scholarly journals Health and disease as practical concepts: exploring function in context-specific definitions

2021 ◽  
Author(s):  
Rik van der Linden ◽  
Maartje Schermer
Keyword(s):  
General Definition ◽  
Future Research ◽  
Disease Concepts ◽  
Health And Disease ◽  
Context Specific ◽  
The Way

AbstractDespite the longstanding debate on definitions of health and disease concepts, and the multitude of accounts that have been developed, no consensus has been reached. This is problematic, as the way we define health and disease has far-reaching practical consequences. In recent contributions it is proposed to view health and disease as practical- and plural concepts. Instead of searching for a general definition, it is proposed to stipulate context-specific definitions. However, it is not clear how this should be realized. In this paper, we review recent contributions to the debate, and examine the importance of context-specific definitions. In particular, we explore the usefulness of analyzing the relation between the practical function of a definition and the context it is deployed in. We demonstrate that the variety of functions that health and disease concepts need to serve makes the formulation of monistic definitions not only problematic but also undesirable. We conclude that the analysis of the practical function in relation to the context is key when formulating context-specific definitions for health and disease. At last, we discuss challenges for the pluralist stance and make recommendations for future research.

Cut Flowers Being Sold as Impulse Items: A Look at Factors Affecting Impulse Product Merchandising

HortScience ◽  
1998 ◽  
Vol 33 (3) ◽  
pp. 558c-558
Author(s):  
Jennifer B. Neujahr ◽  
Karen L.B. Gast
Keyword(s):  
Consumer Behavior ◽  
Marketing Strategies ◽  
Easy Access ◽  
Future Research ◽  
Grocery Stores ◽  
Cut Flowers ◽  
Factors Affecting ◽  
New Type ◽  
The 1950S ◽  
The Way

Consumer behavior research seems to play an big role in determining the wants and needs of an industry. This research helps to shape the way we market to the consumers and helps make marketing strategies more effective. In the 1950s grocery stores began to sell horticulture products in order to alleviate the growers' surplus. Supermarkets now have seem to found their niche in this market due to the fact that they can influence their consumers to buy their flowers right along with their bread, and get all of their shopping done at once. This new type of sale, commonly referred to as the impulse sale, can relate directly to how well the store is merchandised and maintained. A study was conducted at a local supermarket, to determine the following: good locations for impulse sales items, special conditions affecting impulse sales items, and what types of things could affect demand for impulse items. It was discovered that certain locations make better sales than other locations. Locations that were front and center and allowed easy access to seeing the mixed flower bouquet without having to touch it yielded the best results. The variables used to show a change in demand showed little to some variability and has raised some questions which may be used to conduct future research.

scholarly journals Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs

2021 ◽  
Vol 22 (2) ◽  
pp. 933
Author(s):  
Maria E. Street ◽  
Karine Audouze ◽  
Juliette Legler ◽  
Hideko Sone ◽  
Paola Palanza
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Current Understanding ◽  
Future Research ◽  
Developmental Origins ◽  
Research Needs ◽  
Important Class ◽  
Testing Strategies ◽  
Endocrine Disrupting ◽  
Health And Disease

Endocrine disrupting chemicals (EDCs) are exogenous chemicals which can disrupt any action of the endocrine system, and are an important class of substances which play a role in the Developmental Origins of Health and Disease (DOHaD) [...]

scholarly journals Role of Insulin in Health and Disease: An Update

2021 ◽  
Vol 22 (12) ◽  
pp. 6403
Author(s):  
Md Saidur Rahman ◽  
Khandkar Shaharina Hossain ◽  
Sharnali Das ◽  
Sushmita Kundu ◽  
Elikanah Olusayo Adegoke ◽  
...  
Keyword(s):  
Insulin Signaling ◽  
Basic Research ◽  
Future Research ◽  
Protective Effects ◽  
Glucose Levels ◽  
Physiological Processes ◽  
Blood Glucose Levels ◽  
Wide Range ◽  
Health And Disease

Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose levels; insulin acts via an anabolic pathway, while glucagon performs catabolic functions. Insulin regulates glucose levels in the bloodstream and induces glucose storage in the liver, muscles, and adipose tissue, resulting in overall weight gain. The modulation of a wide range of physiological processes by insulin makes its synthesis and levels critical in the onset and progression of several chronic diseases. Although clinical and basic research has made significant progress in understanding the role of insulin in several pathophysiological processes, many aspects of these functions have yet to be elucidated. This review provides an update on insulin secretion and regulation, and its physiological roles and functions in different organs and cells, and implications to overall health. We cast light on recent advances in insulin-signaling targeted therapies, the protective effects of insulin signaling activators against disease, and recommendations and directions for future research.

scholarly journals Developmental Origins of Kidney Disease: Why Oxidative Stress Matters?

