Treatment of mild to moderate major depressive disorder with agomelatine in patients with cardiovascular disorders (national observational multicenter study “pulse”)

2016 ◽  
Vol 33 (S1) ◽  
pp. S417-S418 ◽  
Author(s):  
V. Medvedev
Keyword(s):  
Depressive Disorders ◽  
Depression Scale ◽  
Subjective Assessment ◽  
Life Questionnaire ◽  
Physical And Mental Health ◽  
Conduction Disturbances ◽  
Treatment Of Depression ◽  
Sf 36 ◽  
Patient Health ◽  
Competing Interest

IntroductionThe urgency of depression treatment in patients with cardiovascular diseases (CVD) is determined by the increasing prevalence of affective disorders. For these patients, tolerance and safety of antidepressants are of great importance.ObjectiveTo obtain additional data on therapeutic efficacy and tolerance of agomelatine in the treatment of mild to moderate depressive disorders in cardiologic practice in Russia.MethodsEight hundred and ninety-six adult patients with CVD (86.5% arterial hypertension, 29.5% stable angina, 16% myocardial infarction, 23.6% conduction disturbances, 17.6% chronic heartfailure) were treated with agomelatine 25-50 mg for 12 weeks. Depression and anxiety symptoms were evaluated via Hospital Anxiety and Depression Scale (HADS), Clinical Global Impression (CGI-S and CGI-I), Visual Analog Scale (VAS), Spielberger Anxiety Scale (SAS), Whitely Hypochondria Index (WHI) and quality of life questionnaire (SF-36). Safety and tolerance were also monitored according to the summary of product characteristics recommendations.ResultsHADS scores decreased throughout the study and severe anxiety rate decreased from 95.9% to 15%. After 12 weeks of treatment, remission (HADS < 7) rate was 84.6%. Subjective assessment of patient health significantly improved (P < 0.00001). WHI decreased significantly (P < 0.00001). Physical and mental health significantly improved (P < 0.00001). Heart rate and blood pressure decreased. Treatment acceptability was considered “excellent” by 82% of doctors and 75% of patients.ConclusionAgomelatine significantly improved depressive symptoms, anxiety and hypochondria in depressed patients with CVD and demonstrated good tolerance. This suggests the possibility of wide and safe use of agomelatine for treatment of depression in patients with CVD.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Abstract 30: Role For Adverse Childhood Experiences And Depression In Preeclampsia

Hypertension ◽  
2021 ◽  
Vol 78 (Suppl_1) ◽  
Author(s):  
Monica C Myers ◽  
Mark K Santillan ◽  
Debra S Brandt ◽  
Amy K Stroud ◽  
Julie A Vignato ◽  
...  
Keyword(s):  
Postpartum Depression ◽  
Adverse Childhood Experiences ◽  
Depression Scale ◽  
Severe Depression ◽  
Late Pregnancy ◽  
Physical And Mental Health ◽  
Childhood Experiences ◽  
Adverse Experiences ◽  
Adverse Childhood ◽  
Patient Health

Hypertensive diseases are associated with adverse experiences in childhood as well as depression. In order to determine if these associations were present in women with preeclampsia (PreE), a particularly devastating hypertensive disease in pregnancy, the scores from three questionnaires: Adverse Childhood Experiences (ACE), Edinburgh Postnatal Depression Scale (EPDS), and the Patient Health Questionnaire-9 (PHQ-9) were compared between women with PreE (n=32) and women without PreE (n=46) between 9 and 48 months postpartum (IRB# 201808705). ACE scores are calculated by summing an individual’s affirmative responses to specific adverse experiences during childhood. In our study, the average ACE score of individuals with PreE was higher than that of women without PreE (1.69 vs. 1.02, P=.04). We also divided women into groups based on whether their ACE score was ≤3 or ≥4 due to evidence that individuals who have experienced ≥4 ACEs are at greatest risk for physical and mental health conditions. Among our participants, 80% of women with an ACE score ≥4 (n=10) had PreE while only 35.3% of women with a score ≤3 (n=68) developed the condition (P=0.01). As well, the odds of having PreE were higher in those with ACE scores ≥4, compared with those with scores ≤3 (OR= 7.34; 95% CI = 1.44, 37.33). In a subset of participants, scores were available from EPDS, survey that identifies women who have postpartum depression 6 weeks after birth, and from the PHQ-9, another assessment for depression. Among our participants, the average EPDS score was higher in women with PreE than women without PreE (6.38, n=21 vs. 3.71, n=42 P=0.01), indicating more severe symptoms of postpartum depression in women who also had PreE. In addition, the average PHQ-9 score among women with PreE was higher than that of women without PreE (3.71, n=15 vs 1.86, n=37 P=.02) with a higher score indicating more severe depression. The average PHQ-9 score was also higher in women who had ACE scores ≥4 than women with scores ≤3 (4.00, n=4 vs. 2.27, n=48 P=.01) indicating that women with more adverse childhood events were more likely to experience depression. Together, these findings indicate that PreE may be associated with adverse events during childhood as well as depression in late pregnancy and/or postpartum.

