scholarly journals The Use of Innovative Materials in the Organization of Clinical Treatment in Dentistry

2021 ◽  
pp. 6-12
Author(s):  
Zaurbek Magomedovich Aliev ◽  
Marina Karapetovna Nersisyan ◽  
Valeriia Vadimovna Denisova ◽  
Aleksandr Zazaevich Bigvava ◽  
Diana Igorevna Luchkovskaya ◽  
...  
Keyword(s):  
Antimicrobial Properties ◽  
Clinical Treatment ◽  
Composite Resins ◽  
Luting Cements ◽  
Restorative Treatment ◽  
Antimicrobial Protection ◽  
Innovative Materials ◽  
Bacterial Cell Membrane ◽  
High Level ◽  
Adhesive Materials

The article examines the features of the use of innovative materials in the organization of clinical treatment in dentistry. In modern conditions, solving the problem of patient safety is one of the main conditions for the functioning of medicine in general and dentistry in particular.  For this reason, the search for innovations in the field of antimicrobial protection and, together with it, the functionality of various materials is one of the main tasks of researchers in the field of dentistry. Nanomaterials, which are made on the basis of graphene, are able to demonstrate excellent antimicrobial properties. These materials have the ability to disrupt the integrity of the bacterial cell membrane and produce reactive oxygen species (ROS). These materials are widely used in the manufacture of dentures, they are incorporated in the composition of composite resins and luting cements in the organization of restorative treatment, are used for the manufacture of adhesive materials.  Many experts recognize that these materials are the future of dental practice, since they have the ability to provide a high level of functionality and safety.

A Review on Quantum Dots: Synthesis to In- silico Analysis as Next Generation Antibacterial Agents

2019 ◽  
Vol 20 (3) ◽  
pp. 255-262 ◽  
Author(s):  
Sounik Manna ◽  
Munmun Ghosh ◽  
Ranadhir Chakraborty ◽  
Sudipto Ghosh ◽  
Santi M. Mandal
Keyword(s):  
Quantum Dots ◽  
Pathogenic Bacteria ◽  
Antibacterial Agents ◽  
Antimicrobial Properties ◽  
Binding Potential ◽  
Antibacterial Drug ◽  
Next Generation ◽  
Mechanism Of Reaction ◽  
High Level ◽  
Membrane Components

Succumbing to Multi-Drug Resistant (MDR) bacteria is a great distress to the recent health care system. Out of the several attempts that have been made to kill MDR pathogens, a few gained short-lived success. The failures, of the discovered or innovated antimicrobials, were mostly due to their high level of toxicity to hosts and the phenomenal rate of developing resistance by the pathogens against the new arsenal. Recently, a few quantum dots were tested against the pathogenic bacteria and therefore, justified for potential stockpiling of next-generation antibacterial agents. The key players for antimicrobial properties of quantum dots are considered to be Reactive Oxygen Species (ROS). The mechanism of reaction between bacteria and quantum dots needs to be better understood. They are generally targeted towards the cell wall and membrane components as lipoteichoic acid and phosphatidyl glycerol of bacteria have been documented here. In this paper, we have attempted to simulate ZnS quantum dots and have analysed their mechanism of reaction as well as binding potential to the above bacterial membrane components using CDOCKER. Results have shown a high level of antibacterial activity towards several pathogenic bacteria which specify their potentiality for future generation antibacterial drug development.

scholarly journals Evaluation of the Antimicrobial Protection of Pharmaceutical Kaolin and Talc Modified with Copper and Zinc

Materials ◽  
2021 ◽  
Vol 14 (5) ◽  
pp. 1173
Author(s):  
Fotini Martsouka ◽  
Konstantinos Papagiannopoulos ◽  
Sophia Hatziantoniou ◽  
Martin Barlog ◽  
Giorgos Lagiopoulos ◽  
...  
Keyword(s):  
Cation Exchange ◽  
Photoelectron Spectroscopy ◽  
Antimicrobial Properties ◽  
Exchange Capacity ◽  
Elevated Concentration ◽  
Chemical Mapping ◽  
Exchange Method ◽  
X Ray ◽  
Copper And Zinc ◽  
Antimicrobial Protection

