Performance analysis of gravity chemical blockers in the treatment of rising damp in masonry walls

The objective of this work is the performance analysis of the rising damp treatment in walls, through the use of chemical blockers (i.e., crystallizing and water repellant) available in the Brazilian market, with their introduction by gravity. As there are no standardized tests for such a study, experiments conducted by other researchers were used as a reference. The evaluation of the rising damp was achieved by the calculation of the water absorption rate in the specimens, allied with the images obtained by the thermographic camera. From the results, it was concluded that the treatment did not completely reduce the pathological manifestation in the walls, but both products performed well and managed to reduce the water absorption rate considerably.

REVIEW OF VRANASHOPHA W.S.R. TO INFLAMMATORY SWELLINGS

Acharya Sushruta had a complete knowledge of Vranashopha and described Vranashopha into 3 progressive stages. Inflammation in Ayurveda is known by different names in different contexts namely Shotha, Shopha, Svayatu and Utsedha. Inflammation is duly recognised in Ayurveda as a pathological manifestation, while Modern Medicine considers Inflammation as a symptom or rather as a healing response of the body. Ayurveda treats the concepts of Inflammation as symptom of a disease, an independent disease and complication of disease. Vranashopha shares common pathological features of Inflammation. The disturbances in micro channel circulation in Inflammation are due to Srotodusti (clogging of channels) by Amma (toxic waste of metabolism). The proper clinical approch to Vranashopha with Modern concept plays a important role in management and preventing complication of Vranashopha.

FEATURES OF NEUROPLASTIC VARIABILITY OF PROJECTION NEURONS IN THE CONDITIONS OF EXPERIMENTAL DESTRUCTION OF VARIOUS STRUCTURES OF THE CENTRAL NERVOUS SYSTEM

The morphological manifestations of neuroplastic variability of projection neurons were studied under conditions of experimental destruction of various structures of the central nervous system in animals. Various forms of pathological manifestations of neuroplastic variability of “survivors” (after exposure to a damaging factor) marked through the axonal transport system of neurons are shown. Marked nerve cells of an unusual, bizarre shape, denoted by the term "ugly neurons", are proposed to be considered as one of the criteria for the pathological manifestation of neuroplastic variability of projection neurons.

Concomitant atlantoaxial and atlanto-occipital rotatory dislocation in children: Radiological features, diagnostic pitfalls, and long-term outcome

While the pathological manifestation of atlantoaxial rotatory dislocation has been well described in the medical literature, the combined dislocation of the atlantoaxial and atlanto-occipital joints, or OAARD – short for occipital-atlantoaxial rotatory dislocation – is a condition which has been poorly elucidated and probably underdiagnosed. We believe that the pathogenesis of combined atlantoaxial and atlanto-occipital dislocation is most likely a result of untreated atlantoaxial rotatory dislocation leading to chronic secondary compensation measures occurring at the occiput-C1 joints. Unique clinical and radiological features lead to difficulty in diagnosis, and conventional treatment algorithms may not apply. This paper describes a combination of clinical and radiological features which can help clinicians correctly diagnose and treat OAARD.

Pathophysiological Significance of Neutrophilic Transfer RNA-Derived Small RNAs in Asymptomatic Moyamoya Disease

Understanding asymptomatic moyamoya disease (aMMD), for which treatment options are currently limited, is key to the development of therapeutic strategies that will slow down the progression of this disease, as well as facilitate the discovery of therapeutic targets for symptomatic MMD. Newly found transfer RNA-derived small RNAs (tsRNAs) perform potential regulatory functions in neovascularization, which is a well-known pathological manifestation of MMD. In this study, the neutrophilic tsRNA transcriptome in aMMD was profiled using next-generation RNA sequencing in five patients and five matched healthy subjects. A negative binominal generalized log-linear regression was used to identify differentially expressed (DE)-tsRNAs in aMMD. Gene Ontology and functional pathway analyses were used to identify biological pathways involved with the targeted genes of the DE-tsRNAs. Four tsRNAs were selected and validated using quantitative reverse transcription polymerase chain reaction. In total, 186 tsRNAs were DE between the two groups. Pathophysiological events, including immune response, angiogenesis, axon guidance, and metabolism adjustment, were enriched for the DE-tsRNAs. The expression levels of the four DE-tsRNAs were consistent with those in the neutrophilic transcriptome. These aberrantly expressed tsRNAs and their targeted pathophysiological processes provide a basis for potential future interventions for aMMD.

Biomarkers of cholestasis

Cholestasis is a major pathological manifestation, often resulting in detrimental liver conditions, which occurs in a variety of indications collectively termed cholestatic liver diseases. The frequent asymptomatic character and complexity of cholestasis, together with the lack of a straightforward biomarker, hampers early detection and treatment of the condition. The ‘omics’ era, however, has resulted in a plethora of cholestatic indicators, yet a single, clinically applicable biomarker for a given cholestatic disease remains missing. The criteria to fulfil as ideal biomarker as well as the challenging molecular pathways in cholestatic liver diseases advocate for a scenario in which multiple biomarkers, originating from different domains, will be assessed concomitantly. This review gives an overview of classical clinical and novel molecular biomarkers in cholestasis, focusing on their benefits and drawbacks.

