Comparative accuracy of cervical cancer screening strategies in healthy asymptomatic women: a systematic review and network meta-analysis

To compare all available accuracy data on screening strategies for identifying cervical intraepithelial neoplasia grade ≥ 2 in healthy asymptomatic women, we performed a systematic review and network meta-analysis. MEDLINE and EMBASE were searched up to October 2020 for paired-design studies of cytology and testing for high-risk genotypes of human papillomavirus (hrHPV). The methods used included a duplicate assessment of eligibility, double extraction of quantitative data, validity assessment, random-effects network meta-analysis of test accuracy, and GRADE rating. Twenty-seven prospective studies (185,269 subjects) were included. The combination of cytology (atypical squamous cells of undetermined significance or higher grades) and hrHPV testing (excepting genotyping for HPV 16 or 18 [HPV16/18]) with the either-positive criterion (OR rule) was the most sensitive/least specific, whereas the same combination with the both-positive criterion (AND rule) was the most specific/least sensitive. Compared with standalone cytology, non-HPV16/18 hrHPV assays were more sensitive/less specific. Two algorithms proposed for primary cytological testing or primary hrHPV testing were ranked in the middle as more sensitive/less specific than standalone cytology and the AND rule combinations but more specific/less sensitive than standalone hrHPV testing and the OR rule combination. Further research is needed to assess these results in population-relevant outcomes at the program level.

Cultural Adaptation and Testing of the Italian Version of the Edmonton Functional Assessment Tool-2 (EFAT2-I)

Background Physiotherapy in Palliative Care (PC) is effective in the management of a series of respiratory, circulatory and motor symptoms, and often has a positive impact on the patient's mood. The Edmonton Functional Assessment Tool (EFAT) is the only existing validated tool specifically designed for functional assessment in PC, and its use has been recommended in clinical practice. To date, no Italian version of the tool has been validated. The aim of this study was to translate, cross-culturally adapt, and evaluate the psychometric properties of the Italian version of the EFAT2. Method After receiving formal permission from the author, Beaton guidelines for cross-cultural adaptation were followed, namely: (1) forward translation; (2) a multidisciplinary focus group (including 4 physiotherapists, 1 physician, 3 nurses, 1 occupational therapist, 1 psychologist) to assess semantic, idiomatic, experiential, and conceptual equivalence; (3) backward translation. The Content Validity Index (CVI) was used to assess content validity of the tool. Construct and concurrent validity were also evaluated. To evaluate the reliability of the EFAT2-I, reliability was measured using Cronbach alfa, item-total correlation, and Cohen's Kappa. Results 119 patients admitted to a Palliative Care Unit (Italy) agreed to participate in the study. The EFAT2-I mean score was 11.3, ranging from 0 to 30. Very good CVI scores were achieved, both in terms of single item validity (I-CVI) and of whole scale validity (S-CVI). Positive results were obtained from construct, concurrent validity assessment and measures of reliability. Discussion The EFAT2-I showed good psychometric properties and can be used as a rehabilitation assessment tool in palliative care settings. The validation of the Italian version will allow comparison of different centres and palliative care facilities on national and international levels.

Prioritization and assessment of safety key performance indicators in an automotive industry

The performance of any management system needs to be monitored with adequate and proper indicators. This study aimed to identify, set priorities and assess key indicators for implementing an effective performance evaluation system. This descriptive-analytical study was carried out in three phase. In first phase, a semi-structured interview as well as a review of the company's documentation and studies carried out, then a set of key indicators were collected and selected. The validity of the indicators were determined by experts (N = 11) and indicators were prioritized using Analytic Hierarchy Process (AHP) according to SMART (Specific, Measurable, Achievable, Relevant, and Time- bound) criteria. Following the study framework, a primary set of 60 Key Performance Indicators (KPIs) were collected. The results of the validity assessment showed 23 indicators had acceptable validity. The results of examining the relationships between the indicators showed that the percentage of corrected non- compliance and the number of risk assessments had a significant relationships with the total number of work-related lost time injuries as a lagging indicator. According to the results, the four the most important key performance indicators to assess the safety performance in the automotive industry were as follows: the number of risk assessments conducted, the percentage of corrected non- compliance, the percentage of safety educational programs implemented for workers, and Frequency Severity Index (FSI) index.

