GEOGRAPHICAL, POLITICAL AND ECONOMICAL ASPECTS OF MOVING TOWARDS A NEW QUALITY OF TECHNOLOGY, ECONOMY AND SOCIETY

Целью представленных исследований является геополитэкономический анализ вероятных изменений по мере продвижения к новому качеству технологий, экономики и общества. Показано, как закономерная смена технологических укладов в обществе, сопровождающаяся появлением качественно новых технологий, существенными изменениями в экономике и социальной сфере, сопряжена с геополитическими и социально-экономическими изменениями в развитии общества. С помощью метода сценарного анализа определены вероятные тенденции геополитических и социально-экономических процессов развития общества в период шестого технологического уклада экономики. Научная новизна исследования продвижения к новому качеству технологий, экономики и общества заключается в том, что использование метода TESP-анализа позволило установить, что наиболее вероятным геополитэкономическим сценарием следует считать сочетание аспектов: в производственно-технологической сфере - закономерный переход от производственных технологий пятого технологического уклада к технологиям шестого технологического уклада; в экономике - «цифровое обнуление»; в социальной сфере - реализация радикальных реформ; в политике - продолжение и наращивание масштабов гибридных войн. The aim of the research is to analyze the likely geopolitical changes as we’re moving towards a new quality of technology, economy and society. It is shown how a natural change of technological structures in society, accompanied by the emergence of qualitatively new technologies, significant changes in the economy and social sphere, is associated with geopolitical and political economic aspects of the development of society. With the help of the scenario analysis method, the probable tendencies of geopolitical and political economic processes of society development in the period of the sixth technological structure of the economy are determined. The scientific novelty of the research lies in the fact that, based on the TESP-analysis method, studies of the prospects for the development of world civilization made it possible to establish that the most probable geopolitheconomic scenario should be considered a combination of aspects: in the production and technological sphere - a natural transition from production technologies of the fifth technological order to technologies of the sixth technological order. way of life; in economics - «digital zeroing»; in the social sphere - the implementation of radical reforms; in politics - the continuation and escalation of the scale of hybrid wars.

Effects of Hormone Therapy and Flavonoids Capable on Reversal of Menopausal Immune Senescence

Menopause, probably the most important natural change in a woman’s life and a major component of female senescence, is characterized, inter alia, by cessation of ovarian estrogen and progesterone production, resulting in a gradual deterioration of the female immune system. Hormone replacement therapy (HRT) is used in postmenopausal women to relieve some of the peri- and postmenopausal symptoms, while there is also evidence that the therapy may additionally partially reverse menopausal immune senescence. Flavonoids, and especially isoflavones, are widely used for the treatment of menopausal symptoms, although it is not at present clear whether they can reverse or alleviate other menopausal changes. HRT reverses the menopausal CD4/CD8 ratio and also limits the general peri- and postmenopausal inflammatory state. Moreover, the increased levels of interleukins (IL)-1β, IL-6, and IL-8, as well as of tumor necrosis factor-α (TNF-α) are decreased after the initiation of HRT. However, some reports show no effect of HRT on IL-4, IL-10, and IL-12. It is thus evident that the molecular pathways connecting HRT and female immune senescence need to be clarified. Interestingly, recent studies have suggested that the anti-inflammatory properties of isoflavones possibly interact with inflammatory cytokines when applied in menopause treatments, thereby potentially reversing immune senescence. This narrative review presents the latest data on the effect of menopausal therapies, including administration of flavonoid-rich products, on age-associated immune senescence reversal with the aim of revealing possible directions for future research and treatment development.

Caregiver Involvement in Early Intervention Services: Service Providers' Perspectives

Communication skills are critical for young children with developmental disabilities or delays (DD) to increase their inclusion in school and community settings. Thus, many early intervention (EI) services focus on improving children's communication skills. The involvement of the caregivers, the natural change agents, in EI sessions could significantly impact the communication skills development of young children with DD. EI service providers' perspectives could be one of the factors that increase caregiver involvement. Their perspectives may work as a discernment variable through which they reject or accept the practices related to caregiver involvement, based on their beliefs (Campbell & Halbert, 2002). The purpose of this pilot study was to understand service providers' perspectives on caregiver involvement in EI services. Survey methodology was used, and 129 service providers' responses were analyzed. Overall, the service providers reported that they believed caregiver involvement in EI sessions, and, more specifically, in communication intervention, is critical. Also, service providers reported that they were trying to involve caregivers in their EI services, with some variation between subgroup characteristics. Findings from the survey data have implications related to professional development in the area of building strong partnerships between professionals and families to support children's communication and inclusion.

The company’s innovation development and marketing communication as a driver of the country’s macroeconomic stability: A quantitative analysis of tendencies

The work aims to analyse the activities of business structures in the issue of quantitative analysis of communication policy, as quantitative is more common and allows assessing the various aspects of communication policy of an enterprise in quantitative units. The tendency formed in conducting the communication policy of business structures is a natural change of the process in a certain time series. The paper graphically presents the relationship among the fundamental aspects of trend formation: time, place, and action. The study allows each promising trend selected from the previous stage of communication policy analysis to assess the success of the factors contributing to the speed of its spread to build input data for grouping trends that will further form promising areas of innovative development of industrial enterprises.

