Comparative analysis of anthropometric indices with serum uric acid in Iranian healthy population

Objective This study aims to investigate the relationship between serum uric acid and arterial stiffness in a healthy population. Methods Among the 979 participants, baPWV was non-invasively measured, the circulating levels of uric acid were tested, and the uric acid polymorphisms (rs2231142 and rs11722228) were genotyped. Then, the Mendelian randomization method was employed to test the relationship between serum uric acid and arterial stiffness in a healthy population. Results After adjusting for age, gender, antihypertensive medication, body mass index, waist-to-hip ratio, urea nitrogen, creatinine and diabetic mellitus, there was a significant allelic difference in uric acid levels for each genotype ( P < 0.0001 for rs2231142; P = 0.007 for rs11722228). However, there were no differences on the potential confounders between the genotypes of rs2231142 and rs11722228 ( P > 0.05). The baPWV was significantly associated with circulating levels of uric acid after adjusting for cardiovascular risk factors and other potential confounders ( P = 0.002). However, neither the single polymorphism, nor the accumulation of culprit alleles was associated with baPWV ( P = 0.92 for rs2231142; P = 0.60 for rs11722228; P for trend = 0.77 for the combined analysis of culprit alleles). Conclusion These results do not support the causal role of circulating levels of uric acid in the development of arterial stiffness.

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Serum uric acid: Association with anthropometric, lipid and complete blood count parameters in Iranian healthy population

10.21203/rs.3.rs-20016/v1 ◽

2020 ◽

Author(s):

Hamid Soori ◽

Parinaz Rezapour ◽

Hadis Najafimehr ◽

Toktam Alirezaei

Keyword(s):

Uric Acid ◽

Lipid Profile ◽

Multiple Regression ◽

Serum Uric Acid ◽

Body Fat ◽

Serum Lipid ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Healthy Population ◽

Lymphocyte Ratio

Abstract Objectives A relationship between elevated serum uric acid (SUA) and hypertension, metabolic syndrome and cardiovascular disease has been established. In this study, the relationship of SUA levels and anthropometric measures, serum lipid profile and neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) was examined.Methods Anthropometric parameters including body-mass index (BMI), waist circumference (WC), waist to height ratio(WHtR), waist to hip ratio(W/H), waist to pelvic ratio(W/P), neck circumference(NC), body fat mass(BFM) were obtained, and serum lipid profile containing, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol, triglycerides(TG), also, NLP, PLR, basal metabolic rate (BMR), visceral fat level (VFL) and percent body fat (PBF) were measured among 2921 healthy subjects of young and middle-aged Iranian people. Statistical analysis was performed using SPSS 21 software. To assess the normality of data, the Kolmogorov–Smirnov test was used. Logarithmic transformation was performed for some variables with non-normal distribution. The association between 2 quantitative variables was measured using bivariate correlation (Pearson or Spearman). Pearson correlations and multiple regression analysis were performed to assess the correlation between variables. Simple and multiple regression analyses were performed to predict some variables. P- value <0.05 was considered significant.Results There were 1113 males (mean age, 41.49 ± 8.62 years) and 1808 females (mean age, 42.36 ± 9.07 years) in this study. the male group had a mean SUA level of 4.81± 1.2 mg/dl and the female group had a mean of 4.76 ± 1.1 mg/dl. The results of data analysis showed all studied factors were correlated with SUA level except VFL, BFM, and PLR. The highest correlation was related to skinfold fat thickness, BMR and HDL.Conclusion According to the finding of this study, SUA level measurement might be advisable in healthy population to identify those at increased risk of health problems who might benefit from further evaluation.

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Abstract TP203: Serum Uric Acid is Associated With Arterial Stiffness, Pulse Pressure and Stroke in Apparently Healthy Population

Stroke ◽

10.1161/str.50.suppl_1.tp203 ◽

2019 ◽

Vol 50 (Suppl_1) ◽

Author(s):

Kwang-Yeol Park ◽

Jeong-Min Kim ◽

Won-Tae Yoon ◽

Pil-Wook Chung

Keyword(s):

Uric Acid ◽

Arterial Stiffness ◽

Serum Uric Acid ◽

Pulse Pressure ◽

Healthy Population ◽

Apparently Healthy

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P1683Optimal serum uric acid levels for hypertension: 5-year cohort study

European Heart Journal ◽

10.1093/eurheartj/ehz748.0439 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

M Kuwabara ◽

K Niwa ◽

I Hisatome

Keyword(s):