Utilization of psychotropic drugs in Europe: Why is Portugal such a particular case?

2016 ◽  
Vol 33 (S1) ◽  
pp. s225-s226
Author(s):  
T. Alves-dos-Reis ◽  
M.A. Matias
Keyword(s):  
Mental Health ◽  
Comparative Analysis ◽  
Psychotropic Drugs ◽  
Depressive Disorders ◽  
European Countries ◽  
World Health ◽  
Sf 36 ◽  
Competing Interest ◽  
Relationship Of ◽  
The Relationship

IntroductionPsychotropic drugs are among the most utilized medications in Europe.ObjectivesTo perform an international comparison of the utilization trends of antidepressants, anxiolytics, hypnotics and sedatives (AHS).MethodsWe used data from the Organization for Economic Cooperation and Development (OECD). We used the World Health Organization's Defined Daily Dosage (DDD) per 1000 inhabitants per day (DHD) methodology. We performed a general comparison between 14 European countries and a more detailed comparative analysis between Portugal, Italy, Spain and Germany. These countries were selected according to the following criteria: similar 12-month prevalence of mental health disorders, similar results for negative mental health (SF-36 questionnaire) and similar standardized death rates for suicide.ResultsPortugal had the highest overall utilization of antidepressants and AHS in 2011, amounting to 110.7 DHD, and the highest increase in utilization of AHS (1.8%) from 2003 and 2011. Concerning antidepressants, Portugal had the third highest utilization of these drugs in 2011 (78.3 DHD). Regarding the more detailed comparative analysis, utilization of AHS was still significantly higher in Portugal. Considering antidepressants, Portugal experienced an increasing utilization, which grew by approximately 11.4% from 2003 and 2008. From 2009 onward the utilization increased but at a slower pace.ConclusionThe very high utilization of these drugs, especially of AHS, is a worrying fact since this might indicate an inadequate treatment choice for anxiety and depressive disorders. Further research is needed to better understand the relationship of these findings with regulations concerning utilization of psychotropic drugs and compliance with best medical practices between distinct European countries.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Postpartum depression and the scarcity of generalizable evidence: A mini-review of existing literature and the way forward

2021 ◽  
Vol 11 (2) ◽  
pp. 81-84
Author(s):  
Fidelis E Uwumiro ◽  
Victory O Okpujie ◽  
Kingsley O Anokwuru
Keyword(s):  
Postpartum Depression ◽  
Mental Health Professionals ◽  
Depressive Disorders ◽  
Early Recognition ◽  
Depression Scale ◽  
Diagnostic Tools ◽  
Diagnostic And Statistical Manual ◽  
The Bible ◽  
Patient Health ◽  
Distinct Disease

The first known reference to Postpartum Depression (PPD), was Hippocrates’ 4th century hypothesis that drainage of lochia, if suppressed, could flow to the brain resulting in agitation, delirium, and episodes of mania. This hypothesis became dogma and lasted over a millennium. Over the years, knowledge of PPD has evolved but researchers still struggle to establish it as a distinct disease entity. It was initially recognized as Major Depressive Disorder (MDD) with postpartum onset in the 1994 revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), the “bible” of diagnostic criteria for mental health professionals and researchers. It is currently recognized as MDD with peripartum onset (DSM-V) and researchers have admitted that persuasive evidence to indicate that postpartum depression is distinct from other existing depressive disorders, has not been found. Several diagnostic tools such as the Edinburg Postpartum Depression Scale (EDPS), the Beck Depression Inventory (BDI-II), Patient Health Questionnaire (PHQ-9), and the Postpartum Depression Screening Scale (PDSS) are available for use but none of these is universally accepted. With much of the published literature plagued with bias and structural inconsistencies, the credibility of the evidence has been greatly diminished. The difficulty with disease designation, the absence of a universally accepted tool for diagnosis and the scarcity of generalizable evidence on the subject has impaired the early recognition and effective management of PPD. It is therefore expedient, to critically appraise some of the available literature and proffer solutions to navigating this conundrum.

