scholarly journals Vitamin D Deficiency and Pain: Clinical Evidence of Low Levels of Vitamin D and Supplementation in Chronic Pain States

2015 ◽  
Vol 4 (1) ◽  
pp. 67-87 ◽  
Author(s):  
Elspeth E. Shipton ◽  
Edward A. Shipton
Keyword(s):  
Vitamin D ◽  
Chronic Pain ◽  
Vitamin D Deficiency ◽  
Clinical Evidence ◽  
Low Levels

scholarly journals Vitamin D Deficiency Induces Chronic Pain and Microglial Phenotypic Changes in Mice

2021 ◽  
Vol 22 (7) ◽  
pp. 3604
Author(s):  
Nicola Alessio ◽  
Carmela Belardo ◽  
Maria Consiglia Trotta ◽  
Salvatore Paino ◽  
Serena Boccella ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Vitamin D ◽  
Chronic Pain ◽  
Vitamin D Deficiency ◽  
Morphological Analysis ◽  
Pain Perception ◽  
Ex Vivo ◽  
Ros Generation ◽  
Peroxisome Proliferator ◽  
Neuroprotective Effects

The bioactive form of vitamin .D, 1,25-dihydroxyvitamin D (1,25D3), exerts immunomodulatory actions resulting in neuroprotective effects potentially useful against neurodegenerative and autoimmune diseases. In fact, vitamin D deficiency status has been correlated with painful manifestations associated with different pathological conditions. In this study, we have investigated the effects of vitamin D deficiency on microglia cells, as they represent the main immune cells responsible for early defense at central nervous system (CNS), including chronic pain states. For this purpose, we have employed a model of low vitamin D intake during gestation to evaluate possible changes in primary microglia cells obtained from postnatal day(P)2-3 pups. Afterwards, pain measurement and microglia morphological analysis in the spinal cord level and in brain regions involved in the integration of pain perception were performed in the parents subjected to vitamin D restriction. In cultured microglia, we detected a reactive—activated and proliferative—phenotype associated with intracellular reactive oxygen species (ROS) generation. Oxidative stress was closely correlated with the extent of DNA damage and increased β-galactosidase (B-gal) activity. Interestingly, the incubation with 25D3 or 1,25D3 or palmitoylethanolamide, an endogenous ligand of peroxisome proliferator-activated-receptor-alpha (PPAR-α), reduced most of these effects. Morphological analysis of ex-vivo microglia obtained from vitamin-D-deficient adult mice revealed an increased number of activated microglia in the spinal cord, while in the brain microglia appeared in a dystrophic phenotype. Remarkably, activated (spinal) or dystrophic (brain) microglia were detected in a prominent manner in females. Our data indicate that vitamin D deficiency produces profound modifications in microglia, suggesting a possible role of these cells in the sensorial dysfunctions associated with hypovitaminosis D.

scholarly journals Vitamin D Deficiency Is a Potential Risk for Blood Pressure Elevation and the Development of Hypertension

Medicina ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 1297
Author(s):  
Yusuf Karadeniz ◽  
Fatma Özpamuk-Karadeniz ◽  
Süleyman Ahbab ◽  
Esra Ataoğlu ◽  
Günay Can
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Blood Pressure Elevation ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Low Levels ◽  
Optimal Blood Pressure ◽  
Hypertension Development

Background and objectives: Hypertension is a global health problem and a major risk factor for cardiovascular diseases. Vitamin D deficiency is closely related to high blood pressure and the development of hypertension. This study investigated the relationship between the vitamin D and blood pressure status in healthy adults, and their 8-year follow-up was added. Materials and Methods: A total of 491 healthy middle-aged participants without any chronic illness, ages 21 to 67 at baseline, were divided into two groups as non-optimal blood pressure (NOBP) and optimal blood pressure (OBP). NOBP group was divided into two subgroups: normal (NBP) and high normal blood pressure (HNBP). Serum 25-hydroxy vitamin D levels were measured with the immunoassay method. 8-year follow-up of the participants was added. Results: The average vitamin D level was detected 32.53 ± 31.50 nmol/L in the OBP group and 24.41 ± 14.40 nmol/L in the NOBP group, and a statistically significant difference was found (p < 0.001). In the subgroup analysis, the mean vitamin D level was detected as 24.69 ± 13.74 and 24.28 ± 14.74 nmol/L in NBP and HNBP, respectively. Together with parathyroid hormone, other metabolic parameters were found to be significantly higher in the NOBP. During a median follow-up of 8 years, higher hypertension development rates were seen in NOBP group (p < 0.001). Conclusions: The low levels of vitamin D were significantly associated with NBP and HNBP. The low levels of vitamin D were also associated with the development of hypertension in an 8-year follow-up.