Another One Bites the Gut: Nuclear Receptor LRH-1 in Intestinal Regeneration and Cancer

The process of self-renewal in normal intestinal epithelium is characterized by a fine balance between proliferation, differentiation, migration, and cell death. When even one of these aspects escapes the normal control, cellular proliferation and differentiation are impaired, with consequent onset of tumorigenesis. In humans, colorectal cancer (CRC) is the main pathological manifestation of this derangement. Nowadays, CRC is the world’s fourth most deadly cancer with a limited survival after treatment. Several conditions can predispose to CRC development, including dietary habits and pre-existing inflammatory bowel diseases. Given their extraordinary ability to interact with DNA, it is widely known that nuclear receptors play a key role in the regulation of intestinal epithelium, orchestrating the expression of a series of genes involved in developmental and homeostatic pathways. In particular, the nuclear receptor Liver Receptor Homolog-1 (LRH-1), highly expressed in the stem cells localized in the crypts, promotes intestine cell proliferation and renewal in both direct and indirect DNA-binding manner. Furthermore, LRH-1 is extensively correlated with diverse intestinal inflammatory pathways. These evidence shed a light in the dynamic intestinal microenvironment in which increased regenerative epithelial cell turnover, mutagenic insults, and chronic DNA damages triggered by factors within an inflammatory cell-rich microenvironment act synergistically to favor cancer onset and progression.

The mechanism of ions in pulmonary hypertension

Pulmonary hypertension（PH）is a kind of hemodynamic and pathophysiological state, in which the pulmonary artery pressure (PAP) rises above a certain threshold. The main pathological manifestation is pulmonary vasoconstriction and remodelling progressively. More and more studies have found that ions play a major role in the pathogenesis of PH. Many vasoactive substances, inflammatory mediators, transcription-inducing factors, apoptosis mediators, redox substances and translation modifiers can control the concentration of ions inside and outside the cell by regulating the activity of ion channels, which can regulate vascular contraction, cell proliferation, migration, apoptosis, inflammation and other functions. We all know that there are no effective drugs to treat PH. Ions are involved in the occurrence and development of PH, so it is necessary to clarify the mechanism of ions in PH as a therapeutic target for PH. The main ions involved in PH are calcium ion (Ca2+), potassium ion (K+), sodium ion (Na+) and chloride ion (Cl–). Here, we mainly discuss the distribution of these ions and their channels in pulmonary arteries and their role in the pathogenesis of PH.

Evaluation of the behavior of mortars produced with fibers from the straw of carnauba: effects of the content of addition and length used

ABSTRACT The rendering mortars must be able to absorb small deformations, in order to guarantee the stability of the masonry (performance and durability). When this premise is not met, there is a greater propensity for the appearance of cracks, one of the main and worrying pathological manifestations in mortar coverings. One of the alternatives to combat this pathological manifestation is the addition of natural/artificial fibers in order to improve the mechanical properties (mainly the traction strength) and, consequently, the deformation capacity of the mortar. In this perspective, this work analyzed the behavior in the fresh and hardened state of mortars with the addition of fibers obtained from the straw of the carnauba (Copernicia prunifera), an abundant tree in the region of the Açu valley/RN (Brazil). For this purpose, mortars were produced in a 1:3 mass ratio (binder:aggregate) with the addition of 3% and 5% fiber from the carnauba straw (CSF) in relation to the cement mass and with the water/cement ratio (w/c) fixed at 0.72 for all mixtures. The effects of using fibers with different lengths (20, 40 and 60 mm) were also investigated. The properties of mortars were evaluated in a fresh (consistency) and hardened (compression and flexural strengths) state. The results indicated that the addition of CSF results in mortar with less consistency and mechanical strength. However, in general, the best performance was obtained for additions of up to 3% and for longer fiber lengths (20 mm).

Pathological manifestation of autoimmune myocarditis is detected prior to glomerulonephritis in a murine model of lupus nephritis

Objective Since enhanced cardiac magnetic resonance imaging (cMRI) signals have been associated with lupus disease activity in humans prior to renal failure and novel, cardiac-focused therapeutic strategies could be investigated with an associated animal model, autoimmune myocarditis was characterized in murine lupus nephritis (NZM2410). Methods Weekly blood urea nitrogen (BUN) levels and weights were recorded. Cardiac function was assessed by echocardiogram. Myocardial edema was measured with quantitative T2 cMRI mapping. Endpoint serum and cardiac tissue were collected for histopathological analysis and cytokine measurements. Results Despite showing no signs of significant renal disease, mice displayed evidence of myocarditis and fibrosis histologically at 30–35 weeks. Moreover, T2 cMRI mapping displayed robust signals and analysis of sagittal heart sections showed significant myocardium thickening. Cytokine expression levels of IL-2, IL-10, TNF-α, CXCL1, and IL-6 were significantly enhanced in serum. Echocardiograms demonstrated significantly increased ventricular diameters and reduced ejection fractions, while immunohistochemical staining identified CD4+ and CD8+ T cells, and IL-17 in cardiac infiltrates. Human lupus cardiac tissue showed similar histopathology with enhanced infiltrates by H&E, fibrosis, and CD4+ detection. Conclusions Histopathology, functional abnormalities, and enhanced cMRI signals indicative of myocarditis are detected in NZM2410 mice without glomerulonephritis, which supports the primary pathological role of autoimmune-mediated, cardiac-targeted inflammation in lupus.