Antioxidants ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 33
Author(s):  
Chien-Ning Hsu ◽  
You-Lin Tain
Keyword(s):  
Oxidative Stress ◽  
Kidney Disease ◽  
Current Knowledge ◽  
Future Research ◽  
Antioxidant Systems ◽  
Developmental Origins ◽  
Adult Onset ◽  
Functional Changes ◽  
Health And Disease ◽  
Developing Kidney

The “developmental origins of health and disease” theory indicates that many adult-onset diseases can originate in the earliest stages of life. The developing kidney has emerged as being particularly vulnerable to adverse in utero conditions leading to morphological and functional changes, namely renal programming. Emerging evidence indicates oxidative stress, an imbalance between reactive oxygen/nitrogen species (ROS/RNS) and antioxidant systems, plays a pathogenetic role in the developmental programming of kidney disease. Conversely, perinatal use of antioxidants has been implemented to reverse programming processes and prevent adult-onset diseases. We have termed this reprogramming. The focus of this review is twofold: (1) To summarize the current knowledge on oxidative stress implicated in renal programming and kidney disease of developmental origins; and (2) to provide an overview of reprogramming effects of perinatal antioxidant therapy on renal programming and how this may prevent adult-onset kidney disease. Although early-life oxidative stress is implicated in mediating renal programming and adverse offspring renal outcomes, and animal models provide promising results to allow perinatal antioxidants applied as potential reprogramming interventions, it is still awaiting clinical translation. This presents exciting new challenges and areas for future research.

Internal marketing of attitudes in Caribbean tourism

2003 ◽  
Vol 15 (3) ◽  
pp. 161-166 ◽  
Author(s):  
Anne P. Crick
Keyword(s):  
Internal Marketing ◽  
Marketing Strategies ◽  
Future Research ◽  
The People ◽  
The Matrix ◽  
The Caribbean ◽  
Caribbean Tourism ◽  
The Way

Tourism is the mainstay of the Caribbean and the attitude of the people in the region may have a significant impact on the success of the industry. This paper analyzes the way in which tourism authorities of three Caribbean destinations have internally marketed tourism to their host populations in order to encourage the desired attitudinal expressions. A matrix of five possible responses to tourism was developed and each of the three countries was found to occupy different positions in the matrix. An analysis of the internal marketing strategies determined that the countries adopted different approaches based on their particular challenges but none of the approaches had achieved lasting success. The study concludes with recommendations for future research.

Blockchain as supply chain technology: considering transparency and security

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Pei Xu ◽  
Joonghee Lee ◽  
James R. Barth ◽  
Robert Glenn Richey
Keyword(s):  
Supply Chain ◽  
Text Mining ◽  
Information Security ◽  
Design Methodology ◽  
Use Cases ◽  
Future Research ◽  
Content Type ◽  
Blockchain Technology ◽  
Twitter Data ◽  
The Way

PurposeThis paper discusses how the features of blockchain technology impact supply chain transparency through the lens of the information security triad (confidentiality, integrity and availability). Ultimately, propositions are developed to encourage future research in supply chain applications of blockchain technology.Design/methodology/approachPropositions are developed based on a synthesis of the information security and supply chain transparency literature. Findings from text mining of Twitter data and a discussion of three major blockchain use cases support the development of the propositions.FindingsThe authors note that confidentiality limits supply chain transparency, which causes tension between transparency and security. Integrity and availability promote supply chain transparency. Blockchain features can preserve security and increase transparency at the same time, despite the tension between confidentiality and transparency.Research limitations/implicationsThe research was conducted at a time when most blockchain applications were still in pilot stages. The propositions developed should therefore be revisited as blockchain applications become more widely adopted and mature.Originality/valueThis study is among the first to examine the way blockchain technology eases the tension between supply chain transparency and security. Unlike other studies that have suggested only positive impacts of blockchain technology on transparency, this study demonstrates that blockchain features can influence transparency both positively and negatively.

Organizational change for sustainability education: a case study of one university’s efforts to create and implement institution-wide sustainability competencies

2021 ◽  
Vol 22 (3) ◽  
pp. 497-515
Author(s):  
Vanessa R. Levesque ◽  
Cameron P. Wake
Keyword(s):  
Organizational Change ◽  
Sustainability Education ◽  
Similar Process ◽  
Future Research ◽  
Content Type ◽  
Institutional Level ◽  
Institutional Sustainability ◽  
Context Specific ◽  
The University

Purpose The purpose of this study is to examine how the process of creating and implementing sustainability competencies across a university illuminate dynamics of organizational change. The push to advance education for sustainable development in higher education will likely require transformation of existing policies and practices. A set of shared sustainability competencies could guide the integration of sustainability throughout an institution. Design/methodology/approach This paper reports on a case study of one US university, the University of New Hampshire (UNH) that developed institutional-level sustainability competencies. The process used to create and implement sustainability competencies is outlined, and key factors that influenced the associated organizational change are identified. Findings Very few US universities have institutional-level sustainability competencies. At UNH, drivers of organizational change such as overcoming disciplinary boundaries, developing a common vision and working from the bottom-up enabled the creation of institutional sustainability competencies, but the same processes were not enough to drive deeper implementation of the competencies. Originality/value This paper not only identifies the context-specific drivers of the development of institutional sustainability competencies, but also identifies universal themes that can be applied to other institutions embarking on a similar process. Additionally, this paper serves as a foundation for future research exploring how the process of creating institutional sustainability competencies may be linked to how effective they are in shaping subsequent sustainability education.