Six pharmaceutical pastes were prepared using chemically modified kaolin and talc powders. Tests were conducted to determine their structural and chemical characteristics as well as their antimicrobial protection, thus rendering them suitable for cosmetic and pharmaceutical uses. Kaolin and talc were treated chemically via the cation exchange method to load the clay particles with copper and zinc ions, two cations well known for their antimicrobial properties. Mineralogical analyses were conducted by using X-ray diffraction (XRD) before and after the modification, confirming the mineralogical purity of the samples. Scanning electron microscopy was also used in conjunction with energy dispersed spectroscopy (SEM-EDS) to obtain chemical mapping images, revealing the dispersion of the added metals upon the clay minerals surfaces. Moreover, chemical analysis has been performed (XRF) to validate the enrichment of the clays with each metal utilizing the cation exchange capacity. All modified samples showed the expected elevated concentration in copper or zinc in comparison to their unmodified versions. From the X-ray photoelectron spectroscopy (XPS), the chemical state of the samples’ surfaces was investigated, revealing the presence of salt compounds and indicating the oxidation state of adsorbed metals. Finally, the resistance of pastes in microbial growth when challenged with bacteria, molds, and yeasts was assessed. The evaluation is based on the European Pharmacopeia (EP) criteria.

scholarly journals Interfacial Fracture Toughness Comparison of Three Indirect Resin Composites to Dentin and Polyether Ether Ketone Polymer

2020 ◽  
Vol 14 (03) ◽  
pp. 456-461
Author(s):  
Rayhaneh Khalesi ◽  
Mahdi Abbasi ◽  
Zahra Shahidi ◽  
Masoumeh Hasani Tabatabaei ◽  
Zohreh Moradi
Keyword(s):  
Fracture Toughness ◽  
Bond Strength ◽  
Testing Machine ◽  
Composite Resins ◽  
High Wear Resistance ◽  
Luting Cements ◽  
Anterior Teeth ◽  
Polyether Ether Ketone ◽  
Ether Ketone

Abstract Objectives Advances in laboratory composites and their high wear resistance and fracture toughness have resulted in their growing popularity and increasing use for dental restorations. This study sought to assess the fracture toughness of three indirect composites bonded to dental substrate and polyether ether ketone (PEEK) polymer. Materials and Methods This in vitro study was conducted on two groups of dental and polymer substrates. Each substrate was bonded to three indirect composite resins. Sixty blocks (3 × 3 × 12 mm) were made of sound bovine anterior teeth and PEEK polymer. Sixty blocks (3 × 3 × 12 mm) were fabricated of CRIOS (Coltene, Germany), high impact polymer composite (HIPC; Bredent, Germany), and GRADIA (Indirect; GC, Japan) composite resins. Composites were bonded to dentin using Panavia F 2.0 (Kuraray, Japan). For bonding to PEEK, Combo.lign (Bredent) and Visio.Link (Bredent) luting cements were used. In all samples, a single-edge notch was created by a no. 11 surgical blade at the interface. The samples were subjected to 3,500 thermal cycles, and their fracture toughness was measured in a universal testing machine (Zwick/Roell, Germany) by application of four-point flexural load. Statistical Analysis Data were analyzed using one-way analysis of variance, Kruskal–Wallis. Results The fracture toughness of CRIOS–PEEK interface was significantly higher than HIPC–PEEK. The fracture toughness of GRADIA–PEEK was not significantly different from that of HIPC and CRIOS. The fracture toughness of GRADIA–dentin was significantly higher than HIPC–dentin. Conclusion Considering the limitations of this study, GRADIA has the highest bond strength to dentin, while CRIOS shows the highest bond strength to PEEK.

