scholarly journals Bacterial Antibiotic Resistance: The Most Critical Pathogens

Pathogens ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1310
Author(s):  
Giuseppe Mancuso ◽  
Angelina Midiri ◽  
Elisabetta Gerace ◽  
Carmelo Biondo
Keyword(s):  
Antibiotic Resistance ◽  
Bacterial Infections ◽  
Resistance Mechanisms ◽  
World Health ◽  
Health Concern ◽  
Resistant Bacteria ◽  
Antimicrobial Drugs ◽  
Secondary Importance ◽  
Drug Resistant Bacteria ◽  
Health Organization

Antibiotics have made it possible to treat bacterial infections such as meningitis and bacteraemia that, prior to their introduction, were untreatable and consequently fatal. Unfortunately, in recent decades overuse and misuse of antibiotics as well as social and economic factors have accelerated the spread of antibiotic-resistant bacteria, making drug treatment ineffective. Currently, at least 700,000 people worldwide die each year due to antimicrobial resistance (AMR). Without new and better treatments, the World Health Organization (WHO) predicts that this number could rise to 10 million by 2050, highlighting a health concern not of secondary importance. In February 2017, in light of increasing antibiotic resistance, the WHO published a list of pathogens that includes the pathogens designated by the acronym ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) to which were given the highest “priority status” since they represent the great threat to humans. Understanding the resistance mechanisms of these bacteria is a key step in the development of new antimicrobial drugs to tackle drug-resistant bacteria. In this review, both the mode of action and the mechanisms of resistance of commonly used antimicrobials will be examined. It also discusses the current state of AMR in the most critical resistant bacteria as determined by the WHO’s global priority pathogens list.

scholarly journals Non-Antimicrobial Drugs: Etodolac as a Possible Antimicrobial or Adjuvant Agent Against ESKAPE Pathogens

2018 ◽  
Vol 12 (1) ◽  
pp. 288-296
Author(s):  
Sónia G. Pereira ◽  
Vanessa S. Domingues ◽  
João Theriága ◽  
Maria de Jesus Chasqueira ◽  
Paulo Paixão
Keyword(s):  
Biofilm Formation ◽  
World Health ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Antimicrobial Drugs ◽  
Similar Work ◽  
Drug Resistant Bacteria ◽  
Health Organization ◽  
Approved Drugs ◽  
Novel Therapeutic

Introduction:Multiple-drug resistant bacteria are emerging exponentially in healthcare units, threatening public health and requiring novel therapeutic approaches. In 2017, World Health Organization published a list that frames antimicrobial resistant bacteria into priority levels for research of novel drugs to fight them.Methods & Materials:Antimicrobial resistant ESKAPE (Enterococcus faecium,Staphylococcus aureus,Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa,Enterobactersp.) andEnterococcus faecalisandEscherichia colipathogens are present in this list. Representative isolates of each species were used to test the Antibacterial and anti-biofilm formation activities of Etodolac (a Non-Steroidal Anti-Inflammatory Drug, NSAID) at 10 and 1 mM using a broth microdilution technique.Results & Discussion:Statistically significant (p< 0,05) results were observed against all tested gram-positives, particularly anti-biofilm activity againstE. faecium. Etodolac had an almost null influence on tested gram-negatives, with the exception of oneA. baumanniiclinical isolate regarding biofilm formation inhibition. Observed differences deserve further analysis and prospection of the involved mechanisms, to unravel possible novel bacterial targets for drug development. Similar work with other NSAID’s may also be worth exploring to ascertain novel therapeutic applications for these drugs, particularly regarding biofilm formation inhibition,per sior as adjuvants of current antibiotherapy, mainly against gram-positives, as suggested by present work.Conclusion:Already approved drugs in terms of pharmacokinetics and safety may deploy faster solutions for antimicrobial therapy against priority pathogens. Current work intends to bring attention to that possibility, particularly regarding NSAIDs, anti-biofilm formation and top priority pathogens.

scholarly journals MULTIDRUG-RESISTANT AND EXTREMELY DRUG-RESISTANT BACTERIA: ARE WE FACING THE END OF THE ANTIBIOTIC ERA?