scholarly journals Post-Surgical Quality of Life, Psychological State and what Patients Think about the Effectiveness of Heller Myotomy in the Treatment of Achalasia

2016 ◽  
Vol 29 (2) ◽  
pp. 107 ◽  
Author(s):  
Telma Vale-Fonseca ◽  
Luis Ferreira-Pinto ◽  
Margarida Figueiredo-Braga ◽  
Silvestre Carneiro
Keyword(s):  
Quality Of Life ◽  
Heller Myotomy ◽  
Pearson Correlation ◽  
Depression Scale ◽  
Laparoscopic Heller Myotomy ◽  
Psychological State ◽  
Life Questionnaire ◽  
Emotional States ◽  
Sf 36

<p><strong>Introduction:</strong> The disruption of esophageal motility that characterizes achalasia typically provokes dysphagia, pain, loss of weight and malnutrition. Therefore, patients frequently report a reduction in quality of life and negative emotional states. Laparoscopic Heller myotomy proved to be an effective therapy, enabling the resumption of good quality of life.<br /><strong>Material and Methods:</strong> The authors studied 45 patients previously submitted to laparoscopic Heller myotomy. Postoperative evaluation was performed using a customized version of the achalasia disease-specific quality of life questionnaire. Quality of life and the presence of depressive and anxiety symptoms were assessed using the Portuguese versions of the Medical Outcomes Study SF-36 and the Hospital Anxiety and Depression Scale.<br /><strong>Results:</strong> Thirty-one patients responded to the survey. Dysphagia was the main clinical symptom before surgery. A clear improvement in dysphagia, regurgitation, pain and weight loss was found after surgery (<em>p</em> &lt; 0.001). The Mental Health domain of SF-36 presented a Pearson correlation coefficient of -0.689 with HADS-D and of -0.557 with HADS-A (<em>p</em> &lt; 0.001 and <em>p</em> = 0.002, respectively).<br /><strong>Conclusion:</strong> This study demonstrates that the Heller myotomy is associated with a good quality of life in patients with achalasia and strengthens the evidence that this is a safe and reliable procedure.</p>

scholarly journals Factors Differentiating Rural and Urban Population in Determining Anxiety and Depression in Patients with Chronic Cardiovascular Disease: A Pilot Study

2021 ◽  
Vol 18 (6) ◽  
pp. 3231
Author(s):  
Elżbieta Szlenk-Czyczerska ◽  
Marika Guzek ◽  
Dorota Emilia Bielska ◽  
Anna Ławnik ◽  
Piotr Polański ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cardiovascular Disease ◽  
Depressive Disorders ◽  
Depression Scale ◽  
Rank Correlation ◽  
Cross Sectional Study ◽  
Anxiety And Depression ◽  
Life Questionnaire ◽  
Cross Sectional

The aim of this cross-sectional study was to analyze selected variables differentiating rural from urban populations, as well as identify potentially increased levels of depression and anxiety in patients with chronic cardiovascular disease. The study was carried out in 193 patients. The study used the Camberwell Assessment of Need Short Appraisal Schedule (CANSAS), the Health Behavior Inventory Questionnaire (HBI), the WHOQOL-BREF Quality of Life Questionnaire, and the Hospital Anxiety and Depression Scale–Modified Version (HADS-M). Spearman’s rank correlation coefficient test and logistic regression were used for analyses. In rural patients, we observed a relationship between anxiety and age (1/OR = 1.04; 95% CI: 0.91–0.99), the assessment of satisfied needs (1/OR = 293.86; 95% CI: 0.00001–0.56), and quality of life (QoL) in physical (OR = 1.56; 95% CI: 1.11–2.33), social (1/OR = 1.53; 95% CI: 0.04–0.94), and environmental domains (OR = 1.67; 95% CI: 1.06–3.00), as well as between depression and QoL in physical (1/OR = 1.39; 95% CI: 0.50–0.97) and psychological (OR = 1.37; 95% CI: 1.01–1.93) domains. In city patients, we observed a relationship between the drug and Qol in the physical (1/OR = 1.25; 95% CI: 0.62–0.98) and psychological (OR = 1.49; 95% CI: 1.13) domains. Younger patients living in a rural area with a lower assessment of met needs, a higher level of QoL in physical and environmental domains, and a lower social domain, as well as patients living in a city with a lower QoL in the physical domain and a higher psychological domain, have a greater chance of developing anxiety and depressive disorders.

