scholarly journals Classification of advanced methods for evaluating neurotoxicity

2021 ◽  
Author(s):  
Kyung-Seok Han ◽  
Dong Ho Woo
Keyword(s):  
Animal Model ◽  
Private Sector ◽  
Drug Research ◽  
Alternative Methods ◽  
Research Institutes ◽  
Related Drug ◽  
Cell Circuit ◽  
And Behavior ◽  
A Current

Abstract Purpose of review As fields such as neurotoxicity evaluation and neuro-related drug research are increasing in popularity, there is a demand for the expansion of neurotoxicity research. Currently, neurotoxicity is assessed by measuring changes in weight and behavior. However, measurement of such changes does not allow the detection of subtle and inconspicuous neurotoxicity. In this review, methods for advancing neurotoxicity research are divided into molecule-, cell-, circuit-, and animal model-based methods, and the results of previous studies assessing neurotoxicity are provided and discussed. Recent findings In coming decades, cooperation between universities, national research institutes, industrial research institutes, governments, and the private sector will become necessary when identifying alternative methods for neurotoxicity evaluation, which is a current goal related to improving neurotoxicity assessment and an appropriate approach to neurotoxicity prediction. Many methods for measuring neurotoxicity in the field of neuroscience have recently been reported. This paper classifies the supplementary and complementary experimental measures for evaluating neurotoxicity.

THE ISSUE OF CONTEXT AND SOCIOLOGICAL POETICS OF THE "BAKHTIN'S CIRCLE"

2020 ◽  
pp. 10-18
Author(s):  
Grigorii I. Nesmeyanov ◽  
Keyword(s):  
Discourse Analysis ◽  
Intellectual History ◽  
Literary Theory ◽  
Philosophical Hermeneutics ◽  
Research Fields ◽  
Interdisciplinary Field ◽  
Scientific Disciplines ◽  
Methodological Approaches ◽  
A Current

The article formulates main questions related to the concept of context. The issue of context is considered as a current-day interdisciplinary field of research. There are many definitions of context in dictionaries and in various humanities (including scientific disciplines). In connection with that issue various methodological approaches arise in the humanities, which can be designated by the umbrella term “contextual”. By the example of one of such approaches to the sociological poetics of the “Bakhtin’s circle”, the author substantiates the possibility of creating an interdisciplinary classification of contextual approaches. That classification may include scientific developments of different years and research fields, including: philosophical hermeneutics, a number of approaches to the Russian and foreign literary theory (M.M. Bakhtin, Yu.M. Lotman, B.M. Eichenbaum, F. Moretti, A. Compagnon, etc.), intellectual history, discourse analysis, etc.

130 Utilization of Nutrack to Assess Variance Components and Heritability of Activity Traits

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 17-17
Author(s):  
Lexi M Ostrand ◽  
Melanie D Trenhaile-Grannemann ◽  
Garrett See ◽  
Ty B Schmidt ◽  
Eric Psota ◽  
...  
Keyword(s):  
Animal Model ◽  
Mixed Models ◽  
Variance Components ◽  
Average Speed ◽  
Genetic Variances ◽  
Sow Longevity ◽  
Selection Decisions ◽  
Recorded Data ◽  
Residual Variances ◽  
And Behavior

