A Review on Traditional Plant Azadirachta indica: Natural Source for Disease Curability and Health Promotion

2021 ◽  
pp. 1-7
Author(s):  
Preeti Gautam ◽  
Payal Mittal
Keyword(s):  
Azadirachta Indica ◽  
Citrus Sinensis ◽  
Therapeutic Effects ◽  
Pharmacological Effects ◽  
Neem Tree ◽  
Medicinal Uses ◽  
Biochemical Pathways ◽  
Online Databases ◽  
Eye Disorders ◽  
Loss Of Appetite

Neem (Azadirachta indica) is a medicinal plant, mostly found in the Himalayan region. The neem leaf is commonly and historically used in medicine to treat a variety of illnesses such as eye disorders, nose bleeding, loss of appetite and liver problems etc. Because of its various pharmacological and therapeutic effects, it is included in the Ayurvedic pharmacopoeia. As a result, this review provides current information on ethno-medicinal uses, phytochemistry, pharmacological effects, adverse effects of Azadirachta indica with future advancement. Several references were checked for identification, in-depth literature including online databases, documents, and blogs. Around 29% of the compounds in Azadirachta indica have been isolated and characterised. The limonoids in the neem tree have a wide variety of antimicrobial and insecticidal properties. Complex azadirachtin, salanin are active principles extracted from neem seed. These metabolites' biochemical pathways in the neem tree are completely unknown. Citrus sinensis is related to the neem tree phylogenetically. 62 percent of neem genomic was anchored into citrus chromosomes according to comparative study. The azadirachtin, nimbin, salanin and nimbidin from neem tissues were quantified by using LC-MS. This paper shows the various use of neem in different disorder.

scholarly journals Carum copticumL.: A Herbal Medicine with Various Pharmacological Effects

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Mohammad Hossein Boskabady ◽  
Saeed Alitaneh ◽  
Azam Alavinezhad
Keyword(s):  
Therapeutic Effects ◽  
Pharmacological Effects ◽  
Volatile Oils ◽  
The Past ◽  
Abdominal Tumors ◽  
The World ◽  
Carum Copticum ◽  
Calcium Phosphorus ◽  
Phosphorus Iron ◽  
Loss Of Appetite

Carum copticumL. commonly known as “Ajwain” is cultivated in many regions of the world including Iran and India, states of Gujarat and Rajasthan. Traditionally,C. copticumhas been used in the past for various therapeutic effects including bloating, fatigue, diarrhea, abdominal tumors, abdominal pain, respiratory distress, and loss of appetite. It has other health benefits such as antifungal, antioxidant, antibacterial, antiparasitic, and hypolipidemic effects. This plant contains different important components such as carbohydrates, glucosides, saponins and phenolic compounds (carvacrol), volatile oils (thymol), terpiene, paracymene and beta-pinene, protein, fat, fiber, and minerals including calcium, phosphorus, iron, and nicotinic acid (niacin). In the previous studies, several pharmacological effects were shown forC. copticum. Therefore, in this paper, the pharmacological effects of the plant were reviewed.

Traditional, Pharmacological and Patenting Potential of Neem (Azadirachta indica): A Review

2017 ◽  
Vol 3 (4) ◽  
pp. 383-391
Author(s):  
Mohd Asif Khan ◽  
Shashi Bhooshan Tiwari ◽  
Himanshu Gupta ◽  
Huma Noor
Keyword(s):  
Azadirachta Indica ◽  
Indian Subcontinent ◽  
National Academy Of Sciences ◽  
Neem Tree ◽  
Commercial Plant ◽  
Pharmacological Potential ◽  
Pharmacologically Active ◽  
In The Beginning ◽  
Prevention And Cure ◽  
Academy Of Sciences

Since ancient time, herbal drugs were highly used in the prevention and cure of various human illnesses. In India, Azadirachta indica being commonly known as Neem or Margosa is one of the multi-functional trees; belonging to Meliaceae family. In 1992, the US National Academy of Sciences was published a report entitled ‘Neem- a tree for solving global problems’. It is still considered as ‘village dispensary’ throughout the India. There are two species of Azadirachta which have been investigated; Azadirachta indica that is found in the Indian subcontinent and Azadirachta excelsa Kack that is homegrown to Indonesia and Philippines. A large number of pharmacologically active substances have been identified and isolated from the different parts of neem including azadirachtin, meliacin, gedunin, salanin, nimbin, valassin and various other components which are derived from these main compounds. Many different studies have been evaluated and authenticated for its various traditional and pharmacological activities like itching, leprosy, wound healing, spermicidal, anti-inflammatory, insecticidal, antidiabetic and analgesic etc. In the beginning of 1979, patenting on neem was started by CSIR to separate the active compounds from neem oil. Its great implantation fights with soil erosion, global warming, deforestations and desertification world-wide. In 2002, World Neem Conference raised the neem tree as an industrial or commercial plant. This review is going to explore comprehensively; traditional, pharmacological potential along with patenting, environmental & industrial significant of various parts of neem tree with safety concerns.