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
G.M. Rossolini
Keyword(s):  
Antibiotic Resistance ◽  
Bacterial Infections ◽  
Multidrug Resistant ◽  
Modern Medicine ◽  
Infectious Complications ◽  
Future Perspective ◽  
Resistant Bacteria ◽  
Bacterial Strains ◽  
Public Health Agencies ◽  
Drug Resistant Bacteria

Antibiotics are one of the most significant advancements of modern medicine. They have changed the prognosis of several bacterial infections, and made possible advanced medical practices associated with a high risk of infectious complications. Unfortunately, antibiotics are affected by the phenomenon of antibiotic resistance, which jeopardizes their efficacy. In recent years, antibiotic discovery and development has been lagging, due to a lower appeal of this sector for the pharmaceutical industry, while antibiotic resistance has continued to evolve with the eventual emergence and dissemination of bacterial strains which are resistant to most available antibiotics and pose a major challenge to antimicrobial chemotherapy. This worrisome scenario, indicated as the “antibiotic resistance crisis”, has been acknowledged by Scientific Societies and Public Health Agencies, and is now gathering an increasing attention from the Media and Governments. This article reviews the antibiotic-resistant pathogens which currently pose major problems in terms of clinical and epidemiological impact, and briefly discuss future perspective in this field.

scholarly journals Antibiotic resistance trends and mechanisms in the foodborne pathogen,Campylobacter

2017 ◽  
Vol 18 (2) ◽  
pp. 87-98 ◽  
Author(s):  
Yizhi Tang ◽  
Liangxing Fang ◽  
Changyun Xu ◽  
Qijing Zhang
Keyword(s):  
Antibiotic Resistance ◽  
Efflux Pump ◽  
Foodborne Pathogen ◽  
Resistance Mechanisms ◽  
World Health ◽  
Antibiotic Resistant ◽  
Innovative Strategies ◽  
Control And Prevention ◽  
Antibiotic Selection Pressure ◽  
Health Organization

AbstractCampylobacteris a major foodborne pathogen and is commonly present in food producing animals. This pathogenic organism is highly adaptable and has become increasingly resistant to various antibiotics. Recently, both the Centers for Disease Control and Prevention and the World Health Organization have designated antibiotic-resistantCampylobacteras a serious threat to public health. For the past decade, multiple mechanisms conferring resistance to clinically important antibiotics have been described inCampylobacter, and new resistance mechanisms constantly emerge in the pathogen. Some of the recent examples include theerm(B)gene conferring macrolide resistance, thecfr(C)genes mediating resistance to florfenicol and other antimicrobials, and a functionally enhanced variant of the multidrug resistance efflux pump, CmeABC. The continued emergence of new resistance mechanisms illustrates the extraordinary adaptability ofCampylobacterto antibiotic selection pressure and demonstrate the need for innovative strategies to control antibiotic-resistantCampylobacter. In this review, we will briefly summarize the trends of antibiotic resistance inCampylobacterand discuss the mechanisms of resistance to antibiotics used for animal production and important for clinical therapy in humans. A special emphasis will be given to the newly discovered antibiotic resistance.

Antimicrobial stewardship in equine practice

UK-Vet Equine ◽  
2019 ◽  
Vol 3 (6) ◽  
pp. 200-205
Author(s):  
David Rendle ◽  
Sarah Gough
Keyword(s):  
World Health Organization ◽  
Antimicrobial Stewardship ◽  
Bacterial Infections ◽  
One Health ◽  
World Health ◽  
Resistant Bacteria ◽  
Veterinary Profession ◽  
The World ◽  
Considerable Impact ◽  
Health Organization

The veterinary profession's use of critically important antimicrobials is a One Health issue that has come under the scrutiny of the World Health Organization and the European Parliament. Failure by the veterinary profession to demonstrate the ability to self-regulate may result in restriction on the freedom to dispense antimicrobials, in an effort to protect human health. The implementation of such legislation would have a considerable impact on veterinary practices and would likely impair our ability to treat some conditions. These concerns, and the increasing frequency of multi-resistant bacterial infections in equine patients, should prompt implementation and audit of antimicrobial stewardship practices and measures to limit the development and spread of multi-resistant bacteria.

Photosensitized reactive chlorine species-mediated therapeutic destruction of drug-resistant bacteria using plasmonic core–shell Ag@AgCl nanocubes as an external nanomedicine

Nanoscale ◽  
2020 ◽  
Vol 12 (24) ◽  
pp. 12970-12984 ◽  
Author(s):  
Suresh Thangudu ◽  
Sagar Sunil Kulkarni ◽  
Raviraj Vankayala ◽  
Chi-Shiun Chiang ◽  
Kuo Chu Hwang
Keyword(s):  
Antibiotic Resistance ◽  
Rapid Growth ◽  
Bacterial Infections ◽  
Resistant Bacteria ◽  
Core Shell ◽  
Drug Resistant ◽  
Bacterial Antibiotic Resistance ◽  
Drug Resistant Bacteria

Due to the rapid growth of drug-resistant bacterial infections, there is an urgent need to develop innovative antimicrobial strategies to conquer the bacterial antibiotic resistance problems.

