scholarly journals Correlation between Serum Iron, Serum Ferritin and Bile Cholesterol Level in Gallstone Disease

Author(s):  
Bindesh Ashok Kumar Dube ◽  
KS Kher

Introduction: The cholesterol stones are formed by super-saturation of the bile with cholesterol. Iron deficiency alters activity of several hepatic enzymes, leading to increased cholesterol saturation of bile in gall bladder thus promoting cholesterol crystallisation. Iron has a role in gallstone pathogenesis and ferritin is the most specific marker for iron levels in the body, but there are less studies which depict correlation between serum iron, serum ferritin and bile cholesterol. Aim: To study the correlation between serum iron, serum ferritin and bile cholesterol level in gallstone patients. Materials and Methods: The observational study was conducted in the Department of Surgery. The study population was 45 patients with gallstone disease. Serum iron, Serum ferritin and Bile cholesterol contents were analysed. Serum cholesterol levels were estimated using Folch method and estimation of bile cholesterol was done by Enzopak kit.Statistical analysis was done by using descriptive and inferential statistics using chi square test and software used in the analysis were SPSS 24.0 version and p<0.05 was considered as level of significance. Results: A positive but negligible correlation between serum iron and serum ferritin was observed (Pearson’s correlation coefficient of 0.247). Negative correlation between serum iron vs serum cholesterol and serum ferritin vs serum cholesterol was observed. Conclusion: It can be concluded that a low value of serum iron and serum ferritin is a risk factor for cholelithiasis, whereas, if the value of bile cholesterol increases then there is a high probability of cholelithiasis.

2020 ◽  
Vol 3 (1) ◽  
pp. 42-27
Author(s):  
Madhukar Rajaram Wagh ◽  
Sunil Joshi

Background: Cholelithiasis is a common abdominal disorder resulting in increasing hospital admissions. About 10-12% of adults develop gallstones. Aim of this study was to find out any association of serum iron and ferritin levels in patients of cholelithiasis. Subjects and Methods: Present study was conducted at the department of surgery, tertiary care institute of for the period 1 year. For the study purpose 70 gall stone cases and 70 normal healthy matched controls were taken as study participants. After explaining about the study to the subjects, an informed consent will be obtained, followed by a detailed history with clinical examination with more emphasis on the parameters given below in outcome variable (ultrasonography finding, serum iron level, serum ferritin level, serum cholesterol). Results: The mean age in the case group (gallstones present) is 43.12 years, as compared to the control group the mean age is 41.05 years, The study shows in the case group 64% of patient was female and 36% was male and in the control group 76% of patient was female and 24% was male. In this study 46 (65.7%) patients with gallstones have the value of serum iron less than normal (normal value: >40 µg/dl). Our study shows, there are 35 female patients with gallstone disease who have serum iron levels below the normal value Most of the patients with gallstone disease whose serum iron levels are subnormal are females. Our study shows that the mean serum iron between cases and control was statistically significant p 0.05. There is no effect of anemia on serum cholesterol. In this study the mean serum cholesterol between cases and control was statistical insignificant (p>0.7)) In the case group, 20 of male and 36 of female patients have normal serum ferritin levels. The number of females having normal serum ferritin levels (in both case and control groups) is more. Conclusion: Gallstones are more prevalent in female population than males. Serum ferritin association is insignificant as it increases other condition with inflammation also. Low serum iron level associated with high risk of cholelithiasis as this may lead to super saturation of bile.