Uric Acid ◽

Cohort Study ◽

Serum Uric Acid ◽

Cumulative Incidence ◽

Healthy Population ◽

Drinking Habits ◽

Logistic Analysis ◽

Baseline Systolic Blood Pressure ◽

History Of ◽

Acid Range

Abstract Background Although hyperuricemia is known as a risk factor for hypertension, the optimal range of serum uric acid (SUA) for preventing hypertension has not been established, especially in a healthy population. Methods This is a 5-year cohort study to clarify the optimal SUA for hypertension. Subjects consisted of Japanese adults between 30 and 85 years of age were enrolled in the study at our Center for Preventive Medicine, and available at enrollment (2004) and at 5-year follow-up (2009). We excluded the study subjects who were hypertensive, diabetic, dyslipidemic, had a history of gout or hyperuricemia on medications, or if they had chronic kidney disease as estimated glomerular filtration rate <60 ml/min/1.73m2. Linear and logistic regression analyses were used to examine the relationship between each 1 mg/dL of serum uric acid range and development of hypertension with multiple adjustments for age, smoking, drinking habits, body mass index and baseline systolic blood pressure. Results Of 13,070 subjects enrolled at this step, we included 6,476 subjects (46.9±10.1 years old, 34.6% men) without comorbidities. The cumulative incidences of hypertension over 5 years were 5.9% in women and 12.1% in men. The lowest cumulative incidences of hypertension were 2.6% in 2.0–3.0 mg/dL of serum uric acid in women and 6.9% in 4.0–5.0 mg/dL in men. In contrast, the highest uric acid range showed highest cumulative incidence of hypertension both in women (28.6% in 8.0–9.0 mg/dL) and men (21.0% in ≥9.0 mg/dL). Hypouricemic (<2.0 mg/dL) subjects had higher cumulative incidences of hypertension than subjects with 2.0–3.0 mg/dL of serum uric acid levels, we excluded these subjects in multivariable logistic analysis. The odds ratio of 1 mg/dL increase of serum uric acid for developing hypertension was 1.395 (95% CI, 1.182–1.648) in women and 1.139 (95% CI, 1003–1.294) in men after multiple adjustments. Conclusion The optimal serum uric acid range for preventing hypertension was 2.0–3.0 mg/dL in women and 4.0–5.0 mg/dL in men. Higher uric acid levels increase cumulative incidence of hypertension. Acknowledgement/Funding None

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The Optimal Range of Serum Uric Acid for Cardiometabolic Diseases: A 5-Year Japanese Cohort Study

Journal of Clinical Medicine ◽

10.3390/jcm9040942 ◽

2020 ◽

Vol 9 (4) ◽

pp. 942 ◽

Cited By ~ 7

Author(s):

Masanari Kuwabara ◽

Ichiro Hisatome ◽

Koichiro Niwa ◽

Petter Bjornstad ◽

Carlos A. Roncal-Jimenez ◽

...

Keyword(s):

Uric Acid ◽

Cohort Study ◽

Serum Uric Acid ◽

Protective Factor ◽

Serum Urate ◽

Healthy Population ◽

Optimal Range ◽

Lower Serum ◽

Cardiometabolic Diseases ◽

Japanese Cohort

The optimal range of serum uric acid (urate) associated with the lowest risk for developing cardiometabolic diseases is unknown in a generally healthy population. This 5-year cohort study is designed to identify the optimal range of serum urate. The data were collected from 13,070 Japanese between ages 30 and 85 at the baseline (2004) from the Center for Preventive Medicine, St. Luke’s International Hospital, Tokyo. We evaluated the number of subjects (and prevalence) of those free of the following conditions: hypertension, diabetes, dyslipidemia, and chronic kidney disease (CKD) over 5 years for each 1 mg/dL of serum urate stratified by sex. Furthermore, the odds ratios (ORs) for remaining free of these conditions were calculated with multiple adjustments. Except for truly hypouricemic subjects, having lower serum urate was an independent factor for predicting the absence of hypertension, dyslipidemia, and CKD, but not diabetes. The OR of each 1 mg/dL serum urate decrease as a protective factor for hypertension, dyslipidemia, and CKD was 1.153 (95% confidence interval, 1.068–1.245), 1.164 (1.077–1.258), and 1.226 (1.152–1.306) in men; 1.306 (1.169–1.459), 1.121 (1.022–1.230), and 1.424 (1.311–1.547) in women, respectively. Moreover, comparing serum urate of 3–5 mg/dL in men and 2–4 mg/dL in women, hypouricemia could be a higher risk for developing hypertension (OR: 4.532; 0.943–21.78) and CKD (OR: 4.052; 1.181–13.90) in women, but not in men. The optimal serum urate range associated with the lowest development of cardiometabolic diseases was less than 5 mg/dL for men and 2–4 mg/dL for women, respectively.