scholarly journals A REVIEW ARTICLE ON: ANTIBIOTIC RESISTANCE

2020 ◽  
Vol 9 (3) ◽  
Author(s):  
Ajid K. Mule ◽  
Suraj Malpani ◽  
Shradha T. Nemane ◽  
Sushil S. Kore ◽  
Ayaj S. Pathan
Keyword(s):  
Antibiotic Resistance ◽  
Bacterial Infections ◽  
Animal Husbandry ◽  
World Health ◽  
Resistant Bacteria ◽  
High Morbidity ◽  
Antibiotic Resistant ◽  
The World ◽  
Tract Infections ◽  
The U.S

Antibiotics are the ‘wonder drugs’ to combat microbes. For decades, various types of antibiotics have not only been used for therapeutic purposes but practiced prophylactically across other industries such as agriculture and animal husbandry. Antibiotic-resistant infections correlate with the level of antibiotic consumption. Non-judicial use of antibiotics is one of the reason for making the microbes resistant. The antibiotic therapy store for emerging hard-to-treat multidrug-resistant bacterial infections is limited, resulting in high morbidity and mortality report. As per the World Health Organization “First worldwide Report on Antibiotic Resistance”, and the U.S. Centers for Disease Control & Prevention (CDC&P) and the spread of “superbugs” - bacteria that have changed in ways that provided antibiotics non effective against them - is a severe and growing threat around the world. Once common treatments for not only everyday intestinal and urinary tract infections but also pneumonia as well as infections in newborn and diseases like gonorrhea are no longer working in people. Thus, in 2013, two million people in the U.S. were affected by antibiotic-resistant bacteria, and 23,000 of them die each year as a result. Keywords: Wonder drugs, antibiotic resistance, CDC&P, Superbugs etc.

scholarly journals MgrB Inactivation Confers Trimethoprim Resistance in Escherichia coli

2021 ◽  
Vol 12 ◽  
Author(s):  
Hongmei Shi ◽  
Ting Li ◽  
Jintian Xu ◽  
Jifang Yu ◽  
Shanshan Yang ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Gene Knockout ◽  
Single Gene ◽  
Resistance Mechanisms ◽  
Transcriptional Analysis ◽  
World Health ◽  
Antimicrobial Drugs ◽  
Health Organization

After several decades of use, trimethoprim (TMP) remains one of the key access antimicrobial drugs listed by the World Health Organization. To circumvent the problem of trimethoprim resistance worldwide, a better understanding of drug-resistance mechanisms is required. In this study, we screened the single-gene knockout library of Escherichia coli, and identified mgrB and other several genes involved in trimethoprim resistance. Subsequent comparative transcriptional analysis between ΔmgrB and the wild-type strain showed that expression levels of phoP, phoQ, and folA were significantly upregulated in ΔmgrB. Further deleting phoP or phoQ could partially restore trimethoprim sensitivity to ΔmgrB, and co-overexpression of phoP/Q caused TMP resistance, suggesting the involvement of PhoP/Q in trimethoprim resistance. Correspondingly, MgrB and PhoP were shown to be able to modulated folA expression in vivo. After that, efforts were made to test if PhoP could directly modulate the expression of folA. Though phosphorylated PhoP could bind to the promotor region of folA in vitro, the former only provided a weak protection on the latter as shown by the DNA footprinting assay. In addition, deleting the deduced PhoP box in ΔmgrB could only slightly reverse the TMP resistance phenotype, suggesting that it is less likely for PhoP to directly modulate the transcription of folA. Taken together, our data suggested that, in E. coli, MgrB affects susceptibility to trimethoprim by modulating the expression of folA with the involvement of PhoP/Q. This work broadens our understanding of the regulation of folate metabolism and the mechanisms of TMP resistance in bacteria.

scholarly journals Mechanistic Insights into the Antimicrobial Actions of Metallic Nanoparticles and Their Implications for Multidrug Resistance

2019 ◽  
Vol 20 (10) ◽  
pp. 2468 ◽  
Author(s):  
Sibhghatulla Shaikh ◽  
Nazia Nazam ◽  
Syed Mohd Danish Rizvi ◽  
Khurshid Ahmad ◽  
Mohammad Hassan Baig ◽  
...  
Keyword(s):  
Metallic Nanoparticles ◽  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Health Concern ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Drug Resistant Bacteria ◽  
Multiple Drug Resistant ◽  
Bacterial Drug Resistance

