scholarly journals Treatment outcome of an intensive psychiatric home treatment for children and adolescents: a non-randomized controlled pilot evaluation

Author(s):  
Daniel Graf ◽  
Stefan Lerch ◽  
Ulrich Böhnke ◽  
Corinna Reichl ◽  
Jochen Kindler ◽  
...  

AbstractHome treatment (HT) may offer an effective and cost-efficient alternative to inpatient treatment for children and adolescents with acute mental disorders. This study introduces and evaluates a pilot HT project from Bern, Switzerland, with HT completely replacing an inpatient treatment. A total of n = 133 children and adolescents with acute mental disorders and inpatient treatment needs were treated either in the new HT program (n = 37) or in an active control group with inpatient treatment as usual (I-TAU, n = 96). Psychopathological burden was assessed by the Health of the Nation Outcome Scale for Children and Adolescents clinician-rated (HoNOSCA) and self-rated (HoNOSCA-SR) at the time of admission and at discharge. Treatment effects were assessed and compared using Augmented Inverse Probability Weights to adjust for baseline differences and to control for treatment duration. Participants ranged in age from 6 to 17 years (M = 13.71 years, SD = 2.93), 54% were female. HT resulted in significant improvements in the HoNOSCA (d = 0.79, p < .001) and HoNOSCA-SR (d = 0.63, p = .006). No significant differences on treatment effects were observed between HT and the reference group I-TAU in the HoNOSCA (d = 0.01, p = .96) or the HoNOSCA-SR (d = 0.11, p = .63). Overall, results indicate HT to be an effective alternative for children and adolescents with acute mental health disorders instead of hospitalization. Further evaluation with random group allocation and long-term follow-up should attempt to replicate and extend the current findings.

Author(s):  
Y. Indira Muzib ◽  
E. Ramya ◽  
Y. R. Ambedkar

Pioglitazone HCl is an oral anti-diabetic agent used for the treatment of diabetes mellitus type II. The aim of the present work is to evaluate the pharmacodynamic activity of solid lipid nanoparticles of pioglitazone HCL prepared by using solvent injection technique and to compare with the control and test group. Among all the formulations, F5 was found to possess highest in-vitro drug release within 24 hrs i.e., 95.02±1.26%. The in vivo studies were performed using male albino rats of wistar strain (150-200g). Rats were divided in to five groups (n=6), group-I normal, group-II diabetes control, group-III   placebo control, group-IV reference, group-V test group. Diabetes was induced by streptazocin (60 mg/kg) by intraperitonial route. The reference group was treated with marketed tablet of pioglitazone HCL, test groups were treated with SLNs suspended in 0.1% Tween 80 and given to animals through oral gavages. Blood samples were collected by retro-orbital puncture before treatment, and after treatment at time intervals 0, 2, 4, 6, 8, 10, 12 and 24h in anti-coagulated vials. Parameters like glucose, tri glycerides (TG), total cholesterol (TC) and HDL-C were estimated by calorimetric method.  Diabetes induced rats showed elevated levels of glucose, TG, TC and reduced HDL. The oral administration of drug loaded SLNs in 0.1% Tween 80 solution showed reduced levels of glucose, TG and elevated levels of HDL-C and slightly reduced levels of TG in 24 h where as the marketed tablet showed reduced levels of glucose, TG and TC up-to 12 h and in 24thh  the glucose levels get elevated. Thus the optimized SLNs showed prolonged activity.


2011 ◽  
Vol 68 (12) ◽  
pp. 1021-1025
Author(s):  
Marija Igic ◽  
Dragan Mihailovic ◽  
Ljiljana Kesic ◽  
Mirjana Apostolovic ◽  
Ljiljana Kostadinovic ◽  
...  