Neem tree (Azadirachta indica) extract specifically suppresses the growth of tumors in H22-bearing Kunming mice

2016 ◽  
Vol 71 (7-8) ◽  
pp. 201-208 ◽  
Author(s):  
Zhenxiang He ◽  
Cuihua Jiang ◽  
Jian Zhang ◽  
Zhiqi Yin ◽  
Zengfang Yin ◽  
...  
Keyword(s):  
Body Weight ◽  
Survival Rate ◽  
Azadirachta Indica ◽  
Normal Liver ◽  
Positive Control ◽  
High Dose ◽  
Intragastric Administration ◽  
Neem Tree ◽  
Specific Cytotoxicity ◽  
The Right

Abstract Recently, neem tree (Azadirachta indica) extract (NTE) has been reported to have various antitumor activities against gastric, breast, prostate, and skin cancer, respectively. The current study was designed to evaluate the effect of NTE on hepatic cancer in a mouse model. The possible side effects elicited by NTE were also evaluated. The components in NTE were analyzed by liquid chromatography–mass spectrometry (LC-MS). H22 cells-bearing Kumming mice were generated by injecting H22 cells subcutaneously into the right forelimb armpit of the mice. Then the mice were treated daily for 27 days with NTE (150, 300, and 600 mg/kg body weight) by intragastric administration, using carboxymethyl cellulose (CMC, 1%) as blank control and cyclophosphamide (CTX, 20 mg/kg) as positive control. The antitumor effect of NTE was evaluated by assessment of survival rate, body weight, tumor volume and weight, tumor histology, thymus and spleen indexes, and liver histology. The tumor weight and volume in groups of NTE and CTX were significantly lower than those in the CMC group. The survival rate in the NTE group receiving the high dose (600 mg/kg) was significantly higher than that in the CTX and CMC groups. Compared with CTX, NTE was observed to have a tumor-specific cytotoxicity without impairing the normal liver tissue. Additionally, the higher indexes of thymus and spleen indicated that NTE could facilitate the growth of immune organs. The results indicate that NTE is a promising candidate for the antitumor treatment with high efficacy and safety.

scholarly journals The Ethnopharmacological and Nutraceutical Relevance of Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Michael Buenor Adinortey ◽  
Justice Kwabena Sarfo ◽  
Jeffery Kwarteng ◽  
Cynthia Ayefoumi Adinortey ◽  
William Ekloh ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Literature Search ◽  
Metabolic Diseases ◽  
Search Process ◽  
Pharmacological Effects ◽  
Tropical Africa ◽  
Medicinal Uses ◽  
Future Studies ◽  
One Stop ◽  
Phytochemical Constituents

Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey is a herb found mostly in tropical Africa. The plant, commonly found in West Africa, is used in the management of many diseases including cardiovascular, respiratory, haematological, endocrine, and metabolic diseases in Ghana, Nigeria, Benin, Serra Leone, and Senegal. This piece provides comprehensive and updated information on the traditional uses, phytochemical constituents, and pharmacological and toxicological information available on Launaea taraxacifolia to support its medicinal uses and also unearth knowledge gaps for future studies. An electronic literature search using search engines, namely, Google Scholar, ScienceDirect, and PubMed, was carried out to obtain information on the plant. Both common and scientific names of the plant were used as keywords for the search process. This paper captured information on Launaea taraxacifolia from 1985 to 2018. The search revealed that the leaves of the plant possess nutritional/pharmacological effects on diseases such as diabetes mellitus, hypertension, cancer, malaria, bacterial infections, and arthritis. The leaf has been shown to be a rich source of phytoconstituents such as flavonoids, phenolic acids, tannins, alkaloids, glycosides, coumarins, triterpenoids, ascorbic acid, lycopene, and β-carotene. Also, isolated phytoconstituents as well as the safety profile of the plant have been documented. This review on Launaea taraxacifolia has provided a one-stop documentation of information in support of the several purported ethnopharmacological uses of the plant. It also reveals information gaps such as the need to research into its pharmacokinetics, interactions with drugs of importance, and its development into a plant-based drug in order to expand its clinical use.

Carbon Monoxide as a Therapeutic for Airway Diseases: Contrast and Comparison of Various CO Delivery Modalities

2021 ◽  
Vol 21 ◽  
Author(s):  
Ravi Tripathi ◽  
Xiaoxiao Yang ◽  
Stefan W. Ryter ◽  
Binghe Wang
Keyword(s):  
Carbon Monoxide ◽  
Respiratory Diseases ◽  
Controlled Delivery ◽  
Therapeutic Effects ◽  
Pharmacological Effects ◽  
Dosing Regimen ◽  
Respiratory Illnesses ◽  
Airway Diseases ◽  
Cytoprotective Agent ◽  
Co Gas

: The quest to find novel strategies to tackle respiratory illnesses has led to the exploration of the potential therapeutic effects of carbon monoxide (CO) as an endogenous signaling molecule and a cytoprotective agent. Further, several studies have demonstrated the pharmacological efficacy of CO in animal models of respiratory disorders such as acute lung injury and pulmonary hypertension. Because of the gaseous nature of CO and its affinity for multiple targets, its controlled delivery has been a challenge. Past studies have employed different delivery modalities including CO gas, HO-1 inducers, and CO donors, sometimes leading to substantive variations of the resulting pharmacological effects for various reasons. Herein, this review summarizes and analyzes the differences among the profiles of various CO-delivery modalities in terms of their efficacy, dosing regimen, and pharmacokinetics in airways models. We believe that analysis of these issues will help in understanding the fundamental roles of CO in airways and eventually contribute to its development as a medicine for respiratory diseases.

Antiproliferative effect on human cancer cell lines after treatment with nimbolide extracted from an edible part of the neem tree (Azadirachta indica)

2007 ◽  
Vol 21 (3) ◽  
pp. 245-250 ◽  
Author(s):  
Molay Kumar Roy ◽  
Masuko Kobori ◽  
Makiko Takenaka ◽  
Kazuhiko Nakahara ◽  
Hiroshi Shinmoto ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Azadirachta Indica ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Antiproliferative Effect ◽  
Human Cancer Cell ◽  
Neem Tree ◽  
Human Cancer Cell Lines ◽  
Edible Part
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