Development of Plant Physiology E-Modules Based on Contextual Teaching and Learning (CTL) on Photosynthesis and Metabolism Materials Nitrogen Using Software Appypie of Results Student Learning Biology

The strategy and implementation of learning is strongly influenced by the development of science and technology. So the technology that is currently developing must be integrated into the learning process to improve the quality of learning. One of the technology integration is E-Modul. E-Modul is a form of presentation of self-study materials that are arranged systematically into the smallest learning units to achieve certain learning objectives which are presented in an electronic format for each learning activity. E-Modules developed using a contextual approach will This causes students to get more meaningful learning, because they can relate the material to real everyday life. E-Modules are presented systematically so that they contain relevant text, images and videos. Therefore, Appypie Software is used in the development of the Plant Physiology E-Module. The purpose of this research is to produce an E-Module of Plant Physiology based on CTL on the material of Photosynthesis and Nitrogen Metabolism using Appypie Software which is valid, practical and effective. This type of research is development research using the Plomp model. The development phase of this model begins with the Preliminary Research Phase , Development or Prototyping Phase, and the Assessment Phase. The instruments in this study were in the form of a validity assessment sheet, a practicality assessment sheet, a skill and attitude competency assessment sheet and multiple choice questions to assess knowledge competence. The data analysis technique is validity, practicality using modified Likert scale scoring and effectiveness data using t-test using SPSS version 17. The results showed that the CTL-based Plant Physiology E-Module on the materials of Photosynthesis and Nitrogen Metabolism was very valid with a value of 92.21%. The practicality assessment by the lecturers scored 95% with very practical criteria and the student assessment with a score of 82.17% with very practical criteria. The results of the effectiveness test showed that the class that used the CTL-based Plant Physiology E-Module had a higher score than the class that did not use the CTL-based Plant Physiology E-Module, so the use of the E-Module equipped with pictures, animations and videos could help students understand material. It can be concluded that the CTL-based Plant Physiology E-Module that has been developed is in the very valid, very practical, and very effective category in improving student learning outcomes.

A Systematic Review and Recommendations Around Frameworks for Evaluating Scientific Validity in Nutritional Genomics

Background: There is a significant lack of consistency used to determine the scientific validity of nutrigenetic research. The aims of this study were to examine existing frameworks used for determining scientific validity in nutrition and/or genetics and to determine which framework would be most appropriate to evaluate scientific validity in nutrigenetics in the future.Methods: A systematic review (PROSPERO registration: CRD42021261948) was conducted up until July 2021 using Medline, Embase, and Web of Science, with articles screened in duplicate. Gray literature searches were also conducted (June-July 2021), and reference lists of two relevant review articles were screened. Included articles provided the complete methods for a framework that has been used to evaluate scientific validity in nutrition and/or genetics. Articles were excluded if they provided a framework for evaluating health services/systems more broadly. Citing articles of the included articles were then screened in Google Scholar to determine if the framework had been used in nutrition or genetics, or both; frameworks that had not were excluded. Summary tables were piloted in duplicate and revised accordingly prior to synthesizing all included articles. Frameworks were critically appraised for their applicability to nutrigenetic scientific validity assessment using a predetermined categorization matrix, which included key factors deemed important by an expert panel for assessing scientific validity in nutrigenetics.Results: Upon screening 3,931 articles, a total of 49 articles representing 41 total frameworks, were included in the final analysis (19 used in genetics, 9 used in nutrition, and 13 used in both). Factors deemed important for evaluating nutrigenetic evidence related to study design and quality, generalizability, directness, consistency, precision, confounding, effect size, biological plausibility, publication/funding bias, allele and nutrient dose-response, and summary levels of evidence. Frameworks varied in the components of their scientific validity assessment, with most assessing study quality. Consideration of biological plausibility was more common in frameworks used in genetics. Dose-response effects were rarely considered. Two included frameworks incorporated all but one predetermined key factor important for nutrigenetic scientific validity assessment.Discussion/Conclusions: A single existing framework was highlighted as optimal for the rigorous evaluation of scientific validity in nutritional genomics, and minor modifications are proposed to strengthen it further.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=261948, PROSPERO [CRD42021261948].

