scholarly journals The Efficacy of Coil Embolization to Obtain Intrahepatic Redistribution in Radioembolization: Qualitative and Quantitative Analyses

2019 ◽  
Vol 43 (3) ◽  
pp. 391-401 ◽  
Author(s):  
Ahmed A. Alsultan ◽  
Caren van Roekel ◽  
Maarten W. Barentsz ◽  
Arthur J. A. T. Braat ◽  
Pieter Jan van Doormaal ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Qualitative Analysis ◽  
Coil Embolization ◽  
Progressive Disease ◽  
Activity Concentration ◽  
Post Treatment ◽  
Qualitative Assessment ◽  
Qualitative And Quantitative ◽  
Recist 1.1 ◽  
Quantitative Analyses

Abstract Purpose To evaluate the efficacy of coil embolization to obtain intrahepatic redistribution in patients undergoing radioembolization. Materials and Method All patients treated with radioembolization at our institute were retrospectively analyzed, and all cases in which a tumor-feeding vessel was coil-embolized were selected. Two nuclear medicine physicians visually assessed the effect of redistribution. Furthermore, the redistribution of microspheres was measured by quantifying the activity distributed to the coil-embolized (dependent) segment relative to the other (non-dependent) segments and to the tumor(s) in that segment. Quantitative analysis was performed on post-treatment 90Y-PET and 166Ho-SPECT using Simplicit90Y software. Lesion response was measured according to RECIST 1.1 criteria at 3 months post-treatment. Results Out of 37 cases, 32 were suitable for quantitative analysis and 37 for qualitative analysis. In the qualitative analysis, redistribution was deemed successful in 69% of cases. The quantitative analysis showed that the median ratio of the activity to the dependent embolized segments and the non-dependent segments was 0.88 (range 0.26–2.05) and 0.80 (range 0.19–1.62) for tumors in dependent segments compared with tumors in non-dependent segments. Using a cutoff ratio of 0.7 (30% lower activity concentration in comparison with the rest of the liver), 57% of cases were successful. At 3 months post-treatment, 6% of dependent tumors had partial response, 20% progressive disease, and 74% stable disease. In non-dependent tumors, this was, respectively, 16%, 20%, and 64%. Conclusion Coil embolization of hepatic arteries to induce redistribution of microspheres has a limited success rate. Qualitative assessment tends to overrate redistribution.

scholarly journals Differentiation between benign and malignant vertebral compression fractures using qualitative and quantitative analysis of a single fast spin echo T2-weighted Dixon sequence

2021 ◽  
Author(s):  
Sebastien Bacher ◽  
Steven David Hajdu ◽  
Yael Maeder ◽  
Vincent Dunet ◽  
Tom Hilbert ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Qualitative Analysis ◽  
Diagnostic Performance ◽  
Spin Echo ◽  
Fast Spin Echo ◽  
Vertebral Compression Fractures ◽  
Compression Fractures ◽  
Qualitative And Quantitative ◽  
Quantitative Analyses ◽  
Fast Spin

Abstract Objectives To determine and compare the qualitative and quantitative diagnostic performance of a single sagittal fast spin echo (FSE) T2-weighted Dixon sequence in differentiating benign and malignant vertebral compression fractures (VCF), using multiple readers and different quantitative methods. Methods From July 2014 to June 2020, 95 consecutive patients with spine MRI performed prior to cementoplasty for acute VCFs were retrospectively included. VCFs were categorized as benign (n = 63, mean age = 76 ± 12 years) or malignant (n = 32, mean age = 63 ± 12 years) with a best valuable comparator as a reference. Qualitative analysis was independently performed by four radiologists by categorizing each VCF as either benign or malignant using only the image sets provided by FSE T2-weighted Dixon sequences. Quantitative analysis was performed using two different regions of interest (ROI1-2) and three methods (signal drop, fat fraction (FF) from ROIs, FF maps). Diagnostic performance was compared using ROC curves analyses. Interobserver agreement was assessed using kappa statistics and intraclass correlation coefficients (ICC). Results The qualitative diagnostic performance ranged from area under the curve (AUC) = 0.97 (95% CI: 0.91–1.00) to AUC = 0.99 (95% CI: 0.95–1.0). The quantitative diagnostic performance ranged from AUC = 0.82 (95% CI: 0.73–0.89) to AUC = 0.97 (95% CI: 0.91–0.99). Pairwise comparisons showed no statistical difference in diagnostic performance (all p > 0.0013, Bonferroni-corrected p < 0.0011). All five cases with disagreement among the readers were correctly diagnosed at quantitative analysis using ROI2. Interobserver agreement was excellent for both qualitative and quantitative analyses. Conclusions A single FSE T2-weighted Dixon sequence can be used to differentiate benign and malignant VCF with high diagnostic performance using both qualitative and quantitative analyses, which can provide complementary information. Key Points • Qualitative analysis of a single FSE T2-weighted Dixon sequence yields high diagnostic performance and excellent observer agreement for differentiating benign and malignant compression fractures. • The same FSE T2-weighted Dixon sequence allows quantitative assessment with high diagnostic performance. • Quantitative data can readily be extracted from the FSE T2-weighted Dixon sequence and may provide complementary information to the qualitative analysis, which may be useful in doubtful cases.