2018 ◽  
Vol 1 (1) ◽  
pp. 046
Author(s):  
Yusni Podungge ◽  
Puspita Sukmawaty Rasyid

Undernutrition in infants is a condition where the baby does not growand develop optimally because of the unfulfilled intake of nutritionsubstances in the body. Under-nutrition in infants can be overcome bythe provision of balanced nutritious foods, one sign of improvednutrition can be seen from normal weight gain for age. One of the foodsthat can boost the improvement of nutrients is a food that containsproteins and vitamins, such as yellow pumpkin and chicken, whereyellow pumpkin contains vitamin A and chicken meat as a source ofanimal protein that contains good nutrients. The purpose of this studywas to analyze the effect of yellow pumpkin and chicken meat onweight growing infant 12 months in work area of Talaga JayaCommunity Health Center. The research method used experimentalresearch model with design non equivalent control group for eachgroup of intervention and control. Sampling using purposive samplingaccording to inclusion and exclusion criteria. With a sample number of30 malnourished infants less than 12 months of age. Analyticaltechniques was used in the chi square test. The result of this researchwas showed that value of chi square count 22,634 highger than chisquare table Df 1 = 3,841. There was influence giving yellow pumpkinpumper and chicken to enhancement nutritional weight infant weight12 month in work area Puskesmas Talaga Jaya. The conclusion wasthe provision of pumpkin porridge can raise the weight of infants lessthan 12 months of age as a benchmark nutritional improvements ininfants less nutrition.


Author(s):  
Aprilia Aprisanti Reyani

Latar Belakang :Kehangatan dada ibu dapat menghangatkan bayi, sehingga apabila bayi diletakan di dada ibunya segera setelah melahirkan atau dilakukan Inisiasi Menyusu Dini, dapat menurunkan resiko hipotermia dan menurunkan kematian bayi baru lahir akibat kedinginan atau hipotermia. Tujuan : Tujuan dari penelitian ini adalah untuk mengetahui perbedaan suhu tubuh bayi baru lahir antara bayi yang berhasil melakukan IMD dan bayi yang tidak berhasil melakukan IMD Metode  :Analitik,desain cross sectional,populasi semua bayi baru lahir, sampel bayi barulahir, teknik Non Random Sampling, pengumpulan data dengan menggunakan Lembar Observasi dengan menggunakan uji Chi-Square dengan nilai signifikan α = 0.05 yaitu bila hasil uji statistik menunjukan p ≤ α maka H0 ditolak. Hasil      :Suhu tubuh bayi baru lahir yang berhasil melakukan IMD sebagianbesardengansuhutubuhtidakhipotermisebanyak 20 bayi (87%) Suhu tubuh bayi baru lahir yang tidak berhasil melakukan IMD sebagianbesardengansuhutubuhhipotermisebanyak 8 bayi (66,7%). Dari hasil uji statistik diperoleh hasil nilai p = 0,005 < α = 0.05 maka H1 diterima, artinya ada Perbedaan suhu tubuh bayi baru lahir yang berhasil melakukan IMD dan yang tidak berhasil melakukan IMD Kesimpulan :Terdapat perbedaan suhu tubuh bayi baru lahir antara bayi yang berhasil melakukan IMD dan bayi yang tidak berhasil melakukan IMD.   Kata kunci : Inisiasi Menyusu Dini, Suhu Tubuh Bayi Baru Lahir                                                                                               THE DIFFERENCE BODY TEMPERATURE BETWEEN BABIES WHO SUCCESSFULLY INITIATE BREASTFEEDING EARLY AND BABIESWHO FAIL TO INITIATE EARLY BREASTFEEDING AT RSIA KIRANA SIDOARJO 2019  Background : The warmth of the mother’s chest can warm the baby, so that when the baby is in the mother’s breast immediately after birth or initiated early breastfeeding can reduce the mortality rate of newborns due to hypotermia.Purpose :the purpose of this study was to determine the difference in body temperature of newborns between infants who successfully initiated early breastfeeding and infants who did not succeed in initiating early breastfeedingMethods : analytical, cross sectional design, population 40 newborns, samples 35 newborns, Non Random Sampling techniques, the data accumulation using observation sheets and using chi-square test, with significant value α = 0.05 is when the statistical test results show p ≤ α then Ho is rejected.Result : The body temperature of the newborn who succeeded in initiating early breastfeeding was 36.78ºC with 23 (65.7%) of infants none having hypothermia, the newborn baby's body temperature that did not succeed in doing this early breastfeeding was 35.78ºC With 8 infants experiencing hypothermia, while 4 babies with normal temperature. From the results of statistical tests obtained results with the value p = 0,000 <α = 0.05 then H1 accepted, meaning there is a difference in body temperature of a newborn who successfully initiated early breastfeeding and who did not succeed in Early Breastfeeding Initiation. Conclusion : There is a difference in the body temperature of a newborn between infants who successfully initiated breastfeeding and infants who are not successful in initiating early breastfeeding....Keywords : Early breastfeedinginitiation, newborns temperature