Development of Augmented Reality-Based Learning Media on Concept of Hydrocarbon to Improve Multi-representation Ability

This study aims to design and develop learning media based on augmented reality on hydrocarbon material and its validity to determine the media's feasibility and increase students' multi-representation ability. This research is a type of development research using Design Research and Development (R&D). The product validity test phase was carried out by two material experts and three media experts. In addition, testing was carried out on the responses of the participating students. The implementation stage of learning was carried out by class X TKJ 2 SMK Gondang Pekalongan with a total of 32 students. The data analysis technique used a questionnaire instrument and the technical descriptive statistical analysis. The results of this study are: (1) the development of augmented reality-based learning media on hydrocarbon material in the form of an android application consisting of five main menus, namely basic competencies and indicators, materials, AR camera, practice questions, and the identity of the researcher, as well as seven molecular cards of the structure chemical compound molecules; (2) validity assessment by material experts with an average score of 85% in the "very valid" category and the validity assessment by media experts with an average score of 94% in the "very valid" category; (3) the feasibility test results for using media in the implementation of learning obtained an average student response score of 78%, with the "feasible" category used as learning media. The increase in multi-representation abilities is shown by increasing student learning outcomes using multi-representation questions, including macroscopic, submicroscopic, and symbolic levels. The macroscopic level increased by 27.50%, the submicroscopic increased by 36.70%, and the symbolic level increased by 33.30%. The results of this study indicate that augmented reality-based learning media on hydrocarbons is very suitable for use in chemistry learning and has been proven to increase students' multi-representation abilities

Teaching Physics to Students With Intellectual Disabilities Using Digital Learning Objects

Digital Learning Objects (DLOs) as pedagogical complete structures of learning content contribute to science education. DLOs especially in the form of interactive simulations seem to be promising tools in physics teaching and learning for students with intellectual disabilities (ID). This study used an AB single subject design to evaluate the effects of four DLOs on students’ learning of transverse waves and simple pendulum motion in a special education high school setting. A functional relationship was found between students’ correct responses concerning both scientific terminology and physical phenomena understanding during probe sessions and the DLOs intervention. In addition, a social validity assessment that evaluated students’ attitudes on learning, quality, and engagement, showed that the DLOs helped students with ID to acquire physics content. The students also reported satisfaction from using the DLOs. Suggestions for future research include the design of DLOs especially for students with ID.

A new theoretical understanding of big data analytics capabilities in organizations: a thematic analysis

Big Data Analytics (BDA) usage in the industry has been increased markedly in recent years. As a data-driven tool to facilitate informed decision-making, the need for BDA capability in organizations is recognized, but few studies have communicated an understanding of BDA capabilities in a way that can enhance our theoretical knowledge of using BDA in the organizational domain. Big Data has been defined in various ways and, the past literature about the classification of BDA and its capabilities is explored in this research. We conducted a literature review using PRISMA methodology and integrated a thematic analysis using NVIVO12. By adopting five steps of the PRISMA framework—70 sample articles, we generate five themes, which are informed through organization development theory, and develop a novel empirical research model, which we submit for validity assessment. Our findings improve effectiveness and enhance the usage of BDA applications in various Organizations.