scholarly journals Vitamin D deficiency and associated factors in Jordan

2019 ◽  
Vol 7 ◽  
pp. 205031211987615
Author(s):  
Mohammed El-Khateeb ◽  
Yousef Khader ◽  
Anwer Batieha ◽  
Hashem Jaddou ◽  
Dana Hyassat ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Representative Sample ◽  
Associated Factors ◽  
Vitamin D Status ◽  
Face To Face ◽  
Low Level ◽  
Health Authorities ◽  
Low Levels ◽  
National Representative Sample

Background: In Jordan, many studies reported various rates of vitamin D deficiency and insufficiency among different groups. This study aimed to determine the prevalence of low vitamin D level among Jordanian adults and determine its association with selected variables. Methods: The vitamin D level was assessed in a national representative sample of 4056 subjects aged >17 years. The study involved face-to-face interviews with the subjects and measurement of serum 25(OH)D. Low vitamin D level was defined as 25(OH)D < 30 ng/mL. Deficiency was defined as 25(OH)D < 20 ng/mL, and insufficiency was defined as 25(OH)D level of 20–30 ng/mL. Results: The overall prevalence of low vitamin D status (25(OH)D < 30 ng/mL) was 89.7%, with higher prevalence in males (92.4%) than in females (88.6%). Vitamin D was sufficient in 7.6% of males, insufficient in 38.4% of males, and deficient in 54% of males. Among females, vitamin D was insufficient in 10.1% and deficient in 78.5%. The prevalence of vitamin D deficiency was much higher in females than in males ( p = 0.001). The only variables that were significantly associated with low level of vitamin D were gender, age, obesity, and employment. Conclusion: The prevalence of low vitamin D level is extremely high in Jordan. Age, gender, obesity, and unemployment were associated with low levels of vitamin D. Health authorities in Jordan need to increase the level of awareness about vitamin D deficiency and its prevention, particularly among women.

scholarly journals Bronchial asthma and the vitamin D deficiency.

2018 ◽  
Vol 96 (7) ◽  
pp. 590-596 ◽  
Author(s):  
D. S. Fomina ◽  
T. N. Markova ◽  
V. V. Sadovskaya
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bronchial Asthma ◽  
Inflammatory Diseases ◽  
Positive Effects ◽  
Low Levels ◽  
Tissue Cells ◽  
Relationship Of ◽  
The Relationship

The variety of tissue cells express receptors of vitamin D. The possible causative connection between lack of vitamin D and a number of inflammatory diseases such as bronchial asthma has stimulated interest in the potentially positive effects of vitamin D in the theraputic schemes. Conflicting data was demonstrated by numerous studies concerning the relationship of vitamin D and development of asthma . Most of them stress attention on the lack of studies with targeting population excluding subclasters and phenotypes of bronchial asthma, especially groups associated with low levels of vitamin D obesity, COPD and asthma, atopic patients. The question of prescribing of vitamin D in asthma, in the case of laboratory-proven deficiency or lack of vitamin D can be an option in therapy.

scholarly journals Association between Vitamin D Level, Vitamin D Receptor Gene Polymorphisms, and Cathelicidin Level to Acute Lower Respiratory Infections, and the Picture of Exon 2-Vitamin D Receptor Gene Polymorphisms in Children under 5 years old

2020 ◽  
Vol 8 (B) ◽  
pp. 536-541
Author(s):  
Ida Bagus Subanada ◽  
I. Made Bakta ◽  
I. Wayan Bikin Suryawan ◽  
Putu Astawa ◽  
Bagus Komang Satriyasa
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Gene Polymorphism ◽  
Vitamin D Deficiency ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Vdr Gene ◽  
Exon 2 ◽  
Vdr Gene Polymorphism ◽  
Low Levels

