Symptomatic SARS-CoV-2 Infection with Ageusia after Two mRNA Vaccine Doses

To raise awareness about preventive measures in COVID-19 pandemic, even though fully vaccinated. Although recent trials showed high efficacy of vaccines in preventing symptomatic infections, there are some individuals experiencing symptomatic SARS-CoV-2 infection. In this case report, a fully vaccinated young dental practitioner experienced symptomatic SARS-CoV-2 infection 55 days postvaccination with BNT162b2 Pfizer vaccine with evident ageusia. Diagnostic swabs were performed and used for viral genome sequencing. The patient fully recovered 15 days after diagnosis. Loss of smell and taste, together with nasal congestion were the main reported symptoms. The use of personal protective equipment prevented spread of infection in patients and co-workers. With the increase of people being fully vaccinated, it is still necessary to follow infection preventive protocols by correctly applying personal protective equipment. Although high efficacy has been proved, some individuals may still be vulnerable to symptomatic infection and new guidelines and markers should be adopted and investigated to find out patients for whom vaccination may not determine full immunization.

Associations of Nutritional Status with Full Immunization Coverage and Safe Hygiene Practices among Thai Children Aged 12–59 Months

Prevailing prevention measures against morbidity, such as vaccination and safe hygiene practices, vary among local cultural contexts, and little is known about the extent to which these behaviors mitigate poor nutritional status in young children in Southeast Asia. We examined the associations between nutrition status with full immunization coverage, and water, sanitation and hygiene status among children aged 12–59 months in the 2015–2016 Thailand Multiple Indicator Cluster Survey (n = 9060). When adjusted for confounding factors, children with incomplete immunization status were more likely to be stunted (adjusted odds ratio (aOR) 1.47; 95% confidence interval (CI): 1.24–1.75, p < 0.001), wasted (aOR 1.67, 95% CI: 1.31–2.12, p < 0.001), and overweight (aOR 1.24, 95% CI: 1.01–1.51, p < 0.05), whereas children who used unimproved water sources were more likely to be overweight (aOR 2.43, 95% CI: 1.27–4.64, p < 0.01). The further implementation of simple and cost-effective health promotion activities and practices at the household level may be important interventions for healthy child growth and development, particularly under restricted living conditions due to COVID-19.

Full immunization coverage and associated factors among children aged 12–23 months in Somali Region, Eastern Ethiopia

Objective Despite those efforts in expanded programs of immunization, nearly one fifth of children in developing countries miss out basic vaccines. Moreover, many children who started vaccination fail to complete immunization.Identifying associated factorswhich is scarce in the study area, is crucial for interventions. This study assessed full-immunization and associated factors among children aged 12–23 months in Somali region, Eastern Ethiopia. Methods A community-based cross-sectional study design was conducted from October 1–30, 2018, in selected rural and urban kebeles in Somali regionamong 612 children. Cluster sampling was employed and data was collected using structured questionnaire. Full-immunization was measured by maternal recall and vaccination card.Data entry and analysis was done by EpiData3.1 and SPSSversion.20 respectively. Binary logistic regression with Bivariate and Multivariable model was usedto identify predictors of full-immunization. Odd ratios were computed and P-value <0.05 was considered as statistically significant. Results Based on maternal recall plus vaccination card 249(41.4%) of children were completed immunization, while vaccination only by card was 87(29.7%). Only 238(39.5%) of participants had good knowledge about vaccination. Not knowing to come back for next visits 197(55.8%) were the major reason for dropout. Residing in urban (AOR = 2.0, 95%CI: 1.0, 3.9),primary educated mothers(AOR = 2.2, 95%CI: 1.0, 5.0), married mothers (AOR = 4.2, 95%CI:1.0, 18), higher average monthly income (AOR = 2.5, 95%CI 1.1, 5.2)and delivered at health facilities (AOR = 3.8, 95%CI 1.9, 7.3)were significantly associated with full-immunization. Conclusion Coverage of full immunization was found to be low compared to the targets set in the Global Vaccine Action Plan(2011–2020).Two-third of the participants has poor knowledge about vaccination. Urban residence, mother education, higher family income, male child and institutional delivery were factors. This study suggests that awareness creation, behaviour change on vaccination and enhancing utilization of maternal health service including delivery service, should be stressed.

