A Case Report of Diabetes Mellitus Type 2 with Adjuvant Use of Bauhinia forficata in Pharmacological Treatment

Introduction: Bauhinia forficata, has presented in several interesting effects for the diabetic human organism as the adjuvant treatment. Its effects have been tested and proven in scientific studies in the Unified Health System in Brazil. Aims: Verify the effects of the medicinal plant Bauhinia forficata as an aid in the control of glycemic indexes. Methodology: Case report with exploratory descriptive study with a quantitative approach, using direct observation techniques of the Dáder method adapted to the use of herbal medicines such as Bauhinia forficata. Results: In this study, there was a decrease in triglyceride levels with a drop of 77%, which despite not reaching the recommended values for diabetic patients (<150 mg/dl) is quite significant. Conclusion: Bauhinia forficata used in the treatment of diabetes mellitus has anti-inflammatory actions that contribute to reduce glycated hemoglobin and, thus decrease fasting and postprandial glucose.

Download Full-text

Dopaminergic agonist bromocriptin in treatment of diabetes mellitus type 2

Obesity and metabolism ◽

10.14341/2071-8713-5298 ◽

2011 ◽

Vol 8 (4) ◽

pp. 16-22

Author(s):

O A Gerasimenko ◽

E Pigarova ◽

L K Dzeranova

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Animal Studies ◽

Hepatic Glucose Production ◽

Glucose Production ◽

Postprandial Glucose ◽

Hepatic Glucose ◽

Treatment Of Diabetes

Bromocriptine is a sympatholytic agonist of dopamine receptors, which is now proposed for treatment of type 2 diabetes mellitus. In animal studies bromocriptine elevates the decreased levels of dopamine in hypothalamus and blocks excessive sympathetic innervations in central nervous system that results in decrease of postprandial glucose. Bromocriptine decreases hepatic glucose production and increases insulin secretion and muscle insulin sensitivity. This article reviews experimental and clinical data on the use of bromocriptine for treatment of type 2 diabetes mellitus

Download Full-text

Unsaturated fatty acid as functional food for the treatment of Diabetes mellitus type 2

Research Society and Development ◽

10.33448/rsd-v10i9.17231 ◽

2021 ◽

Vol 10 (9) ◽

pp. e41410917231

Author(s):

Naiane Silva Cardoso ◽

Julia Rosental de Souza Cruz ◽

Ramon Alves de Oliveira Paula ◽

Stella Maris da Silveira Duarte ◽

Maria Rita Rodrigues ◽

...

Keyword(s):

Diabetes Mellitus ◽

Fatty Acids ◽

Polyunsaturated Fatty Acids ◽

Glucose Transporter ◽

Unsaturated Fatty Acids ◽

Monounsaturated Fatty Acids ◽

Pancreatic Function ◽

Diabetic Patients ◽

Treatment Of Diabetes

Several studies have been demonstrating to a relationship between unsaturated fatty acids, improvement of pancreatic function and insulin secretion. In this context, this review presents the most recent findings on the pathophysiology of type 2 diabetes mellitus, the action mechanism of unsaturated fatty acids on pancreatic function, and clinical studies in diabetic patients. We evaluated here articles from MedLine/PubMed and the Science direct database, published between 2014 and 2020. Of the 637 results, 13 were selected. From their analysis, we could observe that mono and polyunsaturated fatty acids can improve glycemic control as well as reduce cardiovascular risk. The most recurrent antidiabetic action regarding monounsaturated fatty acids is the ability to preserve insulin signaling, whereas polyunsaturated fatty acids action consists in the increasing expression of the type 4 glucose transporter. However, a complete understanding of the relationship between fatty acids, insulin and inflammation should be considered in future investigations.

Download Full-text

Role and Efficacy of “Katankateriyadi Kwatha” in Patients of Madhumeha (Diabetes Mellitus Type 2): A Clinical Trial

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v11i5-s.5085 ◽

2021 ◽

Vol 11 (5-S) ◽

pp. 25-32

Author(s):

Vandana Singh ◽

Bhuwal Ram

Keyword(s):