Multiple drug-resistant bacteria are a severe and growing public health concern. Because relatively few antibiotics have been approved over recent years and because of the inability of existing antibiotics to combat bacterial infections fully, demand for unconventional biocides is intense. Metallic nanoparticles (NPs) offer a novel potential means of fighting bacteria. Although metallic NPs exert their effects through membrane protein damage, superoxide radicals and the generation of ions that interfere with the cell granules leading to the formation of condensed particles, their antimicrobial potential, and mechanisms of action are still debated. This article discusses the action of metallic NPs as antibacterial agents, their mechanism of action, and their effect on bacterial drug resistance. Based on encouraging data about the antibacterial effects of NP/antibiotic combinations, we propose that this concept be thoroughly researched to identify means of combating drug-resistant bacteria.

scholarly journals Applications of Nanodiamonds in the Detection and Therapy of Infectious Diseases

Materials ◽  
2019 ◽  
Vol 12 (10) ◽  
pp. 1639 ◽  
Author(s):  
Eva Torres Sangiao ◽  
Alina Maria Holban ◽  
Mónica Cartelle Gestal
Keyword(s):  
Drug Delivery ◽  
Antibiotic Resistance ◽  
Infectious Diseases ◽  
Antimicrobial Agents ◽  
Multidrug Resistant ◽  
World Health ◽  
Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Great Opportunity ◽  
Health Organization

We are constantly exposed to infectious diseases, and they cause millions of deaths per year. The World Health Organization (WHO) estimates that antibiotic resistance could cause 10 million deaths per year by 2050. Multidrug-resistant bacteria are the cause of infection in at least one in three people suffering from septicemia. While antibiotics are powerful agents against infectious diseases, the alarming increase in antibiotic resistance is of great concern. Alternatives are desperately needed, and nanotechnology provides a great opportunity to develop novel approaches for the treatment of infectious diseases. One of the most important factors in the prognosis of an infection caused by an antibiotic resistant bacteria is an early and rigorous diagnosis, jointly with the use of novel therapeutic systems that can specifically target the pathogen and limit the selection of resistant strains. Nanodiamonds can be used as antimicrobial agents due to some of their properties including size, shape, and biocompatibility, which make them highly suitable for the development of efficient and tailored nanotherapies, including vaccines or drug delivery systems. In this review, we discuss the beneficial findings made in the nanodiamonds field, focusing on diagnosis and treatment of infectious diseases. We also highlight the innovative platform that nanodiamonds confer for vaccine improvement, drug delivery, and shuttle systems, as well as their role in the generation of faster and more sensitive clinical diagnosis.

scholarly journals Determination of antibiotic resistance patterns of Vibrio parahaemolyticus from shrimp and shellfish in Selangor, Malaysia

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Vengadesh Letchumanan ◽  
Nurul-Syakima Ab Mutalib ◽  
Sunny Hei Wong ◽  
Kok-Gan Chan ◽  
Learn-Han Lee
Keyword(s):  
Antibiotic Resistance ◽  
Vibrio Parahaemolyticus ◽  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Large Scale ◽  
Health Concern ◽  
Resistance Pattern ◽  
Resistant Bacteria ◽  
Resistance Patterns ◽  
Plasmid Profiling

High consumer demand for seafood has led to the need for large-scale, reliable supply through aquaculture farming. However, bacterial infections - which can spread rapidly among the dense farming area pose a major threat to this industry. The farmers therefore often resort to extensive use of antibiotics, both prophylactically and therapeutically, in order to protect their stocks. The extensive use of antibiotics in aquaculture has been postulated to represent a major contributing factor in the rising incidence of antimicrobial resistant pathogenic bacteria in seafood; which may then lead to the spread of antimicrobial resistant bacteria in the environment as well as posing a significant threat to human health. This study aimed to characterize antibiotic resistance of Vibrio parahaemolyticus from shrimp and shellfish in Selangor, Malaysia. The antibiotic susceptibility of 385 V. parahaemolyticus isolates was investigated against 14 antibiotics followed by plasmid profiling and plasmid curing to determine the antibiotic mediation. A large number of isolates showed resistance to ampicillin (85%), amikacin (66.8%), and kanamycin (50.1%). A notable resistance pattern was also observed to the third generation cephalosporins (cefotaxime 55.8% and ceftazidime 34%). Only 338 V. parahaemolyticus isolates had 1-7 different plasmids and could be categorized into 27 patterns based on the number and pattern of plasmid present. Interestingly, there was no correlation between the number of plasmids and antibiotic resistant patterns seen in the isolates. The antibiotic resistance was mediated by both chromosomal and plasmid mediation among the resistant isolates. In summary, our results demonstrate that incidence of pathogenic V. parahaemolyticus in seafood in Selangor remains in relatively assuring levels, however the identification of antibiotic resistance among the isolates does rises a public health concern and warrants for continuous surveillance.

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