 90.0%, resp.). In both ethnic groups age and parental history of hypertension were predictors of awareness and treatment, body mass index being predictor of hypertension diagnosis. In Chinese participants, where the optimum cut-off point for body mass index was ≥23.9 kg/m2, the sensibility and specificity prediction for hypertension were 61.7% and 59.8%, respectively (area under the ROC curve = 0.629). Implementation of specific, culturally adapted health programs for the Chinese community is now needed.

The impact of age on general and bladder cancer-specific quality of life among bladder cancer survivors.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 463-463
Author(s):  
Pauline Filippou ◽  
Sean McCabe ◽  
Hannah McCloskey ◽  
Kathryn Gessner ◽  
Judy Hamad ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bladder Cancer ◽  
Cancer Survivors ◽  
Cancer Patients ◽  
Multivariable Analysis ◽  
Multiple Linear Regression Model ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
The Impact

463 Background: Quality of life among cancer survivors has been shown to vary by age. Our objective was to evaluate differences in general and bladder cancer-specific quality of life based on age among a large cross-sectional bladder cancer cohort. Methods: We performed a cross-sectional survey of bladder cancer patients using the Bladder Cancer Advocacy Network Patient Survey Network and Inspire platforms to determine general and bladder cancer-specific quality of life (QOL) using the EORTC QLQ-C30 and Bladder Cancer Index. Patients were also queried regarding demographic, socioeconomic and clinical characteristics. We present descriptive statistics and a multiple linear regression model to identify factors independently associated with QOL domain score. Results: 972 respondents self-identified as patients with bladder cancer, of whom 41% were female and 97 % were white. The mean age was 67.6 years (range 29 to 93 years). Respondents were highly educated (67% completed college). 63% of patients identified as having non-invasive (NMIBC) cancer (n=578), 30% had MIBC (n=270), and 7% had metastatic bladder cancer (n=63). On multivariable analysis, older age was significantly associated with better generic QOL and urinary function ( Table), but not sexual function (p=0.19) or bowel function (p=0.73), controlling for sex, race, stage, comorbidity and years since diagnosis. Conclusions: Higher general and domain-specific QOL scores are more common among older bladder cancer patients. Differential impact by age may be important for the development of tailored interventions to improve QOL for bladder cancer patients. [Table: see text]

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