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ASSESSMENT OF SERUM AND URINE URIC ACID LEVEL IN RELATION WITH ANTHROPOMETRIC INDICES IN OVERWEIGHT AND OBESE UNIVERSITY UNDERGRADUATE STUDENTS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i9.27995 ◽

2018 ◽

Vol 11 (9) ◽

pp. 443

Author(s):

Emmanuel Ikechukwu Onwubuya ◽

Nkiruka Rose Ukibe ◽

Ofia Anya Kalu ◽

Solomon Nwabueze Ukibe ◽

Obinwanne Chikamnario Osuagwu

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Normal Control ◽

Undergraduate Students ◽

Uric Acid Level ◽

Acid Level ◽

Anthropometric Indices ◽

Age Range ◽

And Control ◽

Serum And Urine

Objectives: Elevated uric acid level is related to a variety of adverse metabolic conditions including gout, obesity, and risk factor for cardiovascular diseases. This prospective study designed to assess the serum and urine uric acid level in relation with anthropometric indices in overweight and obese undergraduate students at NAU, Nnewi, Nigeria.Methods: A total of 302 undergraduate students aged between 18 and 40 years were randomly recruited for the present study. They were grouped based on their body mass index (BMI) as overweight, obese, and control participants. 132 participants were males, of which 21 were obese, 34 were overweight while 77 were normal (control) males. 170 participants were females, of which 56 were obese, 62 were overweight while the remaining 52 were normal (control) females. Fasting blood and 24 h urine sample were aseptically collected from all the participants for determination of serum and urine uric acid.Results: The study observed significantly higher serum uric acid level in obese and overweight males than female and control counterparts (p=0.000, respectively). Urine uric acid level was significantly higher in obese males and females than in their overweight and control counterparts (p=0.000). This shows increase production and accumulation of monosodium urate with decreased uric acid excretion which may result in hyperuricemia and hyperuricosuria which may result in gout. Serum and urine uric acid levels were significantly higher among age range (26–32) and (33–40) years compared with those among age range (18–25) (p<0.05) signifying that uric acid level increases with age. Serum and urine uric acid were significantly positively correlated with BMI, waist circumference, and waist hip ratio (p<0.05).Conclusions: High serum uric acid is a prerequisite for gout and also associated with the metabolic syndrome and risk factors for cardiovascular disease. Proper awareness of the implication of hyperuricemia among undergraduate students is necessary.

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Relationship between uric acid, blood pressure and anthropometric indices in a healthy Ghanaian adult population

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20205286 ◽

2020 ◽

Vol 8 (12) ◽

pp. 4185

Author(s):

Perez Quartey ◽

Bright Afriyie Owusu ◽

Lawrence Marfo ◽

Emmanuel Appiah

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Uric Acid ◽

Waist Circumference ◽

Serum Uric Acid ◽

Body Mass ◽

Statistical Significance ◽

Anthropometric Indices ◽

Significant Difference ◽

Positive Correlations

Background: Age- and sex-dependent variations in the relationship between uric acid and blood pressure and anthropometric indices have been reported in some populations. However, this has not been studied in a Ghanaian adult population.Methods: Body mass index, waist circumference, blood pressure and serum uric acid levels were measured. Categorical differences were analysed with chi-square. Differences between groups were assessed by t-test and one-way analysis of variance. Association between serum uric acid and baseline characteristics of age, body mass index, waist circumference and blood pressure was assessed by Pearson’s correlation. Statistical significance was pegged at p<0.05.Results: Prevalence of hyperuricemia was 3.2%. There was no significant difference in prevalence of hypertension between males (28.6%) and females (28.9%). General obesity and central obesity prevalence were significantly higher among females. In males, serum uric acids levels had statistically non-significant positive correlations with age, blood pressure, waist circumference and body mass index. In females, the results showed that among women less than 45 years, serum uric acid had significant positive correlations with only body mass index and waist circumference. However, significant positive correlations were observed between all the baseline parameters and uric acid among women who are 45 years and above.Conclusions: Increasing serum uric acid levels are significantly associated with higher blood pressure, body mass index and waist circumference. This relationship is stronger in females than in males, with the age group ≥45 years being the main determinant of this relationship.

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