Dynamics of morphological and immunohistochemical changes in myocardium during hypothyroidism modeling in experiment

An experimental model of hypothyroidism was obtained by thyroidectomy. The operation was carried out on 57 sexually mature male rats weighing 250–300 g. The experiment lasted 45 days. Laboratory animals were removed from the experiment on days 7th, 14th, 21st, 28th, 35th and 45th. As a control, 15 rats were used that were not operated on. For histological examination, pieces of rat myocardium were taken from the left and right ventricles. The pieces were fixed in 10% buffered formalin for 10 days. Histological sections were prepared in a standard manner. Sections were stained with hematoxylin and eosin, picrofuchsin according to van Gieson, toluidine blue, according to Mallory. Results of the study: In the myocardium of rats, hemodynamic disorders, edema, hydropic degeneration of cardiomyocytes, myocytolysis, fragmentation of muscle fibers, colliquation necrosis, compression and atrophy of muscle fibers were found. An immunohistochemical study revealed a decrease in the expression of desmin and sarcomeric actin.

Epistemologi Tasawuf Hamzah Fansuri dalam Kitab Sharb Al-Ashîqîn

The highest knowledge of the Sufis is ma'rifah which is obtained through disciplinary practice, through riyadhah and mujahada which are here referred to as Sufi epistemology. These paths are cultivated in a disciplined, methodological and objective manner so as to enable the Sufis to compile their treatises in a standard manner. As one of the most famous scholars in the archipelago, Hamzah Fansuri in the book Sharb Al-Ashiqĭn also compiled standard treatises regarding this Sufi path. Through this philosophical analysis, Hamzah Fansuri's model of Sufism epistemology is explained. The results of this study indicate that to reach the state of knowledge, a person must take spiritual steps, be under the guidance of a teacher, lead a simple life and always put their trust in Allah SWT.

The grammatical representation of expletive negation

Expletive negation refers to constructions where a negator in the complement of certain lexical items does not change the polarity of the complement proposition. Jin & Koenig (2021) show that expletive negation occurs rather widely in languages of the world and in very similar environments. They propose a language production model of why such apparently illogical uses of negation arise in language after language. But their study does not address the grammatical status and representation of expletive negation. In this paper, we argue that expletive negation is part of the lexical knowledge speakers have of their language and that the negator in expletive negation constructions contributes a negation to a non-at-issue content associated with expletive negation triggers. We provide a Lexical Resource Semantics analysis of how triggers combine in a non-standard manner with the standard semantic content of their complements: the negation (and in some cases an additional modal operator) of the content of their complement is part of the trigger’s non-at-issue content while the scope of the negation is an argument of the trigger’s MAIN content. Finally, we suggest that the expletive use of the French negator ne includes a lexical constraint that requires it to modify a verb that reverse selects for an expletive negation trigger.

Bioethical Issues in Antarctica

This paper describes the Antarctic environment, the mission and work setting at the U.S. research stations, the general population and living conditions, and the healthcare situation. It also dispels some common misconceptions that persist about this environment and about the scope and quality of medicine practiced there. The paper then describes specific ethical issues that arise in this environment, incorporating examples drawn from both the author’s experiences and those of his colleagues. The ethics of providing healthcare in resource-poor environments implies two related questions. The first is: What can we do with the available resources? This suggests that clinicians must not only know how to use all available equipment and supplies in the standard manner, but also that they must be willing and able to go beyond standard procedures and improvise, when necessary. The second question is: Of all the things we can do, which ones should we do? This paper addresses both questions in relation to Antarctic medical care. It describes the wide range of activities required of healthcare providers and some specific ethical issues that arise. Finally, it suggests some remedies to ameliorate some of those issues.

Professional role of family assistants in the light of qualitative analyses

The aim of the study was to identify the role fulfilled by family assistants, along with the subject-matter of their tasks, obstacles they encounter, and favourable factors. Professional role was treated as a framework for professional functioning and experiences of the family assistants participating in the study. The presented material originates from five individual, semi-structured in-depth interviews with family assistants. The results of the study revealed that, to some extent, almost all assistants fulfil their own professional roles in a non-standard manner, although the statements they made have a common characteristic: awareness of the importance of trust in their joint work with families. Moreover, family assistants are characterised as experiencing some difficulties that appear to be the combination of various components. The participants verbalise the conviction that they create their professional roles themselves, which are determined, to some extent, also by the families they support, their managers, and social workers.