Diabetes Mellitus ◽

Clinical Study ◽

Diabetic Patients ◽

Open Label ◽

High Prevalence ◽

Comparative Clinical Study ◽

Treatment Of Diabetes ◽

Oral Hypoglycaemic Drugs ◽

Trial Drug

Madhumeha (Diabetes Mellitus) is a by-product of urbanization, proclaimed thousands of years back by Acharya Charaka. India has a high prevalence of diabetes which is increasing in number at an alarming rate. The introduction of oral hypoglycaemic drugs in modern therapeutics materialize to be a breakthrough in the treatment of Diabetes Mellitus initially but subsequently, it was experienced that most of the hypoglycaemic drugs were inadequately effective and were associated with many major side effects. To get rid of this problem, here we aimed to find out an effective and safe remedy to control the disease. This study is an Open-label, standard control, randomized and comparative clinical study with the 3-month assessment of the response of the trial drug “Katankateriyadi Kwatha” on the diabetic patients through subjective and objective parameters. Keywords: Diabetes mellitus, Clinical study, Madhumeha, Katankateriyadi Kwatha.

Download Full-text

Metformin and Lactic Acidosis in Diabetic Patients

Journal of Endocrinology Research ◽

10.30564/jer.v3i1.2849 ◽

2021 ◽

Vol 3 (1) ◽

pp. 21

Author(s):

Baiyan Zhao ◽

Zhilu Li ◽

Zhangyi He ◽

Xinxin Zhou ◽

Yiying Yu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Lactic Acidosis ◽

Clinical Treatment ◽

Diabetic Patients ◽

Fatality Rate ◽

Basic Drug ◽

Treatment Of Diabetes ◽

The Relationship

Metformin is the basic drug in the clinical treatment of Diabetes, often used in the treatment of Type 2 Diabetes Mellitus (T2DM).Its effect has been fully verified in the clinical treatment of T2DM. However, in the treatment of T2DM with metformin, there is still a certain probability of related lactic acidosis, and the fatality rate is high. Therefore, is the use of metformin drug treatment a direct risk factor for lactic acidosis in diabetic patients? This paper will review the hypoglycemic mechanism of metformin and related studies on lactic acidosis, so as to further explore the relationship between metformin and lactic acidosis in diabetic patients, and provide help and reference for metformin drugs in the clinical treatment of T2DM.

Download Full-text

Exploring the Knowledge on Herbal Medicine (HM) usage in Disease Management among People with Type 2 Diabetes Mellitus (T2DM) in Negeri Sembilan, Malaysia

Malaysian Journal of Social Sciences and Humanities (MJSSH) ◽

10.47405/mjssh.v5i12.555 ◽

2020 ◽

Vol 5 (12) ◽

pp. 272-279

Author(s):

Rosnani Kassim ◽

Norbaidurah Ithnain ◽

Albeny Joslyn Panting ◽

Nadia Amirudin ◽

Manimaran Krishnan

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Herbal Medicine ◽

Diabetes Management ◽

Herbal Medicines ◽

Insulin Injection ◽

Modern Medicine ◽

Diabetic Patients

It is estimated that diabetes affects approximately 415 million people worldwide and this is expected to increase to 642 million by 2040. There are several methods used in managing diabetes which include nutritional control, taking medications, insulin injection and/or consuming herbal medicine (HM). This study explored the knowledge of herbal medicine usage among people with Type 2 Diabetes Mellitus (T2DM) in regard to diabetes management. A qualitative study was conducted among 28 diabetic patients from government clinics in Negeri Sembilan. They were interviewed face-to-face and all information about their herbal medicine consumption were analysed thematically. Findings showed that the main source of information on herbal usage were from family members, friends and/or neighbours. This study discovered that knowledge on herbal medicine among T2DM patients was greatly influenced from such sources and it is also hereditary. In addressing herbal medicine safety issues, some patients were unaware of the proper channel while others chose to accept any arising consequences without informing the healthcare authorities. This study also revealed that most of the informants were aware on the types and ways of consuming herbal medicine. Besides, patients understood that diabetes can only be controlled and cannot be cured. However, knowledge on complementary intake with modern medicine should be enlightened. Therefore, it is suggested that the healthcare provider need to update their knowledge on herbal medicines and be able to give informative insights to their patients.