Introduction/Aim. Gingivitis is a common occurrence in children and may well be thought as a risk factor for the appearance and progression of the diseases of parodontal tissues. It is thus necessary to react in a timely and adequate fashion to prevent the disease to become serious and produce parodontopathy. The aim of the study was to establish the efficacy of hyaluronic acid in the treatment of chronic gingivitis in children. Methods. The study enrolled 130 children with permanent dentition. All of the examinees were divided into three groups: group I - 50 patients with chronic gingivitis in which only the basic treatment was applied; group II - 50 patients with chronic gingivitis in which hyaluronic acid was applied in addition to basic treatment; group III - 30 examinees with healthy gingiva (control group). Assessment of oral hygiene and status of the gingiva and parodontium was done using the appropriate indexes before and after the treatment. Inflammation of the gingiva was monitored by way of cytomorphometric studies. Results. The pretreatment values of the plaque index (PI) were high: in the group I PI was 1.94; in the group II PI was 1.68. After the treatment, the PI value was reduced to null in both groups (PI = 0). In the group III PI was 0.17. The bleeding index (BI) in the group I was 2.02 before and 0.32 after the treatment; the BI value in the group II was 1.74 before and 0.16 after the treatment. In the group III BI was 0. In the group I, the Community Periodontal Index of Treatment Needs (CPITN) was 1.66 before and 0.32 after the treatment; in the group II, the CPITN value was 1.5 before and 0.24 after the treatment. In the group III, the CPITN value was 0. In the group I, the size of the nuclei of the stratified squamous epithelium of the gingiva was reduced, although not so much as the nuclear size in the group II of examinees. Conclusion. Basic treatment is able to successfully treat chronic gingivitis in children. The use of hyaluronic acid together with the basic treatment can markedly improve the treatment effect.


Author(s):  
Matthias Domhardt ◽  
Lena Steubl ◽  
Harald Baumeister

Abstract. This meta-review integrates the current meta-analysis literature on the efficacy of internet- and mobile-based interventions (IMIs) for mental disorders and somatic diseases in children and adolescents. Further, it summarizes the moderators of treatment effects in this age group. Using a systematic literature search of PsycINFO and MEDLINE/PubMed, we identified eight meta-analyses (N = 8,417) that met all inclusion criteria. Current meta-analytical evidence of IMIs exists for depression (range of standardized mean differences, SMDs = .16 to .76; 95 % CI: –.12 to 1.12; k = 3 meta-analyses), anxiety (SMDs = .30 to 1.4; 95 % CI: –.53 to 2.44; k = 5) and chronic pain (SMD = .41; 95 % CI: .07 to .74; k = 1) with predominantly nonactive control conditions (waiting-list; placebo). The effect size for IMIs across mental disorders reported in one meta-analysis is SMD = 1.27 (95 % CI: .96 to 1.59; k = 1), the effect size of IMIs for different somatic conditions is SMD = .49 (95 % CI: .33 to .64; k = 1). Moderators of treatment effects are age (k = 3), symptom severity (k = 1), and source of outcome assessment (k = 1). Quality ratings with the AMSTAR-2-checklist indicate acceptable methodological rigor of meta-analyses included. Taken together, this meta-review suggests that IMIs are efficacious in some health conditions in youths, with evidence existing primarily for depression and anxiety so far. The findings point to the potential of IMIs to augment evidence based mental healthcare for children and adolescents.


2016 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Eka Fitrianda ◽  
Wida Ningsih

Eupatorium odoratum L. is traditionally used to treat open wounds. Aim of this study was toinvestigate the healing activity of ointment containing extract of E. odoratum in burns induced in malealbino mice. Mice were divided into 5 groups, all were induced for burn wound using a heat stamp intemperature 80°C for 20 minutes. Group I was treated with ointment base (control), group II, III and IVwere treated with extract ointment in concentration of 5%, 10%, and 20% w/w respectively, and the lastgroup V was treated with ointment reference. Observations were made during 21 days exactly on the 7th,14th and 21st day, which included parameters: percentage of healed area, epithelialization time andcollagen scores. The result showed that on 14th day, mean of healed area in group III (75.89%±7.76%)and IV (76.29%±6.981%) were significantly higher than other groups (P<0.05). On the 14th and 21th day,collagen scores in groups III (2.33±0.577 and 2.67±0.577) and IV (2.67±0.577 and 2.33±0.577) are equalwith reference group, these score are significantly higher than in groups I and II (P<0.05). Meanwhile,though epithelialization time in group III and IV (both 14.33 days±0.577days) are more quickly thanothers, statistical analysis showed that there is no significant difference on time between all groups(P>0.05).