PRINCIPLES OF BUSINESS ENTITIES SOCIO-ECONOMIC INTERACTION IN THE CONDITIONS OF GLOBAL CHALLENGES

The definitions of interaction as a socio-economic category, the main categories of the methodological basis of socio-economic interaction are analyzed. The concept of "interaction" can be defined as a system of joint actions of several objects or entities, in which the action result of one of them affects the others. Global challenges lead to the need to change the interaction basis of economic entities due to the natural change of the general socio-economic and political-ideological formation of social development, which necessitates the definition and analysis of basic principles of business entities interaction in various global challenges. The basic principles of business entities socio-economic interaction in the context of global challenges are identified, among which the principle of commonality and feedback; openness and transparency; responsibility, the principle of professionalism and efficiency; social justice and corporate responsibility; concentrating on short-term planning and moving some issues from long-term to short-term planning; the principle of strategicity and changes in long-term development strategies; the principle of ethics; innovation and creativity of interaction; the principle of globality and global security; the principle of systematics and pluralism; tolerance and inclusion; integrity; the principle of changing established ties due to global political instability; the principle of global community; dynamism; laying a higher level of risk; compliance with environmental regulations and the principle of minimizing conflicts and institutionalizing compromises during interaction. In the context of global challenges and shocks, businesses are encouraged to abandon socio-economic determinism and resort to creative, innovative interaction because in the context of global challenges, creativity, innovation, knowledge, access to information, the ability to interact in socio-behavioral constraints are powerful engines of development of states, business entities and individuals. Creative interaction should be a constantly changing concept based on creative forms of cooperation, the result of which is not only survival in global shocks and imbalances, but also the activities of economic entities capable of generating impact on economic growth and development.

Sustainable development and tolerance in the socializing and resocializing of the architectural environment of cities

The article considers the sustainable development of the city public spaces and the penitentiary complexes problems from the Synergetics and Socionics standpoint. These approaches provide consideration of the opposite processes of public spaces socialization and correctional complexes resocialization, sustainability, and dynamism its organization, and self-organization. The regularities of sustainable development are present in the cyclical nature of historical changes in public spaces and the penitentiary system. Cycles unfold in the alternation order of pairwise polarized processes, on the one hand, dispersion and concentration, and, on the other, – self-organization and adaptation. We have found that the interaction of universal processes and the natural change of cycles stimulates, on the one hand, growth and stabilization, and, on the other, – transformation and metamorphosis, which lead to the emergence of new forms and structures of public spaces and penitentiary complexes. We have proposed to use Socionical methods for increasing tolerance and democracy in the architectural environment of settlements. We have described the methodological tools to achieve the harmonization of the architectural environment of settlements.

MODEL KEWIRAUSAHAAN STRATEGIK PADA USAHA EKONOMI KREATIF

<p><em>This investigation looks at vital business models to dissect the effect of the utilization of imagination, ecological change and innovative culture on upper hand through the administration of vital assets as a go-between factor. The exploration test was the imaginative economy business people in the city of Semarang, adding up to 54 business people. The example is chosen utilizing certain standards. The rules are imaginative small medium entrepreneurs who have been maintaining the business for at any rate one year and utilizing at least five specialists. Way investigation is utilized as an information examination apparatus. The outcomes demonstrated that the utilization of inventiveness, natural changes, pioneering society and key asset the board positively affected upper hand. Vital asset the executives has been demonstrated to be a moderate variable between the utilization of imagination, natural change and enterprising society to increase competitive advantage.</em></p><p>Penelitian ini mengkaji model kewirausahaan strategis untuk menganalisis pengaruh penerapan kreativitas, perubahan lingkungan dan budaya kewirausahaan terhadap keunggulan bersaing melalui pengelolaan sumber daya strategis sebagai variabel perantara. Sampel penelitian adalah para pelaku UMKM ekonomi kreatif di Kota Semarang yang berjumlah 54 wirausaha. Teknik pengambilan sampel menggunakan purposive random sampling. Adapun Kriteria sampel adalah pelaku UMKM kreatif yang telah menjalankan usaha minimal satu tahun dan mempekerjakan minimal lima tenaga kerja. Analisis jalur digunakan sebagai alat analis data. Hasil penelitian menunjukkan bahwa penerapan kreativitas, perubahan lingkungan, budaya kewirausahaan dan pengelolaan sumber daya strategis berpengaruh positif terhadap keunggulan bersaing. Manajemen sumber daya strategis telah terbukti menjadi variabel perantara antara penerapan kreativitas, perubahan lingkungan dan budaya kewirausahaan untuk menciptakan keunggulan kompetitif.</p>

Hidden geographies of population implosion in Bosnia and Herzegovina

Bosnia and Herzegovina has witnessed continuous depopulation since 1991. Depopulation was foreseen even without the emergence of war, but not nearly to that extent or that early. Bosnia and Herzegovina is in a worse demographic position than the European Union countries that show similar demographic trends. Very low birth rates, low fertility and low natural population growth have been recorded in the time of weaker economic development, which increasingly accelerates the emigration of the educated population in particular, and permanently adversely affects the reproductive potential of the country. This paper considers a hidden mutual relationship between the demographic situation (natural change, population ageing) in Bosnia and Herzegovina and its citizens' system of values. According to the survey conducted on 614 respondents, Bosnia and Herzegovina's citizens have fewer children than they would like.

Method vs. Metaphysics

This article discusses Descartes’s preferred focus on morally and theologically neutral subjects and points out the impact of this focus on the scientific status of theology. It does so by linking Descartes’s method to his transformation of the notion of substance. Descartes’s Meditations centred around epistemological questions rather than non-human intelligences or the life of the mind beyond this world. Likewise, in his early works, Descartes consistently avoided referring to causal operators. Finally, having first redefined the notion of substance in the Principia, Descartes would completely abandon making use of this notion in his later years. Indeed, in contrast to many authors before and after him, Descartes never showed any interest in the long-established metaphysical interpretation of substances as being causal factors of natural change. With God, nature, and mind commonly serving as instances of substantial causality, Descartes’s philosophy had a huge impact on the place of God in science and discreetly excluded theology as a subject to which his method might be applied.