Preface

2012 ◽  
Vol 84 (12) ◽  
pp. iv
Author(s):  
Yuping Wu ◽  
Shiyou Guan ◽  
Guoxiu Wang
Keyword(s):  
Basic Research ◽  
Ceramic Materials ◽  
The Sustainable Development ◽  
Biobased Materials ◽  
Novel Materials ◽  
Research Areas ◽  
Academic Exchange ◽  
Fine Chemistry ◽  
Innovative Materials ◽  
High Level

In 2005 at the centennial anniversary of Fudan University, Shanghai, China, a new conference venue began [1]. This venue, the International Conference on Novel Materials and Synthesis (NMS) together with the International Symposium on Fine Chemistry and Functional Polymers (FCFP), is targeted to provide high-level academic exchange for both local and international chemists, materialists, physicists, engineers, and technologists in the fields of materials and synthesis. The year 2011 was the International Year of Chemistry, and it is well known that chemistry is an essential creative science for the sustainable development of humankind. As a result, the joint NMSVII/ FCFP-XXI event (www.nms-iupac.org), held in Shanghai, China, 16-21 October 2011, was more important than ever. The Conference received much support from IUPAC, The National Natural Science Foundation of China, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, the Science and Technology Commission of the Shanghai Municipality, and the National Basic Research Program of China (2007CB209700), and was carried out under the auspices of IUPAC. The Conference was attended by 430 participants from 40 countries and areas. The scientific program comprised 10 plenary lectures, 56 keynote lectures, 206 invited lectures, and 94 posters. Detailed, active, and lively discussions were covered by the following themes: - innovative chiral and achiral compounds - innovative bio- and biobased materials and composites - innovative polymers such as conducting, semiconducting ones, supramolecular (supermolecular, dynamers) - innovative energy systems including fuel cells, solar cells, lithium batteries, and supercapacitors - innovative nanomaterials such as 1D, 2D, and 3D nanomaterials - new ceramic materials such as superconductors, electronic, diaelectronic, ferroelectric, piezoelectric, optoelectric, and magnetic materials - new metallic materials including alloys - other novel materials including drugs, perfumes, agricultural chemicals, and photosensitive materials, displaying materials and fine ceramics; and - neutron scattering and its application in fundamental and applied research on new materials. The program served to emphasize that novel materials and their preparation are dynamic research areas that are attracting growing interest from researchers, engineers, industries, and policy-makers. Furthermore, novel materials continue to find applications that serve the needs and interests of producers and consumers. A selection of 13 papers based on specially invited presentations at NMSVII/ FCFP-XXI is published in this issue to demonstrate the quality and scope of the themes of this Conference. During the Conference, the role and contributions of this high-level academic platform to novel materials and their synthesis are well realized by the participants, sponsors, and exhibitors. In addition, the organization committee established the Distinguished Award 2011 for Novel Materials and their Synthesis along with IUPAC; Prof. Guoxiu Wang (Australia), Dr. Dr. Fusayoshi Masuda (Japan), Prof. Dr. André-Jean Attias (France), and Prof. Bao-Lian Su (Belgium) received the award for their excellent work. The IUPAC Prof. Jiang Novel Materials Youth Prize was awarded to two winners, Prof. Zhibo Li (China) and Dr. Jr-Hau He (Taiwan, China), for the first time. This will next be awarded in 2013. Three winners for the IUPAC Poster Prize were also awarded. Yuping Wu, Shiyou Guan, and Guoxiu Wang Conference Editors [1] Y. P. Wu. Pure Appl. Chem. 78 (10), iii (2006).

Targeted DNA and RNA sequencing of paired urothelial and squamous bladder cancers to reveal discordant genomic and transcriptomic events and unique therapeutic opportunities.