2015 ◽  
Vol 10 (3) ◽  
pp. 584 ◽  
Author(s):  
Hammad Saleem ◽  
Irshad Ahmad ◽  
M. Shoaib Ali Gill

<p>The aim of this study was to evaluate diuretic activity of aqueous methanolic extract of <em>Euphorbia granulate</em> in rats. Albino rats were divided into five groups. Group I served as reference, Group II as standard and Group III, IV and V served as test. The three doses of extract (30, 50 and 100 mg/kg) were given to rats (i.p) in acute diuretic model. Furosemide (10 mg/kg i.p) was used as standard drug. The extract induced diuretic effects and induced electrolytes excretion in a dose-dependent manner when compared with control. The extract (100 and 50 mg/kg) significantly (p&lt;0.01) increased the volume of urine in comparison to control group. Similarly, the excretion of potassium and sodium were also significantly (p&lt;0.05) increased following extract administration. However, there was no significant change in the pH of urine samples of the extract-treated group compared with control. The result of this study thus offers support to the traditional folker use of this plant as a diuretic agent.</p><p> </p>


2021 ◽  
Author(s):  
Sara Levati ◽  
Zefiro Benedetto Mellacqua ◽  
Maria Caiata Zufferey ◽  
Emiliano Soldini ◽  
Emiliano Albanese ◽  
...  

BACKGROUND Crisis Resolution and Home Treatment (CRHT) teams represent a community-based mental health service offering a valid alternative to hospitalisation. CRHT teams have been widely implemented in various mental health systems worldwide and their goal is to take care of people with severe acute mental disorders that would be considered for admission to acute psychiatric wards. The evaluation of several home-treatment experiences shows promising results; however, it remains unclear which specific elements and characteristics of CRHT are more effective and acceptable. OBJECTIVE This study aims to assess the acceptability, effectiveness and cost-effectiveness of a new CRHT intervention in Ticino, Southern Switzerland. METHODS The study includes an interventional non-randomised quasi-experimental study combined with a qualitative study and an economic evaluation over a 48-month period. The quasi-experimental evaluation will involve two groups: patients in the northern area of the region will be offered with the CRHT service and be defined as the intervention group; patients in the southern area of the region will act as the control group and receive care as usual. Individual interviews with patients receiving the home treatment intervention and their family members will be conducted. CRHT members will be asked to take part in a focus group. The economic evaluation will include a cost-effectiveness analysis. RESULTS As of February 2021, data for the non-randomised quasi-experimental study have been collected and results are expected to be published by the end of the year. Data are currently being collected for the qualitative study and the economic evaluation, and the results will be disseminated through publication when the analysis is complete. CONCLUSIONS Compared to other Swiss CRHT experiences, the CRHT intervention in Ticino represents a unique case, as the introduction of the service is backed by the closing of one of its acute wards. The proposed study will address several areas where there are evidence gaps or contradictory findings relating to the home treatment of acute mental crisis. Findings from this study will allow local services to improve their effectiveness in a challenging domain of public health and contribute to improving access to more effective care for people with severe mental disorders. CLINICALTRIAL Trial registration ISRCTN38472626 (ISRCTN registry)


Author(s):  
Sarah Ibrahim El Shall ◽  
Ahmed Mohamed Hassan ◽  
Wesam Salah Mohamed ◽  
Mona Hasan Hafez ◽  
Adel Ali Erfan