BACKGROUND: Acute lower respiratory infections (ALRIs) are infectious diseases with high morbidity and mortality in children under five. There are several factors associated with ALRIs (bronchiolitis or pneumonia) that have been established. In recent years, Vitamin D level, Vitamin D receptor (VDR) gene polymorphism, and cathelicidin level are also associated with ALRIs. Until now, there was no VDR gene other than Fok1 identified at the exon 2-VDR gene. OBJECTIVE: The objective of this study was to establish whether Vitamin D deficiency, ff genotype-Fok1 VDR gene polymorphism, and low levels of cathelicidin are risk factors of ALRIs and to determine the pictures of exon 2-VDR genes polymorphisms in children under five. METHODS: A matched case–control study was conducted in children under the age of five. There were 35 subjects who suffered from bronchiolitis or pneumonia and 35 healthy subjects as a control group. These groups were matched based on age and gender, and the children originated from the same neighborhood. Level of 25(OH) D, exon 2-VDR genes sequencing, and level of cathelicidin were investigated. Data were analyzed by the Chi-square test or Fisher exact test and logistic regression with a significant level of p < 0.05. RESULTS: This study found that Vitamin D deficiency and low levels of cathelicidin were risk factors of ALRIs (odds ratio [OR] = 5.82 [95% confidence interval [CI] = 1.71–19.89], p = 0.005 and OR = 4.07 [95% CI = 1.10–15.12], p = 0.036, respectively), while ff genotype-Fok1 VDR gene polymorphism was not (OR = 1.12 [95% CI = 0.26–4.86], p = 1.000). Fok1 VDR gene polymorphism was the picture of exon 2-VDR gene polymorphisms. CONCLUSION: It is concluded that Vitamin D deficiency and low levels of cathelicidin are risk factors, but ff genotype-Fok1 VDR gene polymorphism is not a risk factor of ALRIs. Fok1 VDR gene polymorphism is the picture of exon 2-VDR genes polymorphisms.

Role of vitamin D deficiency in the development obstetric and perinatal complications (Literature review)

2018 ◽  
pp. 93-96
Author(s):  
O.O. Korchinska ◽  
◽  
N.O. Loya ◽  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Birth Defects ◽  
Premature Birth ◽  
Geographical Location ◽  
Perinatal Complications ◽  
Adverse Health Outcomes ◽  
High Prevalence ◽  
Low Levels

The article gives an overview of the literature that shows the high prevalence of deficiency and insufficiency of vitamin D in pregnant women in countries irrespective of their geographical location, leading to adverse health outcomes, such as miscarriage, premature birth defects, preeclampsia, gestational diabetes, risk Caesarean section, low birth weight and an increase in the number of autoimmune diseases associated with low levels of vitamin D during pregnancy. Key words: vitamin D deficiency, pregnancy, obstetric complications, perinatal complications.

scholarly journals Vitamin D deficiency in community-acquired pneumonia: low levels of 1,25(OH)2 D are associated with disease severity

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Mathias W Pletz ◽  
◽  
Christoph Terkamp ◽  
Ulrike Schumacher ◽  
Gernot Rohde ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Disease Severity ◽  
Community Acquired Pneumonia ◽  
Low Levels

scholarly journals STUDY OF VITAMIN D DEFICIENCY IN PATIENTS WITH DEPRESSIONWHETHER IT IS THE REASON FOR THE HIGH RATES OF SOMATIC PRESENTATION OF DEPRESSION.

2021 ◽  
pp. 1-3
Author(s):  
Debasish Sanyal ◽  
Priya Mukherjee
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Somatic Symptom ◽  
The Body ◽  
Control Group ◽  
Cross Sectional ◽  
Study Materials ◽  
The Mean ◽  
Low Levels ◽  
The Difference

Background: Several studies have shown a relationship between depression and low levels of Vitamin D in the body. At the same time, somatisation is found to be a significant complaint in many patients of depression. Whether somatisation has any relationship with the low levels of Vitamin D, needs further research. Aims: To compare the prevalence of Vitamin D deficiency between depressed and non depressed subjects, and see if somatic presentation of depression has any correlate with Vitamin D deficiency. Design: Observational, cross-sectional, hospital- based study. Materials & Methods: The study was conducted in the Department of Psychiatry, in a Private Hospital. Diagnosed MDD patients consenting to participate in the study, & sex matched controls, comprising of close family members of patients were selected. Detailed assessment of depression symptomatology was done. Assessment of somatization was done using Bradford Somatic Inventory. Blood samples were collected for routine tests and Vitamin D (total) estimation. Results: In the group of MDD patients, the mean age of females is 52 years, & mean age of males is 50 years. In the MDD group, the mean Vitamin D level is 17.12; in the control group, the mean Vitamin D level is 22.19. The difference is statistically significant. Among MDD patients, 70% had deficiency of Vitamin D. In the Severe somatic symptom category, 68.3% had deficiency of Vitamin D; in the Mild somatic symptom category, 66.7% had deficiency of Vitamin D. The difference is not statistically significant. Conclusion: Depression patients have significantly higher proportion of Vitamin D deficiency cases. Depressed patients with higher number of somatic symptoms have lower vitamin D level, but the difference is not significant.

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