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. 296-296 ◽  
Author(s):  
Daniel H. Hovelson ◽  
Lorena Lazo De La Vega ◽  
Andrew McDaniel ◽  
Aaron Udager ◽  
Rohit Mehra ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Rna Sequencing ◽  
Copy Number ◽  
Clinical Treatment ◽  
Gene Copy ◽  
Molecular Heterogeneity ◽  
Copy Number Alterations ◽  
Dna And Rna ◽  
Divergent Differentiation ◽  
High Level

296 Background: Expression-based molecular subtypes thought to be intrinsic in bladder cancer have been widely reported, carrying important potential clinical treatment implications. Histologically, bladder cancers are also heterogeneous diseases, with a large portion of urothelial carcinomas exhibiting divergent differentiation. Previous subtyping efforts have been carried out using predominantly fresh frozen tissue samples, potentially obscuring this known differentiation heterogeneity. Methods: Here we performed targeted multiplexed, amplicon-based DNA and RNA sequencing on 100 formalin-fixed paraffin-embedded (FFPE) bladder cancer samples (including 12 paired urothelial / squamous lesions). High-confidence somatic point mutations, short insertions/deletions (indels), and copy number alterations were detected using the DNA component of the Oncomine Comprehensive Assay (OCP). Targeted RNA sequencing was carried out using a custom Ampliseq panel comprised of 8 housekeeping genes and 103 target genes assessing major transcriptional programs as identified from publically available data. Results: By DNA analysis, we observe frequent TP53 (35%) and activating hotspot PIK3CA (23%) somatic mutations across the cohort, as well as targetable high-level (log-2 copy number ratio > = 1.5) focal amplifications of ERBB2 (3%) or EGFR (3%) in a subset of samples. We report a novel approach for detecting sub-gene copy-number alterations, and confirm several detectable multi-exon losses using whole transcriptome RNA sequencing. Pairing targeted RNA expression analysis with DNA-based alterations, we show high level expression of EGFR and ERBB2 in focally-amplified samples. Most importantly, we show that despite identical prioritized somatic genomic alterations, we observe divergent expression-based profiles in 3 of 12 (25%) paired urothelial and squamous samples. Conclusions: Taken together, these results highlight the importance of molecular heterogeneity in bladder cancer and suggest important considerations for using existing expression-based clustering approaches to guide clinical treatment decisions.

scholarly journals Strong Antibacterial Properties of Cotton Fabrics Coated with Ceria Nanoparticles under High-Power Ultrasound

Nanomaterials ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2704
Author(s):  
Anna V. Abramova ◽  
Vladimir O. Abramov ◽  
Igor S. Fedulov ◽  
Alexander E. Baranchikov ◽  
Daniil A. Kozlov ◽  
...  
Keyword(s):  
High Power ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Healthcare Sector ◽  
Power Ultrasound ◽  
E Coli ◽  
Advantages And Disadvantages ◽  
High Power Ultrasound ◽  
Low Toxicity ◽  
High Level

Flexible materials, such as fabric, paper and plastic, with nanoscale particles that possess antimicrobial properties have a significant potential for the use in the healthcare sector and many other areas. The development of new antimicrobial coating formulations is an urgent topic, as such materials could reduce the risk of infection in hospitals and everyday life. To select the optimal composition, a comprehensive analysis that takes into account all the advantages and disadvantages in each specific case must be performed. In this study, we obtained an antimicrobial textile with a 100% suppression of E. coli on its surface. These CeO2 nanocoatings exhibit low toxicity, are easy to manufacture and have a high level of antimicrobial properties even at very low CeO2 concentrations. High-power ultrasonic treatment was used to coat the surface of cotton fabric with CeO2 nanoparticles.

scholarly journals Postbiotics, as Dynamic Biomolecules, and Their Promising Role in Promoting Food Safety

2021 ◽  
Vol 11 (6) ◽  
pp. 14529-14544
Keyword(s):  
Food Safety ◽  
Antimicrobial Agents ◽  
Antimicrobial Properties ◽  
Energy Regulation ◽  
Bacterial Cells ◽  
Food Spoilage ◽  
New Approach ◽  
Functional Changes ◽  
Food Borne ◽  
Bacterial Cell Membrane

