Pengaruh Budaya Organisasi dan Motivasi Intrinsik terhadap Komitmen Afektif dengan Kepuasan Kerja sebagai Variabel Pemediasi pada Karyawan Dinas Koperasi dan UKM Kabupaten Sleman

This study aims to examine the effect of organizational culture and intrinsic motivation on affective commitment. This study also aims to examine whether job satisfaction acts as a mediating variable on the influence of organizational culture and intrinsic motivation on affective commitment to the employees of the Cooperatives and SMEs Service Office of Sleman Regency. This study uses the Associative method with a quantitative approach. The population in this study were all employees of the Department of Cooperatives and SMEs in Sleman Regency, with a sample of 45 employees. The sampling technique used saturated sampling with data collection using a questionnaire. The data analysis technique in this study used multiple linear regression, Sobel test, coefficient of determination, and standard beta. This study resulted in the findings that organizational culture has an effect on job satisfaction, and intrinsic motivation has an effect on job satisfaction. Likewise, organizational culture influences affective commitment. However, intrinsic motivation has no effect on affective commitment. Other findings show that job satisfaction has an effect on affective commitment. This study also produces findings that job satisfaction mediates the effect of organizational culture on affective commitment, and job satisfaction also mediates the effect of intrinsic motivation on affective commitment. Keywords: organizational culture, intrinsic motivation, job satisfaction, affective commitment.

Using the Shapley value of stocks as systematic risk

Purpose This study aims to propose the Shapley value that originates from the game theory to quantify the relative risk of a security in an optimal portfolio. Design/methodology/approach Systematic risk as expressed by the relative covariance of stock returns to market returns is an essential measure in pricing risky securities. Although very much in use, the concept has become marginalized in recent years because of the difficulties that arise estimating beta. The idea is that portfolios can be viewed as cooperative games played by assets aiming at minimizing risk. With the Shapley value, investors can calculate the exact contribution of each risky asset to the joint payoff. For a portfolio of three stocks, this study exemplifies the Shapley value when risk is minimized regardless of portfolio return. Findings This study computes the Shapley value of stocks and indices for optimal mean-variance portfolios by using daily returns for the years 2016–2019. This results in the risk attributes allocated to securities in optimal portfolios. The Shapley values are analyzed and compared to the standard beta estimates to determine the ranking of assets with respect to pertinent risk and return. Research limitations/implications An alternative approach to value risk and return in optimal portfolios is presented in this study. The logic and the mechanics of Shapley value theory in portfolio analysis have been explained, and its advantages relative to standard beta analysis are presented. Hence, financial analysts when adding or removing specific assets from present positions will have the true and exact impact of their actions by using the Shapley value instead of the beta. Practical implications When computing the Shapley value, portfolio risk is decomposed exactly among its assets because it considers all possible coalitions of portfolios. In that sense, financial analysts when adding or removing specific securities from present holdings will be able to predict the true and exact impact of their transactions by using the Shapley value instead of the beta. The main implication for investors is that risk is ultimately priced relative to their holdings. This prevents the subjective mispricing of securities, as standard beta is not used and might allow investors to gain from arbitrage conditions. Originality/value The logic and the methodology of Shapley value theory in portfolio analysis have been explained as an alternative to value risk and return in optimal portfolios by presenting its advantages relative to standard beta analysis. The conclusion is that the Shapley value theory contributes much more financial optimization than to standard systematic risk analysis because it enables looking at the contribution of each security to all possible coalitions of portfolios.

Effect of Alkali-Free Synthesis and Post-Synthetic Treatment on Acid Sites in Beta Zeolites

Beta zeolites with Si/Al around 14 were prepared using three new alkali-free synthesis methods based on the application of amorphous aluminosilicate precursor and calcined in ammonia or air. All samples exhibit structural and textural properties of standard beta zeolite. Comprehensive study by 27Al and 29Si MAS NMR, together with FTIR adsorption of d3-acetonitrile and pyridine were used to characterize the influence of both the synthesis and calcination procedure on the framework Al atoms and related Brønsted and Lewis acid sites. While calcination in ammonia preserves all framework Al atoms, calcination in air results in 15% release of framework Al, but without restrictions of the accessibility of the beta zeolite channel system for bulky pyridine molecules. Terminal (SiO)3AlOH groups present in the hydrated zeolites were suggested as a precursor of framework Al-Lewis sites. Surprisingly, the mild dealumination of the air-calcined zeolites result in an increase of the concentration of Brønsted acid sites and a decrease of the total concentration of Lewis sites with the formation of the extra-framework ones.