Abstract Overall activity and behavior are integral components of sows remaining productive in the herd. This investigation studied overall activity of group housed replacement gilts and the heritability of various activity traits. Beginning around 20 wk of age, video recorded data of approximately 75 gilts/group for a total of 2,378 gilts over 32 groups was collected for 7 consecutive d using the NUtrack System, which tracks distance travelled (m), avg speed (m/s), angle rotated (degrees), and time standing (s), sitting (s), eating (s), and laying (s). The recorded phenotypes were standardized to the distribution observed within a pen for each group. The final values used for analysis were the average daily standardized values. Data were analyzed using mixed models (RStudio V 1.2.5033) including effects of sire, dam, dam’s sire and dam, dam’s grandsire and granddam, farrowing group, barn, pen, and on-test date. Sire had an effect on every activity trait P < 0.001), and dam had an effect on average speed (P < 0.001). The dam’s sire had an effect on all activity traits (P < 0.001) and the dam’s grandsire had an effect on average speed (P < 0.001). Heritabilities and variance components of activity traits were estimated in ASReml 4 using an animal model with a two-generation pedigree. Genetic variances are 0.17 +/- 0.029, 0.19 +/- 0.034, and 0.11 +/- 0.024, residual variances are 0.37 +/- 0.023, 0.41 +/- 0.027, and 0.41 +/- 0.022, phenotypic variances are 0.54 +/- 0.018, 0.60 +/- 0.020, and 0.52 +/- 0.016, and heritabilities are 0.32 +/- 0.048, 0.32 +/- 0.049, and 0.21 +/- 0.044 for average speed, distance, and lie respectively. NUtrack offers potential to aid in selection decisions. Given the results presented herein, continued investigation into these activity traits and their association with sow longevity is warranted.

Conditions for the Application of Alternative Methods of Resolving Criminal Conflicts to Protect Public Interests

2021 ◽  
pp. 50-53
Author(s):  
Eduard S. Kaminsky ◽  
Keyword(s):  
Alternative Methods ◽  
Criminal Prosecution ◽  
Criminal Proceedings ◽  
Public Interests ◽  
Alternative Measures ◽  
And Behavior

Public interests in criminal proceedings can be served not only through the perpetrator’s conviction, but also through alternative measures for resolving criminal conflicts. Their expediency is due, inter alia, to the fact that they are aimed at minimizing criminal repression in situations when society is not interested in the conviction and punishment of the offender who made amends for the damage caused. Such measures significantly rationalize the procedural resources used in this case, expedite criminal proceedings, and prevent the perpetrator’s stigmatization. Alternative methods can be used due to a set of conditions related to the committed act: offender’s personality and behavior, procedural expediency and organization of criminal prosecution, rationalization, acceleration, and consent of the parties and society.

Brachydactyly and Pseudo-Pseudohypoparathyroidism

1968 ◽  
Vol 17 (3) ◽  
pp. 428-438 ◽  
Author(s):  
Keith P. Hertzog
Keyword(s):  
Middle Phalanx ◽  
Albright’S Hereditary Osteodystrophy ◽  
Albright's Hereditary Osteodystrophy ◽  
Epiphyseal Union ◽  
A Current ◽  
Little Finger

SummaryShortened fifth middle phalanges, defined as being less than half the length of the fourth middle phalanx, were found in 12 of 96 Philadelphia Chinese and none of 200 Philadelphia Negro children. At least nine of these can be characterized as having stunted cratered diaphyses, with precocious cone epiphyses, which underwent very early epiphyseal union.The possible extension of a current vascular hypothesis for cone epiphyses, to include inherited osseous variation in this region of the little finger, is discussed.A classification of metacarpal brachydactyly is presented, with the intention of investigating the syndrome of pseudopseudohypoparathyroidism. Reports of cases which have been held to negate the theory that Albright's hereditary osteodystrophy is sex linked were found to have the pattern of phalangeal shortening exhibited by one of the forms of metacarpal brachydactyly. This finding lends support to the contention of others that these reported cases are not pseudo-pseudohypoparathyroidism.

scholarly journals Analysis of Presupposition in Cosmetics Advertisements

2020 ◽  
pp. 142-146
Author(s):  
Kang Lihan
Keyword(s):  
Systemic Functional Grammar ◽  
Fashion Magazines ◽  
Significant Difference ◽  
Food Advertisements ◽  
Advertising Language ◽  
And Behavior ◽  
The Relationship ◽  
Chinese And English ◽  
Pragmatic Presupposition