scholarly journals Determination of Flavonoids Compounds of Three Species and Different Harvesting Periods in Crataegi folium Based on LC-MS/MS

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1602
Author(s):  
Ya-Ping Guo ◽  
Hong Yang ◽  
Ya-Li Wang ◽  
Xiao-Xiang Chen ◽  
Ke Zhang ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Qualitative Analysis ◽  
Quantitative Method ◽  
Total Content ◽  
Qualitative And Quantitative Analysis ◽  
Pharmacological Activities ◽  
Time Saving ◽  
Qualitative And Quantitative ◽  
First Time

Crataegi folium have been used as medicinal and food materials worldwide due to its pharmacological activities. Although the leaves of Crataegus songorica (CS), Crataegus altaica (CA) and Crataegus kansuensis (CK) have rich resources in Xinjiang, China, they can not provide insights into edible and medicinal aspects. Few reports are available on the qualitative and quantitative analysis of flavonoids compounds of their leaves. Therefore, it is necessary to develop efficient methods to determine qualitative and quantitative flavonoids compounds in leaves of CS, CA and CK. In the study, 28 unique compounds were identified in CS versus CK by qualitative analysis. The validated quantitative method was employed to determine the content of eight flavonoids of the leaves of CS, CA and CK within 6 min. The total content of eight flavonoids was 7.8–15.1 mg/g, 0.1–9.1 mg/g and 4.8–10.7 mg/g in the leaves of CS, CA and CK respectively. Besides, the best harvesting periods of the three species were from 17th to 26th September for CS, from 30th September to 15th October for CA and CK. The validated and time-saving method was successfully implemented for the analysis of the content of eight flavonoids compounds in CS, CA and CK for the first time.

scholarly journals The toxic effects of chloroquine and hydroxychloroquine on skeletal muscle: a systematic review and meta-analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Claudia Cristina Biguetti ◽  
Joel Ferreira Santiago Junior ◽  
Matthew William Fiedler ◽  
Mauro Toledo Marrelli ◽  
Marco Brotto
Keyword(s):  
Systematic Review ◽  
Quantitative Analysis ◽  
Qualitative Analysis ◽  
Observational Studies ◽  
Skeletal Muscles ◽  
Case Reports ◽  
Meta Analysis ◽  
Toxic Effects ◽  
Drug Induced ◽  
Qualitative And Quantitative