Download Full-text

Association of Major Dietary Patterns with General and Abdominal Obesity in Iranian Patients with Type 2 Diabetes Mellitus

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000233 ◽

2015 ◽

Vol 85 (3-4) ◽

pp. 145-155 ◽

Cited By ~ 9

Author(s):

Marjan Ghane Basiri ◽

Gity Sotoudeh ◽

Mahmood Djalali ◽

Mohammad Reza Eshraghian ◽

Neda Noorshahi ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Abdominal Obesity ◽

Dietary Patterns ◽

Dietary Pattern ◽

Diabetic Patients ◽

General Obesity ◽

Healthy Dietary Pattern

Abstract. Background: The aim of this study was to identify dietary patterns associated with general and abdominal obesity in type 2 diabetic patients. Methods: We included 728 patients (35 - 65 years) with type 2 diabetes mellitus in this cross-sectional study. The usual dietary intake of individuals over 1 year was collected using a validated semi-quantitative food frequency questionnaire. Weight, height, and waist circumference were measured according to standard protocol. Results: The two major dietary patterns identified by factor analysis were healthy and unhealthy dietary patterns. After adjustment for potential confounders, subjects in the highest quintile of the healthy dietary pattern scores had a lower odds ratio for the general obesity when compared to the lowest quintile (OR = 0.45, 95 % CI = 0.26 - 0.79, P for trend = 0.02), while patients in the highest quintile of the unhealthy dietary pattern scores had greater odds for the general obesity (OR = 3.2, 95 % CI = 1.8 - 5.9, P for trend < 0.001). There were no significant associations between major dietary patterns and abdominal obesity, even after adjusting for confounding factors. Conclusion: This study shows that in patients with type 2 diabetes mellitus, a healthy dietary pattern is inversely associated and an unhealthy dietary pattern is directly associated with general obesity.

Download Full-text

ESTIMATION OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETIC PATIENTS AND ITS RELATION WITH HbA1C LEVEL.

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i8.456 ◽

2019 ◽

Vol 3 (8) ◽

Author(s):

Shah Namrata Vinubhai ◽

Pardeep Agarwal ◽

Bushra Fiza ◽

Ramkishan Jat

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Blood Sugar ◽

Serum Ferritin ◽

Inflammatory Marker ◽

Control Group ◽

Diabetic Patients ◽

Positive Correlation

Background: Serum ferritin is known as an index for body iron stores also as an inflammatory marker and it is influenced by several disease. We were looking for a correlation between HbA1c and S. Ferritin in type 2 DM. Methodology: The present study a total of 150 participants were enrolled of which 100 were confirmed cases of Type 2 Diabetes Mellitus and rest 50 age and sex matched healthy subjects constituted the control group. All were screened for HbA1c, Fasting blood sugar, Post prandial blood sugar and S.Ferritin. Results: A highly significant variation and positive correlation was observed with respect to S.Ferritin and HbA1c levels. Mean S.Ferritin was high in the subgroup with poor glycemic control. Conclusion: The fasting, post prandial sugar levels, HbA1c and S.Ferritin were significantly higher in the diabetic subjects. This study shows a positive correlation between HbA1c and S. Ferritin levels. So we can conclude that in diabetic patients S. Ferritin may serve as an independent marker of poor glycemic and metabolic control. Keywords: Serum ferritin, Type 2 Diabetes Mellitus, HbA1c.

Download Full-text

A Narrative Review on Sarcopenia in Type 2 Diabetes Mellitus: Prevalence and Associated Factors

Nutrients ◽

10.3390/nu13010183 ◽

2021 ◽

Vol 13 (1) ◽

pp. 183

Author(s):

Anna Izzo ◽

Elena Massimino ◽

Gabriele Riccardi ◽

Giuseppe Della Pepa

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Elderly Population ◽

The Elderly ◽

Narrative Review ◽

Macrovascular Complications ◽

Diabetic Patients ◽

Age Related

Type 2 diabetes mellitus (T2DM) represents a major health burden for the elderly population, affecting approximately 25% of people over the age of 65 years. This percentage is expected to increase dramatically in the next decades in relation to the increased longevity of the population observed in recent years. Beyond microvascular and macrovascular complications, sarcopenia has been described as a new diabetes complication in the elderly population. Increasing attention has been paid by researchers and clinicians to this age-related condition—characterized by loss of skeletal muscle mass together with the loss of muscle power and function—in individuals with T2DM; this is due to the heavy impact that sarcopenia may have on physical and psychosocial health of diabetic patients, thus affecting their quality of life. The aim of this narrative review is to provide an update on: (1) the risk of sarcopenia in individuals with T2DM, and (2) its association with relevant features of patients with T2DM such as age, gender, body mass index, disease duration, glycemic control, presence of microvascular or macrovascular complications, nutritional status, and glucose-lowering drugs. From a clinical point of view, it is necessary to improve the ability of physicians and dietitians to recognize early sarcopenia and its risk factors in patients with T2DM in order to make appropriate therapeutic approaches able to prevent and treat this condition.