Pragmatic presupposition focuses on the study of the relationship between the speaker and the hearer at the time of communication and the language they used. It can effectively serve advertising language from the linguistic field. In other words, pragmatic presupposition can meet some of the requirements of the advertisements. Nowadays people confront a variety of commercial advertisements, such as food advertisements, drink advertisements, digital product and cosmetic advertisements, etc. In fact, advertising language is the core factor which determines the success or failure of one commercial advertisement. Most domestic and overseas scholars have studied advertising language through cooperative principles，rhetoric and systemic-functional grammar, etc. However, they do not pay enough attention to the pragmatic presupposition manifested in both Chinese and English cosmetic advertisements. Therefore, this paper conducts a comparative study based on previous studies of pragmatic presupposition with new data. The data analyzed in this study are taken from some major fashion magazines in America, United Kingdom and China, such as VOGUE, Cosmopolitan，Trends health，etc. These cosmetic advertisements were advertised in the recent 20 years. Through the analysis, it is found that there is no significant difference between Chinese and English cosmetic advertisements in terms of types of pragmatic presupposition manifested. Both Chinese and English advertisers mainly adopt four types of pragmatic presupposition: existential presupposition, factive presupposition, state presupposition and behavior presupposition, and state presupposition takes up the largest proportion. The present study provides a more comprehensive analysis of pragmatic presupposition and classification of it. In addition, the results of this study also could help advertisers and consumers increase their mutual understanding.

scholarly journals Classification of Evaluation Methods for the Effective Assessment of Simulation Games: Results from a Literature Review

2019 ◽  
Vol 9 (1) ◽  
pp. 19 ◽  
Author(s):  
Niluefer Deniz Faizan ◽  
Alexander Löffler ◽  
Robert Heininger ◽  
Matthias Utesch ◽  
Helmut Krcmar
Keyword(s):  
Literature Review ◽  
Current Trend ◽  
Evaluation Methods ◽  
Simulation Game ◽  
Simulation Games ◽  
Research Papers ◽  
Free Environment ◽  
Effective Assessment ◽  
A Current

As a current trend in teaching, simulation games play an active and important role in the area of technology-based education. Simulation games create an envi-ronment for scholars to solve real-world problems in a risk-free environment. Therefore, they aim to increase the knowledge base as well as learning experienc-es for students. However, assessing the effectiveness of a simulation game is necessary to optimize elements of the game and increase their learning effect. In order to achieve this aim, different evaluation methods exist, which do not always involve all phases when running a simulation game. In this study, we conduct a literature review to analyze evaluation methods for three phases of simulation games: pre-game, in-game, and post-game. Thirty-one peer-reviewed research papers met specified selection criteria and we classified them according to a di-dactic framework that illustrates four phases of running simulation games: Prepa-ration, Introduction, Interaction and Conclusion phase. Based on the results, we provide a concrete evaluation strategy that will be a guide to assess simulation games during all phases. This study contributes to theory by providing an over-view of evaluation methods for the assessment of simulation games within the different game phases. It contributes to practice by providing a concrete evalua-tion strategy that can be adapted and used to assess simulation games.

scholarly journals ICF Personal Factors Strengthen Commitment to Person-Centered Rehabilitation – A Scoping Review

2021 ◽  
Vol 2 ◽  
Author(s):  
Maarit Karhula ◽  
Sari Saukkonen ◽  
Essi Xiong ◽  
Anu Kinnunen ◽  
Tuija Heiskanen ◽  
...  
Keyword(s):  
Scoping Review ◽  
International Classification Of Functioning ◽  
Personal Factors ◽  
Inclusion Criteria ◽  
Physical Context ◽  
Holistic Understanding ◽  
Socio Demographic Factors ◽  
And Behavior