Morphological Variation and Beta Carotene Contents of Several Clones of Ubi Kuning Cassava Genotype Derived from Irradiated Shoot in vitro

In line with the increase in cassava production and the development of nutrient-rich cassava in order to support national food diversification and biofortification programs, the selection of selected varieties of cassava varieties, which are superior in nutrients especially rich in beta carotene is very necessary. Beta carotene is an important source of antioxidants to scavange free radicals and is a provitamin A precusor to form vitamin A. The development of superior cassava riching in beta carotene can be done through the mutation approach with gamma irradiation. The observation of changes in morphological characters and levels of beta carotene from irradiated cassava need to be done to get the superior beta carotene cassava clone candidates, which could be developed in the future. This experiment was conducted at the Biotechnology Research Center, LIPI. The sample used in this study originated from in vitro shoots from several Ubi Kuning clones resulting from 10 Gy radiation, which were then transferred to the field. Observations of morphological characters and levels of beta carotene of Ubi Kuning were carried out in the third generation, which was harvested at the age of 10 months. The morphological analysis of irradiated Ubi Kuning showed that there was a difference in the intensity of tuber color between some of irradiated Ubi Kuning clones compared to the control. The determination of beta carotene levels based on the standard beta carotene curve found that the highest content of beta carotene was found in the UK Rad 3.4 clone with beta carotene content of 0.252 μg / mL compared to the control (0.219 μg / mL). The lowest beta carotene content was obtained in UK Rad 3.3 (0.048 μg / mL), followed by UK Rad 3.2 (0.221 μg / mL) and UK Rad 4.1 (0.120 μg / mL). This shows that the irradiated Ubi Kuning at dosage of 10 Gy caused variations in the intensity of tuber colors and the content of beta carotene from the cassava.Keywords: Ubi Kuning, beta carotene, Gamma light irradiation

Evaluation of novel and superior formulation CaroTexTM developed by Biofusion Technology

Per WHO, vitamin A deficiency is a systemic disease affecting cells, organs throughout the body. The gradual depletion of vitamin A stores results in xerophthalmia, night blindness, xerosis etc., reversed by vitamin A therapy. Beta-Carotene, a carotenoid, is the precursor of vitamin A, which cannot be synthesized by the human body. Hence beta carotene formulation has gathered considerable attention in the healthcare industry. Hydrophobicity of Beta carotene being a major challenge in the formulation, Zeushygia Life Sciences Pvt. Ltd (Telangana India) developed a novel beta carotene formulation, CaroTex, with enhanced bioavailability. The present study assesses the bioavailability of CaroTex in a rodent model. The animals were divided into 5 groups, Normal Control, Vehicle Control, Standard beta Carotene, Comparator and CaroTex. As rats efficiently convert beta carotene into vitamin A, high dose of beta-carotene (50mg/kg) was given orally for 7 consecutive days. Beta carotene, its metabolic product retinal were measured in rat liver. It was observed that beta carotene concentration in rats fed with CaroTex was about 1.70, 2.55 times higher than Comparator and control respectively whereas the concentration of retinal was the same in all groups. It is evident from this study that novel formulation technology (BioFusion Technology) of CaroTex reflects in relatively higher concentration levels of beta carotene.

Correlation between symptoms and functioning in psychiatric patients and temporal patterns of medication refills derived from pharmacy prescription claims

Objectives: Pharmacy dispensing claims data provide longitudinal records of prescriptions and refill events. Previous studies in psychiatric patients have utilised these data to derive indicators of medication adherence based on information regarding the amount of medication supplied and its dosage. An alternative approach was developed in which the regularity of medication refill events was analysed as a potential indicator of psychiatric patient symptoms and functioning. Methods: A method to quantify the regularity of medication refills was developed and subsequently used to investigate how the resulting regularity index (RI), derived from retrospective prescription refill records, correlated with symptomatic and functional assessments of 89 psychiatric patients after adjusting for covariates. Results: A two-step hierarchical regression model indicated that variances explained by prior hospitalisation and the RI were significant for patient scores on the Kessler 10 Psychological Distress Scale (K10), standard beta value 0.22, p < 0.05, for the SF-12 MC, standard beta value −0.31, p < 0.01, and the Work and Social Adjustment Scale (WSAS), standard beta value 0.31, p < 0.01. Conclusions: This method to quantify the regularity of medication refills using prescription supply date alone may provide valuable information about patients’ symptoms and functioning.

ARE SEXUALLY ABUSED CHILDREN AT RISK FOR VICTIMIZATION BY PEERS?