Frequency of depressive disorders in a representative sample of Nicosia, Cyprus

2017 ◽  
Vol 41 (S1) ◽  
pp. S536-S537
Author(s):  
I. Papapetrou ◽  
G. Charalambous ◽  
A. Sissouras ◽  
E. Jelastopulu
Keyword(s):  
Chronic Diseases ◽  
Depressive Disorders ◽  
Family Income ◽  
Cross Sectional Study ◽  
Medical Attention ◽  
Anxiety And Depression ◽  
Physical And Mental Health ◽  
Cross Sectional ◽  
Negative Effect ◽  
Competing Interest

Introduction“Health Profile” of Nicosia was conducted in 2013–2014, within the framework of the program “Healthy Cities” in order to collect and analyse information on the state of health and health-related behaviors of the citizens of Nicosia in Cyprus.AimsTo estimate the frequency of self-reported depressive disorders and examine burdening as well as factors influencing it.MethodsBased on the 2011 census, a cross-sectional study was carried out on a representative random stratified sample, which was selected to be interviewed, including 477 men and 525 women, from the city area. Participants answered a questionnaire, which required among other items on self-perceived physical and mental health. Participants were also asked the following questions: “Do you have/had in the past depression or/and anxiety?” and “Have you received a medical diagnosis for this disorder?”ResultsApproximately 70% of the sample reported they had experienced anxiety and depression (37% moderate and 33% severe episodes). Diagnosed depression was reported by 4%. Severe depressive disorders were more frequently reported by women (41%, P < 0.001), older aged citizens (70.2%, P < 0.001) widowed/divorced (45.5%, P < 0.001), persons with lower family income (< 1000 €, 79.7%, P < 0.001) and among people with chronic diseases (45.3%, P < 0.001).ConclusionsThe self-reported prevalence of anxiety and depression in the citizens of Nicosia is very high – probably reflecting a negative effect of the economic crisis –, and contrariwise diagnosis of the disorder is rarely provided and consequently therapy rarely offered. Specific population groups, such as women, elderly citizens, patients with chronic diseases are more vulnerable to depressive disorders requiring specialized medical attention.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Updated norms of the MOS-SF36 in the young French population

2021 ◽  
Author(s):  
Arthur Trognon ◽  
Emilie Tinti ◽  
Blandine Beaupain ◽  
Jean Donadieu ◽  
Michel Musiol
Keyword(s):  
Quality Of Life ◽  
French Language ◽  
Life Questionnaire ◽  
French Population ◽  
Young Population ◽  
Physical And Mental Health ◽  
Sf 36 ◽  
French People ◽  
Generic Quality

Abstract Background The SF-36 is a generic quality of life questionnaire, massively translated and widely used to obtain physical and mental health status. However, validation work in the French language was carried out over a generation ago. The objective of this study was to obtain the norms of the SF-36 in the French young population. Method The sample consisted of 1134 non-pre-screened French people aged between 18 and 39 years. Results The internal consistencies of the scales were high and the metrics associated with the factor structure were satisfactory. In general, women presented significantly higher scores than men. Conclusion Our results suggest that the SF-36 remains a reliable tool for studying quality of life in the young French population.

Post-partum depression risk factors in pregnant women

2016 ◽  
Vol 33 (S1) ◽  
pp. s279-s280
Author(s):  
A. Ugarte ◽  
P. López ◽  
C. Serrulla ◽  
M.T. Zabalza ◽  
J.G. Torregaray ◽  
...  
Keyword(s):  
Risk Factors ◽  
Depressive Symptoms ◽  
Postpartum Depression ◽  
Depressive Disorders ◽  
Post Partum ◽  
Depression Scale ◽  
Personal History ◽  
Assisted Reproductive Technique ◽  
History Of ◽  
Competing Interest