Background: The International Classification of Functioning, Disability and Health (ICF) classification is a biopsychosocial frame of reference that contributes to a holistic understanding of the functioning of a client and the factors involved. Personal factors (PFs) are not currently classified in the ICF due to large societal and cultural diversity and lack of clarity in the scope of such factors.Aims: To ascertain which factors in the ICF classification have been defined as PFs in different studies and what conclusions have been drawn on their role in the ICF classification.Methods: The study was a scoping review. A systematic search for articles published in 2010–2020 was performed on the Cinahl, Pubmed, ScienceDirect, and Sport Discus databases. The PFs specified in the articles were classified according to the seven categories proposed by Geyh et al. socio-demographic factors; position in the immediate social and physical context; personal history and biography; feelings; thoughts and beliefs; motives; and general patterns of experience and behavior.Results: The search yielded 1,988 studies, of which 226 met the inclusion criteria. The studies had addressed a wide variety of PFs that were linked to all seven categories defined by Geyh et al. Some studies had also defined PFs that were linkable to other components of the ICF or that did not describe functioning. Approximately 22% (51) of the studies discussed the role of PFs in rehabilitation.Conclusions: The range of PFs in the ICF classification addressed in the reviewed studies is wide. PFs play an important role in rehabilitation. However, according to the reviewed studies, a more precise coding of PFs is not yet warranted.

scholarly journals ON THE PROBLEM OF THE RELATIONSHIP BETWEEN SECULARISM AND RELIGIOSITY

Adam alemi ◽  
2021 ◽  
Vol 90 (4) ◽  
pp. 173-180
Author(s):  
D. Kussainov ◽  
◽  
M. Nurov ◽  
Keyword(s):  
Religious Life ◽  
Religious Organization ◽  
Religious Behavior ◽  
Ethical Assessment ◽  
Scope Of Application ◽  
Qualitative State ◽  
And Behavior ◽  
The Relationship ◽  
Contextual Meaning

The purpose of the article is to study the relationship between secularism and religiosity, to reveal the internal structure of their contextual meaning. The first part of the article examines the place of the principle of secularism in the system of spiritual and religious values. Secularization, secular, and references to secularization in most cases may be unclear. Currently, there is no easy way to standardize each term by associating it with only one concept. But the fact that different terms have a single linguistic root should not hide that they work in different conceptual frameworks with different histories. Although they sometimes inform each other, we must distinguish between the scope of application, such as a reference to temporary life or secular life, Constitutions that separate religion from politics, and the possible collapse of religion. The second part reveals the place of the concept of religiosity in the system of philosophical knowledge. The inconsistency and multilevel nature of religious life can be traced from the earliest time, primarily in religious analysis. The problem of determining the qualitative state of a believing person, aspirations, values, optimality of human behavior is reflected in this ideological scientific search for determining her religiosity, classification of types religion, religious behavior. Therefore, to date, the authors have not been able to avoid, firstly, an ethical assessment of the situations under consideration, and secondly, not to link the analysis conducted with the tasks and activities of a religious organization. The problem of religiosity in the consciousness and behavior of people, radical changes took place in society, which led to the emergence of new religious trends and changes in traditional trends. The terms denoting the main phenomena in religious life have undergone changes following religious life.

scholarly journals ANALYSIS OF PHYSICS LEARNING MATTER INTEGRATED DISASTER IN WEST SUMATERA

2019 ◽  
Vol 6 (2) ◽  
pp. 114
Author(s):  
Muhammad Arif ◽  
Dina Syaflita
Keyword(s):  
Natural Disasters ◽  
Natural Disaster ◽  
Teaching Material ◽  
Learning Material ◽  
Physics Learning ◽  
Descriptive Research ◽  
Prone Area ◽  
Almost All ◽  
And Behavior

West Sumatera is a disaster prone area, especially disasters such as earthquakes, landslides, floods,tsunamis, and volcanoes. The high potential of natural disasters has consequences for the importance ofdisaster mitigation efforts. School is an effective tool in shaping of mindset and behavior of students. Oneeffort that can be done is integrate the topic of natural disaster into learning, especially physics learning.Integrating physical matter in learning requires material analysis aimed at making disaster topics integratedin accordance with learning topic. The type of this research is descriptive research. The results of theresearch indicate that an analysis of the relevance of learning material to the topic of integrated disastersneeds to be done so that the integration between teaching material and the topic of disasters is carried out inharmony. Almost all physics learning material can be integrated with the topic of disasters that often hit theWest Sumatra region. The classification of material on the topic of integrated disasters is classified into factand metacognitive material.

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