Many factors threaten food safety, such as physical, chemical, and biological hazards. In this regard, biological hazards are of paramount importance. Among them, the bacteria play important roles in causing food spoilage and food-borne diseases. Besides, a new approach has been used in recent years, which is based on probiotics and postbiotics to control the growth of pathogenic germs and their mediated corruption due to their significant antimicrobial properties. The outcomes of recent investigations suggest that postbiotics might be appropriate alternative elements for probiotic cells and can be employed as novel antimicrobial agents. The main antimicrobial mechanisms of postbiotics include acidifying the cellular cytoplasm and preventing energy regulation and production, suppressing the growth of pathogenic microorganisms by the formation of pores in cell membranes, and morphological and functional changes of sensitive components such as proteins and peptides by creating acidity in the bacterial cell membrane as well as inducing the oxidation of bacterial cells. Therefore, presently scientific literature approves that postbiotics can be applied as promising tools in food practice to prevent microbial corruption and develop functional foods due to their unique features. This review addresses the latest postbiotic applications with regards to food safety. Potential postbiotic applications in the inhibition of food spoilage and pathogenic microbes, food biopreservation, and biofilm control are also reviewed.

scholarly journals Minimally Invasive Therapies for the Management of Dental Caries—A Literature Review

2021 ◽  
Vol 9 (12) ◽  
pp. 147
Author(s):  
Hetal Desai ◽  
Cameron A. Stewart ◽  
Yoav Finer
Keyword(s):  
Literature Review ◽  
Minimally Invasive ◽  
Dental Materials ◽  
Antimicrobial Properties ◽  
Treatment Modalities ◽  
Atraumatic Restorative Treatment ◽  
Resin Infiltration ◽  
Restorative Treatment ◽  
Caries Removal ◽  
Invasive Techniques

In recent years, due to a better understanding of the caries pathology and advances in dental materials, the utilization of non-invasive and minimally invasive techniques that delay/obviate the need for traditional restorations has started gaining momentum. This literature review focuses on some of these approaches, including fluoride varnish, silver diamine fluoride, resin sealants, resin infiltration, chemomechanical caries removal and atraumatic restorative treatment, in the context of their chemistries, indications for use, clinical efficacy, factors determining efficacy and limitations. Additionally, we discuss strategies currently being explored to enhance the antimicrobial properties of these treatment modalities to expand the scope of their application.

Radiopacity of posterior composite resins, composite resin luting cements, and glass ionomer lining cements

1993 ◽  
Vol 70 (4) ◽  
pp. 351-355 ◽  
Author(s):  
H.B.M. Akerboom ◽  
C.M. Kreulen ◽  
W.E. van Amerongen ◽  
A. Mol
Keyword(s):  
Composite Resin ◽  
Composite Resins ◽  
Glass Ionomer ◽  
Luting Cements

scholarly journals Draft Genome Sequence of Bacillus toyonensis VU-DES13, Isolated from Folsomia candida (Collembola: Entomobryidae)

2017 ◽  
Vol 5 (19) ◽  
Author(s):  
Thierry K. S. Janssens ◽  
Tjalf E. de Boer ◽  
Valeria Agamennone ◽  
Niels Zaagman ◽  
Nico M. van Straalen ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Genome Sequence ◽  
Draft Genome ◽  
Antimicrobial Properties ◽  
Gene Clusters ◽  
Folsomia Candida ◽  
Content Type ◽  
Genome Data ◽  
High Level ◽  
Bacillus Toyonensis

ABSTRACT We present here the draft genome of Bacillus toyonensis VU-DES13, which was isolated from the midgut of the soil-living springtail Folsomia candida. Previous research revealed the presence of gene clusters for the biosynthesis of various secondary metabolites, including β-lactam antibiotics, in the host's genome. The genome data are discussed in the light of the antimicrobial properties against fungi and oomycetes and a high level of β-lactam resistance of the isolate.

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