2017 ◽  
Vol 3 (1) ◽  
pp. 52
Author(s):  
Lidia Widia

Immunization is a process to make the body's immune defense system against invading microorganisms (bacteria and viruses) that can cause infections before these microorganisms have a chance to invade our bodies. Hepatitis B immunization is the immunization to prevent the body less susceptible to hepatitis B virus. The purpose of this study was to identify whether there is the Relationship Between Hepatitis B Immunization Status Completed At Age 0-6 Month With Events Hepatitis B in the Work Area Puskesmas Perawatan Simpang Empat Kecamatan Simpang Empat Kabupaten Tanah Bumbu.This research method is analytical survey and cross sectional approach for studying the dynamics of the correlation between risk factors and the effects of the approach, observation or data collection at once at a time (point time approach), the sampling technique is taken with total sampling technique that met the inclusion criteria and exclusion of mothers with babies were recorded in the register Puskesmas Simpang Empat Kecamatan Simpang Empat Kabupaten Tanah Bumbu. The data obtained were analyzed using chi-square test with significance of 0.05. Chi-Square test results obtained there is a significant relationship between the completeness status of hepatitis B immunization (P = 0.005) with the occurrence of Hepatitis B, for the conclusion in this study found no relationship between the completeness status of hepatitis B immunization with Hepatitis B in Puskesmas Simpang Empat Kecamatan Simpang Empat Kabupaten Tanah Bumbu. It is hoped that no more infants are immunized against the completeness of incomplete hepatitis B immunization to reduce the incidence of hepatitis and reduce infant mortality


2016 ◽  
Vol 14 (2) ◽  
pp. 35
Author(s):  
Sigit Tri Ambarwanto ◽  
Nurjazuli Nurjazuli ◽  
Mursid Raharjo

Background: The problem of heavy metal pollution is a serious problem in Indonesia. This metal has been known to be stored in the body for long periods of time as toxins accumulate. Preliminary test results BLL on workers in the metal casting Ceper, found as many as 16 (5.61%) BLL on workers is under (NAB) and 17 (5.28%) workers above (NAB). The research was conducted to determine the relationship between the exposure of lead (Pb) in blood with hypertension in foundry workers CV. Fortification Jaya Batur, Ceper, Klaten. Methods: It was an observational study with Cross Secional design. The population in this study were all workers CV. Jaya fortification. Samples are workers CV. Fortification Jaya who met the inclusion criteria. Gathering data using questionnaires tools, inspection PB in the air using Gravimetry, Pb in the blood examination using AAS (automatic Absorption Spectrophotometer) and hypertension examination tension meter is measured using a needle. Results: The average air Pb 0.13756 mg / dl, the average BLL was 14.38096μg/dl. Chi Square test results showed that there was no relationship between the type of work with hypertension (p = 0.625), There is a relationship between levels of air Pb Pb levels in blood (p = 0.019), There is a relationship between levelsof lead in blood with hypertension(p=0.042).Conclusions:Levels of Air Pb Pb levels in the blood affects that can cause hypertension. Keywords: Hypertension, Blood Lead Level, Klaten


Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 5382-5382
Author(s):  
Rodolfo D Cancado ◽  
Paulo CJL Santos ◽  
Samuel Rostelato ◽  
Cristiane T Terada ◽  
Iris Gonzales ◽  
...  