BACKGROUND A few studies suggest that children who suffered maltreatment are more at risk for victimization by peers. However, there is little knowledge about factors that may influence the risk of re-victimization by peers for sexually abused (SA) children. OBJECTIVES Identify if self-blame and post-traumatic stress symptoms (PTSS) are risk factors for SA children victimization by peers. DESIGN/METHODS 376 children (248 girls and 128 boys) between 5 to 14 years of age were recruited within five centers for child and youth SA evaluation. Victimization by peers was measured with the Report Victimization Scale answered by the child, his parent and his teacher. PTSS were measured with the subscale of the Children’s Impact of Traumatic Events Scale (CITES II) and self-blame was measured with three items from the subscale guilt/blame of ​CITES II. Characteristics of the abuse were abstracted from the medical chart. Description of SA was done according to Russell’s classification: less severe (physical contact over clothing), severe (physical contact without penetration, and without using of force), very severe (attempted or actual penetration). Statistical analysis was done through logistic regression. RESULTS Abuse was very severe in 61% of cases and chronic in 37.4% of cases. Aggressors were family members in 53.3% of cases. Clinical level of peer victimization was reported for 19.2% of children by their own score, 9.2% by parental score and 3.6% by teacher’s score. PTSS were at the clinical level for 53.3% of children Around 60% of the sample reported feelings of blame, as indicated by at least one score of “somewhat true”on one of the three items. The dichotomized analysis (clinical vs subclinical score of victimization by peers) showed that PTSS were positively associated with the child’s peer victimization score (Exp (B) = 1.05, p<.02), and self-blame was positively associated with the parent’s peer victimization score (Exp(B)=1.23, p<.05). Results of a Sobel test revealed that PTSS completely mediated the positive relationship between self-blame and peer victimization (Standard Beta = .37, p<.01). In the final model, self-blame was positively associated with PTSS (Standard Beta = .54, p<.01), while the latter were positively associated with victimization by peers (Standard Beta = .44, p<.01). The final model explained 26.7% of the variance of victimization by peers. CONCLUSION These results suggest that PTSS and self-blame are key targets for intervention in order to diminish the risk of victimization by peers in SA children.

The brain health index: Towards a combined measure of neurovascular and neurodegenerative structural brain injury

Background A structural magnetic resonance imaging measure of combined neurovascular and neurodegenerative burden may be useful as these features often coexist in older people, stroke and dementia. Aim We aimed to develop a new automated approach for quantifying visible brain injury from small vessel disease and brain atrophy in a single measure, the brain health index. Materials and methods We computed brain health index in N = 288 participants using voxel-based Gaussian mixture model cluster analysis of T1, T2, T2*, and FLAIR magnetic resonance imaging. We tested brain health index against a validated total small vessel disease visual score and white matter hyperintensity volumes in two patient groups (minor stroke, N = 157; lupus, N = 51) and against measures of brain atrophy in healthy participants (N = 80) using multiple regression. We evaluated associations with Addenbrooke’s Cognitive Exam Revised in patients and with reaction time in healthy participants. Results The brain health index (standard beta = 0.20–0.59, P < 0.05) was significantly and more strongly associated with Addenbrooke’s Cognitive Exam Revised, including at one year follow-up, than white matter hyperintensity volume (standard beta = 0.04–0.08, P > 0.05) and small vessel disease score (standard beta = 0.02–0.27, P > 0.05) alone in both patient groups. Further, the brain health index (standard beta = 0.57–0.59, P < 0.05) was more strongly associated with reaction time than measures of brain atrophy alone (standard beta = 0.04–0.13, P > 0.05) in healthy participants. Conclusions The brain health index is a new image analysis approach that may usefully capture combined visible brain damage in large-scale studies of ageing, neurovascular and neurodegenerative disease.

Perception Factors, Intentions and Attitudes with Market Community Participation to Prevent Occupational Diseases

<p>An Occupational Disease was a disease caused by work or work environment. One of the efficient and effective strategies for controlling Occupational Disease was the empowerment and participation of the community called Occupational Health Unit (Pos UKK) in the workplace. Based on the data of market health inspection in Pos UKK Imogiri market in March 2017, there were only 67 participants (19.17%) from 365 invited people.: The purpose of this research was to know the internal factors with the community participation in Pos UKK Imogiri market Bantul. This research was a quantitative analytic research with cross sectional design. The population was 365 people and the sample was 150 respondents. The sampling used purposive sampling technique. Kendall Tau test showed that there was a relation between perception and community participation (p value &lt;0.05, r = 0.677); Intentions related to community participation (p value &lt;0.05 r = 0.486); Attitudes related to community participation (p value &lt;0.05 , r= 0.802). F test result showed that the variables of Perception, Intentions and Attitudes related simultaneously to community participation (F value = 387.41&gt; F table = 2.67). The dominant independent variable was Attitudes with the highest Standard Beta Coefficient value was 0.776. Perceptions, Intentions and Attitudes related both partially and simultaneously to community participation; the independent variable that had dominant influence was Attitudes. </p>

Μελέτη της παθογένειας των αγγειακών αλλοιώσεων και των διαταραχών οστικού μεταβολισμού σε ασθενείς με χρόνια νεφρική νόσο τελικού σταδίου