AbstractThe aim of this systematic review was to perform qualitative and quantitative analysis on the toxic effects of chloroquine (CQ) and hydroxychloroquine (HCQ) on skeletal muscles. We designed the study according to PRISMA guidelines. Studies for qualitative and quantitative analyses were selected according to the following inclusion criteria: English language; size of sample (> 5 patients), adult (> age of 18) patients, treated with CQ/HCQ for inflammatory diseases, and presenting and not presenting with toxic effects on skeletal muscles. We collected data published from 1990 to April 2020 using PubMed, Cochrane Library, EMBASE, and SciELO. Risk of bias for observational studies was assessed regarding the ROBIN-I scale. Studies with less than five patients (case reports) were selected for an additional qualitative analysis. We used the software Comprehensive Meta-Analysis at the confidence level of 0.05. We identified 23 studies for qualitative analysis (17 case-reports), and five studies were eligible for quantitative analysis. From case reports, 21 patients presented muscle weakness and confirmatory biopsy for CQ/HCQ induced myopathy. From observational studies, 37 patients out of 1,367 patients from five studies presented muscle weakness related to the use of CQ/HCQ, and 252 patients presented elevated levels of muscle enzymes (aldolase, creatine phosphokinase, and lactate dehydrogenase). Four studies presented data on 34 patients with confirmatory biopsy for drug-induced myopathy. No study presented randomized samples. The chronic use of CQ/HCQ may be a risk for drug-induced myopathy. There is substantiated need for proper randomized trials and controlled prospective studies needed to assess the clinical and subclinical stages of CQ/HCQ -induced muscle myopathy.

scholarly journals What’s All the Chatter? A Mixed-Methods Analysis of Emergency Physicians’ Tweets

2019 ◽  
Vol 21 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Jeff Riddell ◽  
Alisha Brown ◽  
Lynne Robins ◽  
Rafae Nauman ◽  
Jeanette Yang ◽  
...  
Keyword(s):  
Social Media ◽  
Content Analysis ◽  
Mixed Methods ◽  
Qualitative Analysis ◽  
Community Of Practice ◽  
Emergency Physicians ◽  
Shared Resources ◽  
Qualitative And Quantitative ◽  
Quantitative Analyses ◽  
Educational Delivery

Introduction: Twitter is growing in popularity and influence among emergency physicians (EP), with over 2200 self-identified EP users. As Twitter’s popularity has increased among EPs so too has its influence. While there has been debate about the value of Twitter as an effective educational delivery tool, little attention has been paid to the nature of the conversation occurring on Twitter. We aim to describe how influential EPs use Twitter by characterizing the language, purpose, frequencies, content, and degree of engagement of their tweets. Methods: We performed a mixed-methods analysis following a combined content analysis approach. We conducted qualitative and quantitative analyses of a sample of tweets from the 61 most influential EPs on Twitter. We present descriptive tweet characteristics and noteworthy themes. Results: We analyzed 1375 unique tweets from 57 unique users, representing 93% of the influential Twitter EPs. A majority of tweets (1104/1375, 80%) elicited some response in the form of retweets, likes, or replies, demonstrating community engagement. The qualitative analysis identified 15 distinct categories of tweets. Conclusion: Influential EPs on Twitter were engaged in largely medical conversations in which most messages generated some form of interaction. They shared resources and opinions while also building social rapport in a community of practice. This data can help EPs make informed decisions about social media engagement.

scholarly journals Quantitative analysis of hydrogen and chalcogen bonds in two pyrimidine-5-carbonitrile derivatives, potential DHFR inhibitors: an integrated crystallographic and theoretical study

RSC Advances ◽  
2020 ◽  
Vol 10 (60) ◽  
pp. 36806-36817
Author(s):  
Lamya H. Al-Wahaibi ◽  
Kushumita Chakraborty ◽  
Nora H. Al-Shaalan ◽  
Mohamed Yehya Annavi Syed Majeed ◽  
Olivier Blacque ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Theoretical Study ◽  
Qualitative And Quantitative ◽  
Quantitative Analyses ◽  
Dhfr Inhibitors

Qualitative and quantitative analyses of hydrogen and chalcogen bonds in two pyrimidine-5-carbonitrile derivatives are described.