Abstract Hereditary hemochromatosis (HH) is a disorder characterized by increased intestinal iron absorption, which leads to a progressive accumulation of iron in the body. This iron overload has been associated with mutations in HFE gene (C282Y, H63D and S65C) and other genes. The objectives of this study were to assess the frequencies of functional mutations in HFE and TFR2 genes and to investigate their relationship with the iron status in a sample of blood donors. Blood donors (n=542) were recruited at the Hemocenter of the Santa Casa Hospital, Sao Paulo, Brazil. The genotypes for HFE (C282Y, H63D and S65C) TFR2 (Y250X and Q690P) gene mutations were evaluated by PCR-RFLP. The concentrations of serum iron and total iron-binding capacity (TIBC) were measured by automation system Advia®(Bayer Diagnostics) and serum ferritin by Axsym System®(Abbott Laboratories). The frequencies of HFE 282Y, HFE 63D and HFE 65C alleles were 2.1, 13.6 and 0.6%, respectively. The frequency C282Y allele (2.1%) in Brazilian blood donors is lower than that observed in blood donors from Northern Europe (5.1 to 8.2%, P&lt;0.05). The TFR2 250X and TFR2 690P alleles were not found in these subjects. The iron status was similar between HFE genotypes in women. However, men carrying HFE 282CY genotype had higher serum ferritin and lower TIBC concentrations when compared to the HFE 282CC genotype carriers. HFE 282CY genotype was also associated with higher transferrin saturation in men who donated blood at the first time. Moreover, male donors with HFE 63DD plus 63HD genotypes had higher serum iron and transferrin saturation when compared to those with HFE 63HH genotype. A relationship between HFE CY/HH/SS haplotype and lower TIBC concentrations was also found in men. The HFE 282Y and HFE 65C alleles were rare while the HFE 63D was frequent in blood donors. The mutations in TFR2 gene were not found in this study. The HFE 282Y and HFE 63D alleles were associated with alterations on iron status only in male blood donors.


Author(s):  
Yunik Windarti ◽  

ABSTRACT Background: Woman who become mother have gone through various life cycles, from pregnancy till childbirth. During this postpartum period, almost all mothers also breastfeed their babies. The process of restoring the body health after childbirth along with caring for the baby often leaves the mother physically and psychologically exhausted. So many mothers cannot provide exclusive breastfeeding. This is where the husband’s role is very important to provide support to the mother. This study aimed to analyze the influence husband’s role on the mother’s interest in giving exclusive breastfeeding. Subjects and Method: A cross-sectional study was conducted for 2 months on 46 postpartum mothers. This study conducted in Wonokromo, Surabaya, in 2020. The independent variable was the husband’s role and the dependent variable was the mother’s interest in giving exclusive breastfeeding. The data were collected using questionnaires and analyzed using Chi Square test. Results: The results showed that out of 21 (57.14%) mothers who had less husband’s role, most had a low interest in giving exclusive breastfeeding. Of the 25 mothers who have a good husband’s role, almost all (92%) have a high interest in exclusive breastfeeding (p< 0.001), and it was statistically significant. Conclusion: The better husband’s role in supporting his wife, the higher the mother’s interest in giving exclusive breastfeeding. Keywords: husband role, mother, exclusive breastfeeding Correspondence: Yunik Windarti. Faculty of Nursing and Midwifery, Universitas Nahdlatul Ulama Surabaya, East Java. Jl. Smea No 57 Surabaya, East Java. Email: [email protected]. Mobile: 081330330090. DOI: https://doi.org/10.26911/the7thicph.03.22