Σκοπός της παρούσας μελέτης ήταν η διερεύνηση σε αιμοκαθαιρόμενους ασθενείς της συσχέτισης των επιπέδων στον ορό της φετουΐνης-Α, της οστεοπροτεγερίνης και του FGF-23, με τη σκλήρυνση του αρτηριακού τοιχώματος και την αρχόμενη αθηροσκλήρωση.Στη μελέτη εντάχθηκαν 81 ασθενείς υπό χρόνια αιμοκάθαρση. Τα επίπεδα φετουΐνης-Α, οστεοπροτεγερίνης, άθικτου μορίου FGF-23 (iFGF-23) και καρβοξυτελικού τμήματος (cFGF-23) προσδιορίστηκαν στον ορό με ανοσοενζυμική μέθοδο. Η σκλήρυνση του αρτηριακού τοιχώματος εκτιμήθηκε με τη μέτρηση της ταχύτητας αγωγής σφυγμικού κύματος (PWV) μεταξύ καρωτίδας και μηριαίας αρτηρίας. Η αρχόμενη αθηροσκλήρωση εκτιμήθηκε με την υπερηχογραφική μέτρηση του πάχους του έσω-μέσου χιτώνα (ΙΜΤ) της κοινής καρωτίδας. Η PWV παρουσίασε αρνητική συσχέτιση με την φετουΐνη-Α (p=0,001), και θετική με την οστεοπροτεγερίνη (p=0,000), ενώ δεν παρουσίασε γραμμική συσχέτιση με τα επίπεδα cFGF-23 και iFGF-23. Σε μοντέλο πολλαπλής γραμμικής παλινδρόμησης, τόσο η φετουΐνη-Α όσο και η οστεοπροτεγερίνη παρουσίασαν ανεξάρτητη συσχέτιση με την PWV (p=0,032, standard beta=-0197 και p=0,041, standard beta=0,227 αντίστοιχα). Σε υποομάδα 59 ασθενών χωρίς στεφανιαία νόσο ταχύτητες αγωγής σφυγμικού κύματος < 9,1m/sec, και >11,1m/sec παρουσίασαν θετική συσχέτιση με τα επίπεδα iFGF-23 (p=0,032), η οποία στην πολυπαραγοντική ανάλυση ήταν ανεξάρτητη από την ηλικία, την παρουσία σακχαρώδους διαβήτου, την πίεση σφυγμού και τα επίπεδα φετουΐνης-Α, οστεοπροτεγερίνης (p=0.049). Στη μονοπαραγοντική ανάλυση το ΙΜΤ παρουσίασε αρνητική συσχέτιση με την φετουΐνη-Α (p=0,005), και θετική με την οστεοπροτεγερίνη (p=0,000). Οι συσχετίσεις όμως αυτές δεν ήταν ανεξάρτητες από την ηλικία. Το ΙΜΤ δεν παρουσίασε γραμμική συσχέτιση με τα επίπεδα cFGF-23 και iFGF-23. Όμως υψηλότερα από το μέσο όρο επίπεδα iFGF-23 συσχετίσθηκαν με υψηλότερες τιμές ΙΜΤ (p=0,035). Η συσχέτιση αυτή ήταν ανεξάρτητη από την ηλικία. Στην πολυπαραγοντική ανάλυση ανεξάρτητη συσχέτιση με το ΙΜΤ παρουσίασαν η ηλικία (p=0,000, standard beta=0,570), η παρουσία καρδιαγγειακής νόσου (p=0,031, standard beta=0,166), και τα υψηλότερα σε σχέση με το μέσο όρο επίπεδα iFGF-23 (p=0,028, standard beta=0,164). Σε μοντέλο που περιελάμβανε μόνο τους ορολογικούς δείκτες που συσχετίσθηκαν με το ΙΜΤ ανεξάρτητη συσχέτιση με το ΙΜΤ παρουσίασαν η οστεοπροτεγερίνη (p=0.000, standard beta=0,420), τα επίπεδα iFGF-23 (p=0.016, standard beta=0,232) και η φετουΐνη-Α (p=0.032, standard beta=-0,223). Συμπερασματικά σε ασθενείς υπό χρόνια αιμοκάθαρση η φετουΐνη-Α και η οστεοπροτεγερίνη παρουσίασαν ανεξάρτητη γραμμική συσχέτιση, αρνητική και θετική αντίστοιχα, με τη σκλήρυνση του αρτηριακού τοιχώματος, ως ταχύτητα αγωγής σφυγμικού κύματος (PWV). Η συσχέτισή τους με την αρχόμενη αθηροσκλήρωση ως πάχυνση του αρτηριακού τοιχώματος (IMT) δεν ήταν ανεξάρτητη από την ηλικία.