Cardiorenal syndrome (CRS) clinical types, prevalence, aetiology, and acute cardiovascular morbidity impact on the outcome of acute kidney function perturbation were determined. Forty-seven of 101 (46.53%) patients with perturbed kidney function had CRS. Types 3 and 5 CRS were found in 10 and 37 patients, respectively. Type 3 CRS was due to acute glomerulonephritis (AGN; ), captopril (), frusemide (), and hypovolaemia (). Malaria-associated haemoglobinuria (), septicaemia (), lupus nephritis (), tumour lysis syndrome (), and acute lymphoblastic leukaemia () caused Type 5 CRS. The cumulative mortality in hypertensive CRS was similar to nonhypertensive CRS (51.4% versus 40.9%; ). Mortality in CRS and non-CRS was similar (45.7% versus 24.5%; ). Type 5 survived better than type 3 CRS (66.7% versus 12.5%; ). Risk factors for mortality were Type 3 CRS (), AGN-associated CRS (), dialysis requiring CRS (), and heart failure due to causes other than anaemia (). All-cause-mortality was 34.2%. Preventive measures aimed at the preventable CRS aetiologies might be critical to reducing its prevalence.