Investigation of Vaccine Breakthrough Infections by Vaccine strategy during the Delta Variant Wave in France

Herein, we describe the characteristics of vaccine breakthrough infections (VBI) in fully vaccinated individuals according to five vaccine strategies during the Delta wave in France. Inclusion criterion was a positive test at least 2 weeks after a full vaccine schedule: homologous vaccination with Pfizer-BioNTech (BNT162b2) or Moderna (mRNA-1273); heterologous vaccination with Astrazeneca and Pfizer-BioNTech (ChadOx1/BNT162b2); single-dose vaccines Johnson & Johnson (Ad26.COV2.S) or Astrazeneca (ChadOx1). A total of 1630 VBI from patients fully vaccinated between February and July were included in this study. SARS-CoV-2 sequencing performed for 1366 samples showed that the delta variant represented 94.1% (1286/1366). Delta-VBI were mainly symptomatic (mild symptoms) with no difference according to the vaccine strategy (p=0.362). The median RT-PCR Ct values at diagnosis were significantly different between symptomatic and asymptomatic cases only for BNT162b2 group (17.7 (15.07, 20.51) vs 19.00 (16.00, 23.00), p=0.004). Up to 50% of VBI was classified as early-VBI (infected less than one month after full immunization) for BNT162b2, mRNA-1273, ChadOx1, and J Ad26.COV2.S. People aged 14-49 yo were overrepresented in early VBI compared to non-early VBI for BNT162b2 and mRNA-1273 (73.92% vs 37.87% for BNT162b2 and 77.78% vs 46.67 % for mRNA-1273, p<0.05). Our data emphasize a high prevalence of Delta-VBI occurring only one month after full immunization in young patients that might be related to relaxation of barrier gestures.

Full childhood immunization coverage and incidence of vaccine preventable disease in Nigeria: a regression analysis

Background: Childhood immunization contributes significantly in the reduction of cases of vaccine preventable diseases in children. DHIS2 data showed that only 60.59% of children under one were fully immunized in 2020. This implies that 39.41% did not receive all recommended vaccinations therefore at risk of contracting vaccine preventable diseases. This study therefore examined the effect of full immunization coverage on incidence of vaccine preventable diseases.Methods: Full childhood immunization coverage and incidence of vaccine preventable disease was examined using simple linear regression model at 5% level of significance and 95% confidence interval. Measles new case for children under five was the dependent variable while children under one fully immunized was the independent variable. Data was retrieved from DHIS2 for the period 2017-2020.Results: The study showed a negative relationship between full immunization coverage and incidence of under-five measles new cases. The study found that any unit increase in full immunization coverage would lead to decrease in measles cases by 6%.Conclusions: Full immunization coverage is still low (below WHO target of 80%) despite effort by government and partners. This implies that a lot of children are at risk of contracting vaccine preventable diseases. In order to avert this risk, health authorities and partners should devise appropriate means of educating the populace on the importance of childhood immunization.

Sociocultural and geographical disparities in immunization among different geographical regions of Maharashtra

Background In Maharashtra, child immunization is an essential factor in maternal and child health services and effective in reduced child morbidity and mortality. The study focuses on the prevalence of child immunization in different geographical regions of Maharashtra. It also depicts the immunization status (no immunization, partial immunization, and full immunization) according to various socio-demographic characteristics and determinants of full Immunization and partial Immunization among children of age 12–23 months in Maharashtra Data source and Methodology: The fourth round of the National Family Health Survey (NFHS-4) has been used for this study. The univariate analysis and simple chi-square test were conducted to test association. The Multinomial logistic regression model was conducted to determine the determinants of partial and full immunization. Result In the wealth category, the middle and richest are more likely to receive full immunization than the poorest people statically significant effect. In religion, Muslims less likely to receive full Immunization, and Buddhists more likely to use full immunization compare to Hindu people. In the different geographical regions of Maharashtra, North-Maharashtra, West-Maharashtra, Konkan is less likely to have full immunization correspond to the Vidarbha region. Mothers who have any media exposure are more likely to have full immunization compare to no media exposure. Conclusions To conclude, the study shows a need to adopt a multi-pronged strategy while formulating an action plan for immunization by keeping in mind that vaccination is a right of every child. An appropriate proportion of childhood immunization is required to develop “Herd Immunity” to protects other unimmunized children. The most “efficient” and “equitable” way should be chosen to deliver vaccination services to identify the population's risk group. Who has remained unimmunized? As immunization in the different geographical regions in Maharashtra remained very far from the target set by Mission Indradhushya. Hence, there is a need to focus more on responsible socio-demographic factors while implementing immunization services.