Background: Valid and reliable methods are essential to assess the presence and the extent of insulin resistance, the associated risk factors and the effect of pharmacological and lifestyle interventions. The aim of this work was to evaluate Homeostatic model assessment of insulin resistance (HOMA-IR) for assessment of insulin resistance among obese children and adolescents. Methods: This case control study included 40 children and adolescent with ages of 6 to 16 years who were classified into: Group I: 20 obese children and adolescents (body mass index (BMI) > 95th percentile on Egyptian growth curves and Group II: 20 healthy children as a control group of matched age and sex to group 1 and who had normal BMI. All subjects underwent 1) Thorough history taking 2) Full clinical examination 3) Laboratory investigations: Fasting blood glucose, Fasting serum insulin level, HOMA-IR, HbA1c.and OGTT. Results: There is no significant statistical difference as regard age, height, sex and puberty staging in both groups. The mean for weight, BMI, waist circumference, hip circumference, waist/hip ratio and acanthosis nigricans were found to be significantly higher in patient group. FBG, fasting serum insulin, HbA1c and HOMA-IR were significantly higher in patient group than in control group (p <0.001). HOMA-IR was significantly correlated with HbA1c and OGTT in obese patients (p<0.001*). Conclusions: HOMA-IR can be used in assessment of insulin resistance among obese children and adolescents.


2003 ◽  
Vol 25 (1) ◽  
pp. 18-25 ◽  
Author(s):  
Sumaia Inaty Smaira ◽  
Florence Kerr-Corrêa ◽  
José Onildo B Contel

INTRODUCTION: Psychiatric consultation (PC) has been considered an efficient tool to develop research, to track and to give assistance benefiting patients, health professionals and the institution. However, it has not been much used in Brazil. Although 30 to 50% of general hospital (GH) inpatients may present a psychiatric disorder, only 1 to 12% of them are referred to assessment. The aims of this study were: to assess mental disorders in a GH; to identify which of these patients are sent to psychiatric care; to verify alleged reasons for referral to psychiatric consultation, and to examine the relationship between PC and psychiatric learning (during medical school and residence). METHODS: A case-control patient study was conducted (47 cases and 94 controls) to analyze in detail the following variables: socio-demographic; clinical; degree of information (about the disease and diagnostic/therapeutic procedures), and relationship between patient and health team. Psychiatric diagnoses were made according to the ICD-10 criteria. The Self Report Questionnaire (SRQ), the CAGE and Brief Psychiatric Rating Scale (BPRS) were used as well as a specifically designed questionnaire to collect clinical and demographic data. RESULTS: Behavioral alterations, either of elation or of depression, were the main for requesting a PC ; 95.8% of the cases and 27.7% of the controls had a mental disorder. Organic mental disorders and alcohol-related disorders were the most frequent diagnoses in group I (cases), while anxiety, depressive and alcohol-related disorders were predominant in group II (controls). Control group patients were better informed and more able to establish an appropriate relationship with the health team than case patients. The logistic regression showed CAGE-positive patients having 12.85 times greater risk of being referred to PC, followed by unemployed patients (2.44 times more PC referrals). DISCUSSION: The SRQ and CAGE were quite useful in the screening of possible patients and might be important for medical students to learn and use as generalists. Further research is needed to verify if and how the newly-established service will improve the diagnostic and treatment skills of our students.