IntroductionPostpartum depression has a prevalence of 15% and has consequences for mother and baby (delayed physical, social and cognitive development). It's essential to prevent the illness with an early identification of Risk Factors (RF).MethodsFive hundred and seventy-two women in 3rd trimester of pregnancy were evaluated and selected those with ≥ 1 RF (n = 290). We re-evaluated in the postpartum with Edinburgh Depression Scale and selected those with subsyndromal depressive symptoms (≥ 7.5) (n = 57). Clinical, demographic and functional data were collected.ResultsA total of 50.7% had RF. A percentage of 48.6 had family history of mental illness (MI), 34.1%had personal history of (MI) and 34.1% had some pregnancy associated illness. Twenty percent had needed some assisted reproductive technique, 14.1% had little family support and 15.2% had little couple support, 3.8% showed anxiety-depressive disorders during pregnancy, 19.7% had depressive symptoms after delivery. The mean age was 33.67. No significant differences between patients with and without RF (T-1858, P 0.064). Among women with RF, 59.6% were married, 35.1% single and 3.0% had other situation. 89.5% live with their own family, 8.8% with their family of origin, 1.8% alone. 50.8% had university studies.ConclusionsAssessing RF during pregnancy can help these women, since we see that the 19.7% will have serious risk of developing postpartum depression. The RF to take more into account are not those related to social-academic development, neither the presence of anxiety-depressive symptoms during pregnancy, but the family or personal history of (MI) and the presence of a pregnancy associated illness. Early detection and treatment may prevent the development of this disease improving the quality of life of mother and babies’ development.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Peripheral sub-inflammation is associated with antidepressant consumption in schizophrenia. Results from the multi-center FACE-SZ dataset

2016 ◽  
Vol 33 (S1) ◽  
pp. S98-S98
Author(s):  
G. Fond ◽  
O. Godin ◽  
P.M. Llorca ◽  
M. Leboyer
Keyword(s):  
Depressive Disorders ◽  
Age Of Onset ◽  
Antidepressant Treatment ◽  
Univariate Analysis ◽  
Depression Scale ◽  
High Sensitivity ◽  
Community Dwelling ◽  
High Rate ◽  
Competing Interest ◽  
Hs Crp

ObjectivesThe relation between C-reactive protein (CRP), depression and antidepressant consumption has been well explored in major depressive disorders but not in schizophrenia, which has a high rate of depression comorbidity. The objectives of this study were:– to determine the prevalence of abnormal CRP levels, depression and antidepressant consumption in a multi-center community-dwelling sample of subjects with schizophrenia;– to determine the association between abnormal CRP levels, depression and antidepressant consumption in schizophrenia.MethodTwo hundred and nineteen stable patients with schizophrenia (mean age = 31.6 years, 75.3% male gender) were systematically included in the multicentre network of FondaMental Expert Center for schizophrenia (FACE-SZ) and assessed with Calgary Depression Scale for depression. High sensitivity CRP (hs-CRP) was measured with an assay using nephelometry (Dade Behring). Abnormal CRP level was defined by levels > 3 mg/L. Current medication was recorded.ResultsOverall, 63 subjects (28.8%) were found to have abnormal CRP levels, 43 (20.1%) received a diagnosis of comorbid current depression, and 51 (31.9%) had ongoing antidepressant treatment. In univariate analysis, abnormal CRP levels were found to be significantly associated with metabolic syndrome (P = 0.0011) and with antidepressant consumption (P = 0.01), while depression, psychotic symptomatology, age of onset, illness duration, sociodemographic characteristics, current tobacco or cannabis status were not (all P > 0.05).In a multivariate model, abnormal CRP was highly associated with antidepressant consumption independently of other confounding variables (adjusted odd ratio = 2.9, 95% confidence interval 1.2–6.8).ConclusionAbnormal CRP levels in schizophrenia were found to be associated with antidepressant consumption, but not with depression.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Implications of Non-Response of Older Women to a Short form of the Center for Epidemiologic Studies Depression Scale

2003 ◽  
Vol 57 (1) ◽  
pp. 37-54 ◽  
Author(s):  
Jennifer R. Powers ◽  
Anne F. Young ◽  
Anne Russell ◽  
Nancy A. Pachana
Keyword(s):  
Short Form ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Future Research ◽  
Physical And Mental Health ◽  
Medical Outcomes ◽  
Epidemiological Surveys ◽  
Sf 36 ◽  
Depression Scales ◽  
Short Form Health

The Center for Epidemiologic Studies Depression Scale (CES-D) is frequently used in epidemiological surveys to screen for depression, especially among older adults. This article addresses the problem of non-completion of a short form of the CES-D (CESD-10) in a mailed survey of 73- to 78-year-old women enrolled in the Australian Longitudinal Study on Women's Health. Completers of the CESD-10 had more education, found it easier to manage on available income and reported better physical and mental health. The Medical Outcomes Study Short Form Health Survey (SF-36) scores for non-completers were intermediate between those for women classified as depressed and not depressed using the CESD-10. Indicators of depression had an inverted U-shaped relationship with the number of missing CESD-10 items and were most frequent for women with two to seven items missing. Future research should pay particular attention to the level of missing data in depression scales and report its potential impact on estimates of depression.

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