Qualitative Analysis and Quantitive Account for Tunnel Fire Location

2010 ◽  
Vol 143-144 ◽  
pp. 1347-1351
Author(s):  
Ling Qi Zhu ◽  
Xin Quan Zhou
Keyword(s):  
Numerical Simulation ◽  
Quantitative Analysis ◽  
Qualitative Analysis ◽  
Fuzzy Clustering ◽  
Qualitative And Quantitative Analysis ◽  
Qualitative And Quantitative ◽  
Tunnel Fire ◽  
Location Judgment ◽  
Sets Theory ◽  
Fire Location

Fire is one of the major hazards in coal mines. After the fire broke out.the primary task of disaster rescue is to judge the location of fire and it is the prerequisite of analyzing the combustion state, the base of fire prediction. In this paper, the method of tunnel fire location judgment combining with qualitative and quantitative analysis is used, it includes the qualitative analysis basing on sets theory and quantitative analysis on fuzzy clustering. The potential location can be conversely reasoned by the warning sensors and the scope can be narrowed down widely. On this basis, the distance and similarity between the veritable time difference and the numerical simulation difference are calculated and by the value we can know the site of the fire.

scholarly journals LABOR CAPACITY OF DEAF WORKERS ON THE WORKPLACE: QUALITATIVE ANALYSIS OF THE ATTITUDES OF DEAF WORKERS AND THEIR CO-WORKERS WITHOUT HEARING IMPAIRMENT

2019 ◽  
Vol 9 (2) ◽  
pp. 40-47
Author(s):  
Admira Beha ◽  
◽  
Husnija Hasanbegović ◽  
Keyword(s):  
Quantitative Analysis ◽  
Qualitative Analysis ◽  
Work Environment ◽  
Hearing Impairment ◽  
Statistical Significance ◽  
Deaf People ◽  
Qualitative And Quantitative Analysis ◽  
Qualitative And Quantitative ◽  
Significant Difference ◽  
Wilks Lambda

The aim of this paper is to determine the opinions of deaf workers on their labor capacity and the opinions of their hearing co-workers about the labor capacities of the deaf. The sample consisted of 247 respondents, of whom 127 were deaf and 120 were hearing workers. Qualitative and quantitative analysis were used in processing the results. Testing was performed by Wilks' Lambda, tested significance in discriminant analysis was done by F test, at the statistical significance of 0.01. It was found that the sub-sample of respondents had a statistically significant difference in views on claims regarding the exploitation of deaf workers by employers, the employment of deaf people in low-paid simple occupations, and the equally successful but insignificant productivity of deaf workers. The statistical differences found indicate that there are differences in the assessment of the labor capacity of deaf workers in the hearing work environment. Qualitative analysis found that hearing impairment and the subjective attitudes of colleagues without hearing impairment have the greatest impact on the assessment of the labor capacity of deaf workers.

scholarly journals Quantitative Analysis by Gas Chromatography / Mass Spectrometry of Heroin Traded in Kuwait during 2016 – 2017, and Its Comparison with Results of Analyzing Heroin Traded during 2012 and Addicts Death Rate Statistics during 2011 – 2018

2020 ◽  
pp. 12-22
Author(s):  
N. A. Al-Abkal ◽  
E. Kh. Metwally ◽  
S. R. Alezzbawy ◽  
Kh. Y. Orabi ◽  
Sh. H. Alshammari
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Quantitative Analysis ◽  
Gas Chromatography Mass Spectrometry ◽  
Qualitative And Quantitative Analysis ◽  
Satisfactory Explanation ◽  
Heroin Addicts ◽  
Qualitative And Quantitative ◽  
Chromatography Mass Spectrometry ◽  
Quantitative Analyses