2021 ◽  
Vol 2 ◽  
pp. 22-26
Author(s):  
V.I. Boyko ◽  
V.A. Terekhov

The objective: to give a comparative assessment of the immediate and long-term results of laparoscopic treatment of postoperative abdominal complications in patients with gynecological pathology.Materials and methods. We carried out a comparative study of the immediate results after repeated laparoscopies and relaparotomies in gynecological patients with postoperative intra-abdominal complications, during which 2 clinical groups of patients were identified. Group I (main) consisted of 62 patients (50,82%) with early postoperative complications who underwent video endoscopic interventions. Group II (control) included 60 (49,18%) patients who underwent traditional «open» laparotomy. The criteria for the course of the early postoperative period were chosen traditionally. At the same time, it was taken into account that after the repeated interventions, the patients of both the main and the control groups received similar intensive therapy aimed at correcting the main symptom complex of the disease.All patients were comprehensively examined using clinical, instrumental and laboratory research methods. The groups were homogeneous in age and structure of operations performed on the pelvic organs, and were statistically comparable.Long-term results were studied among 28 (45,1%) patients of the main group and 21 women from the comparison group (35%) in terms of one to five years after gynecological intervention.Results. In the patients of the control group, the pain syndrome persisted statistically significantly longer and required prescription of anesthetic drugs on average 2 days more. The use of laparoscopy in the treatment of postoperative complications most often (51,7%) made it possible to refuse analgesics, and non-steroidal anti-inflammatory drugs were used on demand only in the first 2–3 days. The average duration of inpatient treatment for patients of group I with postoperative intra-abdominal gynecological complications averaged 10±2,5 days versus 16±2,9 in II (control) (p>0,05). The average duration of inpatient treatment after open surgery was on average 6±1,9 days longer (p<0,05).Long-term results were assessed using a three-point system (the result is good, satisfactory, unsatisfactory) based on the data of clinical and instrumental examination. Good long-term results were found in 13 (46,4%) patients of the main group and in 6 (28,5%) patients from the control group. Satisfactory results in group I were found in 13 (46,4%) patients, in group II – in 13, which amounted to 61,9%. In 2 patients, the results were found unsatisfactory after relaparoscopic manipulations (7,2%), and in 2 (9,5%) – after relaparotomy. One patient, due to frequent, recurrent cramping pains, was operated on as planned (abdominal adhesions were dissected).The study revealed a direct relationship during the early postoperative period and long-term results in women operated traditionally and with the use of laparoscopy. Based on the study of the results of surgical treatment of early postoperative intraperitoneal complications, the high efficiency of the video-laparoscopic method was proved in comparison with the traditional one. Thus, the implementation of the proposed treatment tactics can significantly improve the quality of life of this category of patients. The study of long-term results of laparoscopic operations has shown that the use of diagnostic methods of surgical techniques in the practice of medical institutions will contribute to the improvement of the results of complex treatment of sick women with pathology of the pelvic organs.


2019 ◽  
Vol 100 (3) ◽  
pp. 434-438
Author(s):  
M A Rasulova ◽  
R M Mamedov

Aim. Assessment of the dental status of patients with mental disorders. Methods. Examination of 220 mentally ill and 208 practically healthy individuals was carried out using DCF (decay/missing/filled) and CPITN (Community Periodontal Index of Treatment Needs) indices to determine the prevalence and intensity of caries, periodontal disease, and to identify the need for complex dental care. The group were comparable by the age: 35.2±0.39 и 34.3±0.40 years (р=0.115). The functional state of the salivary glands and mouth fluid was studied. Psychoemotional status was determined before starting the treatment by the clinical psychological method using Spielberger-Khanin scale of reactive and personal anxiety levels. Results. In the study group, the number of patients in whom various forms of caries were detected was 100%, while in the group of mentally healthy subjects the number of such patients was 91.8±1.90% (p=0.001). Due to the high values of intensity of carious disease, especially in terms of the number of teeth extracted, the need of the mentally ill for dentures was recorded to be quite high. The highest intensity of the dental calculi and deep pathological periodontal pockets was found in the study group. Peaks of reduced salivation were more commonly diagnosed in patients with mental illness. Assessing the frequency of occurrence of dentoalveolar anomalies, deep bite and progeny in both groups had the highest ratio relative to other types of anomalies but in the study group, the frequency of cross bite was higher (p=0.015). The rate of reactive anxiety in the course of dental interventions in the study group was 50.1±0.72% versus 31.6±0.57 in the control group (p


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