PHARMACEUTICAL STUDY OF VANGA BHASMA

Pharmaceutical study gives emphasis to prepare drugs in a standard manner and to dispense it. Vanga is classified as a Puti Loha. Here the Puti means bad smell, obnoxious or dirty. All three metals mentioned in this group emit obnoxious smell, while they are melting. Vanga has been widely described in our texts and several therapeutic properties have been stated. Much importance has been given to its efficacy as Vrishya and as a therapy for Meha Roga. The Aim of this study is to prepare Vanga bhasma as per classical guidelines. Raw Vanga metal, plant materials and other drugs used for shodhana, marana, Jarana were collected mainly from pharmacy, N.I.A., Jaipur. Buttermilk (Takra) and Gomutra were obtained from nearby shop and cow husbandry. The Vanga bhasma was prepared following Reference of Siddha Bhaishaja Mani Mala in the Department of Rasa Shastra and Bhaishajya Kalpana, N.I.A., Jaipur. In present study total 470 gm of raw Va­nga was taken, after Shodhana process 463 gm Vanga was obtained. Further by the process of Jarana 440 gm Vanga was yield. From which 420 gm was used in Marana process, from which ultimately total bhasma of Vanga obtained was 438 gm.

Dynamic Ideology of Traditionality in Developing Holy Places at Hindus Family in Cakranegara Territory Mataram City

This study aims to examine the dynamics of traditionality ideology in building holy place among Hindus families in Cakranegara territory, Mataram city. This research was designed in the type of interpretative qualitative research using a case study model. Data collection techniques through observation, interviews, and documentation. Data were analyzed through the stages of classification, reduction, and interpretation. Tri angulation techniques, both tri angulation methods and tri angulation of data sources were used to check the validity of the data. The results showed that the dynamics of traditional ideology in building holy place of Hindu families had been indicated by transformation of cultural traditions at Hinduism practices in four dimensions. First, the position of placing the holy place later no longer applies traditional concepts in a rigid and standard manner. Second, with regard to the spatial size in the construction of holy place in at Hindu families is no longer fixed on the size of the spatial layout that is traditionally applied but adjusted to the situation and condition of karang paumahan (area of home). Third, the form of holy has adapted to the inclusion of external culture. Fourth, the number of pelinggih (holiy place buildings) tends to decrease, especially in the relatively small area of home. Keywords: dynamics, traditionality ideology, holy place, Hindu families.

Development and evaluation of a novel protective device for upper gastrointestinal endoscopy in the COVID-19 pandemic: the EBOX

BackgroundDuring the COVID-19 pandemic, aerosol-generating procedures such as upper gastrointestinal endoscopy (UGIE) have been considered high risk. We designed a novel acrylic box (endoscopy box (EBOX)) with the intention of limiting aerosol and droplet spread during such procedures. We evaluated clinical utility, impact on the endoscopy team and also assessed the impact of the EBOX on macroscopic droplet spread from a simulated cough during UGIE.MethodsClinical utility was evaluated prospectively via EBOX use on 15 patients undergoing endoscopic retrograde cholangiopancreatography (13) or endoscopic ultrasound (2). Feedback was recorded from the endoscopy team regarding ease of positioning, impact of the EBOX on procedural performance and cleaning. A cough was simulated via explosion of a hyperinflated balloon containing 0.75 mL of ultraviolet disclosing lotion within the oral cavity of a mannequin, with and without the EBOX. Macroscopic spread was then evaluated with a ultraviolet torch.ResultsThree endoscopists and the team members found that the EBOX did not hamper the procedure and felt it was a useful adjunct to full personal protective equipment (PPE). Simulated cough without the EBOX identified macroscopic spread up to 2.3 m away from the patient’s mouth as well as onto key areas such as the exposed neck of the endoscopist, which is not considered in current PPE guidance. Simulated cough using the EBOX significantly reduced macroscopic spread onto key areas of the healthcare workers.ConclusionsThe EBOX is a valuable adjunct to recommended PPE for UGIE, but still allows these procedures to be performed in the standard manner.