Epigenetics and DOHaD: how translation to predictive testing will require a better public understanding

2021 ◽  
pp. 1-7
Author(s):  
Fiona Lynch ◽  
Sharon Lewis ◽  
Ivan Macciocca ◽  
Jeffrey M. Craig
Keyword(s):  
Health Professionals ◽  
Early Life ◽  
Predictive Testing ◽  
Public Understanding ◽  
Future Research ◽  
Developmental Origins ◽  
Needed Information ◽  
Genes And Environment ◽  
Increased Risk ◽  
Health And Disease

Abstract Epigenetics is likely to play a role in the mediation of the effects of genes and environment in risk for many non-communicable diseases (NCDs). The Developmental Origins of Health and Disease (DOHaD) theory presents unique opportunities regarding the possibility of early life interventions to alter the epigenetic makeup of an individual, thereby modifying their risk for a variety of NCDs. While it is important to determine how we can lower the risk of these NCDs, it is equally important to understand how the public’s knowledge and opinion of DOHaD and epigenetic concepts may influence their willingness to undertake such interventions for themselves and their children. In this review, we provide an overview of epigenetics, DOHaD, NCDs, and the links between them. We explore the issues surrounding using epigenetics to identify those at increased risk of NCDs, including the concept of predictive testing of children. We also outline what is currently understood about the public’s understanding and opinion of epigenetics, DOHaD, and their relation to NCDs. In doing so, we demonstrate that it is essential that future research explores the public’s awareness and understanding of epigenetics and epigenetic concepts. This will provide much-needed information which will prepare health professionals for the introduction of epigenetic testing into future healthcare.

scholarly journals The Lipocalin Apolipoprotein D Functional Portrait: A Systematic Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Diego Sanchez ◽  
Maria D. Ganfornina
Keyword(s):  
Systematic Review ◽  
Physiological Function ◽  
Physiological Role ◽  
Future Research ◽  
Lipid Management ◽  
Health And Disease ◽  
Apolipoprotein D ◽  
Extracellular Structures ◽  
Cellular Compartments

Apolipoprotein D is a chordate gene early originated in the Lipocalin protein family. Among other features, regulation of its expression in a wide variety of disease conditions in humans, as apparently unrelated as neurodegeneration or breast cancer, have called for attention on this gene. Also, its presence in different tissues, from blood to brain, and different subcellular locations, from HDL lipoparticles to the interior of lysosomes or the surface of extracellular vesicles, poses an interesting challenge in deciphering its physiological function: Is ApoD a moonlighting protein, serving different roles in different cellular compartments, tissues, or organisms? Or does it have a unique biochemical mechanism of action that accounts for such apparently diverse roles in different physiological situations? To answer these questions, we have performed a systematic review of all primary publications where ApoD properties have been investigated in chordates. We conclude that ApoD ligand binding in the Lipocalin pocket, combined with an antioxidant activity performed at the rim of the pocket are properties sufficient to explain ApoD association with different lipid-based structures, where its physiological function is better described as lipid-management than by long-range lipid-transport. Controlling the redox state of these lipid structures in particular subcellular locations or extracellular structures, ApoD is able to modulate an enormous array of apparently diverse processes in the organism, both in health and disease. The new picture emerging from these data should help to put the physiological role of ApoD in new contexts and to inspire well-focused future research.

scholarly journals A Methodology for Architecture Theory and Practices Research: Design Practices Evaluation Studio

2019 ◽  
Vol 8 (4) ◽  
pp. 195
Author(s):  
Fathi Bashier
Keyword(s):  
Knowledge Base ◽  
Design Process ◽  
Design Theory ◽  
Design Research ◽  
Future Research ◽  
Design Problems ◽  
Need To Evaluate ◽  
Research Goal ◽  
Architecture Theory ◽  
The Way

This article presents the initial findings of the design research carried out during the last semester by the master of architecture students at Wollega University, Ethiopia. The research goal is the creation of new knowledge to improve the design process. The dissatisfaction with the outcomes of the conventional design approach has led to rising concern and growing awareness of the need to evaluate design outcomes and to learn from the failure. That inadequate understanding of design problems leads frequently to design failure suggests that the evaluation of design outcomes can be made by assessing the way architects develop understanding of design problems, and how they use that understanding for developing knowledge base of the design process. The assumption is that architects’ understanding of design problems can be assessed by examining the way data is used for developing the knowledge base of the design process. The students surveyed the architects’ views in order to produce knowledge, which can be used to develop methods for discovering how inadequate data contributes to miss-informed design decisions; and methods for assessing the architects’ understanding of design problems. In this article the survey findings are analyzed and documented; and, the way the insight drawn from the inquiry can be used in future research for developing design theory, is discussed.Keywords: design outcomes, failure, evaluation, questionnaire, analyze

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