Download Full-text

Fermented pork fat (Sa-um) and lifestyle risk factors as potential indicators for type 2 diabetes among the Mizo population, Northeast India

Journal of Health Population and Nutrition ◽

10.1186/s41043-021-00257-8 ◽

2021 ◽

Vol 40 (1) ◽

Author(s):

Freda Lalrohlui ◽

Souvik Ghatak ◽

John Zohmingthanga ◽

Vanlal Hruaii ◽

Nachimuthu Senthil Kumar

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Cox Regression ◽

Control Group ◽

Diabetic Patients ◽

Lifestyle Habits ◽

Pork Fat

AbstractOver the last few decades, Mizoram has shown an increase in cases of type 2 diabetes mellitus; however, no in-depth scientific records are available to understand the occurrence of the disease. In this study, 500 patients and 500 healthy controls were recruited to understand the possible influence of their dietary and lifestyle habits in relation with type 2 diabetes mellitus. A multivariate analysis using Cox regression was carried out to find the influence of dietary and lifestyle factors, and an unpaired t test was performed to find the difference in the levels of biochemical tests. Out of 500 diabetic patients, 261 (52.3%) were males and 239 (47.7%) were females, and among the control group, 238 (47.7%) were males and 262 (52.3%) were females. Fermented pork fat, Sa-um (odds ratio (OR) 18.98), was observed to be a potential risk factor along with tuibur (OR 0.1243) for both males and females. Creatinine level was found to be differentially regulated between the male and female diabetic patients. This is the first report of fermented pork fat and tobacco (in a water form) to be the risk factors for diabetes. The unique traditional foods like Sa-um and local lifestyle habits like tuibur of the Mizo population may trigger the risk for the prevalence of the disease, and this may serve as a model to study other populations with similar traditional practices.

Download Full-text

Increased Serum WISP1 Levels are Associated with Lower Extremity Atherosclerotic Disease in Patients with type 2 Diabetes Mellitus

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/a-1474-8220 ◽

2021 ◽

Author(s):

Yangyang Cheng ◽

Xiaohui Du ◽

Bilin Zhang ◽

Junxia Zhang

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Lower Extremity ◽

Interleukin 6 ◽

Atherosclerotic Disease ◽

Enzyme Linked Immunosorbent Assay ◽

Diabetic Patients ◽

Newly Diagnosed

Abstract Background Serum wnt1-induced signaling pathway protein 1 (WISP1) levels are increased with obesity, which is a common complication associated with lower extremity atherosclerotic disease (LEAD). However, to date, the relationship between elevated WISP1 levels and the incidence of lower extremity atherosclerotic disease (LEAD) in type 2 diabetes mellitus (T2DM) remains unclear. Methods 174 newly diagnosed type 2 diabetic patients were enrolled in our study. Patients were divided into two groups, LEAD group (n=100) and control group (n=74). Anthropometric parameters, blood pressure and some biochemical parameters were obtained. Body composition was detected by bioelectrical impedance analysis (BIA). Levels of serum insulin were determined by radioimmunoassay. Serum WISP1 and interleukin 6 (IL-6) levels were determined using an enzyme-linked immunosorbent assay. Results It was shown that serum WISP1 levels in diabetic patients with LEAD were higher than those without LEAD (P<0.001). Serum WISP1 levels were positively related with waist circumference (r=0.237, P=0.003), waist-hip ratio (r=0.22, P=0.006), visceral fat area (r=0.354, P<0.001), serum creatinine (r=0.192, P=0.012), interleukin 6 (r=0.182, P=0.032), c-reactive protein (r=0.681, P<0.001), triglycerides (r=0.119, P<0.001), fasting glucose (r=0.196, P=0.011), glycated hemoglobin (r=0.284, P<0.001), and HOMA-IR (r=0.285, P<0.026). Compared with the lowest tertile, the odds ratio of the middle tertile for LEAD incidence was 3.27 (95% CI, 1.24–8.64) and 4.46 (95% CI, 1.62–12.29) for the highest tertile after adjusting confounding factors. Conclusion The results suggest that increased serum WISP1 levels independently contribute to the incidence of LEAD in patients with newly diagnosed T2DM.

Download Full-text