Household expenditure for immunization among children in India: a two-part model approach

Background Despite the Indian government’s Universal Immunization Program (UIP), the progress of full immunization coverage is plodding. The cost of delivering routine immunization varies widely across facilities within country and across country. However, the cost an individual bears on child immunization has not been focussed. In this context, this study tries to estimate the expenditure on immunization which an individual bears and the factors affecting immunization coverage at the regional level. Methods Using the 75th round of National Sample Survey Organization data, the present paper attempts to check the individual expenditure on immunization and the factors affecting immunization coverage at the regional level. Descriptive statistics and multivariate regression analysis were used to fulfil the study objectives. The two-part model has been employed to inspect the determinants of expenditure on immunization. Results The overall prevalence of full immunization was 59.3 % in India. Full immunization was highest in Manipur (75.2 %) and lowest in Nagaland (12.8 %). The mean expenditure incurred on immunization varies from as low as Rs. 32.7 in Tripura to as high as Rs. 1008 in Delhi. Children belonging to the urban area [OR: 1.04; CI: 1.035, 1.037] and richer wealth quintile [OR: 1.14; CI: 1.134–1.137] had higher odds of getting immunization. Moreover, expenditure on immunization was high among children from the urban area [Rs. 273], rich wealth quintile [Rs. 297] and who got immunized in a private facility [Rs. 1656]. Conclusions There exists regional inequality in immunization coverage as well as in expenditure incurred on immunization. Based on the findings, we suggest looking for the supply through follow-up and demand through spreading awareness through mass media for immunization.

Effectiveness of inactive COVID-19 vaccines against severe illness in B.1.617.2 (Delta) variant-infected patients in Jiangsu, China

The SARS-CoV-2 B.1.617.2 (Delta) variant has caused a new surge in the number of COVID-19 cases. The effectiveness of vaccines against this variant is not fully understood. Using data from a recent large-scale outbreak of COVID-19 in China, we conducted a real-world study to explore the effect of inactivated vaccine immunization on the course of disease in patients infected with Delta variants. We recruited 476 confirmed cases over the age of 18, of which 42 were severe. After adjusting for age, gender, and comorbidities, patients who received two doses of inactivated vaccine (fully vaccinated) had an 88% reduced risk in progressing to the severe stage (adjusted OR: 0.12, 95% CI: 0.02- 0.45). However, this protective effect was not observed in patients who only received only one dose of the vaccine(adjusted OR: 1.11, 95% CI: 0.51- 2.36). The full immunization offered 100% protection from a severe illness among women. The effect of the vaccine was potentially affected by underlying medical conditions (OR: 0.26, 95% CI: 0.03-1.23). This is the largest real-world study confirming the effectiveness of inactive COVID-19 vaccines against severe illness in Delta variant-infected patients in Jiangsu, China.

DETERMINATION OF THE FACTORS THAT AFFECT MOTHERS’ ATTITUDE TOWARDS IMMUNIZATION IN THE SOUTH-SOUTH REGION OF NIGERIA

Vaccination demand and acceptance depends on several factors that are quite broad and complex. The knowledge and attitude of a mother to childhood immunization play a key role in immunization coverage. Low immunization coverage in Nigeria is mostly attributed to poor knowledge, compliance, accessibility and inappropriate attitude among other factors. Poor compliance with full immunization is believed to be the most significant reason for low immunization coverage in the country due to socio-cultural obstacles to the acceptance of immunization. Aim: This study aims to assess the factors that determine the attitude of mothers towards immunization. Methodology: A hundred (100) mothers were recruited into this cross-sectional descriptive study using a simple random sampling technique. Data collection was performed by using a structured questionnaire. This study was carried out in Ukpenu community in Ekpoma, Edo State, Nigeria. This study was carried out in the Ukpenu community in Ekpoma, Edo State, Nigeria. 100 mothers were recruited into the study using a simple random sampling technique. Result: The results showed that the respondents have a positive attitude towards immunization. This was evident in the immunization report. Their record revealed that most of their children were fully immunized. This is seen in their readiness to fully immunize their children against childhood vaccine-preventable diseases (VPDs), their willingness to recommend full immunization of children to their friends, relatives and other women, and their readiness to purchase the vaccines if they are no longer available free of charge to ensure that their children are fully immunized. It was discovered that educational status plays a contributory role in the knowledge and attitude of mothers towards immunization. Conclusion: Maternal health education should be sustained to ensure continuous compliance and a positive attitude of mothers towards immunization.