Left Occipital Craniotomy for Resection of Arteriovenous Malformation: 2-Dimensional Operative Video

Medial parieto-occipital arteriovenous malformations (AVMs) are fed by distal cortical posterior cerebral artery branches and are generally considered eloquent given the proximity to the calcarine fissure and paracentral lobule. This patient was a neurologically intact 12-yr-old girl with an incidentally discovered left occipital AVM. The patient underwent preoperative angiographic evaluation with embolization of a dominant posterior cerebral artery feeding vessel. The AVM was removed in the standard manner using circumdissection. Indocyanine green angiography was utilized to demonstrate disconnection of the AVM before sacrificing the draining veins. The AVM was removed entirely, as evidenced on postoperative angiography. The patient had a partial right hemianopsia after the operation but was otherwise neurologically intact. The patient gave informed consent for surgery and video recording. Institutional review board approval was deemed unnecessary. Used with permission from Barrow Neurological Institute, Phoenix, Arizona.

Konsep Dakwah pada Masyarakat Terasing Suku Akit Sonde Riau

The research aimed to find out the foundation, ideals, and steps taken by the Indonesian Islamic Da'wah Council in making the concept of da'wah to the isolated communities of the Sonde Islands Riau Islands tribe. These objectives are then formulated in the form of questions as follows: What is the basis of DDII, so as to make the concept of da'wah to isolated communities? What are DDII's ideals, so that they make the concept of da'wah to isolated communities? How are the steps of DDII, so as to make the concept of da'wah to isolated communities? This study uses a documentation study method conducted by in-depth interviews of a number of da'wah leaders in DDII and equipped with the collection of various physical evidence from various documents so as to achieve a level of validity that is in accordance with scientific standards. The location of the study took place at the DDII office representing West Java. Jl. Pungkr The findings of the research are as follows: First, Da'wah must be delivered to all humans, not least to isolated communities, by sending preachers on an ongoing basis, so that the needs of isolated communities will be spiritual Second, Save Indonesia through da'wah. Third, it is important to make the concept of da'wah to isolated communities in a standard manner, and to be realized by religious institutions as a whole. Penelitian yang dilakukan bertujuan untuk mengetahui landasan, cita-cita, dan langkah-langkah yang dilakukan Dewan Dakwah Islamiyyah Indonesia dalam membuat konsep dakwah pada masyarakat terasing suku Akit Sonde Kepulauan Riau. Tujuan tersebut kemudian dirumuskan dalam bentuk-bentuk pertanyaan sebagai berikut : Apakah landasan DDII, sehingga membuat konsep dakwah pada masyarakat terasing?. Apakah cita-cita DDII, sehingga membuat konsep dakwah pada masyarakat terasing?. Bagaimana langkah-langkah DDII, sehingga membuat konsep dakwah pada masyarakat terasing?. Penelitian ini menggunakan metode studi dokumentasi yang dilakukan dengan wawancara mendalam dari sejumlah tokoh dakwah di DDII serta dilengkapi dengan pengumpulan berbagai bukti fisik dari berbagai dokumen sehingga mencapai tingkat keabsahan yang sesuai dengan standar ilmiah. Lokasi penelitian berlangsung di kantor DDII perwakilan Jawa Barat. Jl. Pungkr Temuan hasil penelitian adalah sebagai berikut : Pertama, Dakwah harus disampaikan kepada seluruh manusia, tak terkecuali bagi masyarakat terasing, dengan mengirimkan para pendakwah secara berkesinambungan, sehingga kebutuhan masyarakat terasing akan spiritual Kedua, Selamatkan Indonesia melalui dakwah. Ketiga, Penting untuk membuat konsep dakwah pada masyarakat terasing secara baku, serta direalisasikan oleh lembaga-lembaga keagamaan secara menyeluruh.