Aim: To compare the main and additive components of heroin trafficked in the Stateof Kuwait during 2012 with those components of heroin traded recently in the country during 2016 and 2017, and to provide a satisfactory explanation for the increase in deaths among heroin addicts during the period2011 -2018. Study Design: Selected samples of non-pure powder heroin seized in Kuwait during 2016 and 2017, with pure heroin and a set of10 pure different heroin component standards, all have been quantitatively analyzed in the Forensic Laboratories. Place and Duration of Study: All qualitative and quantitative analyses for 2016 and 2017 samples were conducted in the Forensic Laboratories of the General Department of Criminal Evidences – Ministry of Interior – State of Kuwait. Methodology: By using Gas Chromatography/Mass Spectrometry (GC/MS) to qualitative and quantitative analysis have been made on a total of hundred samples of non-pure powder heroin seized in Kuwait during the years 2016 and 2017, in addition to ten pure standards. Results: The concentration of the diacetylmorphine (active substance of heroin) in Kuwait during the year 2017 are much higher than the concentration during the year 2016. The additive substances (adulterants) for the years 2016 and 2017, are shared with the year 2012 by the component's paracetamol, caffeine and diazepam with different concentrations. But new adulterants in recent years are recorded in samples 2016 and 2017, including methamphetamine, dextromethorphan, and methylphenidate which is absent in 2016 samples. Conclusion: The concentration % of illicit heroin traded in Kuwait as diacetylmorphine has increase from 10% to 50% for year 2016, and further from 30% - 70% for year 2017, which marks identified a substantial rising in the purity of heroin. In addition, additive substances in the two years include paracetamol (acetaminophen), caffeine and diazepam, previously recorded in 2012. However, totally different new adulterates are recorded in 2016 and 2017 samples, including methamphetamine, dextromethorphan, and methylphenidate. All new three adulterates are detected in quite a few numbers of samples with methylphenidate recorded in a very low concentration of 0. 01 mg. Both new adulterates and higher purity of heroin constitute the main reasons for rising the rate of deaths between heroin addicts in recent years. Also, recent UN reports (12,18) provide evidence that the GC countries Afghanistan, Iran and Pakistan are still manufacturing and trading the above mentioned new adulterates.

scholarly journals Comprehensive analysis of existing endurance testing methods of flexible dowel crutches of composite reinforced concrete road bridges according to the standards of a number of countries

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Nikolai Kozak
Keyword(s):  
European Union ◽  
Reinforced Concrete ◽  
Quantitative Analysis ◽  
Qualitative Analysis ◽  
The European Union ◽  
Steel Reinforced Concrete ◽  
Qualitative And Quantitative ◽  
Basic Set ◽  
Endurance Testing ◽  
The Usa

In the article, the author considers the verification issue of the endurance of the venture elements of steel-reinforced concrete spans of bridges, in particular, flexible dowel crutches («Nelson’s anchors»). According to the existing domestic regulatory framework, the endurance test of the flexible dowel crutches for road bridges is not required; at the same time, the survey’s results of the operated superstructures indicate the presence of problems associated with the insufficient endurance of these elements. The article presents comprehensive (qualitative and quantitative) comparative analysis results of the world’s existing approaches to testing the endurance of the venture elements. At the stage of qualitative analysis, the author considered methods of checking the endurance of elements in general according to the norms of 8 countries and regions (Russia, the European Union, the USA, Ukraine, Australia, Canada, Japan, China) and highlighted a basic set of methods for checking the endurance of the venture elements (Russia, the European Union, USA, Ukraine). The models of the basic set were subjected to a detailed qualitative analysis according to the criteria of the models used and the parameters included in them. The quantitative analysis of the selected basic set techniques, carried out in relation to the existing bridge, included an analysis of the effects of moving loads on the venture elements, direct elements verification using the considered methods, as well as the design damage comparison of the elements obtained by the Palmgren-Miner linear summation hypothesis. Based on the obtained values of design damage, the values of the use of endurance reserves were determined and analyzed for each of the considered methods and the conditional load model. Based on the results of the qualitative and quantitative analysis, the author draws conclusions based on the comparison of various methods and highlights the rational directions for improving the existing domestic methodology.

Qualitative Phase Analysis Using an X-Ray Powder Diffractometer

1980 ◽  
Vol 24 ◽  
pp. 91-97
Author(s):  
W. N. Schreiner ◽  
C. Surdukowski ◽  
R. Jenkins
Keyword(s):  
Qualitative Analysis ◽  
Phase Analysis ◽  
Powder Diffraction ◽  
X Ray ◽  
Qualitative And Quantitative ◽  
The Past ◽  
Quantitative Analyses ◽  
Improved Performance ◽  
Qualitative Phase ◽  
Self Consistency

During the past three years we have undertaken the development of a complete X-Ray Powder Diffraction, facility with the goal of fully integrating experimental and analytical procedures. Such an approach potentially offers substantially improved performance over previously existing systems by virtue of its internal self-consistency and it opens the possibility of significantly extending analytic procedures for both qualitative and quantitative analyses. Our work to date has resulted in improved performance and significant extensions in both areas, and today I will report on those advances in the area of qualitative analysis.

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