Author(s):  
Bayrakçi Onur

Background: Primary hyperhidrosis is excessive sweating localized to different parts of the body, mostly on the hands. It is exact cause  unknown, negatively affects the psychosocial structure of the person and a clinically important health problem. Aims: In the study, it was aimed to examine the effects of drugs used on primary hyperhidrosis. Study Design: The drugs used by the patients who applied to the thoracic surgery clinic with the complaint of sweating and their effects were analyzed retrospectively. Ersin Arslan Training and Research Hospital Thoracic Surgery Clinic between January 1, 2015, and September 30, 2021 (outcomes of seven years). Methodology: A total of 120 patients(45 female, 75 male and age range 8-67) with sweating complaints were identified. Age, gender, sweating localization and drugs used were examined. Statistically, data were analyzed with 95% confidence interval(CI) and Chi Square test. Results: A total of 120 patients were analyzed. 37.5% were female and 62.5% male.The mean age was 27.1±1.54 years.Patients were use 23.4% Aluminum hydrochloride cream),20.8% Bornaprine hydrochloride, 20% Hyoscine-N-butylbromide.According to sweating localizations;42.6% palmar only, 18.7% palmar and axilla, 18.7% palmar and craniofacial, 7.8% palmar and plantar, 5.9% diffuse, 4.5% cranial, 1.8% palmar and abdomen.It is more often between ages of 21-30 and in male.According to the complaints of patients with a history of using medical treatment; there were 34.5% partial response and 20.2% complete response, and no response to medical treatment in 45.3%. Conclusion: In the study; according to the localization of sweating;Aluminum hydrochloride cream reduces sweating on the palmar, and Hyoscine-N-butylbromide reduces axillary and palmar sweating. Bornaprine hydrochloride reduces sweating on all localizations except craniofacial and abdomen, and is related with a complete response on palmar sweating.According to sweating localizations; although there are localizations where all three drugs used are effective, it has been concluded that these drugs used in primary hyperhidrosis do not respond fully at a high rate.


2018 ◽  
Vol 3 (1) ◽  
pp. 50
Author(s):  
Yuliah Yuliah ◽  
Adriyani Adam ◽  
Muh. Hasyim

Vegetables and fruits consumption in adolescents is very important and contains many nutrients such as vitamins, minerals and fiber in achieving a healthy lifestyle with balanced nutrition. Some vitamins and minerals contained in vegetables and fruits have antioxidant functions that can reduce the incidence of non-communicable diseases associated with nutrition, as a result of overweight or malnutrition. Vegetables and fruits are also rich in vitamins and minerals that play a role in the metabolic system in the body including energy metabolism. The aim of this study is to analysis the relationship vegetable and fruit consumption with the incidence of obesity in SMA Negeri 1 Mamuju 2016. Design of this study is analytic research with cros sectional approach. Samples are 280 students of SMU Negeri 1 Kabupaten Mamuju with sampling method by systematic random sampling. The results of the research for the consumption of vegetable category is quite as many as 114 people (40.7%) and less vegetable consumption of 166 people (59.3%). Chi-square test results obtained p > ​​0.05, there is no relationship between vegetable consumption with the incidence of obesity. For the consumption of enough fruits as many as 92 people (32.9%) and less fruit consumption of 188 people (67.1%). Chi-square test results obtained p value > 0.05 , there is no relationship between fruit consumption with the incidence of obesity. Suggestions in this study is the need for intensive information about the importance of healthy lifestyles and balanced nutrition for adolescents to achieve the ideal body weight.


2017 ◽  
Vol 5 (3) ◽  
pp. 298
Author(s):  
Wismoyo Nugraha Putra

ABSTRACTOverweight is health problem that occurs because of imbalance between input and output energy causing the accumulation of excessive fat tissue in the body. There are several factors that can lead to overweight are excess of dietary pattern, physical activity and sedentary lifestyle. The purpose of this research is to analyze the relationship between dietary pattern, physical activity and the sedentary lifestyle with overweight incidence at SMA Negeri 5 Surabaya. This research is analyitic observational with cross sectional design. Accessible population sizes in this research are 679 students with numbers of samples are 157 students (simple random sampling). Data processing by using computer application with the univariate and bivariate analysis. The results analysed using chi square test with α = 0.05. The results showed correlation between sex (p = 0.041), mother’s job (p = 0.025), dietary pattern (p = 0.035) and physical activity (p= 0.015) with overweight. There was no correlation between parent’s education, father’s job, parent’s income, student’s pocket money, sedentary lifestyle with overweight. Suggestions for school to held morning gymnastics twice a week, also extends the extracurricular duration. Teenagers are expected to increase and balance the diet consumption.Keywords: physical activity, sedentary lifestyle, overweight, dietary pattern


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